Gianluigi Franci

@unisa.it

Dipartimento di Medicina, Chirurgia e Odontoiatria “Scuola Medica Salernitana”/DIPMED
Università degli Studi di Salerno

Gianluigi Franci


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https://researchid.co/gfranci
201

Scopus Publications

Scopus Publications

  • Epidemiology and antimicrobial resistance patterns of Aeromonas species in Europe, 2020-2024 (AEuROMONAS)
    Matteo Boattini, Paulo Bastos, Konstantina Gartzonika, Eirini Christaki, Viktoria Eirini Mavromanolaki, et al.
    Diagnostic Microbiology and Infectious Disease, 2026
  • Targeting Staphylococcus aureus with potent de novo-designed proline-core short antimicrobial lipopeptides
    Antonia D'Aniello, Veronica Folliero, Roberto Bello-Madruga, Vincenzo Mazzarella, Alessandra Del Bene, et al.
    European Journal of Medicinal Chemistry, 2026
  • Driving HCV Elimination Through Dedicated Hospital-Based Teams and Pathways: A Retrospective and Prospective Study
    Pietro Torre, Enrica Serretiello, Giuseppe Di Siervi, Emilia Vaccaro, Tommaso Sarcina, et al.
    Liver International, 2026
  • Minor non-fermenting Gram-negative bacilli in Europe, 2020–2024 (MINOFEu)
    Gabriele Bianco, Paulo Bastos, Konstantina Gartzonika, Eirini Christaki, Viktoria Eirini Mavromanolaki, et al.
    International Journal of Antimicrobial Agents, 2026
  • Micro- and Nanoplastics as Disruptors of Digestive and Hepatopancreatic Homeostasis: Insights into the Plastic-Gut-Liver Axis
    Nicoletta Capuano, Martina Lombardi, Noemi Cafà, Marianna Marino, Flora Salzano, et al.
    International Journal of Molecular Sciences, 2026
    Micro- and nanoplastics (MPs/NPs) have emerged as pervasive environmental contaminants with increasing implications for human health, particularly within the digestive system. This review critically examines the role of MPs/NPs as disruptors of gastrointestinal and liver homeostasis through the lens of the plastic–gut–liver axis. We synthesize current evidence on primary exposure routes—including ingestion, inhalation, dermal contact, and transplacental transfer—and highlight their intestinal uptake, systemic dissemination, and tissue accumulation. Mechanistically, MPs/NPs compromise intestinal barrier integrity, promote oxidative stress, and induce microbiota dysbiosis, facilitating the translocation of microbial-derived signals to the liver via the portal circulation. This process triggers inflammatory signaling cascades, metabolic reprogramming, and immune dysregulation, contributing to hepatic steatosis, insulin resistance, and potential carcinogenic processes. Emerging evidence also implicates pancreatic dysfunction and β-cell stress within a broader gut–liver axis context. We further discuss the systemic propagation of MPs/NPs-induced dysbiosis along multi-organ axes, including gut–lung and gut–brain interactions. Despite robust preclinical data, human evidence remains limited due to methodological heterogeneity and the lack of standardized biomarkers. This review underscores critical knowledge gaps and emphasizes the need for integrative, translational approaches to clarify long-term health risks and inform regulatory strategies within the environmental exposome framework.
  • Effect of dynamics and timing of SARS-CoV-2 vaccination on immune response in people with multiple sclerosis during cladribine treatment
    Claudia Russo, Clorinda Fusco, Fortunata Carbone, Teresa Micillo, Claudia La Rocca, et al.
    Clinical Immunology, 2026
  • Applications, Training Requirements, and Challenges in the Implementation of Ultrasonography in Nursing Practice: A Scoping Review
    Vincenzo Andretta, Carloluigi Bonetti, Ivan Rubbi, Biagio Santella, Rosanna Sorrentino, et al.
    Journal for Vascular Ultrasound, 2026
    Introduction: The use of ultrasound in nursing practice is constantly expanding with applications in numerous clinical settings, for supporting diagnostic assessments, procedural guidance, monitoring, and verification of device placement. However, the patterns of employment, the skills required, and the impact on care outcomes are heterogeneous. Objective: To map the clinical applications, outcomes, training requirements, and main barriers and facilitators to the implementation of nurse-performed ultrasound in different health care settings. Methods: A scoping review was conducted according to the Arksey and O’Malley framework, integrated with the Joanna Briggs Institute indications, and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. The research was conducted in PubMed, Scopus, Web of Science, and Google Scholar without time limits. Studies describing the use of ultrasound by nurses in any clinical setting were included. The data were extracted using a standardized form and narratively synthesized into thematic domains. Results: Twelve studies met the inclusion criteria, including randomized trials, observational, qualitative studies, and reviews. Ultrasonography was used for (1) diagnostic evaluations, including abdominal aorta, bladder volume, and lung; (2) procedural guidance, mainly for peripheral venous access and catheter tip localization; (3) clinical monitoring, such as hemodynamic evaluation and enteral feeding management; (4) verification of device placement. Studies reported improvements in first-time success, suggested fewer procedural complications, increased diagnostic accuracy, and increased patient satisfaction. Among the barriers are insufficient training, limited availability of devices, and cultural resistance. Facilitators include structured training programs, institutional support, and shared protocols. Conclusions: Ultrasound used by nurses shows a reported clinical impact, improving safety, accuracy, and continuity of care. Wider adoptability requires standardized training, access to technologies, and integration into interprofessional paths. Future studies should evaluate long-term outcomes and applications in territorial and home settings.
  • Correction: Optimizing Textile Disinfection in Hospital-Associated Infections Using Gaseous Ozone (Pathogens, (2025), 14, 10, (977), 10.3390/pathogens14100977)
    Francesco De Caro, Federica Dell’Annunziata, Oriana Motta, Nicoletta Capuano, Antonio Faggiano, et al.
    Pathogens, 2026
    In the original publication [...]
  • Emerging Therapeutic Approaches for Modulating the Intestinal Microbiota
    Ilaria Cosimato, Annalisa Brescia, Gianluigi Franci, Vincenzo Casolaro, Veronica Folliero
    Pharmaceutics, 2026
    Background/Objectives: The gut microbiota is increasingly recognized as a key determinant of human health, playing a vital role in metabolism, immunity, and disease susceptibility. Dysbiosis, or microbial imbalance, is associated with gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and Clostridioides difficile infection (CDI), as well as extraintestinal conditions, including obesity, cardiovascular disease, and neuropsychiatric disorders. This review aims to provide an updated overview of emerging therapeutic strategies to modulate the gut microbiota to restore eubiosis and improve health outcomes. Methods: A narrative review of recent literature was conducted, focusing on preclinical and clinical studies investigating microbiota-targeted therapies. The review primarily covers innovative interventional approaches, including fecal microbiota transplantation (FMT), bacterial consortium transplantation (BCT), bacteriophage therapy and outer membrane vesicles (OMVs). Results: Evidence supports the role of probiotics, prebiotics, and synbiotics in remodeling microbial communities and improving host health, although their effects may be strain- and context-dependent. FMT has demonstrated high efficacy in the treatment of recurrent Clostridium difficile infections and is being studied for IBD, IBS and extraintestinal diseases, following the recent Food and Drug Administration approval of the first commercial FMT products. BCT offers a standardized alternative to donor-derived material, with early clinical successes such as FDA-approved SER-109. Phage therapy and OMVs represent promising frontiers, offering targeted microbial modulation and interactions with the immune system, although clinical data remain limited. Conclusions: Emerging gut microbiota modulation strategies offer new perspectives for precision medicine and could transform the prevention and treatment of many diseases, but further studies are needed to ensure their safety, standardization, and clinical application.
  • Linking Cancer Pain Features and Biosignals for Automatic Pain Assessment
    Marco Cascella, Francesco Perri, Alessandro Ottaiano, Mariachiara Santorsola, Maria Luisa Marciano, et al.
    Cancers, 2026
    Background: Pain remains one of the most debilitating and prevalent symptoms in cancer patients. However, assessment based solely on subjective self-report tools is limited by cognitive impairment and the heterogeneous nature of cancer pain. Since evidence on the ability of physiological biosignals to discriminate cancer pain intensity and pain phenotypes in real clinical settings remains limited, this study explored the potential of biosignals to discriminate between pain intensity and pain type. Methods: Electrodermal activity (EDA) and electrocardiogram (ECG) signals were recorded in cancer patients using the BITalino (r)evolution board (sampling frequency 1000 Hz). EDA was processed to extract skin conductance responses (SCRs) using continuous decomposition analysis (CDA) and trough-to-peak (TTP) methods. Heart rate variability (HRV) features were extracted in both time and frequency domains, including low frequency (LF), high frequency (HF), and the LF/HF ratio. Non-parametric Kruskal–Wallis tests were performed to compare biosignal parameters across pain intensity (Numeric Rating Scale, NRS: low 1–3; medium 4–6; and high 7–10) and pain types (nociceptive, neuropathic, mixed, and breakthrough cancer pain—BTCP). Results: Data from 61 patients were analyzed. For EDA, the maximum skin conductance response amplitude (MaxCDA) significantly differed across intensity groups (p = 0.037). Post hoc analysis showed a significant difference between the low- and high-intensity groups (p = 0.015), with the low-intensity group exhibiting a higher mean MaxCDA (0.063 µS) than the high-intensity group (0.024 µS). Several EDA parameters were significantly associated with pain type. The number of SCRs (TTP) (p = 0.015) and maximum SCR amplitude (TTP) (p = 0.040) were significantly lower in the mixed pain group compared with the nociceptive and neuropathic groups. No HRV parameters showed significant associations with pain intensity or pain type. BTCP did not significantly affect any biosignal parameters. Subgroup analyses showed that EDA features discriminating mixed pain were preserved in patients without bone metastases, BTCP, or high opioid burden, whereas no clinical variable modified the association between biosignals and pain intensity and type. Conclusions: In this investigation, selected EDA parameters were associated with cancer pain intensity and pain type, whereas heart rate variability measures did not show significant discrimination under the present methodological conditions. These findings suggest that EDA may provide complementary information on pain-related autonomic alterations in oncology patients. However, biosignals should not be considered standalone indicators of pain, and their interpretation requires integration with clinical variables and pharmacological context. Further studies adopting multimodal and longitudinal approaches are needed to clarify their role in automatic pain assessment in cancer care.
  • Nine-Year Surveillance of Candida Bloodstream Infections in a Southern Italian Tertiary Hospital: Species Distribution, Antifungal Resistance, and Stewardship Implications
    Anna Maria Spera, Veronica Folliero, Chiara D’Amore, Biagio Santella, Flora Salzano, et al.
    Journal of Personalized Medicine, 2026
  • Boosting photocatalytic and antibacterial properties through Schottky heterojunction of N-TiO2/Ag reverse composite under visible light
    Flora Salzano, Nicola Morante, Gianluca Viscusi, Katia Monzillo, Martina D'Alessandro, et al.
    Journal of Water Process Engineering, 2026
  • Feasibility Assessment of Telehealth-Based Cancer Pain Management Through Machine Learning: A Prospective Clinical Study
    Sergio Coluccia, Anna Crispo, Alessandro Ottaiano, Mariachiara Santorsola, Massimo A. Innamorato, et al.
    Pain Research and Management, 2026
  • The Role of the Family and Community Nurse in Improving Quality of Life and Optimizing Home Care Post-COVID: A Systematic Review with Meta-Analysis
    Angelo Cianciulli, Emanuela Santoro, Nicole Bruno, Savino Quagliarella, Salvatore Esposito, et al.
    Nursing Reports, 2025
  • A Nine-Year Review of Acinetobacter baumannii Infections Frequency and Antimicrobial Resistance in a Single-Center Study in Salerno, Italy
    Enrica Serretiello, Mariagrazia De Prisco, Giuseppe Di Siervi, Ilaria Cosimato, Federica Dell’Annunziata, et al.
    Pathogens, 2025
  • Clean to Prevent, Monitor to Protect: A Scoping Review on Strategies for Monitoring Cleaning in Hospitals to Prevent HAIs
    Biagio Santella, Antonio Donato, Luigi Fortino, Vittoria Satriani, Rosaria Flora Ferrara, et al.
    Infectious Disease Reports, 2025
  • Optimizing Textile Disinfection in Hospital-Associated Infections Using Gaseous Ozone
    Francesco De Caro, Federica Dell’Annunziata, Oriana Motta, Nicoletta Capuano, Antonio Faggiano, et al.
    Pathogens, 2025
  • Micro- and Nanoplastics and the Oral Cavity: Implications for Oral and Systemic Health, Dental Practice, and the Environment—A Narrative Review
    Federica Di Spirito, Veronica Folliero, Maria Pia Di Palo, Giuseppina De Benedetto, Leonardo Aulisio, et al.
    Journal of Functional Biomaterials, 2025
  • Modulation of Gut Bacterial and Fungal Microbiota in Fibromyalgia Patients Following a Carb-Free Oloproteic Diet: Evidence for Candida Suppression and Symptom Improvement
    Giuseppe Castaldo, Maria D’Elia, Mariagrazia De Prisco, Veronica Folliero, Carmen Marino, et al.
    Microorganisms, 2025
  • Adaptations of Bacterial Extracellular Vesicles in Response to Antibiotic Pressure
    Dell’Annunziata Federica, Ilaria Cosimato, Flora Salzano, Francesca Mensitieri, Vincenzo Andretta, et al.
    International Journal of Molecular Sciences, 2025
  • Validation of a Questionnaire on the Post-COVID-19 Condition (Long COVID): A Cross-Sectional Study in Italy
    Angelo Cianciulli, Emanuela Santoro, Roberta Manente, Antonietta Pacifico, Gianni Comunale, et al.
    Infectious Disease Reports, 2025
  • The Impact of the S-Adenosylmethionine Analogue Sinefungin on Viral Life Cycles
    Federica Dell’Annunziata, Nicoletta Capuano, Mariagrazia De Prisco, Sandra Rufolo, Veronica Folliero, et al.
    Applied Sciences Switzerland, 2025
  • Silver Nanoparticle-Mediated Antiviral Efficacy against Enveloped Viruses: A Comprehensive Review
    Ekaterine Mosidze, Gianluigi Franci, Federica Dell'Annunziata, Nicoletta Capuano, Marica Colella, et al.
    Global Challenges, 2025
  • Impact of COVID-19 Pandemic on Consumption of Anxiolytics, Antipsychotics, and Antidepressants in South Italian Region
    Vittoria Satriani, Emanuela Santoro, Mario Capunzo, Rosaria Flora Ferrara, Roberta Manente, et al.
    Life, 2025
  • Periodontal Status and Herpesiviridae, Bacteria, and Fungi in Gingivitis and Periodontitis of Systemically Compromised Pediatric Subjects: A Systematic Review
    Federica Di Spirito, Massimo Pisano, Maria Pia Di Palo, Giuseppina De Benedetto, Iman Rizki, et al.
    Children, 2025