Dr. Harsha M B
@srihasanambadental.edu.in
Professor and Head
Sri Hasanamba Dental College and Hospital
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Harsha Mysore Babu, Savita Abdulpur Mallikarjun, Sreedevi Das, Mahesh Ramanna Gowda, Archana Naik, and Pallavi Nanaiah
Jaypee Brothers Medical Publishing
MB Harsha, Athira K Chermmal, and Marenahalli R Vivekananda
Jaypee Brothers Medical Publishing
bstrAct Aim and objective: Over the years, treatment for chronic periodontitis is changing owing to an improved understanding of the pathogenesis of the periodontal disease. Tissue invasive properties of periodontal pathogens have necessitated the use of antimicrobial agents as an adjunct to mechanical plaque control in the treatment of periodontitis. Hence, the study aimed to evaluate the efficacy of ofloxacin–ornidazole combination therapy as an adjunct to scaling and root planing in the treatment of generalized chronic periodontitis. Materials and methods: A total of 40 study participants, aged from 25 to 55 years, with generalized chronic periodontitis were selected. They were randomly divided into two groups—Group I: receiving scaling and root planing along with ofloxacin–ornidazole combination therapy and group II: receiving scaling and root planing. Gingival index (GI), sulcular bleeding index (SBI), and probing pocket depth (PPD) scores were recorded at baseline, 14th day, and after 1 month. Results: Both the groups showed a reduction in GI scores, SBI scores, and mean pocket probing depth from baseline to 14th day and 1 month. However, the improvement in scores was better in a group with the ofloxacin–ornidazole combination, than the group with scaling and root planing alone. The intergroup comparison of the gingival indices, SBI, and mean pocket probing depth at baseline, 14th day, and 1 month have shown the statistically significant difference. Conclusion: It can be concluded that ofloxacin–ornidazole combination therapy is well tolerated by the patients, safe, favorable patient compliance, and proved to be effective in patients with generalized chronic periodontitis when used as an adjunct to mechanical plaque control. Clinical significance: Ofloxacin–ornidazole combination can be used as an adjuvant in the treatment of generalized chronic periodontitis.
HarshaMysore Babu, Chandrappa Vasthavi, VivekanandaMarenahalli Rangaraju, Shivaprasad Dasappa, Leka Jagadish, and Ravindra Shivamurthy
Medknow
Background and Objectives: Mechanical plaque control is an essential part of periodontal therapy. In the present study, the efficacy of ozone water irrigation as an adjunct to scaling and root planing was evaluated in the treatment of generalized chronic periodontitis. Materials and Methods: Twenty-four patients with chronic periodontitis selected for the study were randomly divided into Group A and Group B, receiving ozone water irrigation and distilled water irrigation, respectively, after scaling and root planing. Subgingival plaque was collected from the selected investigational teeth and was analyzed using BANA-Zyme™ Processor to evaluate the “red complex” periodontal pathogens. The clinical and microbiological parameters were recorded at baseline, 14 days, 21 days, and 2 months. Results: The mean probing pocket depth scores for Group A and Group B at the baseline were 6.833 ± 1.193 and 7.833 ± 1.276; on day 14th, they were 6.616 ± 1.403 and 7.083 ± 1.378; on day 21st, they were 5.166 ± 0.937 and 6.083 ± 1.443;and on the 2nd month, they were 4.500 ± 0.797 and 5.166 ± 1.029, respectively. At the 2nd month, in Group A, 9 samples showed BANA negative and 3 samples showed BANA positive, and in Group B, 12 samples showed BANA negative and 0 sample showed BANA positive. The microbiological analysis showed a reduction in periodontal pathogens in both the groups. Conclusion: Significant improvement in both clinical and microbiological parameters suggests that subgingival ozonated water irrigation could be an efficient adjunct to scaling and root planing in the treatment of chronic periodontitis.
Savita Mallikarjun, Abhilash Neelakanti, HarshaMysore Babu, SujathaBallambettu Pai, SachinVaijnathrao Shinde, and Swathi Krishnan
Medknow
Background: Neutrophils are the predominant leukocytes in the periodontium, which prevent infection from periodontal pathogens and subsequent tissue destruction. A potentially destructive role has been elucidated, especially due to elastase enzyme. Controlling its levels might be crucial in minimizing the tissue destruction. Hyaluronan, known to inhibit the release of this enzyme from neutrophils, might be a viable option to treat chronic periodontitis. Aims: The aim of this study is to evaluate and compare the effects of 0.2% hyaluronan gel adjunctive to scaling and root planing on the levels of elastase in gingival crevicular fluid (GCF). Settings and Design: This split-mouth study included eighty (forty experimental and forty control) sites from twenty patients representing both sexes. Materials and Methods: GCF samples were collected from all the eighty sites; simultaneously, clinical periodontal parameters were recorded. Enzyme-linked immunosorbent assay was used to determine the levels of elastase at baseline and 6 weeks after therapy, following mechanical debridement and subsequent subgingival placement of the experimental drug. Statistical Analysis Used: With the aid of statistical software (SPSS Version 13), Student′s t-test and Pearson′s correlation test were performed. Results: There was a mean reduction in the elastase levels from baseline to 6 weeks after therapy in the experimental group. However, the difference between the groups was not statistically significant. Conclusions: Adjunctive use of hyaluronan following mechanical debridement resulted in comparable reduction in the elastase levels, suggesting that this substance has an inhibitory effect on elastase, and subsequent tissue destruction. Further long-term studies are mandatory to validate the results of this study.
Abhilash Neelakanti, SachinVaijnathrao Shinde, Savita Mallikarjun, HarshaMysore Babu, Sreedevi Das, and Charu Dawra
Medknow
Aims: To assess and compare the thickness of gingiva in the anterior maxilla using radiovisiography (RVG) and cone beam computed tomography (CBCT) and its correlation with the thickness of underlying alveolar bone. Settings and Design: This cross-sectional study included 10 male subjects in the age group of 20–45 years. Materials and Methods: After analyzing the width of keratinized gingiva of the maxillary right central incisor, the radiographic assessment was done using a modified technique for RVG and CBCT, to measure the thickness of both the labial gingiva and labial plate of alveolar bone at 4 predetermined locations along the length of the root in each case. Statistical Analysis Used: Statistical analysis was performed using Student's t-test and Pearson's correlation test, with the help of statistical software (SPSS V13). Results: No statistically significant differences were obtained in the measurement made using RVG and CBCT. The results of the present study also failed to reveal any significant correlation between the width of gingiva and the alveolar bone in the maxillary anterior region. Conclusions: Within the limitations of this study, it can be concluded that both CBCT and RVG can be used as valuable tools in the assessment of the soft and hard tissue dimensions.
HarshaMysore Babu, Deepak Prasad, Aishwarya Srinivasan, SheelaKumar Gujjari, and PraveenKumar Sehgal
Medknow
Background: Gingival recession (GR) can result in root sensitivity, esthetic concern to the patient, and predilection to root caries. The purpose of this randomized clinical study was to evaluate (1) the effect of guided tissue regeneration (GTR) procedure using a bioabsorbable collagen membrane, in comparison to autogenous subepithelial connective tissue graft (SCTG) for root coverage in localized gingival recession defects; and (2) the change in width of keratinized gingiva following these two procedures. Materials and Methods: A total of 10 cases, showing at least two localized Miller's Class I or Class II gingival recession, participated in this study. In a split mouth design, the pairs of defects were randomly assigned for treatment with either SCTG (SCTG Group) or GTR-based collagen membrane (GTRC Group). Both the grafts were covered with coronally advanced flap. Recession depth (RD), recession width (RW), width of keratinized gingiva (KG), probing depth (PD), relative attachment level (RAL), plaque index (PI), and gingival index (GI) were recorded at baseline, 3 and 6 months postoperatively. Results: Six months following root coverage procedures, the mean root coverage was found to be 84.84% ± 16.81% and 84.0% ± 15.19% in SCTG Group and GTRC Group, respectively. The mean keratinized gingival width increase was 1.50 ± 0.70 mm and 2.30 ± 0.67 mm in the SCTG and GTRC group, respectively, which was not statistically significant. Conclusion: It may be concluded that resorbable collagen membrane can be a reliable alternative to autogenous connective tissue graft in the treatment of gingival recession.