Hamid Reza Moradi

@shirazu.ac.ir

Basic Sciences, School of Veterinary
Shiraz University

Hamid Reza Moradi


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https://researchid.co/hmoradi20

RESEARCH INTERESTS

Neurosciences; Veterinary Medicine; Reproductive Health
33

Scopus Publications

1302

Scholar Citations

13

Scholar h-index

15

Scholar i10-index

Scopus Publications

  • Protective effects of wheat sprouts extract against acrylamide-induced skin toxicity: Modulation of oxidative stress, apoptosis, and histomorphometric alterations in rats
    Hamid Reza Moradi, Azadeh Vafaeyan, Zabihollah Khaksar, Fatemeh Alipour
    Environmental Science and Pollution Research, 2026
  • Transplacental and lactational transfer of polystyrene nanoplastics leads to long-term ovarian impairment in rat offspring
    Mohammad Bostanifard, Hamid Reza Moradi, Zabihollah Khaksar, Sajjad Abbasi, Behzad Shirkavand Hadavand, Milad Faraji
    Journal of Hazardous Materials Advances, 2026
    • PS-NPs cross placenta and accumulate in fetal and postnatal ovaries. • Maternal PS-NP exposure disrupts folliculogenesis and ovarian structure. • Oxidative stress and hormonal imbalance accompany PS-NP–induced toxicity. • Ovarian damage from PS-NPs persists from gestation through postnatal stages. Polystyrene nanoplastics (PS-NPs) are emerging environmental contaminants that can cross biological barriers and accumulate in the reproductive organs. This study evaluated developmental ovarian toxicity after maternal and lactational PS-NP exposure in rats on gestational day 20 (GD20) and postnatal days 30 and 60 (PD30, PD60). Pregnant Sprague–Dawley rats were administered PS-NPs at doses of 0.1, 1, or 10 mg/kg/day during gestation and lactation. At GD20, fetal ovaries from exposed dams showed a significant reduction in primordial follicle number and diameter, early granulosa cell disorganization, and a lower parenchyma-to-stroma ratio, indicating impaired folliculogenesis. By PD30 and PD60, ovarian alterations intensified in a dose-dependent manner, including granulosa layer thinning, follicular degeneration, and cortical disarray, which were most pronounced in the high-dose group. Fluorescence microscopy confirmed the transplacental and lactational transfer of rhodamine-labeled PS-NPs, with persistent and dose-dependent accumulation in the follicles and stroma. Biochemically, PS-NP exposure increased the total oxidant status (TOS) and oxidative stress index (OSI) while decreasing the total antioxidant capacity (TAC). Serum estradiol and progesterone levels declined markedly, consistent with oxidative and endocrine disruption. Immunohistochemistry revealed the upregulation of P53 and downregulation of BCL-2, indicating apoptosis-mediated ovarian injury. These findings demonstrate that combined gestational and lactational PS-NP exposure causes persistent, dose-dependent ovarian damage from the fetal stage through postnatal development, highlighting the reproductive risks associated with maternal nanoplastic exposure in an increasingly polluted environment.
  • Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels in experimental type 2 diabetes in rats
    Milad Faraji, Mohammad Foad Noorbakhsh, Nasrin Kazemipour, Saeed Nazifi, Hamid Reza Moradi, Nasrollah Ahmadi, Maryam Azadmanesh
    Animal Models and Experimental Medicine, 2025
    BackgroundDiabetes, a metabolic disease marked by endocrine dysfunctions, significantly impacts oxidative stress pathways. This study explores the protective effects of lemongrass extract (LE), citral, and lemongrass extract‐synthesized silver nanoparticles (LE‐AgNP) against hyperglycemia‐induced oxidative stress by modulating the Nrf2 pathway, which is crucial for antioxidant responses.MethodsVarious techniques characterized the nanoparticles, including ultraviolet–visible spectroscopy, dynamic light scattering, zeta potential analysis, Fourier‐transform infrared spectroscopy, scanning electron microscopy and transmission electron microscopy. Seventy rats, divided into seven groups, were used for in vivo experiments. Type 2 diabetes was induced using streptozotocin (65 mg/kg) and nicotinamide (90 mg/kg). After six weeks, biochemical parameters such as total antioxidant capacity, malondialdehyde, Nrf2, and Nrf2 miRNA were evaluated in pancreas tissue and blood serum, along with serum blood glucose levels.ResultsLE‐AgNP significantly improved weight gain, reduced food and water intake, and lowered blood glucose levels in diabetic rats. LE and citral did not significantly alter these parameters but prevented the decline in Nrf2 gene expression. LE‐AgNP showed a significant increase in Nrf2 gene expression compared to the diabetic control group.ConclusionsThis study highlights the potential of LE, citral, and especially LE‐AgNP in mitigating oxidative stress induced by diabetes. LE‐AgNP demonstrated superior therapeutic benefits, including improved oxidative stress conditions and hypoglycemic effects.
  • The Therapeutic Efficacy of MS473, a Fully Human Single-Chain Variable Fragment Targeting Staphylococcus aureus Toxic Shock Syndrome Toxin-1, in a D-Galactosamine-Sensitized Mouse Model of Lethal Shock
    Fatemeh Rahimi-Jamnani, Hamid Reza Moradi, Abolfazl Fateh, Masoumeh Azizi, Farzaneh Nazari, Mahdieh Soezi, Seyed Davar Siadat
    BMC Microbiology, 2025
    Toxic shock syndrome toxin-1 (TSST-1), produced by Staphylococcus aureus, is one of the most potent superantigens involved in causing life-threatening TSS and contributes to the onset of some autoimmune diseases. To this end, we have previously identified a fully human single-chain variable fragment antibody (scFv), MS473, exhibiting high binding affinity and specificity for TSST-1 and demonstrating in vitro neutralization activity. In the present study, the therapeutic activity of MS473 was assessed in a D-galactosamine-sensitized mouse model of lethal shock. D-galactosamine-sensitized mice were injected with TSST-1 and then received a single dose of MS473 intraperitoneally (15 mg per kg of mouse body weight) after five minutes or intravenously (3 mg per kg of mouse body weight) after 10 min. The survival rate was examined for seven days. Furthermore, blood samples from different groups of mice were subjected to biochemical assessment, and their kidneys and livers were analyzed histopathologically 24 h after the toxin injection. The findings demonstrated a 100% survival rate with no significant damage to kidney and liver function in the treated groups, receiving MS473 through two different administration routes compared to the control groups, including the toxin-injected mice receiving normal saline or an unrelated scFv. Targeting disseminated TSST-1 with the scFv, which has appropriate permeability and distribution throughout the body, may be an effective way to alleviate the malfunctioning of the immune system caused by TSST-1.
  • Comparative study of liver injury protection by Akkermansia muciniphila and Faecalibacterium prausnitzii interventions in live and cell-free supernatant forms via targeting the hepcidin – ferroportin axis in mice with CCl₄-induced liver fibrosis
    Sara Ahmadi Badi, Hananeh Tavakoli Aval, Hamid Reza Moradi, Amin Malek, Seyed Amirhesam Seyedi, et al.
    Gut Pathogens, 2025
    BACKGROUND: liver fibrosis is associated with dysregulated iron homeostasis regulated by the hepcidin-ferroportin axis, and dysbiotic gut microbiota. This study aimed to investigate the preventive and ameliorative effects of live and cell-free supernatant (CFS) forms of Akkermansia muciniphila and Faecalibacterium prausnitzii, as important gut microbiota members, on liver fibrosis by targeting the hepcidin-ferroportin axis in both in vitro and in vivo models. METHODS: At the in vitro level, the effects of A. muciniphila and F. prausnitzii on the expression of collagen type I alpha 1 (COL1A1) and ferroportin (SLC40A1) transcripts in hepatic stellate cells (HSCs) were evaluated in transforming growth factor beta (TGFβ)-activated LX-2 cells, a human hepatic stellate cell line. In vivo, male C57BL/6 mice were intraperitoneally (IP) injected with 10% carbon tetrachloride (CCl₄) twice weekly for 6 weeks to establish the liver fibrosis model. Administration of live and CFS forms of A. muciniphila and F. prausnitzii was initiated 10 days before CCl₄ injection and continued until the end of the experiment. Liver injury and fibrosis were assessed using serum markers, hematoxylin and eosin (H&E), and Masson's trichrome staining. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC) were used to evaluate the effects of the interventions on gene expression related to the hepcidin-ferroportin axis in liver, colon and brain samples. Additionally, qPCR was used to determine alterations in the relative abundance of key gut microbiota members in fecal samples. RESULTS: Both A. muciniphila and F. prausnitzii, as well as their CFS, significantly downregulated COL1A1 expression in TGFβ-activated LX-2 cells, accompanied by reduced alpha-smooth muscle actin (α-SMA) protein expression in liver tissue. In vivo, intervention with F. prausnitzii, particularly its CFS, led to a greater induction of hepatic hepcidin and ferroportin expression compared to A. muciniphila and its CFS. Serum liver injury markers (alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH)) and iron levels were markedly improved following treatment with live F. prausnitzii and its CFS. Additionally, F. prausnitzii CFS significantly enhanced hepcidin gene expression in brain tissue, suggesting broader systemic benefits. CONCLUSION: We demonstrated that F. prausnitzii and its CFS had greater beneficial potential than A. muciniphila and its CFS in the prevention and amelioration of liver fibrosis, likely through modulation of the hepcidin-ferroportin axis. These findings may support the development of next-generation probiotics and postbiotics for liver injury, which warrants further investigation.
  • Protective effects of wheat sprout extract on acrylamide-induced toxicity in testis, prostate gland and sperm parameters of rats
    Hamid Reza Moradi, Nasrin Kazemipour, Saeed Nazifi, Melika Khodayari, Laleh Samadi, Alireza Yousefi
    Journal of Molecular Histology, 2025
  • The Role of Small Extracellular Vesicles Derived from Glial Cells in the Central Nervous System under both Normal and Pathological Conditions
    Sajad Sahab Negah, Hamid Reza Moradi, Fatemeh Forouzanfar, Mohammad Ali Sahraian, Milad Faraji
    Neurochemical Research, 2025
  • Effects of drinking water supplemented with apple vinegar, essential oils, or colistin sulfate on growth performance, blood lipids, antioxidant status, intestinal morphology, and gut microflora of broiler chickens
    A. Ashayerizadeh, M.R. Jafarzadeh Shirazi, H.R. Moradi, K. Kazemi, Z. Karimi Akbarabadi, V. Jazi
    Poultry Science, 2025
    With rising concerns about antibiotic resistance and its consequences on public health, the identification of safe and effective alternatives to antibiotics in the poultry industry has become increasingly critical. This study aimed to evaluate the effects of supplementing drinking water with apple vinegar and essential oils, compared to an antibiotic growth promoter, on the growth performance, serum lipid profile, antioxidant status, intestinal morphology, and gastrointestinal microflora population of broiler chickens. A total of 240 one-day-old male broiler chickens were randomly assigned to four treatments, each consisting of six replicate pens with ten birds per pen. The broiler chickens received the following experimental treatments: normal drinking water without additives (control) and drinking water supplemented with antibiotic (0.25 ml/L), apple vinegar (1 ml/L), and essential oils blend (0.5 ml/L). The results showed that adding antibiotic or essential oils blend to drinking water improved body weight gain and feed conversion ratio throughout the entire rearing period (P < 0.05). The serum levels of cholesterol and low-density lipoprotein in broilers that received apple vinegar or essential oils blend were lower than those in the control and antibiotic groups (P < 0.05). The essential oils blend treatment significantly increased the activity of glutathione peroxidase and superoxide dismutase in the serum of broiler chickens compared to the other treatments (P < 0.05). Furthermore, adding essential oils blend to the drinking water increased villus height and villus height to crypt depth ratio in the jejunum of broilers (P < 0.05). The broiler chickens in the apple vinegar and essential oil blend groups also exhibited a lower population of Enterobacteriaceae and a higher count of lactic acid bacteria in the ceca (P < 0.05). In summary, the addition of essential oils blend to the drinking water of broiler chickens has beneficial effects on production performance and can serve as an effective alternative to antibiotic growth promoters.
  • Protective Role of Zingiber officinale Extract on Acrylamide-Induced Toxicity in Rat Testes: Immunohistochemical, Histomorphological, Biochemical, and Sperm Analysis
    Hamid Reza Moradi, Zabihollah Khaksar, Fatemeh Alipour, Saeid Fathollahi, Mohammad-Reza Divar, Mohsen Rashidi
    Andrologia, 2025
    Acrylamide (ACA), a common food and industrial toxin, impairs male reproduction through oxidative stress, hormonal disruption, and apoptosis. This study evaluated the effects of Zingiber officinale (ginger; GING), a natural antioxidant, on testicular changes, including histomorphological, biochemical, and immunohistochemical aspects, as well as sperm quality in rats exposed to ACA. Thirty‐two adult male rats were randomly divided into four groups ( n = 8 per group): control (1 mL distilled water), ACA (10 mg/kg), GING (200 mg/kg), and ACA + GING (co‐treatment). The sample size was determined based on previous toxicological studies and provided sufficient statistical power for intergroup comparisons. All treatments were administered orally once daily for 52 days. The findings demonstrated that ACA harmed sperm quality and testicular health, while GING improved them and preserved testicular structure ( p = 0.001). GING restored testosterone, FSH, and LH levels disrupted by ACA, significantly increasing testosterone and normalizing FSH and LH concentrations to values close to the control values ( p = 0.001). ACA increased MDA and decreased TAC, reduced BCL‐2, and elevated p53 and TNF‐α levels in the testes. GING reversed these effects ( p = 0.001). Ginger extract mitigates ACA‐induced testicular damage by enhancing antioxidant defenses, restoring hormonal balance, and suppressing apoptosis and inflammation, suggesting potential therapeutic benefits against ACA‐related male infertility.
  • Anti-Acinetobacter Baumannii single-chain variable fragments provide therapeutic efficacy in an immunocompromised mouse pneumonia model
    Eilnaz Basardeh, Somayeh Piri-Gavgani, Hamid Reza Moradi, Masoumeh Azizi, Parastoo Mirzabeigi, Farzaneh Nazari, Mostafa Ghanei, Fereidoun Mahboudi, Fatemeh Rahimi-Jamnani
    BMC Microbiology, 2024
    Background The emergence of carbapenem-resistant and extensively drug-resistant (XDR) Acinetobacter baumannii as well as inadequate effective antibiotics calls for an urgent effort to find new antibacterial agents. The therapeutic efficacy of two human scFvs, EB211 and EB279, showing growth inhibitory activity against A. baumannii in vitro, was investigated in immunocompromised mice with A. baumannii pneumonia. Results The data revealed that infected mice treated with EB211, EB279, and a combination of the two scFvs showed better survival, reduced bacterial load in the lungs, and no marked pathological abnormalities in the kidneys, liver, and lungs when compared to the control groups receiving normal saline or an irrelevant scFv. Conclusions The results from this study suggest that the scFvs with direct growth inhibitory activity could offer promising results in the treatment of pneumonia caused by XDR A. baumannii.
  • Effects of nanoplastics and microplastics on the health of the peripheral and central nervous system
    Hamid Reza Moradi, Sohrab Heydarian, Sahar Abdollahinezhad
    Neuroscience Journal of Shefaye Khatam, 2024
  • Comparative Effects of Curcumin Nano-Niosomes and Free Curcumin on Apoptosis, Intracellular ROS, and STAT3/NF-κB Signaling Pathway in A549 Lung Cancer Cells
    Journal of Veterinary Research, 2024
  • Diversity-oriented synthesis of novel sulfonated piperazine derivatives endowing dual biological activities
    Azim Ziyaei Halimehjani, Sahar Bayat, Seyyed Emad Hooshmand, Gholamhossein Tondro, Hamid Reza Moradi, Jafar Jalaei
    Journal of Molecular Structure, 2024
  • Protective Effects of Frankincense Extract on the Histological Structure of the Hippocampus and Cerebellum in Rats Exposed to Acrylamide
    Maede Boroomand, Elham Salehi, Majid Morovati Sharifabad, Hamidreza Morady, Mohsen Rashidi
    Neuroscience Journal of Shefaye Khatam, 2024
  • The Role of Exosomes in the Pathogenesis, Diagnosis, and Treatment of Parkinson’s and Alzheimer’s Diseases
    Hami Reza Moradi, Sahar Abdollahinezhad, Sohrab Heydarian
    Neuroscience Journal of Shefaye Khatam, 2024
  • Effect of Lighting Schedule during Incubation on Embryonic Development and Bone Gene (Col10a1, Spp1, Bglap, and AlpExpression in Broiler Hatchlings
    Iranian Journal of Applied Animal Science, 2024
  • Intraspecific anatomical variations of the extensor tendons of the carpus and digits with a reexamination of their insertion sites in the domestic dog (Canis lupus familiaris): a cadaveric study
    Younes Kamali, Reyhaneh Almasi, Hamid Reza Moradi, Saeid Fathollahi
    BMC Veterinary Research, 2023
  • Fabrication, characterization, and in vivo implantation of eugenol-loaded nanogels and PCL/Cs electrospun nanofibers for wound healing applications
    Fariba Noori, Mahmoud Osanloo, Hamid Reza Moradi, Hamidreza Ghaderi Jafarbeigloo, Mozhgan Jirehnezhadyan, Seyed Amin Kouhpayeh, Mahtab Tirgare, Azam Bozorgi, Arash Goodarzi
    Journal of Bioactive and Compatible Polymers, 2023
  • Protective Effects of Wheat Sprout on Acrylamide Toxicity in the Hippocampus Structure and Spatial Learning and Memory of Rat
    Hamid Reza Moradi, Mahnaz Taherianfard, Mohsen Rashidi, Zahra Javid, Sayed Amir Hesami
    Neuroscience Journal of Shefaye Khatam, 2023
  • The anti-inflammatory effects of Akkermansia muciniphila and its derivates in HFD/CCL4-induced murine model of liver injury
    Shahrbanoo Keshavarz Azizi Raftar, Fatemeh Ashrafian, Sara Abdollahiyan, Abbas Yadegar, Hamid Reza Moradi, Morteza Masoumi, Farzam Vaziri, Arfa Moshiri, Seyed Davar Siadat, Mohammad Reza Zali
    Scientific Reports, 2022
  • Anti-Inflammatory Effects of Nano- Curcumin on a Glioblastoma Cell Line
    Golamhossein Tondro, , Ghadir Rajabzade, , Ali Mohammadi, , Hamidreza Moradi, , Sajad Sahab Negah, and
    Neuroscience Journal of Shefaye Khatam, 2022
  • Comparative effects of alive and pasteurized Akkermansia muciniphila on normal diet-fed mice
    Fatemeh Ashrafian, Shahrbanoo Keshavarz Azizi Raftar, Arefeh Shahryari, Ava Behrouzi, Rezvan Yaghoubfar, Arezou Lari, Hamid Reza Moradi, Shohreh Khatami, Mir Davood Omrani, Farzam Vaziri, Andrea Masotti, Seyed Davar Siadat
    Scientific Reports, 2021
  • Extracellular vesicles and pasteurized cells derived from Akkermansia muciniphila protect against high-fat induced obesity in mice
    Fatemeh Ashrafian, Shahrbanoo Keshavarz Azizi Raftar, Arezou Lari, Arefeh Shahryari, Sara Abdollahiyan, Hamid Reza Moradi, Morteza Masoumi, Mehdi Davari, Shohreh khatami, Mir Davood Omrani, Farzam Vaziri, Andrea Masotti, Seyed Davar Siadat
    Microbial Cell Factories, 2021
  • The protective effects of live and pasteurized akkermansia muciniphila and its extracellular vesicles against HFD/CCl4-induced liver injuryS
    Shahrbanoo Keshavarz Azizi Raftar, Fatemeh Ashrafian, Abbas Yadegar, Arezou Lari, Hamid Reza Moradi, Arefeh Shahriary, Masoumeh Azimirad, Helia Alavifard, Zhaleh Mohsenifar, Mehdi Davari, Farzam Vaziri, Arfa Moshiri, Seyed Davar Siadat, Mohammad Reza Zali
    Microbiology Spectrum, 2021
  • The next step of neurogenesis in the context of Alzheimer’s disease
    H. Moradi, Vahid Hajali, Z. Khaksar, F. Vafaee, F. Forouzanfar, S. S. Negah
    Molecular Biology Reports, 2021
  • Histomorphology of the lower respiratory tract in the Indian crested porcupine (Hystrix indica)
    Behrokh Marzban Abbasabadi, Hamid Reza Moradi, Shirin Arefi, Michal Kyllar
    Journal of Veterinary Medicine Series C Anatomia Histologia Embryologia, 2021
  • Modulation of serotonin signaling/metabolism by Akkermansia muciniphila and its extracellular vesicles through the gut-brain axis in mice
    Rezvan Yaghoubfar, Ava Behrouzi, Fatemeh Ashrafian, Arefeh Shahryari, Hamid Reza Moradi, Samira Choopani, Shima Hadifar, Farzam Vaziri, Seyed Ali Nojoumi, Abolfazl Fateh, Shohreh Khatami, Seyed Davar Siadat
    Scientific Reports, 2020
  • The Impact of Estradiol on Neurogenesis and Cognitive Functions in Alzheimer’s Disease
    Sajad Sahab-Negah, Vahid Hajali, Hamid Reza Moradi, Ali Gorji
    Cellular and Molecular Neurobiology, 2020
  • Histological and Histometrical Study of Prostate Following Administration of Sertraline in Adult Mice
    Hassan Morovvati, Mohammadkazem Koohi, Zabihollah Khaksar, Freshteh Morshedi, Hojat Anbara, Fatemeh Parsaei, Mehdi Hadijafari, Hamidreza Moradi, , , , , , , , and
    Iranian South Medical Journal, 2020
  • Akkermansia muciniphila-Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice
    Fatemeh Ashrafian, Arefeh Shahriary, Ava Behrouzi, Hamid Reza Moradi, Shahrbanoo Keshavarz Azizi Raftar, Arezou Lari, Shima Hadifar, Rezvan Yaghoubfar, Sara Ahmadi Badi, Shohre Khatami, Farzam Vaziri, Seyed Davar Siadat
    Frontiers in Microbiology, 2019
  • The compensation effect of dietary garlic on chicken consuming a minimal level of choline
    Bahman Navidshad, Zeinab Maghsoodi, Saeid Nikbin, Vahid Vahedi, Masoud Adibmoradi, Farzad Mirzaei Aghjehgheshlagh, Hamidreza Moradi
    Italian Journal of Animal Science, 2018
  • Evaluation of sperm quality in mice exposed to camphor and protective role of Vitamin E
    Journal of Veterinary Research, 2016
  • Study of histomorphometric changes in adult rats skin following injection of PRP and PPP
    Journal of Veterinary Research, 2016

RECENT SCHOLAR PUBLICATIONS

  • Protective effects of wheat sprouts extract against acrylamide-induced skin toxicity: Modulation of oxidative stress, apoptosis, and histomorphometric alterations in rats
    HR Moradi, A Vafaeyan, Z Khaksar, F Alipour
    Environmental Science and Pollution Research, 1-13 , 2026
    2026
  • Transplacental and lactational transfer of polystyrene nanoplastics leads to long-term ovarian impairment in rat offspring
    M Bostanifard, HR Moradi, Z Khaksar, S Abbasi, BS Hadavand, M Faraji
    Journal of Hazardous Materials Advances, 101007 , 2026
    2026
  • Oral niacin mitigates heat-induced reproductive impairments in male mice
    M Zahra, DM Reza, J Gholamali, MH Reza, AJ Sanaz, MA Amir, E Davoud
    Scientific Reports 15 (1), 38351 , 2025
    2025
    Citations: 1
  • Comparative study of liver injury protection by Akkermansia muciniphila and Faecalibacterium prausnitzii interventions in live and cell-free supernatant forms via …
    S Ahmadi Badi, H Tavakoli Aval, HR Moradi, A Malek, SA Seyedi, ...
    Gut Pathogens 17 (1), 54 , 2025
    2025
    Citations: 3
  • Effects of Nano-Niosomal Curcumin on Survival, Migration and DNA Fragmentation on A549 Lung Cancer Cells
    HR Moradi, G Tondro, MH Darvishi, S Sahab-Negah, A Mohammadi, ...
    Veterinary Research & Biological Products 38 (2), 53-61 , 2025
    2025
  • Protective effects of wheat sprout extract on acrylamide-induced toxicity in testis, prostate gland and sperm parameters of rats
    HR Moradi, N Kazemipour, S Nazifi, M Khodayari, L Samadi, A Yousefi
    Journal of Molecular Histology 56 (3), 137 , 2025
    2025
    Citations: 6
  • The role of small extracellular vesicles derived from glial cells in the central nervous system under both normal and pathological conditions
    SS Negah, HR Moradi, F Forouzanfar, MA Sahraian, M Faraji
    Neurochemical Research 50 (2), 89 , 2025
    2025
    Citations: 7
  • The Therapeutic Efficacy of MS473, a Fully Human Single-Chain Variable Fragment Targeting Staphylococcus aureus Toxic Shock Syndrome Toxin-1, in a D …
    F Rahimi-Jamnani, HR Moradi, A Fateh, M Azizi, F Nazari, M Soezi, ...
    BMC microbiology 25 (1), 95 , 2025
    2025
    Citations: 2
  • Effects of drinking water supplemented with apple vinegar, essential oils, or colistin sulfate on growth performance, blood lipids, antioxidant status, intestinal morphology …
    A Ashayerizadeh, MRJ Shirazi, HR Moradi, K Kazemi, ZK Akbarabadi, ...
    Poultry Science 104 (2), 104801 , 2025
    2025
    Citations: 16
  • Preventive and therapeutic effects of co-administration of Bacteroides thetaiotaomicron and infliximab on dextran sodium sulfate-induced colitis in mice
    SA Badi, HR Moradi, A Berimipour, S Shojaie, A Kariman, HT Aval, ...
    Intestinal research , 2025
    2025
    Citations: 1
  • Protective Role of Zingiber officinale Extract on Acrylamide‐Induced Toxicity in Rat Testes: Immunohistochemical, Histomorphological, Biochemical, and Sperm …
    HR Moradi, Z Khaksar, F Alipour, S Fathollahi, MR Divar, M Rashidi
    Andrologia 2025 (1), 9324806 , 2025
    2025
    Citations: 4
  • Niacin (Vitamin B3) in Neurodegenerative Disorders: A Comprehensive Review of its Effects on Alzheimer's, Parkinson's, and Huntington's Diseases
    Z Khaksar, HR Moradi
    The Neuroscience Journal of Shefaye Khatam, 0-0 , 2025
    2025
  • Comparison of the effects of metformin, citral, Cymbopogon citratus extract and silver nanoparticles of Cymbopogon citratus extract on oxidative stress indices and Nrf2 levels …
    M Faraji, MF Noorbakhsh, N Kazemipour, S Nazifi, HR Moradi, N Ahmadi, ...
    Animal models and experimental medicine, 1-11 , 2025
    2025
    Citations: 1
  • Effects of Nanoplastics and Microplastics on the Health of the Peripheral and Central Nervous System
    HR Moradi, S Heydarian, S Abdollahinezhad
    The Neuroscience Journal of Shefaye Khatam 12 (4), 97-110 , 2024
    2024
    Citations: 2
  • Diversity-oriented synthesis of novel sulfonated piperazine derivatives endowing dual biological activities
    AZ Halimehjani, S Bayat, SE Hooshmand, G Tondro, HR Moradi, J Jalaei
    Journal of Molecular Structure 1309, 138263 , 2024
    2024
    Citations: 1
  • Proective Effect of Frankincense Extract on the Histological Structure of Hippocampus and Cerebellum of Rats Exposed to Acrylamide
    M Boroomand, E Salehi, H Morady, M Rashidi
    The Neuroscience Journal of Shefaye Khatam 12 (3), 64-76 , 2024
    2024
    Citations: 2
  • Anti- Acinetobacter baumannii single-chain variable fragments provide therapeutic efficacy in an immunocompromised mouse pneumonia model
    E Basardeh, S Piri-Gavgani, HR Moradi, M Azizi, P Mirzabeigi, F Nazari, ...
    BMC microbiology 24 (1), 55 , 2024
    2024
    Citations: 9
  • Comparative Effects of Curcumin Nano-Niosomes and Free Curcumin on Apoptosis, Intracellular ROS, and STAT3/NF-κB Signaling Pathway in A549 Lung Cancer Cells
    G Tondro, MH Darvishi, S Sahab-Negah, G Rajabzadeh, A Mohammadi, ...
    Journal of Veterinary Research 79 (3) , 2024
    2024
    Citations: 2
  • Effect of Lighting Schedule during Incubation on Embryonic Development and Bone Gene (Col10a1, Spp1, Bglap, and Alp) Expression in Broiler Hatchlings.
    SM Hashemian, MJ Zamiri, Z Khaksar, ZA Pirsaraei, HR Moradi
    Iranian Journal of Applied Animal Science 14 (1) , 2024
    2024
  • Fabrication, characterization, and in vivo implantation of eugenol-loaded nanogels and PCL/Cs electrospun nanofibers for wound healing applications
    F Noori, M Osanloo, HR Moradi, H Ghaderi Jafarbeigloo, ...
    Journal of Bioactive and Compatible Polymers 38 (6), 480-492 , 2023
    2023
    Citations: 14

MOST CITED SCHOLAR PUBLICATIONS

  • Akkermansia muciniphila -Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice
    F Ashrafian, A Shahriary, A Behrouzi, HR Moradi, ...
    Frontiers in microbiology 10, 2155 , 2019
    2019
    Citations: 286
  • Modulation of serotonin signaling/metabolism by Akkermansia muciniphila and its extracellular vesicles through the gut-brain axis in mice
    R Yaghoubfar, A Behrouzi, F Ashrafian, A Shahryari, HR Moradi, ...
    Scientific reports 10 (1), 22119 , 2020
    2020
    Citations: 186
  • Extracellular vesicles and pasteurized cells derived from Akkermansia muciniphila protect against high-fat induced obesity in mice
    AM Fatemeh Ashrafian, Shahrbanoo Keshavarz Azizi Raftar, Arezou Lari, Arefeh ...
    Microbial Cell Factories 20 , 2021
    2021
    Citations: 132
  • The protective effects of live and pasteurized Akkermansia muciniphila and its extracellular vesicles against HFD/CCl4-induced liver injury
    S Keshavarz Azizi Raftar, F Ashrafian, A Yadegar, A Lari, HR Moradi, ...
    Microbiology Spectrum 9 (2), e00484-21 , 2021
    2021
    Citations: 117
  • The anti-inflammatory effects of Akkermansia muciniphila and its derivates in HFD/CCL4-induced murine model of liver injury
    MR Shahrbanoo Keshavarz Azizi Raftar, Fatemeh Ashrafian, Sara Abdollahiyan ...
    Scientific Reports 12 , 2022
    2022
    Citations: 115
  • The impact of estradiol on neurogenesis and cognitive functions in Alzheimer’s disease
    S Sahab-Negah, V Hajali, HR Moradi, A Gorji
    Cellular and molecular neurobiology 40 (3), 283-299 , 2020
    2020
    Citations: 90
  • Comparative effects of alive and pasteurized Akkermansia muciniphila on normal diet-fed mice
    F Ashrafian, S Keshavarz Azizi Raftar, A Shahryari, A Behrouzi, ...
    Scientific reports 11 (1), 17898 , 2021
    2021
    Citations: 82
  • The histological and histometrical effects of Urtica dioica extract on rat’s prostate hyperplasia
    HR Moradi, NE Majd, S Esmaeilzadeh, SRF Tabatabaei
    Veterinary Research Forum 6 (1), 23 , 2015
    2015
    Citations: 70
  • Protective effects of wheat sprout on testicular toxicity in male rats exposed to lead
    M Adibmoradi, H Morovvati, HR Moradi, MT Sheybani, JS Amoli, ...
    Reprod Syst Sex Disord 4 (4), 1-9 , 2015
    2015
    Citations: 25
  • Effects of drinking water supplemented with apple vinegar, essential oils, or colistin sulfate on growth performance, blood lipids, antioxidant status, intestinal morphology …
    A Ashayerizadeh, MRJ Shirazi, HR Moradi, K Kazemi, ZK Akbarabadi, ...
    Poultry Science 104 (2), 104801 , 2025
    2025
    Citations: 16
  • The next step of neurogenesis in the context of Alzheimer’s disease
    HR Moradi, V Hajali, Z Khaksar, F Vafaee, F Forouzanfar, SS Negah
    Molecular Biology Reports 48 (7), 5647-5660 , 2021
    2021
    Citations: 16
  • Effect of hydroalcoholic extract of wheat sprout on histology and histometry structure of rat's prostate exposed to lead
    H Morovvati, HR Moradi, M Biabani
    Iranian South Medical Journal 20 (6), 540-552 , 2018
    2018
    Citations: 16
  • Fabrication, characterization, and in vivo implantation of eugenol-loaded nanogels and PCL/Cs electrospun nanofibers for wound healing applications
    F Noori, M Osanloo, HR Moradi, H Ghaderi Jafarbeigloo, ...
    Journal of Bioactive and Compatible Polymers 38 (6), 480-492 , 2023
    2023
    Citations: 14
  • Anti-inflammatory effects of nano-curcumin on a glioblastoma cell line
    G Tondro, G Rajabzade, A Mohammadi, H Moradi, S Sahab Negah
    The Neuroscience Journal of Shefaye Khatam 10 (3), 48-56 , 2022
    2022
    Citations: 12
  • Effect of aspartame on histological and histometrical structure of prostate gland in adult mice
    H Morovvati, Z Khaksar, MT Sheibani, H Anbara, MA Kafiabad, HR Moradi
    Qom Univ Med Sci J 12 (12), 14-27 , 2019
    2019
    Citations: 12
  • Anti- Acinetobacter baumannii single-chain variable fragments provide therapeutic efficacy in an immunocompromised mouse pneumonia model
    E Basardeh, S Piri-Gavgani, HR Moradi, M Azizi, P Mirzabeigi, F Nazari, ...
    BMC microbiology 24 (1), 55 , 2024
    2024
    Citations: 9
  • Neurotransmitters Play as a Key Role in Adult Neurogenesis
    V Hajali, HR Moradi, S Sahab Negah
    The Neuroscience Journal of Shefaye Khatam 6 (4), 61-74 , 2018
    2018
    Citations: 8
  • The role of small extracellular vesicles derived from glial cells in the central nervous system under both normal and pathological conditions
    SS Negah, HR Moradi, F Forouzanfar, MA Sahraian, M Faraji
    Neurochemical Research 50 (2), 89 , 2025
    2025
    Citations: 7
  • Protective effects of wheat sprout on acrylamide toxicity in the hippocampus structure and spatial learning and memory of rat
    HR Moradi, M Taherianfard, M Rashidi, Z Javid, SA Hesami
    The Neuroscience Journal of Shefaye Khatam 11 (2), 10-9 , 2023
    2023
    Citations: 7
  • Wheat sprout effects on histological and histometrical structure and sperm parameters in testis of rat exposed to lead
    M HR, S MT, A J Salar
    2017
    Citations: 7

Publications

1. Moradi Hamid Reza, Erfani Majd Naeem, Esmaeilzadeh Saleh, Fatemi Tabatabaei Reza. The histological and histometrical effects of Urtica dioica extract on rat’s prostate hyperplasia. Veterinary Research Forum, 2015; 6: 23-29.
2. Masood Adibmoradi, Hamid Reza Moradi, Ali Kalantari hesari, Ghazal Adibmoradi. Study of histomorphometric changes in adult rat's skin following injection of PRP and PPP. Journal of Veterinary Research, 2016; 71(1): 1-8.
3. Hassan Morovvati, Hamid Reza Moradi, Masoud Adibmoradi, Mohammad Taghi Sheybani, Jamileh Salar Amoli. Wheat sprout effects on histological and histometrical structure and sperm parameters in testis of rat exposed to lead. Journal of Veterinary Research, 2017; 72(1): 87-101.
4. Bahman Navidshad, Zeinab Maghsoodi, Saeid Nikbin, Vahid Vahedi, Masoud Adibmoradi, Farzad Mirzaei Aghjehgheshlagh & Hamid Reza Moradi. The compensation effect of dietary garlic on chicken consuming a minimal level of choline. Italian Journal of Animal Science, 2018; 17(1): 1-6.
5. Sajad Sahab Negah, Zabihollah Khaksar, Shahin Mohammad Sadeghi, Naeem Erfanimajd, Sayed Mostafa Modarres Mousavi, Hadi Aligholi, Masoud Adibmoradi, Hamid Reza Moradi*. Effect of nettle root extract on histometrical parameters of cerebral and cerebellar cortices in rat following administration of testosterone. The Neuroscience Journal of Shefaye Khatam, 2015; 3(1): 71-78.
6. Morovvati Hassan, Moradi Hamid Reza, Adibmoradi Masoud, Sheybani Mohammad Taghi, Salar Amoli Jamileh, Kalantari Ali. Effects of wheat sprout extract on the quality of sperm in rats exposed to lead. Iranian Veterinary Journal, 2016; 12(3): 76-85.
7. Sohrab Heydarian, Iraj Pousty, Hamid Reza Moradi. Histomorphological study on prenatal development of spleen in partridge (Alectoris Chukar). Anatomy Science Journal, 2017; 14(1): 15-18.
8. Masoud Adibmoradi, Ali Kalantari Hesari, Hassan Morovvati, Farzad Asadi, Hamid Reza Moradi. Evaluation of sperm quality in mice exposed to camphor and protective role of vitamin E. Journal of Veterinary Research, 2016; 71(2): 237-244.
9. Moradi Hamid Reza, Morovvati Hassan, Adibmoradi Masoud, Najafzadeh Varzi Hosein. The effect of wheat sprout extract on skin injury following injection of lead acetate in rat. Armaghane danesh Journal (Yasuj University of Medical Sciences), 2017; 22 (2): 161-175.
10. Hasan morovvati, Masoud Adibmoradi, Ali Kalantari Hesari, Ramin Mazaheri Nezhad, Hamid Reza Moradi. Effects of camphor on histomorphometric and histochemical parameters of testicular tissue in mice. Iranian Journal of Veterinary Medicine, 2016; 10(3): 225-235.
11. Hasan morovvati, Masoud Adibmoradi, Hamid Reza Moradi, Maziar Taghavi. Detection of herbal tissues in raw meat products using histology method. Veterinary Researches & Biological Products, 2018; 31(1): 123-132.
12. Vahid Hajali, Hamid Reza Moradi, Sajad Sahab Negah. Neurotransmitters play as a key role in adult neurogenesis. The Neuroscience Journal of Shefaye Khatam, 2018; 6(4): 1-14.
13. Naeem Erfani Majd, Hamid Reza Moradi, Parisa Moftakhar. The effects of Urtica Dioica L. root extract on rat testis. Anatomy Science Journal, 2016; 13(4): 225-232.
14. Morovvati Hassan, Moradi Hamid Reza*, Biabani Maysam. Effect of hydroalcoholic extract of wheat sprout on histology and histometry structure of rat's prostate exposed to lead. Iran South Medical Journal. 2018; 20 (6): 540-552.
15. Hassan Morovvati, Zabihollah Khaksar, Mohammad Taghi Sheybani, Hojat Anbara, Mohsen Amini, Hamid Reza Moradi*. Effect of aspartame on histological and histometrical structure of prostate glands in adult mice. Qom University of Medical Sciences Journal, 2019, 12(12): 14-27.
16. Hassan Morovvati, Naeem Erfani Majd, Hamid Reza Moradi, Mehdi Hadi Jafari, Mohammad Mehdi Shamsi, Sajad Chenani. Histological and histochemical study on accessory sex glands of mature native water buffaloes from Khuzestan. Iranian Veterinary Journal, 2019; 15(1): 80-88.
17. Zabihollah Khaksar, Hassan Morovvati, Hamid Reza Moradi, Sajad Sahab Negah. The role of extracellular matrix in myelination and oligodendrogenesis of central nervous system. The Neuroscience Journal of Shefaye Khatam, 2019; 7(2): 66-82.
18. Morovvati H, Koohi M, Khaksar Z, Morshedi F, Anbara H, Parsaei F, Hamid Reza Moradi*. Histological and Histometrical Study of Prostate Following Administration of Sertraline in Adult Mice. Iran South Med J. 2020; 23 (3): 205-221.
19. Sahab-Negah, S., Hajali, V., Hamid Reza Moradi, Gorji, A. The Impact of Estradiol on Neurogenesis and Cognitive Functions in Alzheimer’s Disease. Cell Mol Neurobiol 40, 283–299 (2020).
20. Ashrafian F, Shahriary A, Behrouzi A, Hamid Reza Moradi, Keshavarz Azizi Raftar S, Lari A, Hadifar S, Yaghoubfar R, Ahmadi Badi S, Khatami S, Vaziri F and Siadat SD (2019) Akkermansia muciniphila-Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice. Front. Microbiol. 10:2155. doi: 10.3389/
21. Adibmoradi M, Morovvati H, Hamid Reza Moradi, Sheybani MT, Amoli JS, et al. (2015) Protective Effects of Wheat Sprout on Testicular Toxicity in Male Rats Exposed to Lead. Reprod Syst Sex Disord 4: 156. doi:10.4172/2161-038X.1000156