I am a highly motivated researcher and university lecturer with a solid multidisciplinary background in Biological Sciences, holding a PhD in Sciences (2023) and an MSc in Sciences (2019) from the Universidad Nacional Autónoma de México (UNAM), both awarded with Summa Cum Laude honors. My academic trajectory began with a BSc in Biology from the Universitat de València (Spain), specializing in Health Biology. Over the last 8 years, I have developed extensive expertise in Tissue Engineering, Regenerative Medicine, and Cell Biology, working in top-tier bioengineering laboratories.
EDUCATION
PhD in Sciences (Summa cum Laude) - Universidad Nacional Autónoma de México (UNAM), Mexico - 2023
MSc in Sciences (Summa cum Laude) - Universidad Nacional Autónoma de México (UNAM), Mexico - 2019
BSc in Biology (Mention in Health Biology) - Universitat de València, Spain - 2016
Head and Neck Kaposi Sarcoma—An Updated Focus on Clinical and Epidemiological Characteristics: A Comprehensive Review Luis Alberto Gaitán-Cepeda, Brenda Daniela Ortega-Hidalgo, César Esquivel-Chirinos, Iñigo Gaitán-Salvatella, Stephany Paladines-Calle, et al. Diseases, 2026 Background/Objectives: Interest in Oral Kaposi’s sarcoma (OKS) has declined recently, potentially causing diagnostic errors due to physicians’ unfamiliarity with its presentation. This review describes clinical and demographic characteristics of OKS patients across epidemiological groups. Methods: A literature search of studies published from 1957 to December 2024 was conducted using PubMed, Web of Science, Cochrane Library, Scopus, and Google Scholar. Studies with confirmed oral Kaposi sarcoma were included, while those with incomplete data were excluded. Cases were grouped into classic, endemic, epidemic (AIDS-related), iatrogenic, and HIV-negative males who have sex with males. Sex distribution, mean age, clinical appearance, lesion topography, and cause-related information for iatrogenic forms were recorded. Results: A total of 1812 articles were identified through database search. During initial screening, 1162 articles were excluded as duplicates. Of the remaining 650 papers, 338 were dismissed based on title and abstract. Of the remaining 312 articles for full-text review, 93 could not be accessed, leaving 219 articles for analysis. After screening, 123 were excluded, resulting in 117 articles for review. These were categorized as: 16 classical KS, 7 endemic-African, 20 iatrogenic, 70 epidemic-HIV/AIDS-related, and four articles reporting cases among MSM not related to HIV infection. A total of 152 patients with OKS were analyzed. Mean age was 38.04 years (range, 2–86 years), and 75% were male. Of all cases, 64.4% were epidemic, 13.8% iatrogenic, 10.5% classical, and 4.6% endemic. The palate was most common (44.6% of lesions), followed by gingiva (25.3%). Nodular or papular presentations were most frequent. Conclusions. OKS occurs in all KS epidemiological forms, and since this tumor can mimic gingival and periodontal lesions, dentists and physicians must be alert to identify oral Kaposi’s sarcoma.
Synthesis of Hydroxyapatite-Gelatin Composite Hydrogel for Bone Tissue Application José Luis Barrera Bernal, Íñigo Gaytán Salvatella, Bryan Iván Martín del Campo, Marco Antonio Alvarez Perez, David Masuoka-Ito Gels, 2025 Bone tissue engineering has gained attention recently as a method for regenerating bone critical-size defects. This work aims to synthesize a hydrogel based on gelatin, di-amine polyethylene glycol, Polyethylene Glycol-Polypropylene Glycol-Polyethylene glycol, using genipin as a cross-linker and adding hydroxyapatite as a ceramic insert that can be used as a cellular scaffold in bone tissue engineering. Characterization was performed using Fourier transform infrared spectroscopy, identifying the leading absorption bands to verify that the hydrogels cross-linked correctly. The hydrogels with elastic modules and resistances that best adapted to the values reported for the mandibular trabecular bone were identified through mechanical tests. Using scanning electron microscopy, the presence of hydroxyapatite in the hydrogels was verified. The hydrogels with the best results were selected to carry out the biological assays. The cell viability assay verified that the osteoblastic cells proliferated better in the hydroxyapatite scaffolds, and the composite hydrogel induced osteoblast differentiation from undifferentiated mesenchymal stem cells. Hydrogels loaded with hydroxyapatite proved to be a promising biomaterial with potential application in bone regeneration.
In Vitro Bone Differentiation of 3D Microsphere from Dental Pulp-Mesenchymal Stem Cells Iñigo Gaitán-Salvatella, Patricia González-Alva, Juan José Montesinos, Marco Antonio Alvarez-Perez Bioengineering, 2023 Bone defects lead to the structural loss of normal architecture, and those in the field of bone tissue engineering are searching for new alternatives to aid bone regeneration. Dental pulp-mesenchymal stem cells (DP-MSC) could provide a promising alternative to repair bone defects, principally due to their multipotency and capacity to fabricate three-dimensional (3D) spheroids. The present study aimed to characterize the 3D DP-MSC microsphere and the osteogenic differentiation capacity potential cultured by a magnetic levitation system. To achieve this, the 3D DP-MSC microsphere was grown for 7, 14, and 21 days in an osteoinductive medium and compared to 3D human fetal osteoblast (hFOB) microspheres by examining the morphology, proliferation, osteogenesis, and colonization onto PLA fiber spun membrane. Our results showed good cell viability for both 3D microspheres with an average diameter of 350 μm. The osteogenesis examination of the 3D DP-MSC microsphere revealed the lineage commitment, such as the hFOB microsphere, as evidenced by ALP activity, the calcium content, and the expression of osteoblastic markers. Finally, the evaluation of the surface colonization exhibited similar patterns of cell-spreading over the fibrillar membrane. Our study demonstrated the feasibility of forming a 3D DP-MSC microsphere structure and the cell-behavior response as a strategy for the applications of bone tissue guiding.
Case Report: Formation of 3D Osteoblast Spheroid Under Magnetic Levitation for Bone Tissue Engineering Iñigo Gaitán-Salvatella, Edgar Oliver López-Villegas, Patricia González-Alva, Fernando Susate-Olmos, Marco Antonio Álvarez-Pérez Frontiers in Molecular Biosciences, 2021 Skeletal reconstruction is necessary in cases of bone defects created by tumors, trauma, and abnormalities. Regeneration of bone defects remains a critical problem, and current approaches are based on biocompatible scaffolds. Spheroids represent a simple 3D system since no supporting material is required for cell growth. Different techniques are used to generate spheroids, such as hanging drop, low-attachment plates, and magnetic nanoparticles. The idea of using magnetic nanoparticles is to cross-link through cell membrane overnight to create complex 3D cellular spheroid by using magnets to guide the cellular response. Herein, the current study aimed to achieve 3D human fetal osteoblast (hFOB) spheroid under magnetic levitation. Formation of 3D spheroid culture under magnetic levitation was evaluated by cell viability at 3, 7, and 14 days. Morphology of the 3D hFOB spheroid was analyzed by SEM and fluorescence microscopy and the differentiation towards mineralized lineage by ALP assay, qPCR, and alizarin red staining. The cell viability indicated that the 3D hFOB spheroid still viable after 14 days of culture. ALP assay, qPCR analysis expression of Col1, ALP, and Itg-β1 molecules, and calcium deposition with alizarin red showed a high level of bioactivity of the 3D hFOB spheroid. SEM images allowed the morphological analysis of the 3D microtissue-like spheroid with the presence of matrix deposition. These results indicate that magnetic levitation culture enables 3D stable osteoblast spheroids and could be a promising strategy for engineering application in the 3D construct in surgery regeneration of mineralized tissue.
