Humairah Medina Liza Lubis
@umsu.ac.id
Fakultas Kedokteran
Universitas Muhammadiyah Sumatera Utara
RESEARCH INTERESTS
Immunology, Infectious Disease, Pathology
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Humairah Medina Liza Lubis, Mohd Nadjib Dahlan Lubis, and Delyuzar Delyuzar
Scientific Foundation SPIROSKI
BACKGROUND: Interleukin-4 (IL-4) is a cytokine of Th2 response and plays a role as a reducer or silencer of Th1 work. It is more related to allergic processes, with consequent loss of control of the disease (i.e., tuberculosis). Interferon gamma (IFN-γ) is a Type II interferon that inhibits Th2 immune response and inducts Th1 immune response to inhibit tuberculous and viral replication, and any immunostimulatory and immunomodulatory effects. Dark specks (DS) are in the background of eosinophilic granular material seen in aspirations of tuberculous lymphadenitis stained with May–Grunwald Giemsa (MGG). A lesion with DS festers and the disease worsens.
 AIM: This study determines whether the expression of IL-4 is associated with disease severity and compares incidences of expression of IL-4 and IFN-γ in DS lesions.
 MATERIALS AND METHODS: This study includes 100 diagnostic cases of tuberculous lymphadenitis, which were not successfully treated with common antibiotics, but responded to anti-tuberculous drugs (ex juvantibus diagnosis). Out of the 100 cases, 59 cases were with DS and 41 cases were without DS. Out of the 59 cases with DS, 49 cases were IL-4 positive (+) and 10 cases IL-4 negative (–). Of the 41 cases without DS, 10 cases were IL-4 (+) and 31 cases were IL-4 (–). Out of the 59 cases of DS, there were 31 cases with expressions of IL-4 (+) and IFN-γ (–); zero case with IL-4 (–) and IFN-γ (+); 18 cases with IL-4 (+) and IFN-γ (+); and 10 cases with IL-4 (–) and IFN-γ (–). Antigen expressions were determined using rabbit polyclonal to IL-4 (IL-4, ab9622) and rabbit polyclonal to IFN-γ (IFN-γ, ab9657), Abcam. Statistical evaluations were performed using the Chi-square test and Fisher’s exact test. Any p < 0.05 was statistically significant.
 RESULTS: Expression of IL-4 significantly associated with disease severity, compared to IFN-γ expression (p < 0.05). In lesions with DS, IL-4 is more frequently expressed compared with IFN-γ.
 CONCLUSION: IL-4 can be a beneficial indicator of the severity of tuberculous lymphadenitis.
Humairah Medina Liza Lubis, Ratna Akbari Ganie, Delyuzar Delyuzar, Putri Chairani Eyanoer, and Delfitri Munir
Scientific Foundation SPIROSKI
BACKGROUND: We noticed some smears being cytologically diagnosed as common chronic lymphadenitis that cannot be treated with ordinary antibiotics, but succeeded with the anti-tuberculosis drug (ATD), even though it takes longer, up to a year or more. Re-examining the MGG smears, we got cases that show the structure, we call Dark Oval Bodies (DOB). Most of DOB smears express Interferon (IFN)-γ. IFN-γ _plays a role in the protection of infection while interleukin (IL)-4 in the opposite.
 AIM: The purpose of this study is to determine if there is a difference between an expression of IFN-γ _and IL-4 in DOB and whether IFN-γ _is associated with the protection of the disease.
 MATERIALS AND METHODS: Included in this study 41 cases of tuberculous lymphadenopathy with DOB that were not successfully treated with common antibiotics but succeeded with ATD. Antigen expression was determined using rabbit polyclonal to IFN-γ, (ab9657), and IL-4 (ab9622), Abcam. The expression was categorized as positive and negative. The details of the 41 cases were 37 cases (90%) with IFN-γ _(+), 4 (10%) with IFN-γ _(-), 10 (24%) with IL-4 (+), and 31 (76%) with IL-4 (-). Thirty cases expressed IFN-γ _(+) and IL-4 (-), 1: IFN-γ _(-) and IL-4 (+), 8: IFN-γ _(+) and IL-4 (+), and 2: IFN-γ _(-) and IL-4 (-).
 RESULTS: IFN-γ _is more frequently expressed in DOB compared to IL-4 (p<0.05, the Fisher’s exact tests).
 CONCLUSION: IFN-γ _can be benefited as the indicator of protection to the tuberculous process.
Noni Novisari Soeroso, Setia Putra Tarigan, Wina Saragih, Novie Diana Sari, Netty Lubis, and Humairah Lubis
Elsevier BV
Orbital metastasis of lung adenocarcinoma is very rare. The incidence is only found to be approximately 7%–12% of lung cancer cases. The lack of knowledge about orbital metastasis results in misdiagnosis between malignant or benign lesion. This was a case of a 39-year-old woman complaining about a protruding left eye and a blind pain in the left eye characterized by hyperemesis eyeball. A CT scan of the orbital showed a soft tissue tumor in the fronto-naso-superomedial area of the left orbital with suspicion of infiltration of the medial rectus muscle, left bulbus oculi, lamina papyracea, and left frontal sinus wall which causes proptosis and soft tissue tumor in the left temporal region with suspicion of infiltration in the left sphenoid wing with an impression of metastasis. A Fine Needle Aspiration Biopsy (FNAB) in the temporal and intra-orbital region showed metastatic adenocarcinoma. Moreover, findings of the chest x-ray and chest CT scan concluded that there was a tumor in the left lung, and a bronchoscopy found adenocarcinoma as the biopsy results.