Prof. Dr. med. Harald H.H.W. Schmidt

@maastrichtuniversity.nl

Professor and Head of Department of Pharmacology and Personalised Medicine
Universiteit Maastricht

Prof. Dr. med. Harald H.H.W. Schmidt


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https://researchid.co/hhhw_schmidt

RESEARCH, TEACHING, or OTHER INTERESTS

Multidisciplinary, Medicine, Pharmacology, Toxicology and Pharmaceutics, Biochemistry, Genetics and Molecular Biology
44986

Scholar Citations

107

Scholar h-index

241

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • The Concise Guide to PHARMACOLOGY 2025/26: Catalytic receptors
    SPH Alexander, D Fabbro, CJ Peach, AJ Gibb, E Kelly, AA Mathie, ...
    British Journal of Pharmacology 182, S259-S306 , 2025
    2025
    Citations: 36
  • Revisiting soluble guanylate cyclase pharmacology: Additive potential of stimulators and activators
    A Petraina, MH Elbatreek, CT Neullens, T Saridaki, VT Dao, ...
    Biomedicine & Pharmacotherapy 193, 118762 , 2025
    2025
  • Inferring and Evaluating Network Medicine-Based Disease Modules with Nextflow
    J Kersting, C Bucheron, LM Spindler, J Aguirre-Plans, Q Manz, T Pock, ...
    bioRxiv, 2025.11. 20.687681 , 2025
    2025
    Citations: 1
  • Resurrecting Network and Systems Medicine
    AR González, HAM Mucke, P Paci, HHHW Schmidt, S Vasudevan, ...
    Network and Systems Medicine 1 (1), 20250006 , 2025
    2025
  • Receptor guanylyl cyclase (RGC) family in GtoPdb v. 2025.3
    A Beuve, JP Stasch, HHHW Schmidt, M Russwurm, LR Potter, M Kuhn, ...
    IUPHAR/BPS Guide to Pharmacology CITE , 2025
    2025
  • From the Valley of Death to Human-Centric Precision Medicine: The REPO4EU Platform and its Transition into REPOSYSTEM
    HHHW Schmidt
    RExPO Conference Series , 2025
    2025
  • Artificial intelligence and network medicine: Path to precision medicine
    L Altucci, L Badimon, JL Balligand, J Baumbach, AL Catapano, F Cheng, ...
    NEJM AI 2 (9), AIra2401229 , 2025
    2025
    Citations: 7
  • Repurposing Drugs through Network Pharmacology in Advanced Thyroid Cancer: From Bench to Bedside
    P Changoer, Z Mamdouh, C Grätz, J Kersting, A Casas, M Jaeger, ...
    RExPO25 Conference , 2025
    2025
  • An integrative systems medicine framework for ischemic stroke: In silico-based target identification, network pharmacology, and immune mechanistic redefinition
    AI Casas, RRD Szepanowski, J Bahr, S Vanhof, S Erkelenz, B Budeus, ...
    RExPO Conference Series , 2025
    2025
  • Synergistic network pharmacology: Preclinical validation and clinical safety in acute ischemic stroke
    AI Casas, C Nogales, RD Szepanowski, MH Elbatreek, E Anastasi, ...
    Journal of the American Heart Association 14 (10), e039098 , 2025
    2025
    Citations: 5
  • Nutritional L-citrulline and tetrahydrobiopterin in peripheral artery disease: A phase II randomized trial (CIPER Study)
    D Sedding, TM Schmidt, H Bähre, U Bavendiek, AI Casas, S Chen, ...
    JACC: Advances 4 (3), 101590 , 2025
    2025
    Citations: 8
  • Drugst. One DREAM—Drug repurposing through expert annotation and modification
    LM Spindler, J Kersting, Q Manz, M Hartung, A Maier, ZM Mamdouh, ...
    British Journal of Pharmacology , 2025
    2025
    Citations: 2
  • Revising EU pharmaceutical legislation: will it foster drug repurposing?
    M Scholte, SE Grimm, B Pauly, F Verbeeck, AMG Pasmooij, B Bouma, ...
    Drug discovery today 30 (1), 104286 , 2025
    2025
    Citations: 10
  • Advancing Drug Repurposing Science—The Road Ahead
    HHHW Schmidt, H Mucke
    Drug Repurposing 1 (2), 20240019 , 2024
    2024
  • DE-RISKING DRUG REPURPOSING BY SYSTEMS MEDICINE AND NETWORK PHARMACOLOGY
    H Schmidt
    RePo-SUDOE Conference , 2024
    2024
  • Nedrex-web: an interactive web tool for drug repurposing by exploring heterogeneous molecular networks
    A Maier, M Rafiei, E Anastasi, O Zolotareva, J Skelton, ML Elkjaer, ...
    2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM … , 2024
    2024
    Citations: 4
  • DrugRepoChatter: A drug repurposing expert chatbot curated by the REPO4EU consortium
    FM Delgado-Chaves, L Spindler, F Firoozbakht, A Maier, M Hartung, ...
    Drug Repurposing 1 (2), 20240014 , 2024
    2024
    Citations: 1
  • Welcome to the Inaugural Edition of Drug Repurposing
    HHHW Schmidt
    Drug Repurposing 1 (1), 20240001 , 2024
    2024
  • REPO4EU, REPOSystem and Applicable Bioinformatics: REPO-HFpEF and CIPER
    HHHW Schmidt
    RExPO24 Conference , 2024
    2024
  • Targeting Signalling Modules in Thyroid Cancer
    P Changoer, ZM Mamdouh, C Grätz, AM Casas, M Jaeger, R Loewe, ...
    RExPO24 Conference , 2024
    2024

MOST CITED SCHOLAR PUBLICATIONS

  • NO at work
    HHHW Schmidt, U Walter
    Cell 78 (6), 919-925 , 1994
    1994
    Citations: 2061
  • Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.
    JS Pollock, U Förstermann, JA Mitchell, TD Warner, HH Schmidt, ...
    Proceedings of the National Academy of Sciences 88 (23), 10480-10484 , 1991
    1991
    Citations: 1273
  • Isoforms of nitric oxide synthase characterization and purification from different cell types
    U Förstermann, HHHW Schmidt, JS Pollock, H Sheng, JA Mitchell, ...
    Biochemical pharmacology 42 (10), 1849-1857 , 1991
    1991
    Citations: 1184
  • Network pharmacology: curing causal mechanisms instead of treating symptoms
    C Nogales, ZM Mamdouh, M List, C Kiel, AI Casas, HHHW Schmidt
    Trends in pharmacological sciences 43 (2), 136-150 , 2022
    2022
    Citations: 1182
  • Clinical relevance of biomarkers of oxidative stress
    J Frijhoff, PG Winyard, N Zarkovic, SS Davies, R Stocker, D Cheng, ...
    Antioxidants & redox signaling 23 (14), 1144-1170 , 2015
    2015
    Citations: 1148
  • The nitric oxide and cGMP signal transduction system: regulation and mechanism of action
    HHHW Schmidt, SM Lohmann, U Walter
    Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1178 (2), 153-175 , 1993
    1993
    Citations: 1037
  • NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential
    OV Evgenov, P Pacher, PM Schmidt, G Haskó, HHHW Schmidt, JP Stasch
    Nature reviews Drug discovery 5 (9), 755-768 , 2006
    2006
    Citations: 979
  • Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    S Heumüller, S Wind, E Barbosa-Sicard, HHHW Schmidt, R Busse, ...
    Hypertension 51 (2), 211-217 , 2008
    2008
    Citations: 895
  • Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells.
    U Förstermann, JS Pollock, HH Schmidt, M Heller, F Murad
    Proceedings of the National Academy of Sciences 88 (5), 1788-1792 , 1991
    1991
    Citations: 800
  • Cloned human brain nitric oxide synthase is highly expressed in skeletal muscle
    M Nakane, HHHW Schmidt, JS Pollock, U Förstermann, F Murad
    FEBS letters 316 (2), 175-180 , 1993
    1993
    Citations: 748
  • Transcription factor NRF2 as a therapeutic target for chronic diseases: a systems medicine approach
    A Cuadrado, G Manda, A Hassan, MJ Alcaraz, C Barbas, A Daiber, ...
    Pharmacological reviews 70 (2), 348-383 , 2018
    2018
    Citations: 729
  • cGMP: Generators, Effectors and Therapeutic Implications. Handbook of Experimental Pharmacology
    HHHW Schmidt, F Hofmann, JP Stasch, LK Antos
    Springer , 2009
    2009
    Citations: 724
  • 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)
    T Prangemeier, C Reich, H Koeppl
    IEEE , 2020
    2020
    Citations: 711
  • Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase
    RK Ambasta, P Kumar, KK Griendling, HHHW Schmidt, R Busse, ...
    Journal of Biological Chemistry 279 (44), 45935-45941 , 2004
    2004
    Citations: 705
  • Mapping of neural nitric oxide synthase in the rat suggests frequent co-localization with NADPH diaphorase but not with soluble guanylyl cyclase, and novel paraneural functions …
    HH Schmidt, GD Gagne, M Nakane, JS Pollock, MF Miller, F Murad
    Journal of Histochemistry & Cytochemistry 40 (10), 1439-1456 , 1992
    1992
    Citations: 703
  • Evolution of NADPH oxidase inhibitors: selectivity and mechanisms for target engagement
    S Altenhöfer, KA Radermacher, PWM Kleikers, K Wingler, HHHW Schmidt
    Antioxidants & redox signaling 23 (5), 406-427 , 2015
    2015
    Citations: 664
  • Nitric oxide synthase in macula densa regulates glomerular capillary pressure.
    CS Wilcox, WJ Welch, F Murad, SS Gross, G Taylor, R Levi, HH Schmidt
    Proceedings of the National Academy of Sciences 89 (24), 11993-11997 , 1992
    1992
    Citations: 629
  • The concise guide to pharmacology 2019/20: Enzymes
    SPH Alexander, D Fabbro, E Kelly, A Mathie, JA Peters, EL Veale, ...
    British journal of pharmacology 176, S297-S396 , 2019
    2019
    Citations: 565
  • Arginine is a physiological precursor of endothelium-derived nitric oxide
    HHHW Schmidt, H Nau, W Wittfoht, J Gerlach, KE Prescher, MM Klein, ...
    European journal of pharmacology 154 (2), 213-216 , 1988
    1988
    Citations: 561
  • Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    JP Stasch, PM Schmidt, PI Nedvetsky, TY Nedvetskaya, AK HS, S Meurer, ...
    The Journal of clinical investigation 116 (9), 2552-2561 , 2006
    2006
    Citations: 558