Goodnews Onyedikachi Ikeh

@esut.edu.ng

Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences
Enugu State University of Science and Technology

Goodnews Onyedikachi Ikeh


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https://researchid.co/goodnewsonyedikachi

RESEARCH, TEACHING, or OTHER INTERESTS

Analytical Chemistry, Spectroscopy, Pharmacology, Toxicology and Pharmaceutics, Filtration and Separation

FUTURE PROJECTS

Green-synthesized silver nanoparticles for antimalarial applications: Toxicity and biocompatibility

Malaria remains a significant global health burden, necessitating the development of novel and effective therapeutic strategies. This study investigates the potential of green-synthesized silver nanoparticles (AgNPs) as a promising antimalarial agent. AgNPs were synthesized using Gongronema latifolium leaf extracts and characterized for their size, shape, and optical properties using XRD, TEM, SEM, EDX, surface plasmon resonance, and particular size. The antimalarial activity of the green-synthesized AgNPs was evaluated in vitro against Plasmodium falciparum, by drug sensitivity testing approach. The study has yet to explore the toxicity and biocompatibility of the synthesized AgNPs in mammalian cells and in vivo models to assess their potential for safe clinical translation. Preliminary results demonstrate the promising antimalarial activity of green-synthesized AgNPs. However, further in-depth investigations are warranted to fully understand the mechanism of action...


Applications Invited
Collaborators
26

Scholar Citations

3

Scholar h-index

1

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Thermodynamic and Kinetic Elucidation of the Biogenic Capping Mechanism: Evidence of Ordered Self-assembly in Gongronema latifolium-Silver Nanoparticles
    GO Ikeh, HN Okorie, IJ Ali, J Kayanian, RC Okpoto, CC Diovu, S Kaura
    Physical Science International Journal 30 (2), 119-129 , 2026
    2026.0
  • Translational Insight into Gongronema latifolium-silver Nanoparticles: Linking in vivo Safety to Molecular Antimalarial Mechanism
    Goodnews Onyedikachi Ikeh a* , Jasmine Kayanian b , Nkoyo Imelda Nubila c ...
    Journal of Advances in Medical and Pharmaceutical Sciences 28, 22-35 , 2026
    2026.0
    Citations: 1
  • Anti‐Inflammatory, Antioxidant, Molecular Docking and Pharmacokinetics Properties of Cycloeucalenone Isolated From Musa × paradisiaca L. Fruit Peels
    IJ Ali, KA Olofinsan, GO Ikeh, NH Okorie, CC Adonu, RC Omeh, BC Idoko, ...
    Chemistry & Biodiversity 23 (1), e02342 , 2026
    2026.0
    Citations: 1
  • Phytochemical-Mediated ZnO Nanoparticles from Chromolaena odorata: Structural Characterisation and Antimicrobial Efficacy against Multidrug-Resistant Clinical Isolates, Nigeria
    HN Okorie, CP Okorie, GO Ikeh, AC Leonard, NO Chidubem, IC Collins, ...
    Journal of Pharmaceutical Research International 37 (10), 86-105 , 2025
    2025.0
  • Research on Plant-based Management of Haemorrhoids: Evidence from Extracts of Mimosa pudica L
    CP Okorie, HN Okorie, GO Ikeh, K Oluigbo, GI Ani, NO Chidubem, ...
    Journal of Pharmaceutical Research International 37 (10), 28-34 , 2025
    2025.0
  • Research on Plant-based Management of Haemorrhoids: Evidence from Extracts of Mimosa pudica L
    CP Okorie, HN Okorie, GO Ikeh, K Oluigbo, GI Ani, NO Chidubem, ...
    Journal of Pharmaceutical Research International 37 (10), 28-34 , 2025
    2025.0
  • In vivo Pharmacological Evaluation of the Anti-inflammatory and Analgesic Effects of Cola hispida Methanol Leaf Extract and Its Fractions
    NI Ani, NI Nubilla, GO Ikeh, JK Onyia, VU Ude, CC Diovu
    Asian Journal of Research in Medical and Pharmaceutical Sciences 14 (4), 49-69 , 2025
    2025.0
  • Green Synthesis of Zinc Oxide Nanoparticles Characterization and Use for Formulation of Sunscreen Topical Creams.
    RC Omeh, IJ Ali, CC Adonu, JI Ogbonna, LO Ugorji, CC Mbah, CO Ugwu, ...
    Tropical Journal of Natural Product Research 9 (6) , 2025
    2025.0
    Citations: 5
  • Precursor Chemistry and Antimicrobial Performance: A Green Synthesis Approach to the Zinc Oxide Nanoparticles
    NH Okorie
    Asian Journal of Applied Chemistry Research 16 (2), 10.9734 , 2025
    2025.0
    Citations: 3
  • Molecular Spectroscopic (FTIR and UV-Vis) and Hyphenated Chromatographic (GC–MS) Characterization of Bioactive Compounds Present in Different Solvent Fractions of Extract of …
    GO Ikeh, NI Ani, VU Ude, JK Onyia, CC Diovu, RC Okpoto
    South Asian Research Journal of Natural Products 8 (2), 229-252 , 2025
    2025.0
    Citations: 11
  • Biogenic Synthesis and Comparative Assessment of the Antimicrobial Activities of Silver and Zinc Nanoparticles of Dialium guineense Leaf Extract against Human Pathogens
    GO Ikeh, PE Ugwu, RC Okpoto, CC Njoku, Elvira Amarachi, Diovu, ...
    Journal of Complementary and Alternative Medical Research 25 (12), 211-26 , 2024
    2024.0
    Citations: 3
  • Oral Biopharmaceutics and In vitro Pharmacokinetics of Commercially Available Pharmaceutical Formulations of Paracetamol: Implications in Paediatric Medicine
    GO Ikeh, MN Nwafor, MN Ndubuisi, KO Okolo
    Journal of Complementary and Alternative Medical Research 25 (12), 146-64 , 2024
    2024.0
  • DESIGN AND EVALUATION OF ENCAPSULATED COW FAT-BASED SOLID LIPID NANOCARRIER FOR IMPROVED BIOAVAILABILITY OF A POORLY WATER SOLUBLE NON STEROIDAL ANTI- INFLAMMATORY DRUG …
    AA Omeh, R. C., Adonu, C. C., *Ali, I. J., Ikeh, G. O. and Omeh
    FUDMA Journal of Sciences (FJS) 8 (Vol. 8 No. 3 (2024): FUDMA Journal of Sc … , 2024
    2024.0
  • Green Synthesis of Silver Nanoparticles for Antimalarial Activity: Characterisation, Acute Toxicity, and Efficacy Studies in a Murine Model
    GO Ikeh, NI Nubila, CO Nwoke, CN Nwoke, RC Okpoto, CC Igwe, ...
    2024.0
    Citations: 2
  • Isolation and Antidiarrhoeal Activity of Methyl 9, 10-Dimethoxyanthracene-2-Carboxylate from Morinda lucida Stem Bark: A Potential Ethnomedicinal Lead for Diarrhoea Treatment
    CK Onyishi, HN Okorie, G Walter, IJA Ugordi, GO Ikeh, IC Collins, ...

MOST CITED SCHOLAR PUBLICATIONS

  • Molecular Spectroscopic (FTIR and UV-Vis) and Hyphenated Chromatographic (GC–MS) Characterization of Bioactive Compounds Present in Different Solvent Fractions of Extract of …
    GO Ikeh, NI Ani, VU Ude, JK Onyia, CC Diovu, RC Okpoto
    South Asian Research Journal of Natural Products 8 (2), 229-252 , 2025
    2025.0
    Citations: 11
  • Green Synthesis of Zinc Oxide Nanoparticles Characterization and Use for Formulation of Sunscreen Topical Creams.
    RC Omeh, IJ Ali, CC Adonu, JI Ogbonna, LO Ugorji, CC Mbah, CO Ugwu, ...
    Tropical Journal of Natural Product Research 9 (6) , 2025
    2025.0
    Citations: 5
  • Precursor Chemistry and Antimicrobial Performance: A Green Synthesis Approach to the Zinc Oxide Nanoparticles
    NH Okorie
    Asian Journal of Applied Chemistry Research 16 (2), 10.9734 , 2025
    2025.0
    Citations: 3
  • Biogenic Synthesis and Comparative Assessment of the Antimicrobial Activities of Silver and Zinc Nanoparticles of Dialium guineense Leaf Extract against Human Pathogens
    GO Ikeh, PE Ugwu, RC Okpoto, CC Njoku, Elvira Amarachi, Diovu, ...
    Journal of Complementary and Alternative Medical Research 25 (12), 211-26 , 2024
    2024.0
    Citations: 3
  • Green Synthesis of Silver Nanoparticles for Antimalarial Activity: Characterisation, Acute Toxicity, and Efficacy Studies in a Murine Model
    GO Ikeh, NI Nubila, CO Nwoke, CN Nwoke, RC Okpoto, CC Igwe, ...
    2024.0
    Citations: 2
  • Translational Insight into Gongronema latifolium-silver Nanoparticles: Linking in vivo Safety to Molecular Antimalarial Mechanism
    Goodnews Onyedikachi Ikeh a* , Jasmine Kayanian b , Nkoyo Imelda Nubila c ...
    Journal of Advances in Medical and Pharmaceutical Sciences 28, 22-35 , 2026
    2026.0
    Citations: 1
  • Anti‐Inflammatory, Antioxidant, Molecular Docking and Pharmacokinetics Properties of Cycloeucalenone Isolated From Musa × paradisiaca L. Fruit Peels
    IJ Ali, KA Olofinsan, GO Ikeh, NH Okorie, CC Adonu, RC Omeh, BC Idoko, ...
    Chemistry & Biodiversity 23 (1), e02342 , 2026
    2026.0
    Citations: 1
  • Thermodynamic and Kinetic Elucidation of the Biogenic Capping Mechanism: Evidence of Ordered Self-assembly in Gongronema latifolium-Silver Nanoparticles
    GO Ikeh, HN Okorie, IJ Ali, J Kayanian, RC Okpoto, CC Diovu, S Kaura
    Physical Science International Journal 30 (2), 119-129 , 2026
    2026.0
  • Phytochemical-Mediated ZnO Nanoparticles from Chromolaena odorata: Structural Characterisation and Antimicrobial Efficacy against Multidrug-Resistant Clinical Isolates, Nigeria
    HN Okorie, CP Okorie, GO Ikeh, AC Leonard, NO Chidubem, IC Collins, ...
    Journal of Pharmaceutical Research International 37 (10), 86-105 , 2025
    2025.0
  • Research on Plant-based Management of Haemorrhoids: Evidence from Extracts of Mimosa pudica L
    CP Okorie, HN Okorie, GO Ikeh, K Oluigbo, GI Ani, NO Chidubem, ...
    Journal of Pharmaceutical Research International 37 (10), 28-34 , 2025
    2025.0
  • Research on Plant-based Management of Haemorrhoids: Evidence from Extracts of Mimosa pudica L
    CP Okorie, HN Okorie, GO Ikeh, K Oluigbo, GI Ani, NO Chidubem, ...
    Journal of Pharmaceutical Research International 37 (10), 28-34 , 2025
    2025.0
  • In vivo Pharmacological Evaluation of the Anti-inflammatory and Analgesic Effects of Cola hispida Methanol Leaf Extract and Its Fractions
    NI Ani, NI Nubilla, GO Ikeh, JK Onyia, VU Ude, CC Diovu
    Asian Journal of Research in Medical and Pharmaceutical Sciences 14 (4), 49-69 , 2025
    2025.0
  • Oral Biopharmaceutics and In vitro Pharmacokinetics of Commercially Available Pharmaceutical Formulations of Paracetamol: Implications in Paediatric Medicine
    GO Ikeh, MN Nwafor, MN Ndubuisi, KO Okolo
    Journal of Complementary and Alternative Medical Research 25 (12), 146-64 , 2024
    2024.0
  • DESIGN AND EVALUATION OF ENCAPSULATED COW FAT-BASED SOLID LIPID NANOCARRIER FOR IMPROVED BIOAVAILABILITY OF A POORLY WATER SOLUBLE NON STEROIDAL ANTI- INFLAMMATORY DRUG …
    AA Omeh, R. C., Adonu, C. C., *Ali, I. J., Ikeh, G. O. and Omeh
    FUDMA Journal of Sciences (FJS) 8 (Vol. 8 No. 3 (2024): FUDMA Journal of Sc … , 2024
    2024.0
  • Isolation and Antidiarrhoeal Activity of Methyl 9, 10-Dimethoxyanthracene-2-Carboxylate from Morinda lucida Stem Bark: A Potential Ethnomedicinal Lead for Diarrhoea Treatment
    CK Onyishi, HN Okorie, G Walter, IJA Ugordi, GO Ikeh, IC Collins, ...

Publications

1. Biogenic Synthesis and Comparative Assessment of the Antimicrobial Activities of Silver and Zinc Nanoparticles of Dialium guineense
Leaf Extract against Human Pathogens

2. Oral Biopharmaceutics and In vitro
Pharmacokinetics of Commercially
Available Pharmaceutical Formulations
of Paracetamol: Implications in
Paediatric Medicine