Halimah Funmilayo BABAMALE, is a lecturer in the Department of
Industrial Chemistry, Faculty of Physical Sciences, University of Ilorin with about 10 years of university teaching, research, and administrative experience.
She has served as Level Adviser in her department, and Faculty of Physical Science Representative at the Technical Committee on Plastic Production of the Technical and Entrepreneurship Center (TEC). Her areas of research interest cover Synthesis and Characterization of Organic compounds, Biorganic and Medicinal Chemistry.
She has to her credit over Thirty publications in reputable outlets covering journals, edited conference proceedings and chapters in books. She has successfully supervised several undergraduate projects.
Dr. Babamale is a Certified member of the Chemical Society of Nigeria (CSN), Nigerian Institute of Management (NIM), and member of other professional bodies within and outside Nigeria such as Material Society of Nigeria (MSN), Science Association
EDUCATION
Ph.D. Chemistry (Universiti Sains Malaysia)
RESEARCH, TEACHING, or OTHER INTERESTS
Chemistry, Cancer Research, Organic Chemistry, Spectroscopy
Chemoinformatic-aided Antidiabetic Analysis of the Therapeutic Potential of Phytoconstituents in Eremomastax speciosa Extracts Sulyman Olalekan Ibrahim, Halimat Yusuf Lukman, Israel Ehizuelen Ebhohimen, Halimah Funmilayo Babamale, Fatimah Ronke Abdulkadir, et al. Borneo Journal of Pharmacy, 2024 This research attempts to establish the antihyperglycemic potential of Eremomastax speciosa, a medicinal plant utilized in traditional West African diabetes therapy, through virtual simulation. While numerous reports have validated its biological potency, studies on the drug-likeness and antidiabetic properties of its compounds are limited. The in silico pharmacological, and toxicological profile of aqueous, methanolic/methylene phytochemicals from previously reported work was analyzed using Swiss ADME and Protox II online server. The docking process was performed using PyRx-0.8, coupled with AutoDock Vina. Phytochemicals that aligned with Lipinski’s rules for drugs were then subjected to a virtual docking simulation. This simulation replicated the inhibitory effects of E. speciosa phytochemicals on sodium-glucose co-transporters (SGLT2) and α-amylase, similar to metformin, an FDA-approved antidiabetic medicine utilized as a control. Phytochemicals such as 8, 9,10-dimethyltricyclo[4.2.1.1(2,5)]decane-9,10-diol (-6.6 kcal/mol), 11-isopropylidenetricyclo[4.3.1.1(2,5)]undec-3-en-10-one (-7.9 kcal/mol), 4-(1,5-dihydroxy-2,6,6-trimethylcyclohex-2-enyl)but-3-en-2-one (-7.3 kcal/mol), and N-methyl-N-4-[2-acetoxymethyl-1-pyrrolidyl]-2-butynyl]-acetamide (-7.5 kcal/mol) exhibits superior binding affinities to the specific proteins targeted, compared to metformin, implying that E. speciosa is a source of druggable antidiabetic molecules that can be enhanced to achieve better efficacy.
Nanoparticles as Antioxidant Agents: A Comprehensive Review Sulyman Olalekan Ibrahim, Halimat Yusuf Lukman, Fatimat Ronke Abdulkadir, Monsurat Yemisi Bello, Yusuf Oloruntoyin Ayipo, et al. Al Bahir Journal for Engineering and Pure Sciences, 2024
Safe and selective anticancer agents from tetrafluorinated azobenzene-imidazolium ionic liquids: Synthesis, characterization, and cytotoxic effects Halimah F. Babamale, Boon‐Keat Khor, Nelson Jeng‐Yeou Chear, Wan Sinn Yam Archiv Der Pharmazie, 2022 A new series of tetrafluorinated azobenzene‐imidazolium salts is reported. The azobenzene and imidazolium moieties were functionalized with long alkyl chains and connected via a methylene spacer of varying lengths (n = 3–12). They were characterized using FTIR and NMR spectroscopy, and elemental microanalysis. The cytotoxic potential of these ionic dimers against neuroblastoma (SHSY‐5Y), estrogen‐positive breast cancer cells (MCF‐7), triple‐negative breast cancer cells (MDA‐MB‐231), cervical cancer cells (HeLa), and human skin fibroblasts (Hs27) was evaluated using the MTT assay. The cytotoxicity of these ionic liquids (ILs) was dependent on the spacer length. A cut‐off effect was observed, wherein the cytotoxicity of the ILs was enhanced by increasing the nonpolar, hydrophobic spacer length up to a threshold and the potency was leveled off upon chain elongation. All ILs exhibited selective and remarkable inhibition potentials against HeLa cells in a dose‐dependent manner, which was 2–22 times stronger than that of etoposide, a clinical anticancer drug. These ILs were less toxic toward skin fibroblasts as implied by much higher IC50 values. The long‐spacer ILs (n = 7–10) were very selective toward HeLa cells. They had a broad safety window with selectivity indices ranging between 5.6 and 11.0. The selectivity of these compounds toward HeLa cells may serve as a new strategy for the design and development of safe and effective chemotherapeutics.
In Silico Medicinal and Pharmacological Evaluation of Phytochemical Constituents from the Root Bark Extract of Enantia Chlorantha as Potential Antimalarial Drugs S Ibrahim, H Lukman, Y Ayipo, H Babamale, F Abdulkadir, A Hamid, ... Journal of Pure & Applied Sciences 23 (2), 178-188 , 2024 2024 Citations: 1
Chemoinformatic-aided antidiabetic analysis of the therapeutic potential of phytoconstituents in Eremomastax speciosa extracts SO Ibrahim, HY Lukman, IE Ebhohimen, HF Babamale, FR Abdulkadir, ... Borneo Journal of Pharmacy 7 (2), 172-186 , 2024 2024 Citations: 5
Azobenzene-Imidazolium ionic liquid crystals: Phase properties and photoisomerization in solution state HF Babamale, SL Ng, WK Tang, WS Yam Journal of Molecular Structure 1303, 137494 , 2024 2024 Citations: 6
Nanoparticles as Antioxidant Agents: A Comprehensive Review SO Ibrahim, HY Lukman, FR Abdulkadir, MY Bello, YO Ayipo, ... Al-Bahir 5 (1), 3 , 2024 2024 Citations: 2
Mn (II), Fe (III) and Ni (II) Complexes of Mixed Citric acid-Sulphamethoxazole: Synthesis, Characterization and Antibacterial activity A Lawal, S Olowude, AO Rajee, SE Elaigwu, MO Bamigboye, HO Saadu, ... Annals of Science and Technology 8 (1), 46-50 , 2023 2023
Suppressive effects of azobenzene-imidazolium ionic conjugates on human cervical adenocarcinoma cells: Effects of alkyl chains and ortho-fluorination HF Babamale, BK Khor, NJY Chear, WS Yam Journal of Molecular Structure 1270, 133947 , 2022 2022 Citations: 1
Safe and selective anticancer agents from tetrafluorinated azobenzene‐imidazolium ionic liquids: Synthesis, characterization, and cytotoxic effects HF Babamale, BK Khor, NJY Chear, WS Yam Archiv der Pharmazie 355 (8), 2200085 , 2022 2022 Citations: 7
The First tetrafluorinated azobenzene-imidazolium ionic conjugates as potential thermotropic liquid crystalline drugs: Self-assembly properties and cytotoxic effects HF Babamale, BK Khor, NJY Chear, RA Haque, WS Yam Journal of Molecular Structure 1255, 132470 , 2022 2022 Citations: 10
Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives YO Ayipo, WA Osunniran, HF Babamale, MO Ayinde, MN Mordi Coordination Chemistry Reviews 453, 214317 , 2022 2022 Citations: 43
NANOCELLULOSE AS A STABILIZING AGENT IN THE SYNTHESIS OF SILVER NANOPARTICLES UNDER TRACE LEVEL TRISODIUM CITRATE HF Babamale, O DAMILARE, A OLA, I AYINLA, A SAMUEL Faculty of Pure and Applied Science, Ladoke Akintola University of … , 2022 2022
Effect of ferrochrome addition on wear and hardness properties of grey cast iron YO Busari, JA Adebisi, YL Shuaib-Babata, LO Amuzat, HF Babamale Mindanao Journal of Science and Technology 19 (2) , 2021 2021 Citations: 2
Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside YO Ayipo, SN Yahaya, WA Alananzeh, HF Babamale, MN Mordi Infection, Genetics and Evolution 93, 104944 , 2021 2021 Citations: 17
The Roles of Vegetable Fibres in Green Chemistry AT Ajiboye, KO Otun, LB Babamale, H. F and Abdulra'uf Vegetable Fiber Composites and their Technological Applications, Composites … , 2021 2021 Citations: 1
Synthesis and characterization of azobenzene derivatives and azobenzene-imidazolium conjugates with selective antimicrobial potential HF Babamale, T Sangeetha, JS Tan, WS Yam Journal of Molecular Structure 1232, 130049 , 2021 2021 Citations: 21
ß-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: Computational approach YO Ayipo, SN Yahaya, HF Babamale, I Ahmad, H Patel, MN Mordi Turkish Journal of Biology 45 (7), 503-517 , 2021 2021 Citations: 35
Synthesis, characterization and antibacterial study of Co (II) and Cu (II) complexes of mixed ligands of piperaquine and diclofenac Y AYİPO, WA Osunniran, UM Badeggi, IO Saheed, A JIMOH, ... Journal of the Turkish Chemical Society Section A: Chemistry 8 (2), 633-650 , 2021 2021 Citations: 7
Mn (II), Co (II), Ni (II), and Cu (II) complexes of amino acid derived Schiff base ligand: Synthesis, characterization and in-vitro antibacterial investigations A Osunniran, O Sheriff, M Lawal, JA Obaleye Bull. Chem. Soc. Ethiop 35 (1), 97-106 , 2021 2021 Citations: 10
Synthesis, Structural Elucidation and Antimicrobial Activity of Metal (II) Polypyridyl Complexes of 2-Amino-4-(Methylthio) Butanoic Acid AO Rajee, HF Babamale, AA Aliyu, A Lawal, SO Ayinla, WA Osunniran, ... Fountain Journal of Natural and Applied Sciences 9 (1) , 2020 2020 Citations: 4
Kinetic and Thermodynamic Study of Oxidative Decolourisation of a Typical Food Dye (Tartrazine) in an Aqueous Environment. FO Okeola, EO Odebunmi, MA Amoloye, HF Babamale, S Thema, ... Journal of Applied Sciences & Environmental Management 24 (6) , 2020 2020 Citations: 2
A short review on the removal of rhodamine B dye using agricultural waste-based adsorbents SS Imam, HF Babamale Asian J. Chem. Sci 7 (1), 25-37 , 2020 2020 Citations: 87
MOST CITED SCHOLAR PUBLICATIONS
A short review on the removal of rhodamine B dye using agricultural waste-based adsorbents SS Imam, HF Babamale Asian J. Chem. Sci 7 (1), 25-37 , 2020 2020 Citations: 87
Metalloenzyme mimicry and modulation strategies to conquer antimicrobial resistance: Metal-ligand coordination perspectives YO Ayipo, WA Osunniran, HF Babamale, MO Ayinde, MN Mordi Coordination Chemistry Reviews 453, 214317 , 2022 2022 Citations: 43
ß-Carboline alkaloids induce structural plasticity and inhibition of SARS-CoV-2 nsp3 macrodomain more potently than remdesivir metabolite GS-441524: Computational approach YO Ayipo, SN Yahaya, HF Babamale, I Ahmad, H Patel, MN Mordi Turkish Journal of Biology 45 (7), 503-517 , 2021 2021 Citations: 35
Removal of orange G dye from aqueous solution by adsorption: A short review ZUBA ZANGO Journal of Environmental Treatment Techniques , 2020 2020 Citations: 29
Synthesis and characterization of azobenzene derivatives and azobenzene-imidazolium conjugates with selective antimicrobial potential HF Babamale, T Sangeetha, JS Tan, WS Yam Journal of Molecular Structure 1232, 130049 , 2021 2021 Citations: 21
Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside YO Ayipo, SN Yahaya, WA Alananzeh, HF Babamale, MN Mordi Infection, Genetics and Evolution 93, 104944 , 2021 2021 Citations: 17
Synthesis, Characterization and Biological Activity Studies of Mixed Paracetamol-Ascorbic Acid Metal Complexes. HF Babamale, A Lawal, OA Rajee, EA Oloyede Journal of Applied Sciences & Environmental Management 20 (4) , 2016 2016 Citations: 15
Synthesis, Characterization and Biological Studies of Mixed Ligands Nicotinamide-Trimethoprim Metal Complexes A Lawal, PA Ayanwale, JA Obaleye, AO Rajee, HF Babamale, M Lawal International Journal of Chemical, Material and Environmental Research , 2017 2017 Citations: 13
The First tetrafluorinated azobenzene-imidazolium ionic conjugates as potential thermotropic liquid crystalline drugs: Self-assembly properties and cytotoxic effects HF Babamale, BK Khor, NJY Chear, RA Haque, WS Yam Journal of Molecular Structure 1255, 132470 , 2022 2022 Citations: 10
Mn (II), Co (II), Ni (II), and Cu (II) complexes of amino acid derived Schiff base ligand: Synthesis, characterization and in-vitro antibacterial investigations A Osunniran, O Sheriff, M Lawal, JA Obaleye Bull. Chem. Soc. Ethiop 35 (1), 97-106 , 2021 2021 Citations: 10
Mixed metal complexes of isoniazid and ascorbic acid: chelation, characterization and antimicrobial activities M Lawal, JA Obaleye, MO Bamigboye, GG Nnabuike, SO Ayinla, ... Nigerian Journal of Chemical Research 22 (1), 20-28 , 2017 2017 Citations: 10
Preparation, characterization and antibacterial activity of Mn (II), Cu (II) and Zn (II) complexes of methionine and 2, 2-bipyridine co-ligands AO Rajee, AA Aliyu, HF Babamale, A Lawal, SO Ayinla, WA Osunniran, ... J. Kenya Chem. Soc 13, 16-21 , 2020 2020 Citations: 8
Synthesis, characterization and antimicrobial activity of mixed ascorbic acid-nicotinamide metal complexes A Lawal, SA Amolegbe, AO Rajee, HF Babamale, MT Yunus-Issa Bayero Journal of Pure and Applied Sciences 8 (1), 139–142-139–142 , 2015 2015 Citations: 8
Safe and selective anticancer agents from tetrafluorinated azobenzene‐imidazolium ionic liquids: Synthesis, characterization, and cytotoxic effects HF Babamale, BK Khor, NJY Chear, WS Yam Archiv der Pharmazie 355 (8), 2200085 , 2022 2022 Citations: 7
Synthesis, characterization and antibacterial study of Co (II) and Cu (II) complexes of mixed ligands of piperaquine and diclofenac Y AYİPO, WA Osunniran, UM Badeggi, IO Saheed, A JIMOH, ... Journal of the Turkish Chemical Society Section A: Chemistry 8 (2), 633-650 , 2021 2021 Citations: 7
Azobenzene-Imidazolium ionic liquid crystals: Phase properties and photoisomerization in solution state HF Babamale, SL Ng, WK Tang, WS Yam Journal of Molecular Structure 1303, 137494 , 2024 2024 Citations: 6
Chelation, Characterization and Antimicrobial Screening of Some Mixed Antituberculosis–Vitamin Metal Drug Complexes M Bamigboye, M.O., Obaleye, J.A., Lawal, A., Babamale, H.F., Ajibola, A.A ... Al-Hikmah Journal of Pure & Applied Sciences 4, 37-42 , 2017 2017 Citations: 6
Chemoinformatic-aided antidiabetic analysis of the therapeutic potential of phytoconstituents in Eremomastax speciosa extracts SO Ibrahim, HY Lukman, IE Ebhohimen, HF Babamale, FR Abdulkadir, ... Borneo Journal of Pharmacy 7 (2), 172-186 , 2024 2024 Citations: 5
Synthesis, Characterization and Antimicrobial activity of Amodiaquine and Sulphadoxine Ligand Metal Complexes JA Obaleye, A Lawal, AO Rajee, HF Babamale, FB Shittu Nigerian J. Biochemistry and Molecular Biology 29 (2), p170-178 , 2014 2014 Citations: 5
Synthesis, Structural Elucidation and Antimicrobial Activity of Metal (II) Polypyridyl Complexes of 2-Amino-4-(Methylthio) Butanoic Acid AO Rajee, HF Babamale, AA Aliyu, A Lawal, SO Ayinla, WA Osunniran, ... Fountain Journal of Natural and Applied Sciences 9 (1) , 2020 2020 Citations: 4