HARI PRASAD
@klepharmblr.org
Professor,Pharmacology
KLE College of Pharmacy,bengaluru
RESEARCH INTERESTS
Diabetes,Metabolic Diseases,Diabetic complications
FUTURE PROJECTS
Si RNA
Applications Invited
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Rahul Kumar, M. G. Hariprasad, Moqbel Ali Moqbel Redhwan, Vidyabhushan Yadav, Apurwa Dhavale, and Sourav Guha
Informatics Publishing Limited
Anemia, a widespread global health challenge, can be induced through exposure to deleterious substances such as aluminum chloride. The present investigation explores the potential ameliorative effects of Moringa concanensis - a plant acknowledged for its myriad medicinal virtues-against anemia induced by aluminium chloride. The study objective was to scrutinize the impact of Moringa concanensis on aluminium chloride-induced anemia in Wistar rats. In the experimental design, thirty Wistar rats were randomly distributed into five distinct groups: a normal control group (untreated), a diseased control group (administered with aluminium chloride at a dose of 0.5 mg/kg body weight), a standard group (treated with Ferrous ascorbate at 30 mg/kg body weight), and two groups receiving low and high doses of Moringa concanensis (200 mg/kg and 400 mg/kg body weight, respectively). All groups, with the exception of the normal control, were exposed to aluminium chloride at a dosage of 0.5 mg/kg body weight over a span of 14 days. Hematological indicators were evaluated following standard methodologies, serum ferritin levels were assessed through Electrochemiluminescence immunoassay (ECLIA), and vitamin B12 concentration was quantified using atomic absorption spectroscopy. Furthermore, histopathological alterations were identified through Hematoxylin and Eosin staining procedures. Statistical data were interpreted through one-way ANOVA, succeeded by Tukey’s post hoc analysis, considering a p-value below 0.05 as statistically significant. Upon 21 days of continuous treatment with Moringa concanensis, both low and high-dose groups exhibited elevation in hematological parameters, serum ferritin, total iron-binding capacity, and vitamin B12 in comparison to the diseased control group. Noteworthy findings were observed in the high-dose group (400 mg/kg body weight), displaying significant improvement compared to the diseased control group (P<0.001). Remarkably, the high-dose regimen restored hematological parameters to baseline levels and mirrored the efficacy observed with the standard drug (Ferrous ascorbate). These empirical findings underscore the potential of Moringa concanensis as a promising therapeutic candidate for the alleviation of aluminium chloride-induced anemia. These results pave the way for future research endeavors to unravel the precise mechanisms driving these protective effects.
Rajashekar S. Chavan, Nayeem A. Khatib, M.G. Hariprasad, Vishal S. Patil, and Moqbel Ali Moqbel Redhwan
Elsevier BV
Moqbel Ali Moqbel Redhwan, Hariprasad M.G., Suman Samaddar, Sumaia Abdulbari Ahmed Ali Hard, Vidyabhushan Yadav, Apurbo Mukherjee, and Rahul Kumar
Wiley
AbstractBackgroundSmall interference RNA (siRNA) has emerged as the most desired method for researchers and clinicians who wish to silence a specific gene of interest and has been extensively developed as a therapeutic agent. This review points to collecting all clinical trials on siRNA and understanding its benefits, pharmacokinetics and safety by reading articles published in the last 5 years.Materials and MethodsSearching in the PubMed database using ‘siRNA’ and ‘in vivo’ with limits to articles published in the previous 5 years, article type ‘clinical trials’ and language ‘English’ to acquire papers on in vivo studies on siRNA approaches. Features of siRNA clinical trials registered at https://clinicaltrials.gov/ were analysed.ResultsSo far, 55 clinical studies have been published on siRNA. Many published clinical trials on siRNA showed tolerability, safety and effectiveness in treating cancers like breast, lung, colon, and other organs and other diseases like viral infections and hereditary diseases. Many different routes of administration can silence many genes at the same time. Limitations and uncertainties associated with siRNA treatment include the effectiveness of cellular uptake, precise targeting of the intended tissue or cell and prompt elimination from the body.ConclusionsThe siRNA or RNAi method will be one of the most critical and influential techniques to fight against many different diseases. Although the RNAi approach has certain advantages, it also has limitations concerning clinical applications. Overcoming these limitations remains a daunting challenge.
Moqbel Ali Moqbel Redhwan, Hariprasad M．G, Suman Samaddar, and Sumaia Abdulbari Ahmed Ali Hard
Elsevier BV
Ashish Jain, Hariprasad MG, Mohammad Sharique, and Moqbel Ali Moqbel Redhwan
EManuscript Technologies
Naini Bhadri, Tejaswi Sanji, Hariprasad Madakasira Guggilla, and Rema Razdan
Hindawi Limited
Cisplatin or cis-diamminedichloroplatinum (II) (CDDP) is a cytotoxic chemotherapeutic agent with dose-dependent peripheral neuropathy as a foremost side effect characterised by ataxia, pain, and sensory impairment. Cumulative drug therapy of CDDP is known to produce severe oxidative damage. It mainly targets and accumulates in dorsal root ganglia that in turn cause damage resulting in secondary nerve fibre axonopathy. In the present study, we investigated the neuroprotective effect of the combination of monosodium glutamate (MSG) with three individual antioxidants, that is, resveratrol, alpha-lipoic acid (ALA), and coenzyme Q10 (CoQ10), in cisplatin (2 mg/kg i.p. twice weekly) induced peripheral neuropathy in rats. After 8 weeks of treatment the degree of neuroprotection was determined by measuring behavioral and electrophysiological properties and sciatic nerve lipid peroxidation, as well as glutathione and catalase levels. The results suggested that pretreatment with the combination of MSG (500 mg/kg/day po) with resveratrol (10 mg/kg/day i.p.) or ALA (20 mg/kg/day i.p.) or CoQ10 (10 mg/kg weekly thrice i.p.) exhibited neuroprotective effect. The maximum neuroprotection of MSG was observed in the combination with resveratrol.
RECENT SCHOLAR PUBLICATIONS
MOST CITED SCHOLAR PUBLICATIONS
Industry, Institute, or Organisation Collaboration
Green Chem and GIMS Research Institute
INDUSTRY EXPERIENCE
1.5 Years