Scopus Publications
- Production of knowledge using data collected by associations of patients: The fibromyalgia example
Carole Robert, Jean Imbert, Mohamed Lajnef, Camille Noûs, Gilbert Cabiran, et al.
Medecine Sciences, 2021
Pour répondre au défi sociétal de démocratisation de l’accès à la connaissance, différentes initiatives de recherches participatives se développent : actions d’information, de formation ou de consultation des citoyens ou par l’intermédiaire de demandes de financement par des chercheurs auprès des associations. Cependant, peu des collaborations chercheurs-malades sont à l’initiative des personnes concernées, les patients et leurs familles. Nous avons adopté et testé cette démarche à la demande et en coopération avec l’association Fibromyalgie France. - ERBB2b mRNA isoform encodes a nuclear variant of the ERBB2 oncogene in breast cancer
Guoqiang Hua, Aurélie Bergon, Pierre Cauchy, Brigitte Kahn‐Perlès, François Bertucci, et al.
Journal of Cellular Biochemistry, 2020
The presence of nuclear ERBB2 receptor‐type tyrosine kinase is one of the causes of the resistance to membrane ERBB2‐targeted therapy in breast cancers. It has been previously reported that this nuclear location arises through at least two different mechanisms: proteolytic shedding of the extracellular domain of the full‐length receptor and translation of the messenger RNA (mRNA)‐encoding ERBB2 from internal initiation codons. Here, we report a new mechanism and function where a significant portion of nuclear ERBB2 results from the translation of the variant ERBB2 mRNA under the transcriptional control of a distal promoter that is actively used in breast cancer cells. We show that both membrane ERBB2a and nuclear ERBB2b isoforms are prevalently expressed in breast cancer cell lines and carcinoma samples. The ERBB2b isoform, which is translated from mRNA variant 2, can directly translocate into the nucleus due to the lack of the signal peptide which is required for an intermediate membrane location. Small interfering RNA‐mediated gene silencing showed that ERBB2b can repress ERBB2a expression, encoded by variant 1, whereas ERBB2a activates ERBB2b. Nuclear ERBB2 binding to its own promoter was revealed by chromatin immunoprecipitation assay. Altogether, our results provide new insights into the origin and function of nuclear ERBB2 where it can participate at the same time in a positive or a negative feedback autoregulatory loop, dependent on which of its promoters this bona fide transcription factor is acting. They also provide a new understanding for the resistance to therapies targeting the membrane‐anchored ERBB2 in breast cancer. - 2HybridTools, a handy software to facilitate clone identification and mutation mapping from yeast two-hybrid screening
Pierre Cauchy, Brigitte Kahn-Perlès, Pierre Ferrier, Jean Imbert, Patrick Lécine
Peerj, 2019
Yeast Two-Hybrid (Y2H) and reverse Two-Hybrid (RY2H) are powerful protein–protein interaction screening methods that rely on the interaction of bait and prey proteins fused to DNA binding (DB) and activation domains (AD), respectively. Y2H allows identification of protein interaction partners using screening libraries, while RY2H is used to determine residues critical to a given protein–protein interaction by exploiting site-directed mutagenesis. Currently, both these techniques still rely on sequencing of positive clones using conventional Sanger sequencing. For Y2H, a screen can yield several positives; the identification of such clones is further complicated by the fact that sequencing products usually contain vector sequence. For RY2H, obtaining a complete sequence is required to identify the full range of residues involved in protein–protein interactions. However, with Sanger sequencing limited to 500–800 nucleotides, sequencing is usually carried from both ends for clones greater than this length. Analysis of such RY2H data thus requires assembly of sequencing products combined with trimming of vector sequences and of low-quality bases at the beginning and ends of sequencing products. Further, RY2H analysis requires collation of mutations that abrogate a DB/AD interaction. Here, we present 2HybridTools, a Java program with a user-friendly interface that allows addressing all these issues inherent to both Y2H and RY2H. Specifically, for Y2H, 2HybridTools enables automated identification of positive clones, while for RY2H, 2HybridTools provides detailed mutation reports as a basis for further investigation of given protein–protein interactions. - The nature of the electron acceptor (MnIV/NO3) triggers the differential expression of genes associated with stress and ammonium limitation responses in Shewanella algae C6G3
Axel Aigle, Patricia Bonin, Nicolas Fernandez-Nunez, Béatrice Loriod, Sophie Guasco, et al.
FEMS Microbiology Letters, 2018
Shewanella algae C6G3 can dissimilatively reduce nitrate into ammonium and manganese oxide (MnIV) into MnII. It has the unusual ability to anaerobically produce nitrite from ammonium in the presence of MnIV. To gain insight into their metabolic capabilities, global mRNA expression patterns were investigated by RNA-seq and qRT-PCR in cells growing with lactate and ammonium as carbon and nitrogen sources, and with either MnIV or nitrate as electron acceptors. Genes exhibiting higher expression levels in the presence of MnIV belonged to functional categories of carbohydrate, coenzyme, lipid metabolisms and inorganic ion transport. The comparative transcriptomic pattern between MnIV and NO3 revealed that the strain presented an ammonium limitation status with MnIV, despite the presence of a non-limiting concentration of ammonium under both culture conditions. In addition, in the presence of MnIV, ntrB/nrtC regulators, ammonium channel, nitrogen regulatory protein P-II, glutamine synthetase and asparagine synthetase glutamine-dependent genes were over-represented. Under the nitrate condition, the expression of genes involved in the synthesis of several amino acids was increased. Finally, the expression level of genes associated with the general stress response was also amplified in both conditions and among them, katE, a putative catalase/peroxidase present on several Shewanella genomes, was highly expressed with a median value relatively higher in the MnIV condition. - Beyond genome-wide scan: Association of a cis-regulatory NCR3 variant with mild malaria in a population living in the Republic of Congo
Sabrina Baaklini, Sarwat Afridi, Thy Ngoc Nguyen, Felix Koukouikila-Koussounda, Mathieu Ndounga, et al.
Plos One, 2017
Linkage studies have revealed a linkage of mild malaria to chromosome 6p21 that contains the NCR3 gene encoding a natural killer cell receptor, whereas NCR3-412G>C (rs2736191) located in its promoter region was found to be associated with malaria in Burkina Faso. Here we confirmed the association of rs2736191 with mild malaria in a Congolese cohort and investigated its potential cis-regulatory effect. Luciferase assay results indicated that rs2736191-G allele had a significantly increased promoter activity compared to rs2736191-C allele. Furthermore, EMSAs demonstrated an altered binding of two nuclear protein complexes to the rs2736191-C allele in comparison to rs2736191-G allele. Finally, after in silico identification of transcription factor candidates, pull-down western blot experiments confirmed that both STAT4 and RUNX3 bind the region encompassing rs2736191 with a higher affinity for the G allele. To our knowledge, this is the first report that explored the functional role of rs2736191. These results support the hypothesis that genetic variation within natural killer cell receptors alters malaria resistance in humans. - CD8+ T Cells from Human Neonates Are Biased toward an Innate Immune Response
Ariel O. Galindo-Albarrán, Oscar H. López-Portales, Darely Y. Gutiérrez-Reyna, Otoniel Rodríguez-Jorge, José Antonio Sánchez-Villanueva, et al.
Cell Reports, 2016 - Deciphering the adaptation strategies of Desulfovibrio piezophilus to hydrostatic pressure through metabolic and transcriptional analyses
Amira Amrani, Jacques van Helden, Aurélie Bergon, Aicha Aouane, Wajdi Ben Hania, et al.
Environmental Microbiology Reports, 2016
Desulfovibrio piezophilus strain C1TLV30(T) is a mesophilic piezophilic sulfate-reducer isolated from Wood Falls at 1700 m depth in the Mediterranean Sea. In this study, we analysed the effect of the hydrostatic pressure on this deep-sea living bacterium at the physiologic and transcriptomic levels. Our results showed that lactate oxidation and energy metabolism were affected by the hydrostatic pressure. Especially, acetyl-CoA oxidation pathway and energy conservation through hydrogen and formate recycling would be more important when the hydrostatic pressure is above (26 MPa) than below (0.1 MPa) the optimal one (10 MPa). This work underlines also the role of the amino acid glutamate as a piezolyte for the Desulfovibrio genus. The transcriptomic analysis revealed 146 differentially expressed genes emphasizing energy production and conversion, amino acid transport and metabolism and cell motility and signal transduction mechanisms as hydrostatic pressure responding processes. This dataset allowed us to identify a sequence motif upstream of a subset of differentially expressed genes as putative pressure-dependent regulatory element. - A positive feed-forward loop associating EGR1 and PDGFA promotes proliferation and self-renewal in glioblastoma stem cells
Nathalie Sakakini, Laurent Turchi, Aurélie Bergon, Hélène Holota, Samah Rekima, et al.
Journal of Biological Chemistry, 2016
Glioblastomas are the most common primary brain tumors, highly vascularized, infiltrating, and resistant to current therapies. This cancer leads to a fatal outcome in less than 18 months. The aggressive behavior of glioblastomas, including resistance to current treatments and tumor recurrence, has been attributed to glioma stemlike/progenitor cells. The transcription factor EGR1 (early growth response 1), a member of a zinc finger transcription factor family, has been described as tumor suppressor in gliomas when ectopically overexpressed. Although EGR1 expression in human glioblastomas has been associated with patient survival, its precise location in tumor territories as well as its contribution to glioblastoma progression remain elusive. In the present study, we show that EGR1-expressing cells are more frequent in high grade gliomas where the nuclear expression of EGR1 is restricted to proliferating/progenitor cells. We show in primary cultures of glioma stemlike cells that EGR1 contributes to stemness marker expression and proliferation by orchestrating a PDGFA-dependent growth-stimulatory loop. In addition, we demonstrate that EGR1 acts as a positive regulator of several important genes, including SHH, GLI1, GLI2, and PDGFA, previously linked to the maintenance and proliferation of glioma stemlike cells. - Dynamic recruitment of Ets1 to both nucleosome-occupied and -depleted enhancer regions mediates a transcriptional program switch during early T-cell differentiation
Pierre Cauchy, Muhammad A. Maqbool, Joaquin Zacarias-Cabeza, Laurent Vanhille, Frederic Koch, et al.
Nucleic Acids Research, 2016
Ets1 is a sequence-specific transcription factor that plays an important role during hematopoiesis, and is essential for the transition of CD4−/CD8− double negative (DN) to CD4+/CD8+ double positive (DP) thymocytes. Using genome-wide and functional approaches, we investigated the binding properties, transcriptional role and chromatin environment of Ets1 during this transition. We found that while Ets1 binding at distal sites was associated with active genes at both DN and DP stages, its enhancer activity was attained at the DP stage, as reflected by levels of the core transcriptional hallmarks H3K4me1/3, RNA Polymerase II and eRNA. This dual, stage-specific ability reflected a switch from non-T hematopoietic toward T-cell specific gene expression programs during the DN-to-DP transition, as indicated by transcriptome analyses of Ets1−/− thymic cells. Coincidentally, Ets1 associates more specifically with Runx1 in DN and with TCF1 in DP cells. We also provide evidence that Ets1 predominantly binds distal nucleosome-occupied regions in DN and nucleosome-depleted regions in DP. Finally and importantly, we demonstrate that Ets1 induces chromatin remodeling by displacing H3K4me1-marked nucleosomes. Our results thus provide an original model whereby the ability of a transcription factor to bind nucleosomal DNA changes during differentiation with consequences on its cognate enhancer activity. - Natural killer cells in patients with polycythemia vera
Carole Sanchez, Céline Baier, Julien G. Colle, Rabie Chelbi, Pascal Rihet, et al.
Human Immunology, 2015 - Transcription-dependent generation of a specialized chromatin structure at the TCRβ locus
Joaquin Zacarías-Cabeza, Mohamed Belhocine, Laurent Vanhille, Pierre Cauchy, Frederic Koch, et al.
Journal of Immunology, 2015 - Transcriptomics reveal several gene expression patterns in the piezophile desulfovibrio hydrothermalis in response to hydrostatic pressure
Amira Amrani, Aurélie Bergon, Hélène Holota, Christian Tamburini, Marc Garel, et al.
Plos One, 2014 - Sox17 regulates liver lipid metabolism and adaptation to fasting
Samuel Rommelaere, Virginie Millet, Thien-Phong Vu Manh, Thomas Gensollen, Pierre Andreoletti, et al.
Plos One, 2014 - ELOVL5 mutations cause spinocerebellar ataxia 38
Eleonora Di Gregorio, Barbara Borroni, Elisa Giorgio, Daniela Lacerenza, Marta Ferrero, et al.
American Journal of Human Genetics, 2014 - Divergent transcription is associated with promoters of transcriptional regulators
Cyrille Lepoivre, Mohamed Belhocine, Aurélie Bergon, Aurélien Griffon, Miriam Yammine, et al.
BMC Genomics, 2013 - The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells
Yinming Liang, Margot Cucchetti, Romain Roncagalli, Tadashi Yokosuka, Aurélie Malzac, et al.
Nature Immunology, 2013 - Chromatin-to-nucleoprotamine transition is controlled by the histone H2B variant TH2B
Emilie Montellier, Fayçal Boussouar, Sophie Rousseaux, Kai Zhang, Thierry Buchou, et al.
Genes and Development, 2013 - Histone acetyltransferase cofactor Trrap maintains self-renewal and restricts differentiation of embryonic stem cells
Carla Sawan, Hector Hernandez-Vargas, Rabih Murr, Fabrice Lopez, Thomas Vaissière, et al.
Stem Cells, 2013 - Bromodomain-dependent stage-specific male genome programming by Brdt
Jonathan Gaucher, Fayçal Boussouar, Emilie Montellier, Sandrine Curtet, Thierry Buchou, et al.
EMBO Journal, 2012 - TranscriptomeBrowser 3.0: Introducing a new compendium of molecular interactions and a new visualization tool for the study of gene regulatory networks
Cyrille Lepoivre, Aurélie Bergon, Fabrice Lopez, Narayanan B Perumal, Catherine Nguyen, et al.
BMC Bioinformatics, 2012 - H3K4 tri-methylation provides an epigenetic signature of active enhancers
Aleksandra Pekowska, Touati Benoukraf, Joaquin Zacarias-Cabeza, Mohamed Belhocine, Frederic Koch, et al.
EMBO Journal, 2011 - Mechanics of the IL2RA gene activation revealed by modeling and atomic force microscopy
Pascale Milani, Monique Marilley, Albert Sanchez-Sevilla, Jean Imbert, Cédric Vaillant, et al.
Plos One, 2011 - Natural killer cells and malignant haemopathies: A model for the interaction of cancer with innate immunity
C. J. Sanchez, T. Le Treut, A. Boehrer, B. Knoblauch, J. Imbert, et al.
Cancer Immunology Immunotherapy, 2011 - Peripheral T-cell lymphoma gene expression profiling and potential therapeutic exploitations: Review
Régis Costello, Carole Sanchez, Thérèse Le Treut, Pascal Rihet, Jean Imbert, et al.
British Journal of Haematology, 2010 - Transcriptional down-regulation of Bcl-2 by vinorelbine: Identification of a novel binding site of p53 on Bcl-2 promoter
Véronique Bourgarel-Rey, Amandine Savry, Guoqiang Hua, Manon Carré, Céline Bressin, et al.
Biochemical Pharmacology, 2009 - A negative feedback regulatory loop associates the tyrosine kinase receptor ERBB2 and the transcription factor GATA4 in breast cancer cells
Guoqiang Hua, Bing Zhu, Fréderic Rosa, Nicolas Deblon, José Adélaïde, et al.
Molecular Cancer Research, 2009 - A reason why the ERBB2 gene is amplified and not mutated in breast cancer
Daniel Birnbaum, Fabrice Sircoulomb, Jean Imbert
Cancer Cell International, 2009 - ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells
Jonathan Clarhaut, Robert M. Gemmill, Vincent A. Potiron, Slimane Ait-Si-Ali, Jean Imbert, et al.
Neoplasia, 2009 - CoCAS: A ChIP-on-chip analysis suite
Touati Benoukraf, Pierre Cauchy, Romain Fenouil, Adrien Jeanniard, Frederic Koch, et al.
Bioinformatics, 2009 - TranscriptomeBrowser: A powerful and flexible toolbox to explore productively the transcriptional landscape of the Gene Expression Omnibus database
Fabrice Lopez, Julien Textoris, Aurélie Bergon, Gilles Didier, Elisabeth Remy, et al.
Plos One, 2008 - Expression of the tachykinin receptor mRNAs in healthy human colon
Nadia Jaafari, Guoqiang Hua, José Adélaïde, Yvon Julé, Jean Imbert
European Journal of Pharmacology, 2008 - Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46
Thierry Walzer, Mathieu Bléry, Julie Chaix, Nicolas Fuseri, Lionel Chasson, et al.
Proceedings of the National Academy of Sciences of the United States of America, 2007 - Increased Chromatin Association of Sp1 in Interphase Cells by PP2A-mediated Dephosphorylations
Axel Vicart, Tony Lefebvre, Jean Imbert, Anne Fernandez, Brigitte Kahn-Perlès
Journal of Molecular Biology, 2006 - Both integrated and differential regulation of components of the IL-2/IL-2 receptor system
Hyoung Pyo Kim, Jean Imbert, Warren J. Leonard
Cytokine and Growth Factor Reviews, 2006 - Epigenomics: Large scale analysis of chromatin modifications and transcription factors/genome interactions
Thierry Grange, Jean Imbert, Denis Thieffry
Bioessays, 2005 - A rare mRNA variant of the human lymphocyte-specific protein tyrosine kinase LCK gene with intron B retention and exon 7 skipping encodes a putative protein with altered SH3-dependent molecular interactions
Solange Nervi, Rodolphe Guinamard, Bénédicte Delaval, Patrick Lécine, Bernard Vialettes, et al.
Gene, 2005 - Vanin-1-/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress
C. Berruyer, F. M. Martin, R. Castellano, A. Macone, F. Malergue, et al.
Molecular and Cellular Biology, 2004 - Restriction of transgene expression to the B-lymphoid progeny of human lentivirally transduced CD34+ cells
Thomas Moreau, Florence Bardin, Jean Imbert, Christian Chabannon, Cécile Tonnelle
Molecular Therapy, 2004 - No association between lck gene polymorphisms and protein level in type 1 diabetes
Solange Nervi, Sandra Nicodeme, Corinne Gartioux, Catherine Atlan, Marc Lathrop, et al.
Diabetes, 2002 - Erratum: Control of IL-2Rα gene expression: Structural changes within the proximal enhancer/core promoter during T-cell development (Nucleic Acids Research (2002) vol. 30 (1944-1951))
Nucleic Acids Research, 2002 - A defective NF-κB/RelB pathway in autoimmune-prone New Zealand Black mice is associated with inefficient expansion of thymocyte and dendritic cells
René Valéro, Marie-Laurence Baron, Sandrine Guérin, Sophie Béliard, Hugues Lelouard, et al.
Journal of Immunology, 2002 - Control of IL-2Rα gene expression: Structural changes within the proximal enhancer/core promoter during T-cell development
Nucleic Acids Research, 2002 - Sp1 transcriptional activity is up-regulated by phosphatase 2A in dividing T lymphocytes
Isabelle Lacroix, Carol Lipcey, Jean Imbert, Brigitte Kahn-Perlès
Journal of Biological Chemistry, 2002 - Novel CD28-responsive enhancer activated by CREB/ATF and AP-1 families in the human interleukin-2 receptor α-chain locus
Jung-Hua Yeh, Patrick Lecine, Jacques A. Nunes, Salvatore Spicuglia, Pierre Ferrier, et al.
Molecular and Cellular Biology, 2001 - Specific deficiency of p56(lck) expression in T lymphocytes from type 1 diabetic patients
Solange Nervi, Catherine Atlan-Gepner, Brigitte Kahn-Perles, Patrick Lecine, Bernard Vialettes, et al.
Journal of Immunology, 2000 - TCRα enhancer activation occurs via a conformational change of a pre-assembled nucleoprotein complex
EMBO Journal, 2000 - IL-2 and long-term T cell activation induce physical and functional interaction between STAT5 and ETS transcription factors in human T cells
Pascal Rameil, Patrick Lécine, Jacques Ghysdael, Fabrice Gouilleux, Brigitte Kahn-Perlès, et al.
Oncogene, 2000 - Physical interaction of the bHLH LYL1 protein and NF-κB1 p105
Richard Ferrier, Romain Nougarede, Sandrine Doucet, Brigitte Kahn-Perles, Jean Imbert, et al.
Oncogene, 1999 - Secretion of extracellular factor(s) induced by X-irradiation activates the HIV type 1 long terminal repeat through its κB motif
ERIC FAURE, PASCAL RAMEIL, PATRICK LECINE, FRANÇOISE REY, JOSEPHINE SIRE, et al.
AIDS Research and Human Retroviruses, 1998 - Temporal and subunit-specific modulations of the Rel/NF-κB transcription factors through CD28 costimulation
Brigitte Kahn-Perlès, Carol Lipcey, Patrick Lécine, Daniel Olive, Jean Imbert
Journal of Biological Chemistry, 1997 - Relief of cyclin A gene transcriptional inhibition during activation of human primary T lymphocytes via CD2 and CD28 adhesion molecules
Ariane Plet, Xavier Huet, Michèle Algarté, Jocelyne Rech, Jean Imbert, et al.
Oncogene, 1997 - Insulin stimulates haptotactic migration of human epidermal keratinocytes through activation of NF- κ B transcription factor
Anne-Marie Benoliel, Brigitte Kahn-Perles, Jean Imbert, Patrick Verrando
Journal of Cell Science, 1997 - A conserved IL-2 responsive enhancer in the IL-2Rα gene
Philipp Bucher, Patricia Corthésy, Jean Imbert, Markus Nabholz
Immunobiology, 1997 - Cell-to-cell contact activates the long terminal repeat of human immunodeficiency virus 1 through its κB motif
Eric Faure, Patrick Lecine, Carol Lipcey, Serge Champion, Jean Imbert
European Journal of Biochemistry, 1997 - Erratum: Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene (Molecular and Cellular Biology 16:12 (6831))
Molecular and Cellular Biology, 1997 - Detection of CBFβ/MYH11 fusion transcripts in acute myeloid leukemia: Heterogeneity of cytological and molecular characteristics
R Costello, D Sainty, P Lecine, A Cusenier, M-J Mozziconacci, et al.
Leukemia, 1997 - Activation of the HIV type 1 long terminal repeat by X-irradiation involves two main Rel/NF-κB DNA-binding complexes
ERIC FAURE, PATRICK LECINE, JEAN IMBERT, SERGE CHAMPION
AIDS Research and Human Retroviruses, 1996 - Activation of the transcription from the human immunodeficiency virus type 1 (HIV-1) long terminal repeat by autologous and heterologous cell-to-cell contact.
Cellular and Molecular Biology Noisy Le Grand France, 1996 - Elf-1 and Stat5 bind to a critical element in a new enhancer of the human interleukin-2 receptor α gene
Patrick Lécine, Michèle Algarté, Pascal Rameil, Carol Beadling, Philipp Bucher, et al.
Molecular and Cellular Biology, 1996 - Specific Th1 cytokine down-regulation associated with primary clinically derived human immunodeficiency virus type 1 nef gene-induced expression
Journal of Immunology, 1996 - In vivo regulation of interleukin-2 receptor α gene transcription by the coordinated binding of constitutive and inducible factors in human primary T cells
M. Algarté, P. Lécine, R. Costello, A. Plet, D. Olive, et al.
EMBO Journal, 1995 - Rel/NF-κB transcription factor: Activation and regulation
R Costello, P Lecine, B Kahn-Perlès, M Algarté, C Lipcey, et al.
Medecine Sciences, 1995 - Hematological reconstitution and gene therapy: retroviral transfer of the bacterial beta-galactosidase activity into human hematopoietic CD34+ cell populations and into T lymphocytes derived from the peripheral blood
Leukemia, 1995 - Highly efficient retroviral gene transfer into human primary T lymphocytes derived from peripheral blood.
Cancer Gene Therapy, 1994 - Chromosomal location and expression of the genes coding for ku p70 and p80 in human cell lines and normal tissues
Q.-Q. Cai, A. Plet, J. Imbert, M. Lafage-Pochitaloff, C. Cerdan, et al.
Cytogenetics and Cell Genetics, 1994 - Regions of the CD8 molecule involved in the regulation of CD2-mediated activation
Marie-Dominique Franco, Jacques Nunès, Jean-Philippe Boursier, Jean Imbert, Claude Mawas, et al.
Cellular Immunology, 1994 - Erratum: Binding of phosphatidylinositol-3-OH kinase to CD28 is required for T-cell signalling (Nature (1994) 369 (327-329))
Françoise Pagès, Marguerite Ragueneau, Robert Rottapel, Alemseged Truneh, Jacques Nunes, et al.
Nature, 1994 - Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling
Françoise Pagès, Marguerite Ragueneau, Robert Rottapel, Alemseged Truneh, Jacques Nunes, et al.
Nature, 1994 - The role of NF-kappaB1 (p50/p105) gene expression in activation of human blood T-lymphocytes via CD2 and CD28 adhesion molecules
Cell Growth and Differentiation, 1993 - Interleukin-7, a major T-lymphocyte cytokine
European Cytokine Network, 1993 - Activation of primary human T-lymphocytes through CD2 plus CD28 adhesion molecules induces long-term nuclear expression of NF-kappa B.
Cell Growth Differentiation the Molecular Biology Journal of the American Association for Cancer Research, 1993 - Localization of the mcf.2 transforming sequence to the X chromosome.
T. Noguchi, M. G. Mattei, I. Oberlè, J. Planche, J. Imbert, et al.
EMBO Journal, 1987 - Permanent expression of p53 in FR 3T3 rat cells but cell cycle-dependent association with large-T antigen in simian virus 40 transformants.
F. Coulier, J. Imbert, J. Albert, E. Jeunet, J.J. Lawrence, et al.
EMBO Journal, 1985 - Cell lines derived from tumors induced in syngeneic rats by FR 3T3 SV40 transformants no longer synthesize the early viral proteins
Odile De Lapeyriere, Brigitte Hayot, Jean Imbert, Marianne Courcoul, Danièle Arnaud, et al.
Virology, 1984 - Cell cycle-dependent expression of early viral genes in one group of simian virus 40-transformed rat cells.
J. Imbert, J.J. Lawrence, F. Coulier, E. Jeunet, V. Billotey, et al.
EMBO Journal, 1984 - Simian virus 40 T antigen is detected only in cells in the G2 phase of the cell cycle in one group of rat transformants
Jean Imbert, Jean-Jacques Lawrence, Françoise Birg
Virology, 1983 - Stabilization of the large T protein in temperature-independent (Type A) FR 3T3 rat cells transformed with the simian virus 40 tsA30 mutant
J Imbert, P Clertant, B de Bovis, J Planche, F Birg
Journal of Virology, 1983 - Studies of the immune response against a polyoma virus-induced fibrosarcoma in BALB/c mice using the Winn's tumor neutralization assay
Bulletin Du Cancer, 1981 - Multifactorial analysis of prognostic factors in breast cancer
Bulletin Du Cancer, 1977 - Different sensitivities to ultraviolet rays of various functions of the polyoma virus. Stimulation of the synthesis of cellular DNA
Comptes Rendus Hebdomadaires Des Seances De L Academie Des Sciences Serie D Sciences Naturelles, 1977 - Bioassay of 2, 4, 5-trichlorophenoxyacetic acid for carcinogenicity in mice
I Muranyi-Kovacs, G Rudali, J Imbert
British Journal of Cancer, 1976
