HARISH K H

@kaher, belagavi

Associate Professor, Department of Pharmaceutics, KLE College of Pharmacy, Hubli
KLE COLLEGE OF PHARMACY, HUBLI

HARISH K H


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https://researchid.co/harikh79

EDUCATION

M PHARM IN PHARMACEUTICS, PERSUING PhD AT KAHER, BELAGAVI, KARNATAKA

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Pharmacology, Toxicology and Pharmaceutics, Drug Discovery, Multidisciplinary
4

Scopus Publications

33

Scholar Citations

3

Scholar h-index

1

Scholar i10-index

Scopus Publications

  • Comparative Evaluation of Co-Crystallization Methods for the Solubility Enhancement of Poorly Water-Soluble Drug of BCS Class II
    Harish Harish KH, Leejoan Dsouza, Sanatkumar Bharamu Nyamagoud, M Mahesh Yadav
    Indian Journal of Pharmaceutical Education and Research, 2026
  • Amelioration of Motor and Non-Motor Deficits by Agmatine-Loaded Solid Lipid Nanoparticles in a 6-OHDA Rat Model of Neurodegeneration
    Harish KH, Agadi Hiremath Viswanatha Swamy Swamy
    International Journal of Drug Delivery Technology, 2026
    Neurodegenerative diseases are characterized by the progressive loss of neurons, leading to profound impairments in cognitive and motor functions. Conventional medical interventions often fail to impede disease progression and frequently result in enduring adverse effects. This study examined the neuroprotective properties of agmatine and its solid lipid nanoparticle (SLN) formulation in an animal model of induced neurodegeneration. Exposure to neurotoxic substances resulted in significant behavioral alterations. The neurotoxicant group exhibited substantial spatial learning impairments, evidenced by a prolonged escape latency in the Morris Water Maze (74.33 ± 0.70 seconds). Agmatine SLNs demonstrated superior neuroprotective efficacy compared to free agmatine. In the Elevated Plus Maze (EPM), agmatine SLNs significantly improved cognitive recovery by normalizing transfer latency to 59.13 ± 0.78 seconds, which was nearly identical to the normal control value (58.22 ± 0.84 seconds). Furthermore, while the neurotoxicant group showed significant motor impairment with only 185.3 ± 13.05 counts/5 min in locomotor activity, the agmatine SLN-treated group maintained significantly higher activity (270.3 ± 22.36 counts/5 min). These findings suggest that agmatine SLNs effectively ameliorate both motor and non-motor symptoms, offering a promising therapeutic strategy for progressive neuronal degeneration.
  • Asymmetric membrane osmotic capsules for terbutaline sulphate
    NG Gobade, Marina Koland, KH Harish
    Indian Journal of Pharmaceutical Sciences, 2012
    The aim of the present study was to design an asymmetric membrane capsule, an osmotic pump-based drug delivery system of ethyl cellulose for controlled release of terbutaline sulphate. asymmetric membrane capsules contains pore-forming water soluble additive, sorbitol in different concentrations in the capsule shell membrane, which after coming in contact with water, dissolves, resulting in an in situ formation of a microporous structure. The terbutaline sulphate is a β-adrenoreceptor agonist widely used in the treatment of asthma. The oral dosage regimen of terbutaline sulphate is 5 mg twice or thrice daily, the plasma half-life is approximate 3-4 h and it produces GI irritation with extensive first pass metabolism. Hence, terbutaline sulphate was chosen as a model drug with an aim to develop controlled release system. Different formulations of ethyl cellulose were prepared by phase inversion technique using different concentrations of sorbitol as pore forming agent. It was found that the thickness of the prepared asymmetric membrane capsules was increased with increase in concentration of ethyl cellulose and pore forming agent, i.e. sorbitol. The dye release study in water and 10% sodium chloride solution indicates that, the asymmetric membrane capsules follow osmotic principle to release content. The pores formed due to sorbitol were confirmed by microscopic observation of transverse section of capsule membrane. Data of in vitro release study of terbutaline sulphate from asymmetric membrane capsules indicated that, the capsules prepared with 10% and 12.5% of ethyl cellulose and 25% of sorbitol released as much as 97.44% and 76.27% in 12 h, respectively with zero order release rate. Hence asymmetric membrane capsule of 10% ethyl cellulose and 25% of sorbitol is considered as optimum for controlled oral delivery of terbutaline sulphate.
  • Spectrophotometric determination of nebivolol hydrochloride in bulk and in pharmaceutical dosage forms
    Indian Drugs, 2011

RECENT SCHOLAR PUBLICATIONS

  • Comparative Evaluation of Co-Crystallization Methods for the Solubility Enhancement of Poorly Water-Soluble Drug of BCS Class II
    SBNMMY Harish K H*, Leejoan D’souza
    Indian Journal of Pharmaceutical Education and Research 60 (2s), s706-s716 , 2026
    2026
  • Amelioration of Motor and Non-Motor Deficits by Agmatine-Loaded Solid Lipid Nanoparticles in a 6-OHDA Rat Model of Neurodegeneration
    AHVS Harish K H
    International Journal of Drug Delivery Technology 16 (15s), 318-338 , 2026
    2026
  • Formulation and Quality Evaluation of Polyherbal Toothpaste
    HKH Jithin Mathew, Nivedita L. Rao
    Asian Journal of Pharmaceutics 19 (4), 2185-2189 , 2025
    2025
  • An Overview on Migraine From Pathophysiology to Therapies and Innovations
    AHMVSHKH Swetha.S, Vijikumar Meti
    Indian Journal of Natural Sciences 16 (90), 95929-95950 , 2025
    2025
  • 3D Printing in Dentistry: Redefining the Future of Dental Implants
    SSHKH Goutami Krishna Bodake
    Indian Journal of Natural Sciences 16 (89), 92571-92586 , 2025
    2025
  • INNOVATIVE FORMULATION FOR ORAL ULCER TREATMENT: A COMPREHENSIVE REVIEW ON EXISTING THERAPIES AND ADVANCES
    HKHVM Goutham D. Kotekar
    WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 14 (5), 724-753 , 2025
    2025
  • Herbal phytosomal gels: Benefits, challenges, and future directions: A review
    V Meti, A Mohare, A Guddad, H K H, F Dasankoppa
    IP International Journal of Comprehensive and Advanced Pharmacology 10 (1), 3-15 , 2025
    2025
  • Recent advances in intranasal delivery with lipid nanoparticles for brain targeting: A review
    I Sidhaye, A Karadagi, KH Harish, V Meti, FS Dasankoppa, AHV Swamy
    Journal of Young Pharmacists 17 (1), 54 , 2025
    2025
    Citations: 5
  • Formulation and Evaluation of Fast Disintegrating Tablets of Antihistamine Drug Using Natural Super Disintegrants.
    M Mahesh, KH Harish, FS Dasankoppa, K Kshatriya, R Latwade, P Patil, ...
    Journal of Young Pharmacists 16 (4) , 2024
    2024
    Citations: 2
  • A review on 4D printing technology for fabrication of intelligent, programmable and functional structure
    FS Dasankoppa, I Sidhaye, R Yashaswini, AV Karadagi, T Pujar, ...
    TWIST 19 (2), 421-431 , 2024
    2024
    Citations: 3
  • Optimized Ofloxacin Tablet Formulation for Enhanced Floating Drug Delivery: A Full Factorial Design
    AHVSHKH M.Mahesh, Aditya Shivanand Hiremath, Greeshma. S. Habbu, Sumitradevi ...
    Indian Journal of Natural Sciences 15 (85), 76907-76916 , 2024
    2024
  • Design and Statistical Optimization of Fast-Dissolving Buccal Films of Doxylamine Succinate for Allergy Treatment
    FSDAHVS Sumitradevi Choudhary, K H Harish, Amruth M Sansthanmath, M Mahesh ...
    International Journal of Pharmaceutical Investigation 14 (4), 1242-1252 , 2024
    2024
    Citations: 2
  • Agmatine as a Promising Neuroprotective Strategy for Treating Neurological Disorders
    AHVS 2. Harish K H
    Int. J. Pharm. Investigation 14 (3), 670-680 , 2024
    2024
    Citations: 7
  • FROM FITNESS TRACKERS to LIFE-SAVING DEVICES: A REVIEW of WEARABLE MEDICAL TECHNOLOGY
    GAH Mahesh.M , Harish K H* , Greeshma S Habbu
    Journal of Xidian University 17 (10), 299-320 , 2023
    2023
  • Paracetamol Induced Hepatotoxicity in Inpatients of a Tertiary Care Teaching Hospital
    SBN Soma Das Roy, Preetham K, Raj Kumar, Nanjappaiah H M, Harish K H ...
    Xi’an Shiyou University, Natural Science Edition 17 (11), 212-216 , 2021
    2021
  • Evaluation of Anti-venom Activity of Leaf Extract of Wedelia trilobata
    RR Reshma Raghavan, Achala Bhat, Rajesh KS*, Harish KH
    Journal of Xi’an Shiyou University, Natural Science Edition 17 (09), 601-613 , 2021
    2021
  • Assessment of curcuminloaded alginate nanobites in Acetic acid induced colitis model in rats
    RGHJ Harish K.H.*, JayanthiC
    World Journal of Pharmacy and Pharmaceutical Sciences 9 (2), 1098- 1122 , 2020
    2020
  • ASSESSMENT OF CURCUMIN LOADED ALGINATE NANOBITES IN ACETIC ACID INDUCED COLITIS MODEL IN RATS
    H KH, C Jayanthi, G Roopa, H Joshi
    2019
  • IN VITRO DISSOLUTION STUDIES OF SOME COMMERCIAL BRANDS OF ACECLOFENAC TABLETS
    H KH, M Dinesh, C Jayanthi, H Joshi
    2019
  • Harish KH*, Dinesh M, Jayanthi C, Hanumanthachar Joshi
    In Vitro Dissolution Studies of Some Commercial Brands of Aceclofenac Tablets
    World Journal of Pharmaceutical Research, 08(03) 8 (03), 1341-1343 , 2019
    2019

MOST CITED SCHOLAR PUBLICATIONS

  • Asymmetric membrane osmotic capsules for terbutaline sulphate
    NG Gobade, M Koland, KH Harish
    Indian Journal of Pharmaceutical Sciences 74 (1), 69 , 2012
    2012
    Citations: 10
  • Agmatine as a Promising Neuroprotective Strategy for Treating Neurological Disorders
    AHVS 2. Harish K H
    Int. J. Pharm. Investigation 14 (3), 670-680 , 2024
    2024
    Citations: 7
  • Recent advances in intranasal delivery with lipid nanoparticles for brain targeting: A review
    I Sidhaye, A Karadagi, KH Harish, V Meti, FS Dasankoppa, AHV Swamy
    Journal of Young Pharmacists 17 (1), 54 , 2025
    2025
    Citations: 5
  • A review on 4D printing technology for fabrication of intelligent, programmable and functional structure
    FS Dasankoppa, I Sidhaye, R Yashaswini, AV Karadagi, T Pujar, ...
    TWIST 19 (2), 421-431 , 2024
    2024
    Citations: 3
  • Formulation and Evaluation of Fast Disintegrating Tablets of Antihistamine Drug Using Natural Super Disintegrants.
    M Mahesh, KH Harish, FS Dasankoppa, K Kshatriya, R Latwade, P Patil, ...
    Journal of Young Pharmacists 16 (4) , 2024
    2024
    Citations: 2
  • Design and Statistical Optimization of Fast-Dissolving Buccal Films of Doxylamine Succinate for Allergy Treatment
    FSDAHVS Sumitradevi Choudhary, K H Harish, Amruth M Sansthanmath, M Mahesh ...
    International Journal of Pharmaceutical Investigation 14 (4), 1242-1252 , 2024
    2024
    Citations: 2
  • Spectrophotometric Method of the Estimation of Ranolazine in Bulk and Pharmaceutical Formulations
    DMHJ Naveen Kumar G S, Harish K H
    Unique Research Journal of Chemistry 2 (1) , 2014
    2014
    Citations: 2
  • Development and Validation of UV Spectrophotometric Estimation of Balsalazide in Bulk and Capsules
    DMHJ Naveen Kumar G S, Harish K H
    Universal Journal of Pharmacy 2 (01) , 2013
    2013
    Citations: 2
  • Comparative Evaluation of Co-Crystallization Methods for the Solubility Enhancement of Poorly Water-Soluble Drug of BCS Class II
    SBNMMY Harish K H*, Leejoan D’souza
    Indian Journal of Pharmaceutical Education and Research 60 (2s), s706-s716 , 2026
    2026
  • Amelioration of Motor and Non-Motor Deficits by Agmatine-Loaded Solid Lipid Nanoparticles in a 6-OHDA Rat Model of Neurodegeneration
    AHVS Harish K H
    International Journal of Drug Delivery Technology 16 (15s), 318-338 , 2026
    2026
  • Formulation and Quality Evaluation of Polyherbal Toothpaste
    HKH Jithin Mathew, Nivedita L. Rao
    Asian Journal of Pharmaceutics 19 (4), 2185-2189 , 2025
    2025
  • An Overview on Migraine From Pathophysiology to Therapies and Innovations
    AHMVSHKH Swetha.S, Vijikumar Meti
    Indian Journal of Natural Sciences 16 (90), 95929-95950 , 2025
    2025
  • 3D Printing in Dentistry: Redefining the Future of Dental Implants
    SSHKH Goutami Krishna Bodake
    Indian Journal of Natural Sciences 16 (89), 92571-92586 , 2025
    2025
  • INNOVATIVE FORMULATION FOR ORAL ULCER TREATMENT: A COMPREHENSIVE REVIEW ON EXISTING THERAPIES AND ADVANCES
    HKHVM Goutham D. Kotekar
    WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 14 (5), 724-753 , 2025
    2025
  • Herbal phytosomal gels: Benefits, challenges, and future directions: A review
    V Meti, A Mohare, A Guddad, H K H, F Dasankoppa
    IP International Journal of Comprehensive and Advanced Pharmacology 10 (1), 3-15 , 2025
    2025
  • Optimized Ofloxacin Tablet Formulation for Enhanced Floating Drug Delivery: A Full Factorial Design
    AHVSHKH M.Mahesh, Aditya Shivanand Hiremath, Greeshma. S. Habbu, Sumitradevi ...
    Indian Journal of Natural Sciences 15 (85), 76907-76916 , 2024
    2024
  • FROM FITNESS TRACKERS to LIFE-SAVING DEVICES: A REVIEW of WEARABLE MEDICAL TECHNOLOGY
    GAH Mahesh.M , Harish K H* , Greeshma S Habbu
    Journal of Xidian University 17 (10), 299-320 , 2023
    2023
  • Paracetamol Induced Hepatotoxicity in Inpatients of a Tertiary Care Teaching Hospital
    SBN Soma Das Roy, Preetham K, Raj Kumar, Nanjappaiah H M, Harish K H ...
    Xi’an Shiyou University, Natural Science Edition 17 (11), 212-216 , 2021
    2021
  • Evaluation of Anti-venom Activity of Leaf Extract of Wedelia trilobata
    RR Reshma Raghavan, Achala Bhat, Rajesh KS*, Harish KH
    Journal of Xi’an Shiyou University, Natural Science Edition 17 (09), 601-613 , 2021
    2021
  • Assessment of curcuminloaded alginate nanobites in Acetic acid induced colitis model in rats
    RGHJ Harish K.H.*, JayanthiC
    World Journal of Pharmacy and Pharmaceutical Sciences 9 (2), 1098- 1122 , 2020
    2020