Giuseppa Mudò

Scopus Publications

The remarkable impact of Opuntia Ficus Indica fruit administration on metabolic syndrome: Correlations between cognitive functions, oxidative stress and lipid dysmetabolism in the high-fat, diet-fed rat model
Danila Di Majo, Nicolò Ricciardi, Valentina Di Liberto, Mario Allegra, Monica Frinchi, et al.
Biomedicine and Pharmacotherapy, 2024
The stunting effect of an oxylipins-containing macroalgae extract on sea urchin reproduction and neuroblastoma cells viability
Chiara Martino, Rosario Badalamenti, Monica Frinchi, Roberto Chiarelli, Antonio Palumbo Piccionello, et al.
Chemosphere, 2024
An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons
Annela Avarlaid, Kaisa Falkenberg, Karin Lehe, Giuseppa Mudò, Natale Belluardo, et al.
Journal of Biological Chemistry, 2024
Anti-Apoptotic and Anti-Inflammatory Properties of Grapefruit IntegroPectin on Human Microglial HMC3 Cell Line
Miriana Scordino, Giulia Urone, Monica Frinchi, Chiara Valenza, Angela Bonura, et al.
Cells, 2024
In this study, we investigated the beneficial effects of grapefruit IntegroPectin, derived from industrial waste grapefruit peels via hydrodynamic cavitation, on microglia cells exposed to oxidative stress conditions. Grapefruit IntegroPectin fully counteracted cell death and the apoptotic process induced by cell exposure to tert-butyl hydroperoxide (TBH), a powerful hydroperoxide. The protective effects of the grapefruit IntegroPectin were accompanied with a decrease in the amount of ROS, and were strictly dependent on the activation of the phosphoinositide 3-kinase (PI3K)/Akt cascade. Finally, IntegroPectin treatment inhibited the neuroinflammatory response and the basal microglia activation by down-regulating the PI3K- nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB)- inducible nitric oxide synthase (iNOS) cascade. These data strongly support further investigations aimed at exploring IntegroPectin’s therapeutic role in in vivo models of neurodegenerative disorders, characterized by a combination of chronic neurodegeneration, oxidative stress and neuroinflammation.
CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease
Miriana Scordino, Polina Stepanova, Vignesh Srinivasan, Dan Duc Pham, Ove Eriksson, et al.
Frontiers in Molecular Neuroscience, 2024
Canopy Homolog 2 (CNPY2) is an endoplasmic reticulum (ER) localized protein belonging to the CNPY gene family. We show here that CNPY2 is protective against ER stress induced by tunicamycin in neuronal cells. Overexpression of CNPY2 enhanced, while downregulation of CNPY2 using shRNA expression, reduced the viability of neuroblastoma cells after tunicamycin. Likewise, recombinant CNPY2 increased survival of cortical neurons in culture after ER stress. CNPY2 reduced the activating transcription factor 6 (ATF6) branch of ER stress and decreased the expression of CCAT/Enhancer-Binding Protein Homologous Protein (CHOP) involved in cell death. Immunostaining using mouse brain sections revealed that CNPY2 is expressed by cortical and striatal neurons and is co-expressed with the transcription factor, COUPTF-interacting protein 2 (CTIP2). In transgenic N171-82Q mice, as a model for Huntington’s disease (HD), the number of CNPY2-immunopositive neurons was increased in the cortex together with CTIP2. In the striatum, however, the number of CNPY2 decreased at 19 weeks of age, representing a late-stage of pathology. Striatal cells in culture were shown to be more susceptible to ER stress after downregulation of CNPY2. These results demonstrate that CNPY2 is expressed by corticostriatal neurons involved in the regulation of movement. CNPY2 enhances neuronal survival by reducing ER stress and is a promising factor to consider in HD and possibly in other brain diseases.
Impact of “Golden” tomato juice on cognitive alterations in metabolic syndrome: Insights into behavioural and biochemical changes in a high-fat diet rat model
Giuditta Gambino, Monica Frinchi, Giuseppe Giglia, Miriana Scordino, Giulia Urone, et al.
Journal of Functional Foods, 2024
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells (Purinergic Signalling, (2017), 13, 4, (429-442), 10.1007/s11302-017-9571-6)
Mariachiara Zuccarini, Patricia Giuliani, Silvana Buccella, Valentina Di Liberto, Giuseppa Mudò, et al.
Purinergic Signalling, 2023
Neuroprotective and Antioxidant Role of Oxotremorine-M, a Non-selective Muscarinic Acetylcholine Receptors Agonist, in a Cellular Model of Alzheimer Disease
Domenico Nuzzo, Monica Frinchi, Costanza Giardina, Miriana Scordino, Mariachiara Zuccarini, et al.
Cellular and Molecular Neurobiology, 2023
Alzheimer disease (AD) is a multifactorial and age-dependent neurodegenerative disorder, whose pathogenesis, classically associated with the formation of senile plaques and neurofibrillary tangles, is also dependent on oxidative stress and neuroinflammation chronicization. Currently, the standard symptomatic therapy, based on acetylcholinesterase inhibitors, showed a limited therapeutic potential, whereas disease-modifying treatment strategies are still under extensive research. Previous studies have demonstrated that Oxotremorine-M (Oxo), a non-selective muscarinic acetylcholine receptors agonist, exerts neurotrophic functions in primary neurons, and modulates oxidative stress and neuroinflammation phenomena in rat brain. In the light of these findings, in this study, we aimed to investigate the neuroprotective effects of Oxo treatment in an in vitro model of AD, represented by differentiated SH-SY5Y neuroblastoma cells exposed to Aβ1-42 peptide. The results demonstrated that Oxo treatment enhances cell survival, increases neurite length, and counteracts DNA fragmentation induced by Aβ1-42 peptide. The same treatment was also able to block oxidative stress and mitochondria morphological/functional impairment associated with Aβ1-42 cell exposure. Overall, these results suggest that Oxo, by modulating cholinergic neurotransmission, survival, oxidative stress response, and mitochondria functionality, may represent a novel multi-target drug able to achieve a therapeutic synergy in AD. Graphical Abstract Illustration of the main pathological hallmarks and mechanisms underlying AD pathogenesis, including neurodegeneration and oxidative stress, efficiently counteracted by treatment with Oxo, which may represent a promising therapeutic molecule. Created with BioRender.com under academic license.
Manipulation of HSP70-SOD1 Expression Modulates SH-SY5Y Differentiation and Susceptibility to Oxidative Stress-Dependent Cell Damage: Involvement in Oxotremorine-M-Mediated Neuroprotective Effects
Miriana Scordino, Monica Frinchi, Giulia Urone, Domenico Nuzzo, Giuseppa Mudò, et al.
Antioxidants, 2023
The differentiation of neural progenitors is a complex process that integrates different signals to drive transcriptional changes, which mediate metabolic, electrophysiological, and morphological cellular specializations. Understanding these adjustments is essential within the framework of stem cell and cancer research and therapy. Human neuroblastoma SH-SY5Y cells, widely used in neurobiology research, can be differentiated into neuronal-like cells through serum deprivation and retinoic acid (RA) supplementation. In our study, we observed that the differentiation process triggers the expression of Heat Shock Protein 70 (HSP70). Notably, inhibition of HSP70 expression by KNK437 causes a dramatic increase in cell death. While undifferentiated SH-SY5Y cells show a dose-dependent decrease in cell survival following exposure to hydrogen peroxide (H2O2), differentiated cells become resistant to H2O2-induced cell death. Interestingly, the differentiation process enhances the expression of SOD1 protein, and inhibition of HSP70 expression counteracts this effect and increases the susceptibility of differentiated cells to H2O2-induced cell death, suggesting that the cascade HSP70-SOD1 is involved in promoting survival against oxidative stress-dependent damage. Treatment of differentiated SH-SY5Y cells with Oxotremorine-M (Oxo), a muscarinic acetylcholine receptor agonist, enhances the expression of HSP70 and SOD1 and counteracts tert–Butyl hydroperoxide-induced cell death and reactive oxygen species (ROS) generation. It is worth noting that co-treatment with KNK437 reduces SOD1 expression and Oxo-induced protection against oxidative stress damage, suggesting the involvement of HSP70/SOD1 signaling in this beneficial effect. In conclusion, our findings demonstrate that manipulation of the HSP70 signal modulates SH-SY5Y differentiation and susceptibility to oxidative stress-dependent cell death and unravels novel mechanisms involved in Oxo neuroprotective functions. Altogether these data provide novel insights into the mechanisms underlying neuronal differentiation and preservation under stress conditions.
Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus
Anna Andrioli, Paolo Francesco Fabene, Giuseppa Mudò, Vincenza Barresi, Valentina Di Liberto, et al.
International Journal of Molecular Sciences, 2023
Astrocytic networks and gap junctional communication mediated by connexins (Cxs) have been repeatedly implicated in seizures, epileptogenesis, and epilepsy. However, the effect of seizures on Cx expression is controversial. The present study focused on the response of Cxs to status epilepticus (SE), which is in turn an epileptogenic insult. The expression of neuronal Cx36 and astrocytic Cx30 and Cx43 mRNAs was investigated in the brain of rats in the first day after pilocarpine-induced SE. In situ hybridization revealed a progressive decrease in Cx43 and Cx30 mRNA levels, significantly marked 24 h after SE onset in neocortical areas and the hippocampus, and in most thalamic domains, whereas Cx36 mRNA did not exhibit obvious changes. Regional evaluation with quantitative real-time-RT-PCR confirmed Cx43 and Cx30 mRNA downregulation 24 h after SE, when ongoing neuronal cell death was found in the same brain regions. Immunolabeling showed at the same time point marked a decrease in Cx43, microglia activation, and interleukin-1β induction in some microglial cells. The data showed a transient downregulation of astroglial Cxs in the cortical and thalamic areas in which SE triggers neurodegenerative events in concomitance with microglia activation and cytokine expression. This could potentially represent a protective response of neuroglial networks to SE-induced acute damage.
Role of Bioactive Molecules on Neuroprotection, Oxidative Stress, and Neuroinflammation Modulation
Valentina Di Liberto, Giuseppa Mudò
International Journal of Molecular Sciences, 2022
Guanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors
Giuditta Gambino, Giuseppe Giglia, Daniele Gallo, Miriana Scordino, Costanza Giardina, et al.
Pflugers Archiv European Journal of Physiology, 2022
Guanine inhibits the growth of human glioma and melanoma cell lines by interacting with GPR23
Roberta Garozzo, Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Giuseppa Mudò, et al.
Frontiers in Pharmacology, 2022
Bidirectional Control between Cholesterol Shuttle and Purine Signal at the Central Nervous System
Daniela Passarella, Maurizio Ronci, Valentina Di Liberto, Mariachiara Zuccarini, Giuseppa Mudò, et al.
International Journal of Molecular Sciences, 2022
Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Monica Frinchi, Francesco Caciagli, et al.
International Journal of Molecular Sciences, 2022
Protective, antioxidant and antiproliferative activity of grapefruit integropectin on sh-sy5y cells
Domenico Nuzzo, Miriana Scordino, Antonino Scurria, Costanza Giardina, Francesco Giordano, et al.
International Journal of Molecular Sciences, 2021
Serotonin heteroreceptor complexes and their integration of signals in neurons and astroglia—relevance for mental diseases
Dasiel O. Borroto-Escuela, Patrizia Ambrogini, Manuel Narvaez, Valentina Di Liberto, Sarah Beggiato, et al.
Cells, 2021
New neuroprotective effect of lemon integropectin on neuronal cellular model
Domenico Nuzzo, Pasquale Picone, Costanza Giardina, Miriana Scordino, Giuseppa Mudò, et al.
Antioxidants, 2021
Investigating the Role of Guanosine on Human Neuroblastoma Cell Differentiation and the Underlying Molecular Mechanisms
Natale Belluardo, Giuseppa Mudò, Valentina Di Liberto, Monica Frinchi, Daniele F. Condorelli, et al.
Frontiers in Pharmacology, 2021
Beneficial role of exercise in the modulation of mdx muscle plastic remodeling and oxidative stress
Monica Frinchi, Giuseppe Morici, Giuseppa Mudó, Maria R. Bonsignore, Valentina Di Liberto
Antioxidants, 2021
Guanosine-mediated anxiolytic-like effect: Interplay with adenosine a1 and a2a receptors
Monica Frinchi, Vincenzo Verdi, Fulvio Plescia, Francisco Ciruela, Maria Grillo, et al.
International Journal of Molecular Sciences, 2020
Anti-inflammatory and antioxidant effects of muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus
Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Marta Di Carlo, Maria F. Massenti, et al.
Scientific Reports, 2019
Crosstalk between receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCR) in the brain: Focus on heteroreceptor complexes and related functional neurotrophic effects
Valentina Di Liberto, Giuseppa Mudò, Natale Belluardo
Neuropharmacology, 2019
Anti-inflammatory and cognitive effects of interferon-?1a (IFN?1a) in a rat model of Alzheimer's disease
Giuseppa Mudò, Monica Frinchi, Domenico Nuzzo, Pietro Scaduto, Fulvio Plescia, et al.
Journal of Neuroinflammation, 2019
Heat shock protein (Hsp) regulation by muscarinic acetylcholine receptor (mAChR) activation in the rat hippocampus
Monica Frinchi, Pietro Scaduto, Francesco Cappello, Natale Belluardo, Giuseppa Mudò
Journal of Cellular Physiology, 2018

RECENT SCHOLAR PUBLICATIONS

A Tetrahydro-isoquinoline derivative as a novel mGlu2/3 Ago/PAM with therapeutic potential in models of Parkinsonism
G Urone, M Scordino, M Frinchi, A Montalbano, M Barreca, P Barraja, ...
CURRENT NEUROPHARMACOLOGY , 2026
2026
CNPY2 protects against ER stress and is expressed by corticostriatal neurons together with CTIP2 in a mouse model of Huntington’s disease
M Scordino, P Stepanova, V Srinivasan, DD Pham, O Eriksson, ...
Frontiers in Molecular Neuroscience 17, 1473058 , 2024
2024
Citations: 5
The remarkable impact of Opuntia Ficus Indica fruit administration on metabolic syndrome: Correlations between cognitive functions, oxidative stress and lipid dysmetabolism in …
D Di Majo, N Ricciardi, V Di Liberto, M Allegra, M Frinchi, G Urone, ...
Biomedicine & Pharmacotherapy 177, 117028 , 2024
2024
Citations: 10
The stunting effect of an oxylipins-containing macroalgae extract on sea urchin reproduction and neuroblastoma cells viability
C Martino, R Badalamenti, M Frinchi, R Chiarelli, AP Piccionello, G Urone, ...
Chemosphere 359, 142278 , 2024
2024
Citations: 14
An upstream enhancer and MEF2 transcription factors fine-tune the regulation of the Bdnf gene in cortical and hippocampal neurons
A Avarlaid, K Falkenberg, K Lehe, G Mudò, N Belluardo, V Di Liberto, ...
Journal of Biological Chemistry 300 (6), 107411 , 2024
2024
Citations: 11
Anti-apoptotic and anti-inflammatory properties of grapefruit IntegroPectin on human microglial HMC3 cell line
M Scordino, G Urone, M Frinchi, C Valenza, A Bonura, C Cipollina, ...
Cells 13 (4), 355 , 2024
2024
Citations: 12
Selective metabotropic glutamate receptor 3 positive allosteric modulator as new potential therapeutic agent in experimental models of parkinsonism: first in vitro and in vivo …
M Frinchi, G Urone, M Scordino, G Savona, A Montalbano, M Barreca, ...
1° Congresso C4Neuro: Le neuroscienze del domani , 2024
2024
Impact of “Golden” tomato juice on cognitive alterations in metabolic syndrome: Insights into behavioural and biochemical changes in a high-fat diet rat model
G Gambino, M Frinchi, G Giglia, M Scordino, G Urone, G Ferraro, G Mudo, ...
Journal of Functional Foods 112, 105964 , 2024
2024
Citations: 5
Retraction Note: Modulation of the TGF-β1-induced epithelial to mesenchymal transition (EMT) mediated by P1 and P2 purine receptors in MDCK cells
M Zuccarini, P Giuliani, S Buccella, V Di Liberto, G Mudò, N Belluardo, ...
Purinergic Signalling 19 (4), 711 , 2023
2023
Neuroprotective and antioxidant role of oxotremorine-M, a non-selective muscarinic acetylcholine receptors agonist, in a cellular model of Alzheimer disease
D Nuzzo, M Frinchi, C Giardina, M Scordino, M Zuccarini, C De Simone, ...
Cellular and Molecular Neurobiology 43 (5), 1941-1956 , 2023
2023
Citations: 16
Manipulation of HSP70-SOD1 expression modulates SH-SY5Y differentiation and susceptibility to oxidative stress-dependent cell damage: involvement in oxotremorine-M-mediated …
M Scordino, M Frinchi, G Urone, D Nuzzo, G Mudò, V Di Liberto
Antioxidants 12 (3), 687 , 2023
2023
Citations: 10
Downregulation of the astroglial connexin expression and neurodegeneration after pilocarpine-induced status epilepticus
A Andrioli, PF Fabene, G Mudò, V Barresi, V Di Liberto, M Frinchi, ...
International Journal of Molecular Sciences 24 (1), 23 , 2022
2022
Citations: 8
Role of bioactive molecules on neuroprotection, oxidative stress, and neuroinflammation modulation
V Di Liberto, G Mudò
International Journal of Molecular Sciences 23 (24), 15925 , 2022
2022
Citations: 4
Guanosine modulates K+ membrane currents in SH-SY5Y cells: involvement of adenosine receptors
G Gambino, G Giglia, D Gallo, M Scordino, C Giardina, M Zuccarini, ...
Pflügers Archiv-European Journal of Physiology 474 (11), 1133-1145 , 2022
2022
Citations: 3
Guanine inhibits the growth of human glioma and melanoma cell lines by interacting with GPR23
R Garozzo, M Zuccarini, P Giuliani, V Di Liberto, G Mudò, F Caciagli, ...
Frontiers in pharmacology 13, 970891 , 2022
2022
Citations: 10
Bidirectional control between cholesterol shuttle and purine signal at the central nervous system
D Passarella, M Ronci, V Di Liberto, M Zuccarini, G Mudò, C Porcile, ...
International Journal of Molecular Sciences 23 (15), 8683 , 2022
2022
Citations: 9
Adipose stromal/stem cell-derived extracellular vesicles: potential next-generation anti-obesity agents
M Zuccarini, P Giuliani, V Di Liberto, M Frinchi, F Caciagli, V Caruso, ...
International Journal of Molecular Sciences 23 (3), 1543 , 2022
2022
Citations: 6
Protective, antioxidant and antiproliferative activity of grapefruit IntegroPectin on SH-SY5Y cells
D Nuzzo, M Scordino, A Scurria, C Giardina, F Giordano, F Meneguzzo, ...
International Journal of Molecular Sciences 22 (17), 9368 , 2021
2021
Citations: 31
Serotonin heteroreceptor complexes and their integration of signals in neurons and Astroglia—relevance for mental diseases
DO Borroto-Escuela, P Ambrogini, M Narvaez, V Di Liberto, S Beggiato, ...
Cells 10 (8), 1902 , 2021
2021
Citations: 30
Neuroprotective, antioxidant and antiproliferative activity of grapefruit IntegroPectin on SH-SY5Y cells
D Nuzzo, M Scordino, A Scurria, C Giardina, F Giordano, F Meneguzzo, ...
bioRxiv, 2021.07. 21.453202 , 2021
2021

MOST CITED SCHOLAR PUBLICATIONS

Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain
AL Sokka, N Putkonen, G Mudo, E Pryazhnikov, S Reijonen, L Khiroug, ...
Journal of Neuroscience 27 (4), 901-908 , 2007
2007
Citations: 385
Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease
G Mudo, J Mäkelä, VD Liberto, TV Tselykh, M Olivieri, P Piepponen, ...
Cellular and molecular life sciences 69 (7), 1153-1165 , 2012
2012
Citations: 368
Expression of connexin36 in the adult and developing rat brain
N Belluardo, G Mudò, A Trovato-Salinaro, S Le Gurun, A Charollais, ...
Brain research 865 (1), 121-138 , 2000
2000
Citations: 344
Expression of Cx36 in mammalian neurons
DF Condorelli, N Belluardo, A Trovato-Salinaro, G Mudò
Brain Research Reviews 32 (1), 72-85 , 2000
2000
Citations: 328
Central nicotinic receptors, neurotrophic factors and neuroprotection
N Belluardo, G Mudò, M Blum, K Fuxe
Behavioural brain research 113 (1-2), 21-34 , 2000
2000
Citations: 245
The FGF-2/FGFRs neurotrophic system promotes neurogenesis in the adult brain
G Mudò, A Bonomo, V Di Liberto, M Frinchi, K Fuxe, N Belluardo
Journal of neural transmission 116 (8), 995-1005 , 2009
2009
Citations: 222
Comparative localization of fibroblast growth factor receptor‐1,‐2, and‐3 mRNAs in the rat brain: in situ hybridization analysis
N Belluardo, G Wu, G Mudo, AC Hansson, R Pettersson, K Fuxe
Journal of Comparative Neurology 379 (2), 226-246 , 1997
1997
Citations: 162
Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate‐induced seizures and expression in apoptotic neuronal cells
DF Condorelli, A Trovato‐Salinaro, G Mudò, MB Mirone, N Belluardo
European Journal of Neuroscience 18 (7), 1807-1827 , 2003
2003
Citations: 158
Expression of neurotrophins and their receptors in primary astroglial cultures: induction by cyclic AMP‐elevating agents
DF Condorelli, P Dell'Albani, G Mudo, T Timmusk, N Belluardo
Journal of neurochemistry 63 (2), 509-516 , 1994
1994
Citations: 153
Structure, chromosomal localization, and brain expression of human Cx36 gene
N Belluardo, A Trovato‐Salinaro, G Mudo, YL Hurd, DF Condorelli
Journal of neuroscience research 57 (5), 740-752 , 1999
1999
Citations: 150
Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4
N Belluardo, H Westerblad, G Mudó, A Casabona, J Bruton, G Caniglia, ...
Molecular and Cellular Neuroscience 18 (1), 56-67 , 2001
2001
Citations: 147
Nicotinic receptor agonists as neuroprotective/neurotrophic drugs. Progress in molecular mechanisms
G Mudo, N Belluardo, K Fuxe
Journal of neural transmission 114 (1), 135-147 , 2007
2007
Citations: 145
Fibroblast growth factor receptor 1–5-hydroxytryptamine 1A heteroreceptor complexes and their enhancement of hippocampal plasticity
DO Borroto-Escuela, W Romero-Fernandez, G Mudó, M Pérez-Alea, ...
Biological psychiatry 71 (1), 84-91 , 2012
2012
Citations: 144
Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy
V Barresi, N Belluardo, S Sipione, G Mudó, E Cattaneo, DF Condorelli
Cancer gene therapy 10 (5), 396-402 , 2003
2003
Citations: 136
Current disease modifying approaches to treat Parkinson’s disease
D Lindholm, J Mäkelä, V Di Liberto, G Mudo, N Belluardo, O Eriksson, ...
Cellular and Molecular Life Sciences 73 (7), 1365-1379 , 2016
2016
Citations: 128
Fibroblast growth factor-21 enhances mitochondrial functions and increases the activity of PGC-1α in human dopaminergic neurons via Sirtuin-1
J Mäkelä, TV Tselykh, F Maiorana, O Eriksson, HT Do, G Mudò, ...
Springerplus 3 (1), 2 , 2014
2014
Citations: 124
Change in neurotrophins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine
G Mudò, XH Jiang, T Timmusk, M Bindoni, N Belluardo
Epilepsia 37 (2), 198-207 , 1996
1996
Citations: 110
Acute intermittent nicotine treatment induces fibroblast growth factor-2 in the subventricular zone of the adult rat brain and enhances neuronal precursor cell proliferation
G Mudo, N Belluardo, A Mauro, K Fuxe
Neuroscience 145 (2), 470-483 , 2007
2007
Citations: 106
Acute intermittent nicotine treatment produces regional increases of basic fibroblast growth factor messenger RNA and protein in the tel-and diencephalon of the rat
N Belluardo, M Blum, G Mudo, B Andbjer, K Fuxe
Neuroscience 83 (3), 723-740 , 1998
1998
Citations: 106
Neurotrophins and their trk receptors in cultured cells of the glial lineage and in white matter of the central nervous system
DF Condorelli, T Salin, P Dell’Albani, G Mudò, M Corsaro, T Timmusk, ...
Journal of Molecular Neuroscience 6 (4), 237-248 , 1995
1995
Citations: 102

Giuseppa Mudò

RESEARCH INTERESTS

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

MOST CITED SCHOLAR PUBLICATIONS