Hairul islam M Ibrahim

@kfu.edu.sa

Associate professor / Biology department
King faisal university

Hairul islam M Ibrahim
Highly accomplished research scientist and academic with over 10 years of experience in biological sciences, specializing in probiotics, gut microbiota, CRISPR-Cas9, miRNA silencing and Biomarker development research. Proven record of accomplishment in high-impact research (h Index 29, 2200 + citations), and patented innovations (7 US patent) in biomedical and material science.

EDUCATION

Ph.D. in Biotechnology and Immunology
University of Madras, Chennai, India (2012)
Thesis: Isolation of Probiotic and Proteolytic Bacteria from Northeast Himalayas for Management of Inflammatory Bowel Disease and Colitis-Induced Colon Cancer.
M.Tech in Microbial Biotechnology
Anna University, Chennai, India (2016)
Thesis: Development of biomaterial from bovine collagen for wound dressing using mouse model
M.Sc. in Biotechnology
Periyar University, Salem, India (2007)
Thesis: Genetic variation of different cultivars of Bacopa monieri using invitro approach

RESEARCH, TEACHING, or OTHER INTERESTS

Biochemistry, Genetics and Molecular Biology, Multidisciplinary, Bioengineering, Health, Toxicology and Mutagenesis

FUTURE PROJECTS

Meachine learning for biomarker identification and development


Applications Invited
Collaborators
2579

Scholar Citations

30

Scholar h-index

67

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • GC-MS Profiling and Larvicidal Potential of Artabotrys sahyadricus and A. zeylanicus: Terpenoid-Rich Botanical Compounds for Eco-Friendly Mosquito Control
    ZA Moaty, R Haridas, HIM Ibrahim, A Khalifa, S Palanisami, ...
    2026
  • Corrigendum to" Cinnamaldehyde inhibits Enterococcus faecalis biofilm formation and promotes clearance of its colonization by modulation of phagocytes in vitro"[Microb. Pathog …
    BS Akshaya, K Premraj, C Iswarya, S Muthusamy, HIM Ibrahim, HE Khalil, ...
    Microbial pathogenesis 213, 108382 , 2026
    2026
  • Improving growth traits in rabbits: a comparative study of Gabali, New Zealand White, and their hybrids using 18S rDNA sequencing
    HIM Ibrahim, A Sheikh, RT Mathew, M Munir, G Bekhet, ESH Eissa, ...
    Tropical Animal Health and Production 58 (2), 54 , 2026
    2026
  • Antibiofilm and Immunomodulatory Effects of Cinnamaldehyde in Corneal Epithelial Infection Models: Ocular Treatments Approach
    A Khalifa, M Thangavelu, K Thirugnanasambantham, HIM Ibrahim
    Pharmaceutics 18 (1), 5 , 2025
    2025
    Citations: 1
  • Lactobacillus plantarum with lignin prevents Helicobacter pylori mediated DSS-colitis through improved intestinal integrity and reducing colonic inflammation in C57BL/6J mice
    SK Venugopal Kaliyamoorthy 1, Justin Packia Jacop 2, Hairul Islam Mohamed ...
    journal of the science of food and agriculture , 2025
    2025
    Citations: 3
  • 2-Amino-3-Chlorobenzoic Acid from Streptomyces coelicolor : A Cancer Antagonist Targeting PI3K/AKT Markers via miRNA Modulation
    A Khalifa, JD Balthazar, P Subash-Babu, MY Zaky, ZA El-Moaty, ...
    Pharmaceuticals 18 (5), 620 , 2025
    2025
  • Synergistic Anti-Cancer Activity of Melittin and Erlotinib in Non-Small Cell Lung Cancer
    HM Ibrahim, J Alessa, HB Khalil, GA Bekhet, A Khalifa
    International Journal of Molecular Sciences 26 (7), 2903 , 2025
    2025
    Citations: 6
  • Probiotic and Rice-Derived Compound Combination Mitigates Colitis Severity
    EMAHIMI Ashraf Khalifa, Mayyadah Abdullah Alkuwayti , Basem M. Abdallah
    pharmaceuticals 17 (11), 1463 , 2024
    2024
  • Fermented Camel Milk with Propolis-Engineered Probiotic for Treating Adverse Bowel Disorders
    A Khalifa, HIM Ibrahim
    US Patent App. 18/100,626 , 2024
    2024
  • Therapeutic composition including phenolic compounds derived from opuntia littoralis
    HI Abd El-Moaty, HIM Ibrahim, ZH Almansour, RS Hamad
    US Patent 11,975,038 , 2024
    2024
  • Flavipin from fungi as a potential inhibitor of rheumatoid arthritis signaling molecules
    EA Ahmed, AM Alzahrani, SA Abdelsalam, HIM Ibrahim
    Inflammopharmacology 32 (2), 1171-1186 , 2024
    2024
    Citations: 3
  • Cytotoxic activity of bimetallic Ag@Se green synthesized nanoparticles using Jerusalem Thorn ( Parkinsonia aculeata )
    HA Hassanin, A Taha, HIM Ibrahim, EA Ahmed, H Mohamed, H Ahmed
    Frontiers in Chemistry 12, 1343506 , 2024
    2024
    Citations: 9
  • reinforced porous collagen sheet
    muthukumar thangavelu hany ezzat khalil, hairul islam m ibrahim
    US Patent us11925713B1 , 2024
    2024
  • Composition for treating irritable bowel syndrome
    HIM Ibrahim, AYZ Khalifa
    US Patent 11,883,442 , 2024
    2024
  • Composition for treating Irritable Bowel Syndrome
    HIM Ibrahim, AYZ Khalifa
    US Patent 11,878,039 , 2024
    2024
  • Beneficial probiotic bacteria prevalence in different lactating dromedary camel milk of Saudi Arabia
    A Sheikh, HIM Ibrahim, F Almathen, M Alfattah, A Khalifa
    Saudi Journal of Biological Sciences 31 (1), 103879 , 2024
    2024
    Citations: 9
  • Rectal gel with date palm phenolics and vanillic acid
    HEK Ahmed, HIM Ibrahim, K Thirugnanasambantham
    US Patent 11,833,246 , 2023
    2023
  • Therapeutic composition including phenolic compounds derived from Opuntia littoralis
    HI Abd El-Moaty, HIM Ibrahim, ZH Almansour, RS Hamad
    US Patent 11,806,378 , 2023
    2023
  • The Halotolerant Probiotic Bacterium Enterococcus lactis ASF-2 from Al-Asfar Lake, Saudi Arabia, Reduces Inflammation in Carrageenan-Induced Paw Edema
    N Alsaud, A Almajed, A Lwusaybie, A Alsubaie, H Alobaidan, J Alessa, ...
    Microorganisms 11 (10), 2415 , 2023
    2023
    Citations: 5
  • Attenuation of Immunogenicity in MOG-Induced Oligodendrocytes by the Probiotic Bacterium Lactococcus Sp. PO3
    A Khalifa, HIM Ibrahim, A Sheikh, HE Khalil
    Medicina 59 (10), 1731 , 2023
    2023
    Citations: 2

MOST CITED SCHOLAR PUBLICATIONS

  • Swertiamarin attenuates inflammation mediators via modulating NF-κB/I κB and JAK2/STAT3 transcription factors in adjuvant induced arthritis
    S Saravanan, VIH Islam, NP Babu, P Pandikumar, ...
    European Journal of Pharmaceutical Sciences 56, 70-86 , 2014
    2014
    Citations: 145
  • Antimicrobial properties of actinomycetes from the soil of Himalaya
    V Duraipandiyan, AH Sasi, VIH Islam, M Valanarasu, S Ignacimuthu
    Journal de Mycologie Médicale 20 (1), 15-20 , 2010
    2010
    Citations: 113
  • Cinnamaldehyde inhibits Enterococcus faecalis biofilm formation and promotes clearance of its colonization by modulation of phagocytes in vitro
    BS Akshaya, K Premraj, C Iswarya, S Muthusamy, HIM Ibrahim, HE Khalil, ...
    Microbial Pathogenesis 181, 106157 , 2023
    2023
    Citations: 111
  • Role of ethylene response transcription factor (ERF) and its regulation in response to stress encountered by plants
    K Thirugnanasambantham, S Durairaj, S Saravanan, K Karikalan, ...
    Plant Molecular Biology Reporter 33 (3), 347-357 , 2015
    2015
    Citations: 101
  • Significance of microRNA 21 in gastric cancer
    D Sekar, R Krishnan, K Thirugnanasambantham, B Rajasekaran, ...
    Clinics and research in hepatology and gastroenterology 40 (5), 538-545 , 2016
    2016
    Citations: 91
  • Toxic effect of Atalantia monophylla essential oil on Callosobruchus maculatus and Sitophilus oryzae
    GNKBMGPVIHISIV Duraipandiyan
    Environ Sci Pollut Res , 2016
    2016
    Citations: 82
  • The promotive impact of using silicon and selenium with potassium and boron on fruiting of Valencia orange trees grown under Minia region conditions
    HIM Ibrahim, MM Al-Wasfy
    World Rural Observations 6 (2), 28-36 , 2014
    2014
    Citations: 77
  • Role of MicroRNA 21 in Mesenchymal Stem Cell (MSC) Differentiation: A Powerful Biomarker in MSCs Derived Cells
    D Sekar, S Saravanan, K Karikalan, K Thirugnanasambantham, P Lalitha, ...
    Current Pharmaceutical Biotechnology 16, 43-48 , 2015
    2015
    Citations: 63
  • Swertiamarin ameliorates inflammation and osteoclastogenesis intermediates in IL-1β induced rat fibroblast-like synoviocytes
    S Saravanan, VI Hairul Islam, K Thirugnanasambantham, N Pazhanivel, ...
    Inflammation Research 63 (6), 451-462 , 2014
    2014
    Citations: 60
  • Activation of aryl hydrocarbon receptor signaling by a novel agonist ameliorates autoimmune encephalomyelitis
    HH Alzahrani Abdullah , Mohammed Maged , Ibrahim Hairul-Islam M. , Alwassil ...
    Plos one , 2019
    2019
    Citations: 59
  • Novel aryl hydrocarbon receptor agonist suppresses migration and invasion of breast cancer cells
    K Hanieh, H., Mohafez, O., Hairul-Islam, V.I., Alzahrani, A., Ismail, M.B ...
    PLoS ONE 11 , 2016
    2016
    Citations: 57
  • Response of Balady guava trees cultivated in sandy calcareous soil to biofertilization with phosphate dissolving bacteria and/or VAM fungi
    HIM Ibrahim, MMA Zaglol, AMM Hammad
    J. Am. Sci 6 (9), 399-404 , 2010
    2010
    Citations: 56
  • Antibacterial, anti-inflammatory and probiotic potential of Enterococcus hirae isolated from the rumen of Bos primigenius
    S Arokiyaraj, VI Hairul Islam, R Bharanidharan, S Raveendar, J Lee, ...
    World Journal of Microbiology and Biotechnology 30 (7), 2111-2118 , 2014
    2014
    Citations: 52
  • Date Palm Extract ( Phoenix dactylifera ) PEGylated Nanoemulsion: Development, Optimization and Cytotoxicity Evaluation
    HE Khalil, NK Alqahtani, HM Darrag, HIM Ibrahim, PM Emeka, ...
    Plants 10 (4), 735 , 2021
    2021
    Citations: 51
  • Beta-Caryophyllene Enhances the Anti-Tumor Activity of Cisplatin in Lung Cancer Cell Lines through Regulating Cell Cycle and Apoptosis Signaling Molecules
    MEMHIMI Emad A. Ahmed,Hamad Abu Zahra,Rebai Ben Ammar
    molecules , 2022
    2022
    Citations: 50
  • Isolation and Characterization of Putative Probiotic Bacterial Strain, Bacillus amyloliquefaciens, from North East Himalayan Soil Based on In Vitro and In Vivo …
    VI Hairul Islam, N Prakash Babu, P Pandikumar, S Ignacimuthu
    Probiotics and Antimicrobial Proteins 3 (3), 175-185 , 2011
    2011
    Citations: 48
  • Relevance of miR-21 in HIV and non-HIV-related lymphomas
    D Sekar, VI Hairul Islam, K Thirugnanasambantham, S Saravanan
    Tumor Biology 35 (9), 8387-8393 , 2014
    2014
    Citations: 46
  • miRNA-24 and miRNA-466i-5p controls inflammation in rat hepatocytes
    S Saravanan, K Thirugnanasambantham, H Hanieh, K Karikalan, D Sekar, ...
    Cellular & molecular immunology 12 (1), 113-115 , 2015
    2015
    Citations: 45
  • Pinocembrin, a novel histidine decarboxylase inhibitor with anti-allergic potential in in vitro
    H Hanieh, VIH Islam, S Saravanan, M Chellappandian, K Ragul, A Durga, ...
    European Journal of Pharmacology 814, 178-186 , 2017
    2017
    Citations: 44
  • In Vivo and In Vitro Immunomodulatory Potential of Swertiamarin Isolated from Enicostema axillare (Lam.) A. Raynal That Acts as an Anti-inflammatory Agent
    S Saravanan, P Pandikumar, NP Babu, VIH Islam, ...
    Inflammation 37 (5), 1374-1388 , 2014
    2014
    Citations: 42

Publications

Research Articles Published (from 2022 - recent 10 publications)

1. EA Ahmed, AM Alzahrani, SA Abdelsalam, Hairulislam M Ibrahim.
Title- Flavipin from fungi as a potential inhibitor of rheumatoid arthritis signaling molecules.
Journal- Inflammopharmacology, 1-16, 2024. IF. 4.7
2. Hanaa A.H , Amel T, Hairul-Islam MI, Emad A.A, Hisham M, and Hoda Ahmed.
Title- Cytotoxic activity of bimetallic Ag@Se green synthesized nanoparticles using Jerusalem Thorn (Parkinsonia aculeata).
Journal- Frontiers in Chemistry, 2024; 1 – 2024. IF-4.9
3. A Sheikh, Hairulislam M Ibrahim, F Almathen, M Alfattah, A Khalifa.
Title- Beneficial probiotic bacteria prevalence in different lactating dromedary camel milk of Saudi Arabia.
Journal- Saudi Journal of Biological Sciences 31 (1), 103879, 2024. IF. 3.8
4. N Alsaud, A Almajed, A Lwusaybie, A Alsubaie, H Alobaidan, J Alessa, Hairul Islam MI.
Title: The Halotolerant Probiotic Bacterium Enterococcus lactis ASF-2 from Al-Asfar Lake, Saudi Arabia, Reduces Inflammation in Carrageenan-Induced Paw Edema.
Microorganisms 11 (10), 2415, 2023. IF-3.2
5. A Khalifa, HIM Ibrahim, A Sheikh, HE Khalil.
Attenuation of Immunogenicity in MOG-Induced Oligodendrocytes by the Probiotic Bacterium Lactococcus Sp. PO3.
Medicina 59 (10), 1731, 2023. IF-3.1
6. 5.Khalifa, A.; Ibrahim, H.I.M.; Sheikh, A.; Khalil, H.E.
Probiotic-Fermented Camel Milk Attenuates Neurodegenerative Symptoms via SOX5/miR-218 Axis Orchestration in Mouse Models.
Pharmaceuticals 2023, 16, 357.

GRANT DETAILS

• Young Scientist Award from SERB-DST, Government of India (2014-2017) for the value of 65000 US dollar.
• Research Grant Recipient from King Salman Disability Centre, Riyadh, Saudi Arabia (2022, 2023) for the value of 300000 Saudi riyals.

RESEARCH OUTPUTS (PATENTS, SOFTWARE, PUBLICATIONS, PRODUCTS)

1. Inventors list- Dr. Hairul Islam. US patent No: US20240245087A1.
Title of invention: Fermented camel milk with propolis-engineered probiotic for treating adverse bowel disorders.
2. Inventors list- Dr. Hairul Islam. US patent No: US11883442B1.
Title of invention: Composition of treating irritable bowel syndrome.
3. Inventors list- Dr. Hairul Islam. US patent No: US11833246B1. Title of invention: Rectal gel loaded with Date palm phenolics and vanillic acid.
4. Inventors list- Dr. Hairul Islam. US patent No: US11925713B1. Title of invention: Reinforced porous collagen sheet for wound healing ailment.
5. Inventors list: . US patent No: US11975038B1. Title of invention : Therapeutic composition including phenolic compounds derived from opuntia littoralis