Isaac Moura Araujo

Scopus Publications

Modifying Antibiotic Activity of Synthetic Thiadiazine Analogs Against MDR Bacteria and ADMET Analysis
João Arthur de Oliveira Borges, Priscilla Ramos Freitas, Isaac Moura Araújo, Ray Silva de Almeida, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Radosław Kowalski, Grażyna Kowalska, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Ana Carolina Justino de Araújo
Chemistryopen, 2026
The indiscriminate use of antibiotics has led to the selection of resistant bacterial strains, significantly reducing the effectiveness of conventional treatments. In this context, thiadiazines have emerged as promising agents due to their antioxidant and antibacterial properties. This article aims to evaluate the antibacterial potential of synthetic thiadiazine analogs against selected bacterial strains. The synthesized compounds are purified using high‐performance liquid chromatography, and absorption, distribution, metabolism, excretion, and toxicity analyses are performed, including interaction profiling with over 370,000 bioactive compounds. The bacterial strains Staphylococcus aureus 10 and Pseudomonas aeruginosa 24 are used as test organisms. When combined with standard antibiotics, thiadiazine compounds significantly reduced the minimum inhibitory concentration. However, some analogs exhibited antagonistic effects, particularly against gentamicin and erythromycin. Direct antibacterial activity is limited, with compounds IJ26 and IJ28 showing the most notable effects. These findings suggest that thiadiazine analogs may potentiate antibiotic activity, although further studies are needed to fully understand their biological interactions and mechanisms of action.
Modifying Effect of the Antibiotic Action, Membrane Permeability, and ADMET/Toxicity Profile of the Fixed Oil From the Pulp of Mauritia Flexuosa F.L. (Arecaceae)
Isaac Moura Araújo, Cleidiana Tomé de Oliveira, Luís Pereira‐de‐Morais, Andressa Silva Alencar, Cicera Datiane de Morais Oliveira‐Tintino, Maria Alícia Cavalcante Narciso, Anita Oliveira Brito Pereira Bezerra Martins, Sara Tavares de Sousa Machado, Sheila Alves Gonçalves, Daniel Sampaio Alves, Janaina Esmeraldo Rocha, Ana Carolina Ferreira Araújo, Priscilla Ramos Freitas, José Weverton Almeida‐Bezerra, José Thyálisson da Costa Silva, Henrique Douglas Melo Coutinho
Chemistry and Biodiversity, 2026
The increasing bacterial resistance to antibiotics has stimulated the search for natural products capable of modulating antimicrobial activity. In this study, the fixed oil from Mauritia flexuosa pulp was evaluated for its antibacterial activity, modulatory effect on antibiotics, membrane permeability, and ADMET/toxicity profile. The chemical composition of the oil was analyzed by GC–MS after transesterification, revealing fatty acids as the major constituents, particularly palmitic and elaidic acids. Antibacterial activity and modulation assays were performed using standard microdilution methods, while membrane permeability was assessed using SYTOX Green. The fixed oil showed no significant antibacterial activity under the tested conditions; however, it demonstrated a modulatory effect when combined with antibiotics, enhancing their activity. Membrane permeability assays indicated increased bacterial membrane disruption. In silico ADMET analysis suggested low systemic toxicity, with potential irritative effects. These findings indicate that M. flexuosa fixed oil may act as a modulator of antibiotic activity, possibly through membrane interaction mechanisms µg/mL.
Daidzin and Phytol Enhance the Sedative Effect of Diazepam and the Anesthetic Effects of Thiopental Sodium: In Vivo and Computational Assessments
Md. Torequl Islam, Salehin Sheikh, Raihan Chowdhury, Md. Shimul Bhuia, Md. Amirul Islam, Isaac Moura Araújo, Carolina Bandeira Domiciano, Henrique Douglas Melo Coutinho, Md. Saifuzzaman
Iranian Journal of Science, 2026
Ammonium polyoxomolybdate modulates antibiotic activity against resistant Staphylococcus aureus and Escherichia coli
Júlio César Silva, Vitória Beatriz Roberto Silva, Luís Pereira-de-Morais, Raimundo Luiz Silva Pereira, Isaac Moura Araújo, Thiago Mielle Brito Ferreira Oliveira, Cícera Datiane de Morais Oliveira-Tintino, João Arthur de Oliveira Borges, Nair Silva Macedo, Henrique Douglas Melo Coutinho, Francisco Nascimento Pereira Junior
FEMS Microbiology Letters, 2026
This study investigated the antibacterial and potentiating activity of ammonium polyoxomolybdate tetrahydrate (NHMO; (NH4)6Mo7O24·4H2O; 1235.86 g/mol), particularly in combination with ampicillin against Staphylococcus aureus and Escherichia coli strains. Spectroscopic characterization by attenuated total reflectance Fourier transform infrared spectroscopy and microdilution tests with resazurin were used. NHMO showed no direct antibacterial activity, with a minimum inhibitory concentration (MIC) ≥1024 μg/mL (≈0.83 mM). However, when used at a subinhibitory concentration (MIC/8, 128 μg/mL; ≈0.10 mM) with antibiotics initially tested at 1024 μg/mL, NHMO reduced the MIC of ampicillin by ~50% for both bacterial strains. Sulbactam, a known β-lactamase inhibitor, showed superior results, confirming the presence of enzymatic resistance. NHMO also demonstrated a resistance-reversal effect in β-lactamase-producing S. aureus strains, lowering the MIC of ampicillin from 20.16 to 16 μg/mL in K4100 and from 322.54 to 256 μg/mL in K4414. Ciprofloxacin did not show relevant modulation, whereas gentamicin potentiation was observed against S. aureus 10. These findings indicate that NHMO can enhance the activity of antibiotics, particularly ampicillin and gentamicin, in resistant bacterial strains. Its action in β-lactamase-related assays suggests that it is a promising candidate in the search for alternatives to combat antimicrobial resistance.
Chemical synthesis and evaluation of the antibacterial activity of the amino chalcone in efflux pump-carrying strains
Isydório Alves Donato, Cristina Rodrigues dos Santos Barbosa, Antonio Henrique Bezerra, Suieny Rodrigues Bezerra, Ray Silva Almeida, Cícera Datiane de Morais Oliveira Tintino, Isaac Moura Araújo, Ana Luiza Fernandes Romão, André Nilton Silva Dias, Francisco Rogenio da Silva Mendes, Jayza Maria Lima Dias, Paulo Nogueira Bandeira, Roberto Lima de Albuquerque, Hélcio Silva dos Santos, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Francisco Assis Bezerra da Cunha
FEMS Microbiology Letters, 2026
Given the ability of microorganisms to develop drug resistance at a faster pace than the development of new drugs, it becomes urgent to seek alternatives capable of restoring the efficacy of antibiotics, especially against pathogens such as Staphylococcus aureus, known for its versatility in expressing resistance mechanisms. Synthetic chalcones have been extensively investigated as efflux pump inhibitors due to their structural flexibility and ease of chemical modification. Can cite studies that show chalcones derived from Croton anisodontus for their ability to inhibit the NorA and MepA efflux pumps in S. aureus strains (1199B and K2068) and studies chalcones act as inhibitors of the NorA efflux pump in whole cells and everted membrane vesicles of S. aureus. Among these mechanisms, the NorA and MepA efflux pumps stand out, as they are responsible for expelling antibiotics from the bacterial cell interior. In this context, the present study investigated the potential of the chalcone (E)-1-(3-aminophenyl)-3-(4-chlorophenyl)prop-2-en-1-one as a possible inhibitor of these efflux systems. Initial screening was conducted through in silico studies, followed by in vitro assays, determination of minimum inhibitory concentration (MIC), and fluorescence tests using ethidium bromide EtBr and SYTOX Green. Molecular docking results revealed that this chalcone interacts with amino acid residues described in the literature as essential for efflux pump activity (Glu222 and Phe303 in NorA; Tyr35 and Met172 in MepA). The binding distances and energies obtained were consistent with potential inhibitory activity, suggesting that chalcone may interfere with the functionality of these proteins. In vitro assays showed a significant reduction in the MIC of antibiotics such as norfloxacin and ciprofloxacin in resistant strains, indicating a potentiating effect. Furthermore, fluorescence tests demonstrated increased retention of ethidium bromide by up to 736.3% for NorA and 234.8% for MepA, supporting the inhibition of efflux pumps. Increased bacterial membrane permeability was also observed, evidenced by an increase in SYTOX Green fluorescence by 70–855%. Although the results demonstrate the potential of chalcone as a therapeutic adjuvant, the ADMET analyses revealed toxicological alerts that require further investigation. These findings suggest that rational structural modifications may be necessary to ensure its safety and efficacy in combating resistant bacterial infections.
Antibacterial and Antibiotic-Enhancing Activity of 3-Hydroxy-4-methoxycinnamic Acid: Experimental Data and In Silico Predictions
José Thyálisson da Costa Silva, Viviane Bezerra da Silva, Guilherme Fernandes Teixeira, Carlos Alonso Leite dos Santos, Antonia Adeublena de Araujo Monteiro, Janaína Esmeraldo Rocha, Ewerton Yago de Sousa Rodrigues, Rafael Pereira da Cruz, Isaac Moura Araújo, Adrielle Rodrigues Costa, Cicera Laura Roque Paulo, Irwin Rose Alencar de Menezes, Maria Flaviana Bezerra Morais‐Braga, José Maria Barbosa‐Filho, Saulo Almeida de Menezes, Henrique Douglas Melo Coutinho, José Weverton Almeida‐Bezerra
Chemistryselect, 2025
The growing bacterial resistance, driven by the inappropriate use of antibiotics, poses a global health threat and demands new therapeutic strategies. Natural phenolic compounds, such as 3‐hydroxy‐4‐methoxycinnamic acid (3H4MCA), stand out due to their antimicrobial and antioxidant properties, showing potential in combating resistant pathogens. This study aims to evaluate the antibacterial activity and in silico characteristics of 3H4MCA, including ADMET parameters and molecular interactions with protein targets. 3H4MCA, obtained from Sigma‐Aldrich, was assessed for its antibacterial activity by determining the minimum inhibitory concentration (MIC) against Gram‐negative and Gram‐positive bacteria, as well as through synergy analysis with gentamicin, ampicillin, and norfloxacin. ADMET and physicochemical properties were predicted using the ADMETlab 2.0 platform. For molecular docking studies, the proteins 5KDR, 6GJ1, and 4WEL were used with predefined grids. Data were statistically analyzed. Although our results indicate that 3H4MCA did not show direct antibacterial activity against the tested strains (MIC > 512 µg/mL), with the same MIC value observed for all Gram‐negative and Gram‐positive bacteria, it significantly modulated the action of antibiotics, demonstrating previously unreported synergistic effects with gentamicin against Escherichia coli 06 MDR and with ampicillin against Staphylococcus aureus 10 MDR, it is possible to point out as a potential compost for combination therapy. In silico analyses indicate that 3H4MCA exhibits physicochemical features compatible with bioactive compounds, but its predicted toxicity profile suggests the need for further safety assessment. The docking results showed stable binding (4WEL, 5KDR, and 6GJ1 proteins, with binding energies of −5.067, −5.629, and −5.857 kcal/mol) to all evaluated protein targets, mediated by hydrogen bonding, hydrophobic, and electrostatic interactions. Collectively, the findings reveal the novel synergistic potential of 3H4MCA as an antibiotic adjuvant, supporting its relevance as a promising bioactive ligand with therapeutic applications.
Antibacterial and antibiotic modulating activity of the aqueous extract of the fruits of Luffa operculata Cogn.
Luís Pereira-de-Morais, Isaac Moura Araújo, Raimundo Luiz Silva Pereira, Marília Cavalcante Araújo, Edvanildo de Sousa Silva, Jayrton Kelvin Oliveira Lessa, Lindaiane Bezerra Rodrigues Dantas, Ticiano Magalhães Dantas, Mikael Amaro de Souza, Renata Evaristo Rodrigues Duarte, Anita Oliveira Brito Pereira Bezerra Martins, Andressa de Alencar Silva, Henrique Douglas Melo Coutinho
Microbe Netherlands, 2025
The excessive use of antibiotics has driven the development of bacterial resistance, highlighting the importance of new therapeutic alternatives such as plant oils and extracts. This study aimed to evaluate the antibacterial activity of the aqueous extract from the fruit of Luffa operculata against Staphylococcus aureus and Pseudomonas aeruginosa , both alone and in combination with antibiotics. The antibacterial effect of the aqueous fruit extract of L. operculata and its ability to modify antibiotic activity were assessed using the broth microdilution method, and the Minimum Inhibitory Concentration (MIC) was determined. The isolated extract did not show relevant antibacterial activity; however, significant effects were observed when it was combined with antibiotics. For S. aureus , the combination with gentamicin reduced the MIC from 16.0 µg/mL to 5.0 µg/mL, indicating synergism. In P. aeruginosa , the combination with norfloxacin reduced the MIC from 128.0 µg/mL to 50.8 µg/mL, whereas the combination with gentamicin was not significant. In conclusion, although the isolated extract of L. operculata did not demonstrate direct efficacy, its interaction with antibiotics, particularly aminoglycosides (gentamicin) and fluoroquinolones (norfloxacin), showed synergistic potential, highlighting its possible role as an adjuvant in combating multidrug-resistant strains. • Luffa operculata extract did not show direct antibacterial action against the tested strains. • With gentamicin, the extract potentiated the effect against Staphylococcus aureus . • Luffa operculata extract increased the action of erythromycin and norfloxacin against Pseudomonas aeruginosa .
Antibacterial Activity of Chalcone (2E)-3-({4-[(2E)-3-(4-Nitrophenyl) prop-2-enol] phenyl}carbamoyl) prop-2-enoic acid and Its Effect Against Staphylococcus aureus Carrying Efflux Pump and β-Lactamase
Olivia Caroline Maia de Moura, Júlio César Silva, Raimundo Luiz Silva Pereira, Isaac Moura Araújo, Sheila Alves Gonçalves, João Arthur de Oliveira Borges, Daniel Sampaio Alves, Gabriel Gonçalves Alencar, Thiago Sampaio de Freitas, Vanessa Lima-Bezerra, Walber Henrique Ferreira Ribeiro, Francisco Ferdinando Mesquita Cajazeiras, Jesyka Macedo Guedes, Paulo Nogueira Bandeira, Hélcio Silva dos Santos, Henrique Douglas Melo Coutinho, Francisco Nascimento Pereira Junior
Current Microbiology, 2025
Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps
Isydório Alves Donato, Cristina Rodrigues dos Santos Barbosa, Antonio Henrique Bezerra, Suieny Rodrigues Bezerra, Ray Silva Almeida, Cícera Datiane de Morais Oliveira-Tintino, Isaac Moura Araújo, Ewerton Yago de Sousa Rodrigues, Maria Yasmin Cândido de Oliveira, Francisco Ferdinando Cajazeiras, Jayza Maria Lima Dias, Jesyka Macedo Guedes, Jéssica Híade Silva Cristino, Emmanuel Silva Marinho, Márcia Machado Marinho, Hélcio Silva dos Santos, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Francisco Assis Bezerra da Cunha
Pharmaceuticals, 2025
Background/Objectives: The increasing prevalence of multidrug-resistant Staphylococcus aureus represents a major clinical challenge, primarily driven by the acquisition of multiple resistance mechanisms. Among these, efflux pumps such as NorA play a pivotal role in quinolone resistance by promoting active drug extrusion and reducing intracellular antibiotic levels. This study evaluated the synthetic chalcone CMA4DMA as a potential NorA efflux pump inhibitor and modulator of bacterial resistance. Methods: Antimicrobial susceptibility assays were conducted against S. aureus SA1199 (wild-type) and SA1199B (NorA-overexpressing) strains. The minimum inhibitory concentration (MIC) of CMA4DMA and its modulatory effects on norfloxacin and ethidium bromide were determined. Efflux inhibition was assessed by ethidium bromide accumulation and SYTOX Green assays. Molecular docking and in silico ADMET analyses were performed to predict binding affinity and pharmacokinetic parameters. Results: CMA4DMA exhibited no intrinsic antibacterial activity (MIC ≥ 1024 µg/mL) but reduced the MIC of norfloxacin from 32 to 8 µg/mL and that of ethidium bromide from 32 to 8 µg/mL in SA1199. In SA1199B, reductions from 64 to 16 µg/mL and from 64 to 32 µg/mL were observed, respectively. Fluorescence increased by 15% without affecting membrane integrity. Docking revealed a binding affinity of −7.504 kcal/mol, stronger than norfloxacin (−7.242 kcal/mol), involving key residues Leu218, Ile309, Arg310, and Ile313. ADMET data indicated high intestinal absorption (88.76%) and permeability (Papp = 1.38 × 10−5 cm/s). Conclusions: CMA4DMA effectively restored norfloxacin susceptibility in resistant S. aureus strains, highlighting its potential as a promising scaffold for developing novel efflux pump inhibitors and antibiotic adjuvants.
Spondias Tuberosa Seeds as Lignocellulosic Bioadsorbent for Efficient PB (II) Removal: Characterization, Adsorption Modeling, Selectivity, and Reusability
Aliane Cristiane de Sousa Formiga, Isaac Moura Araújo, José Augusto Soares de Araujo, Henrique Douglas Melo Coutinho, Francisco José de Paula Filho, Yannice Tatiane da Costa Santos, Jorge Marcell Coelho Menezes, Raimundo Nonato Pereira Teixeira
Chemistryselect, 2025
The objective of this research was to investigate the efficiency of Spondias tuberosa seeds (SST) as a bioadsorbent for Pb (II) ions in aqueous solutions. Adsorption isotherms and kinetics as well thermodynamics were studied in a batch system. The SST residue was collected from pulp manufacturing industries in the Cariri region of Ceará, specifically in the city of Juazeiro do Norte, Ceará, Brazil. For the characterization of the adsorbent material, point of zero charge (PZC), scanning electron microscopy (SEM), and infrared spectroscopy (FTIR) analyses were performed. The pHPZC obtained had an average value of 5.3, which was adjusted to 5.5. SEM images revealed the presence of roughness and porosity typical of fibrous plant materials. With increased magnification, the material showed varying pore shapes and sizes, generally derived from the structure of the plant cell wall of the precursor biomass. It was also observed that the adsorption rate reached equilibrium within 30 min. Thus, it was concluded that the SST bioadsorbent demonstrated satisfactory performance in the adsorption of Pb (II) ions with a maximum adsorption capacity of 46.0 mg. g−1. These findings support the use of SST as an environmentally friendly low‐cost and efficient biosorbent contributing to sustainable strategies for toxic metals remediation.
Effects of linalyl acetate, (-)-menthone, and myrtenol against bacterial strains carrying efflux pumps and toxicity against Drosophila melanogaster
Maria Jéssica Mendes Brito, Cícera Datiane de Morais Oliveira Tintino, Isaac Moura Araújo, Raimundo Luíz Silva Pereira, Alisson Justino Alves da Silva, Ana Carolina Justino de Araújo, Francisco Assis Bezerra da Cunha, Zildene de Sousa Silveira, Nair Silva Macedo, Gildênia Alves de Araújo, José Maria Barbosa Filho, Francisco Roberto de Azevedo, Samara Alves Brito, Rayane de Tasso Moreira Ribeiro, Saulo Relison Tintino
Pharmacological Research Natural Products, 2025
Toxicological assessment of citral and geraniol: Efflux pump inhibition in Staphylococcus aureus and invertebrate toxicity
Gildênia Alves de Araújo, Cícera Datiane de Morais Oliveira Tintino, Raimundo Luíz Silva Pereira, Isaac Moura Araújo, Cícera Laura Roque Paulo, João Arthur de Oliveira Borges, Ewerton Yago de Sousa Rodrigues, Ângella Eduarda da Silva, Francisco Assis Bezerra da Cunha, Zildene de Sousa Silveira, Nair Silva Macedo, Henrique Douglas Melo Coutinho, José Maria Barbosa Filho, Daniela Maria do Amaral Ferraz Navarro, Francisco Roberto de Azevedo, Saulo Relison Tintino
Toxicology Reports, 2025
Assessment of MepA inhibition potential using thiadiazine derivatives through fluorometry, docking, and qPCR
Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Isaac Moura Araújo, João Arthur de Oliveira Borges, Ray Silva Almeida, José Bezerra de Araújo-Neto, Cícera Datiane de Moraes Oliveira-Tintino, Igor José dos Santos Nascimento, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Helcio Silva dos Santos, Julia Mariana Assis da Silva, Tereza Cristina Leal Balbino, Irwin Rose de Alencar Menezes, Saulo Relison Tintino, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais Braga
Gene Reports, 2025
Evaluating efflux pump inhibition in Staphylococcus aureus 1199B strain using thiadiazine-derived compounds: In vitro and in silico approaches
Priscilla Ramos Freitas, Ana Carolina Justino de Araújo, Isaac Moura Araújo, Ray Silva Almeida, João Arthur de Oliveira Borges, Clara Mariana Gonçalves Lima, Cícera Datiane Morais Oliveira-Tintino, Cícera Laura Roque Paulo, Gustavo Marinho Miranda, José Bezerra de Araújo-Neto, José Weverton Almeida-Bezerra, Igor José dos Santos Nascimento, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonca Junior, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Irwin Rose Alencar de Menezes, Saulo Relison Tintino, Henrique Douglas Melo Coutinho
Biochimie, 2025
Investigation of the vasodilatory, tocolytic and spasmolytic effects of rutin on Wistar rats tissues
Andressa de Alencar Silva, Luís Pereira-de-Morais, Paulo Ricardo Batista, Cícera Georgia Brito Milfont, Isaac Moura Araújo, Carla Mikevely de Sena Bastos, Irwin Rose Alencar de Menezes, Yedda Maria Lobo Soares de Matos, Roseli Barbosa
Pharmacological Research Natural Products, 2025
Pharmacology, toxicology and homeopathy of Luffa operculata (L.) Cogniaux (Cucurbitaceae): Integrative review
Luís Pereira-de-Morais, Paulo Ricardo Batista, Andressa de Alencar Silva, Isaac Moura Araújo, Gabriela Lucena Calixto, Thais de Souza Amorim, Marília Cavalcante Araújo, Verônica Milesi, Roseli Barbosa
Toxicon, 2025
Phytochemical characterization, toxicity and pharmacological profile of the central effects of the fixed fruit pulp oil of Mauritia flexuosa L.F. (buriti)
Isaac Moura Araújo, Andressa de Alencar Silva, Luís Pereira-de-Morais, Debora de Menezes Dantas, Maysa de Oliveira Barbosa, Giovana Mendes Lacerda Leite, Carla de Fátima Alves Nonato, José Galberto Martins da Costa, Raimundo Luiz Silva Pereira, Marta Regina Kerntopf Mendonça, Henrique Douglas Melo Coutinho, Gyllyandeson de Araújo Delmondes
Fitoterapia, 2025
In vitro and in silico effect of meldrum's acid-derived compounds on Staphylococcus aureus strains as NorA efflux pump inhibitors
Isaac Moura Araújo, Raimundo Luiz Silva Pereira, Ana Carolina Justino de Araújo, Sheila Alves Gonçalves, Saulo Relison Tintino, Cícera Datiane de Morais Oliveira-Tintino, Irwin Rose Alencar de Menezes, Renata Salamoni, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Carolina Bandeira Domiciano, Henrique Douglas Melo Coutinho
Biophysical Chemistry, 2025
Potentiating-antibiotic and antibacterial properties of Luetzelburgia auriculata (ALLEMÃO) Ducke against MDR bacterial strains
Thiago S. Freitas, Janaina E. Rocha, Marcos J. F. Lima, Carla F. A. Nonato, Cicera J. Camilo, Cicera L. R. Paulo, Maria A. S. Alencar, Isaac M. Araújo, Karla S. T. G. Belém, Selvina P. Silva, Francisco N. Pereira Junior, Hélcio S. Santos, Jane E. S. A. Menezes, Alexandre M. R. Teixeira, Henrique D. M. Coutinho
Vegetos, 2025
Antibacterial and potentiating activity of 3-methoxycinnamic acid on antibiotics: an in vitro and in silico approach
José Thyálisson da Costa Silva, Rafael Pereira da Cruz, Ewerton Yago de Sousa Rodrigues, Maria Yasmin Cândido de Oliveira, Ademar Maia Filho, Cicera Laura Roque Paulo, Guilherme Fernandes Teixeira, Adrielle Rodrigues Costa, Janaína Esmeraldo Rocha, Isaac Moura Araujo, Viviane Bezerra da Silva, Maria Eloyse de Melo Sousa, Anita Oliveira Brito Pereira Bezerra Martins, Severino Denicio Gonçalves de Sousa, Antonio César Vieira da Silva, Carlos Alonso Leite dos Santos, Jefferson de Sales Diodato, José Maria Barbosa Filho, Henrique Douglas Melo Coutinho, José Weverton Almeida-Bezerra
FEMS Microbiology Letters, 2025
Analysis of the Antibiotic-Potentiating Activity, Absorption, Distribution, Metabolism, and Excretion (ADME) and the Molecular Docking Properties of Phytol Against Multi-Drug-Resistant (MDR) Strains
José Weverton Almeida-Bezerra, Saulo Almeida Menezes, José Thyálisson da Costa Silva, Simone Galdino de Sousa, Daniel Sampaio Alves, Gabriel Gonçalves Alencar, Isaac Moura Araújo, Ewerton Yago de Sousa Rodrigues, Cícera Datiane de Morais Oliveira-Tintino, Rafael Pereira da Cruz, Janaína Esmeraldo Rocha, Saulo Relison Tintino, José Maria Barbosa-Filho, Maria Flaviana Bezerra Morais-Braga, Irwin Rose Alencar de Menezes, António Raposo, Henrique Douglas Melo Coutinho
Antibiotics, 2024
Chemical Characterization and Biological Activity of Varronia curassavica Jacq. Essential Oil (Boraginaceae) and In Silico Testing of α-Pinene
José Thyálisson da Costa Silva, Viviane Bezerra da Silva, Sabrina Bezerra da Silva, Maria Ivaneide Rocha, Adrielle Rodrigues Costa, Jailson Renato de Lima Silva, Marcos Aurélio Figueirêdo dos Santos, Maria Elizete Machado Generino, Jeovane Henrique de Souza, Maraiza Gregorio de Oliveira, Clara Mariana Gonçalves Lima, Raimundo Luiz Silva Pereira, Renata Ferreira Santana, Isaac Moura Araujo, Maria Flaviana Bezerra Morais-Braga, Talha Bin Emran, Henrique Douglas Melo Coutinho, José Weverton Almeida-Bezerra
Analytica, 2024
Antibacterial and Inhibitory Activity of Nora and Mepa Efflux Pumps of Estragole Complexed to β-Cyclodextrin (ES/β-CD) In Vitro Against Staphylococcus aureus Bacteria, Molecular Docking and MPO-Based Pharmacokinetics Prediction
Roger Henrique Sousa da Costa, Renata Torres Pessoa, Eduardo dos Santos Silva, Isaac Moura Araujo, Sheila Alves Gonçalves, Janaína Esmeraldo Rocha, Francisco Nascimento Pereira Junior, Naiara Cipriano Oliveira, Victor Moreira de Oliveira, Matheus Nunes da Rocha, Emmanuel Silva Marinho, Natália Kelly Gomes de Carvalho, José Galberto Martins da Costa, Hélcio Silva dos Santos, Irwin Rose Alencar de Menezes
Pharmaceutics, 2024
Assessment In vitro and In silico of the Activity of Thiadiazines as NorA Efflux Pump Inhibitors
Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Isaac Moura Araújo, João Arthur de Oliveira Borges, Sheila Alves Gonçalves, Cícera Laura Roque Paulo, Ray Silva Almeida, Cícera Datiane de Moraes Oliveira-Tintino, José Bezerra de Araújo-Neto, Igor José dos Santos Nascimento, João Xavier de Araújo-Júnior, Edeildo Ferreira da Silva-Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Helcio Silva dos Santos, Irwin Rose de Alencar Menezes, Saulo Relison Tintino, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais Braga
Current Microbiology, 2024
Thiazine-derived compounds in inhibiting efflux pump in Staphylococcus aureus K2068, mepA gene expression, and membrane permeability alteration
Priscilla R. Freitas, Ana C.J. de Araújo, Isaac M. Araújo, Ray S. de Almeida, João A.O. Borges, Cícera L.R. Paulo, Cícera D.M. Oliveira-Tintino, Gustavo M. Miranda, José B. Araújo-Neto, Igor J.S. Nascimento, João X. Araújo-Júnior, Julia M.A. Silva, Tereza C.L. Balbino, Edeildo F. Silva-Júnior, Thiago M. Aquino, Francisco J.B. Mendonca-Junior, Emmanuel S. Marinho, Hélcio S. Santos, Clara Mariana Gonçalves Lima, Ahmad J. Obaidullah, Talha Bin Emran, Francisco A.B. Cunha, Irwin R.A. Menezes, Saulo R. Tintino, Henrique D.M. Coutinho
Biomedicine and Pharmacotherapy, 2024
Structural, topological, vibrational, and electronic analysis, and ADMET study of methyl-2-(4-isobutylphenyl)propanoate
Maria R. Xavier, Márcia M. Marinho, Murilo S.S. Julião, Emmanuel S. Marinho, Francisco W.Q. Almeida-Neto, Kevin K.A. de Castro, João P. da Hora, Matheus N. da Rocha, Antônio C.H. Barreto, Gilberto D. Saraiva, Paulo N. Bandeira, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Hélcio S. dos Santos, Alexandre M.R. Teixeira
Journal of Molecular Structure, 2024
FTIR analysis and antimicrobial activity of sodium tungstate and calcium tungstate
Júlio César Silva, Talysson Felismino Moura, Raimundo Luiz da Silva Pereira, Thiago Sampaio de Freitas, Janaína Esmeraldo Rocha, Henrique Douglas Melo Coutinho, Gustavo Miguel Siqueira, Daniel Sampaio Alves, Gabriel Gonçalves Alencar, Isaac Moura Araújo, Ana Kamila Medeiros Lima, Paulo de Tarso Cavalcante Freire, Francisco Ferreira de Sousa, Gilberto Dantas Saraiva, Maísa Freire Cartaxo Pires de Sá, Francisco Nascimento Pereira Junior, João Hermínio da Silva
Vibrational Spectroscopy, 2024
Meldrum's acid derivates are MepA efflux pump inhibitors: In vitro and in silico essays
Isaac Moura Araújo, Raimundo Luiz Silva Pereira, Ana Carolina Justino de Araújo, Sheila Alves Gonçalves, Saulo Relison Tintino, Cícera Datiane de Morais Oliveira‐Tintino, Irwin Rose Alencar de Menezes, Renata Salamoni, Iêda Maria Begnini, Ricardo Andrade Rebelo, Luiz Everson da Silva, Ana Pavla Almeida Diniz Gurgel, Henrique Douglas M. Coutinho
Journal of Basic Microbiology, 2024
Potentiating-antibiotic activity and absorption, distribution, metabolism, excretion and toxicity properties (ADMET) analysis of synthetic thiadiazines against multi-drug resistant (MDR) strains
Ana Carolina Justino de Araújo, Priscilla Ramos Freitas, Isaac Moura Araújo, Gustavo Miguel Siqueira, João Arthur de Oliveira Borges, Daniel Sampaio Alves, Gustavo Marinho Miranda, Igor José dos Santos Nascimento, João Xavier de Araújo‐Júnior, Edeildo Ferreira da Silva‐Júnior, Thiago Mendonça de Aquino, Francisco Jaime Bezerra Mendonça Junior, Emmanuel Silva Marinho, Helcio Silva dos Santos, Saulo Relison Tintino, Henrique Douglas Melo Coutinho
Fundamental and Clinical Pharmacology, 2024
ADMET Analysis, Antibacterial and Modified Antibiotic Activities of Thiadiazine Derivatives
Priscilla R. Freitas, Ana C. J., Isaac, Gustavo M. Siqueira, Daniel S. Alves, et al.
Journal of Biological Regulators and Homeostatic Agents, 2024
Antibacterial activity and anxiolytic-like effect of Ziziphus joazeiro Mart. leaves in adult zebrafish (Danio rerio)
Antônio Barros de Souza, Jacqueline Cosmo Andrade Pinheiro, Juliete Bezerra Soares, José Ismael Feitosa de Araújo, Sandra Maria Barbosa de Araújo, Francisco Lucas Alves Batista, Kalina Kelma Oliveira de Sousa, Saulo Relison Tintino, Isaac Moura Araujo, Francisco Ernani Alves Magalhães, Laura Hévila Inocencio Leite, Francisco Roberto de Azevedo
Fish and Shellfish Immunology Reports, 2023
Assessment of Quercetin Antiemetic Properties: In Vivo and In Silico Investigations on Receptor Binding Affinity and Synergistic Effects
Raihan Chowdhury, Md. Shimul Bhuia, Asraful Islam Rakib, Rubel Hasan, Henrique Douglas Melo Coutinho, Isaac Moura Araújo, Irwin Rose Alencar de Menezes, Muhammad Torequl Islam
Plants, 2023
Chemical composition and antibacterial effects of Etlingera elatior (Jack) R.M. Smith against Staphylococcus aureus efflux pumps
Felipe de Sousa Ferreira, José Bezerra de Araújo Neto, Cícera Datiane de Morais Oliveira-Tintino, Ana Carolina Justino de Araújo, Jaime Ribeiro-Filho, Priscilla Ramos Freitas, Isaac Moura Araújo, Micheline Azevedo Lima, Francisco Roberto de Azevedo, Saulo Relison Tintino, Henrique Douglas Melo Coutinho, Daniela Maria do Amaral Ferraz Navarro
Chemico Biological Interactions, 2023
Effect of gallium and strontium salts on the characteristics and biological applications of Sr and Ga-modified titanate nanotubes
Raimundo L.S. Pereira, Ana C.J. de Araújo, Priscilla R. Freitas, Isaac M. Araújo, Sheila A. Gonçalves, Suziete B.S. Gusmão, Ramón R. Peña-Garcia, Yuset G. Dávila, Bartolomeu C. Viana, João H. da Silva, Irwin R.A. de Menezes, Henrique D.M. Coutinho, Alexandre M.R. Teixeira
Results in Chemistry, 2023
Sclareol exerts synergistic antidepressant effects with quercetin and caffeine, possibly suppressing GABAergic transmission in chicks
Hossam Kamli, Ahmad Shaikh, Mehedi Hasan Bappi, António Raposo, Md Faruque Ahmad, Fatema Akter Sonia, Md. Showkoth Akbor, Abdullah Al Shamsh Prottay, Sheila Alves Gonçalves, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Ehab Y. Elbendary, Linda Heejung Lho, Heesup Han, Muhammad Torequl Islam
Biomedicine and Pharmacotherapy, 2023
Evaluation of the antibacterial and inhibitory activity of the MepA efflux pump of Staphylococcus aureus by riparins I, II, III, and IV
Cristina Rodrigues dos Santos Barbosa, Nair Silva Macêdo, Zildene de Sousa Silveira, Janaína Esmeraldo Rocha, Thiago Sampaio Freitas, Débora Feitosa Muniz, Isaac Moura Araújo, Cícera Datiane de Morais Oliveira-Tintino, Emmanuel Silva Marinho, Matheus Nunes da Rocha, Marcia Machado Marinho, Antonio Henrique Bezerra, Gabriela Ribeiro de Sousa, José Maria Barbosa-Filho, Jailton de Souza-Ferrari, Henrique Douglas Melo Coutinho, Hélcio Silva dos Santos, Francisco Assis Bezerra da Cunha
Archives of Biochemistry and Biophysics, 2023
Bioactivities and ethnopharmacology of Sesamum indicum L seed oil
Erik Samyr Correia Alves, Polrat Wilairatana, Maria Joseane Macedo da Cruz, Laize Aparecida Nunes Lopes Campos, Metton Ribeiro Lopes e Silva, Daniel Sampaio Alves, Isaac Moura Araújo, Francisco Antonio Vieira dos Santos, Pablo Antonio Maia de Farias, Eliane Maria Gonçalves Moreira de Vasconcelos, Abolghasem Siyadatpanah, Henrique Douglas Melo Coutinho, Fernando Gomes Figueredo
Lwt, 2023
The preeclampsia condition alters external potassium-evoked contraction of human umbilical vessels
Luís Pereira-de-Morais, Andressa de Alencar Silva, Carla Mikevely de Sena Bastos, Gabriela Lucena Calixto, Isaac Moura Araújo, Marília Cavalcante Araújo, Roseli Barbosa, José Henrique Leal-Cardoso
Placenta, 2023
Eucalyptol prevents pilocarpine-induced seizure and neuronal damage in mice, through the cholinergic, monoaminergic and antioxidant pathways
Daniel Souza Bezerra, Gyllyandeson de Araujo Delmondes, Maria Janice Pereira Lopes, Isaac Moura Araujo, Giovana Mendes de Lacerda Leite, Maysa de Oliveira Barbosa, Roseli Barbosa, Adriano Francisco Alves, Cassio Rocha Medeiros, Sloana Giesta Lemos Florencio, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Cicero Francisco Bezerra Felipe, Marta Regina Kerntopf
Food Bioscience, 2023
Antibacterial Activity of the Essential Oil of Piper tuberculatum Jacq. Fruits against Multidrug-Resistant Strains: Inhibition of Efflux Pumps and β-Lactamase
Lucas Yure Santos da Silva, Cicera Laura Roque Paulo, Talysson Felismino Moura, Daniel Sampaio Alves, Renata Torres Pessoa, Isaac Moura Araújo, Cícera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Carla de Fatima Alves Nonato, José Galberto Martins da Costa, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, Grażyna Kowalska, Przemysław Mitura, Marek Bar, Radosław Kowalski, Irwin Rose Alencar de Menezes
Plants, 2023
Use of essential oils from plants of Araripe National Forest against Aedes aegypti (Diptera: Culicidae)
F. R. Azevedo, R. C. A. B. Ferreira, C. S. Leandro, I. M. Araújo, S. R. Tintino
Brazilian Journal of Biology, 2023
Ethnomedicinal Uses, Phytochemistry, and Therapeutic Potentials of Litsea glutinosa (Lour.) C. B. Robinson: A Literature-Based Review
Sarmin Jamaddar, António Raposo, Chandan Sarkar, Uttam Kumar Roy, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Ali Saleh Alkhoshaiban, Hmidan A. Alturki, Ariana Saraiva, Conrado Carrascosa, Muhammad Torequl Islam
Pharmaceuticals, 2023
Antifungal Effect and Inhibition of the Virulence Mechanism of D-Limonene against Candida parapsilosis
Melyna Chaves Leite-Andrade, Luiz Nascimento de Araújo Neto, Maria Daniela Silva Buonafina-Paz, Franz de Assis Graciano dos Santos, Adryelle Idalina da Silva Alves, Maria Carolina Accioly Brelaz de Castro, Edna Mori, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Grażyna Kowalska, Radosław Kowalski, Tomasz Baj, Rejane Pereira Neves
Molecules, 2022
Modification of Antibiotic Activity by Fixed Oil of the Artocarpus heterophyllus Almond against Standard and Multidrug-Resistant Bacteria Strains
Cícera Janayne Ferreira Dias, António Raposo, Cícera Dayane Thais de Sousa, José Bezerra de Araújo-Neto, Saulo Relison Tintino, Cícera Datiane de Morais Oliveira-Tintino, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Mayra Garcia Maia Costa, Cleidiane Gomes Lima, Mairlane Silva de Alencar, Conrado Carrascosa, Ariana Saraiva, Erlânio Oliveira de Sousa
Biology, 2022
GC–MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study
Chandan Sarkar, Milon Mondal, Khattab Al-Khafaji, Dina M. El-Kersh, Sarmin Jamaddar, Pranta Ray, Uttam Kumar Roy, Mirola Afroze, Md. Moniruzzaman, Mala Khan, Umma Hafsa Asha, Abul Bashar Ripon Khalipha, Edna Mori, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Manik Chandra Shill, Muhammad Torequl Islam
Life Sciences, 2022
Anxiolytic-like Effect of Quercetin Possibly through GABA Receptor Interaction Pathway: In Vivo and In Silico Studies
Md. Shahazul Islam, Rajib Hossain, Taukir Ahmed, Md. Mizanur Rahaman, Khattab Al-Khafaji, Rasel Ahmed Khan, Chandan Sarkar, Mehedi Hasan Bappi, Edlane Martins de Andrade, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Grażyna Kowalska, Radosław Kowalski, Muhammad Asif Hanif, Muhammad Torequl Islam
Molecules, 2022
Possible mechanisms involved in the neuroprotective effect of Trans,trans-farnesol on pilocarpine-induced seizures in mice
Gyllyandeson de Araújo Delmondes, Maria Janice Pereira Lopes, Isaac Moura Araújo, Alex de Sousa Borges, Paulo Ricardo Batista, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes, José Maria Barbosa-Filho, Cícero Francisco Bezerra Felipe, Marta Regina Kerntopf
Chemico Biological Interactions, 2022
Bioactive Natural Products for Chemical Control of Microorganisms: Scientific Prospecting (2001–2021) and Systematic Review
Bruno Fonsêca Feitosa, Charlene Maria de Alcântara, Amanda Beatriz Sales de Lima, Adriano Sant’Ana Silva, Alfredina dos Santos Araújo, Mônica Tejo Cavalcanti, Edna Mori, Isaac Moura Araújo, Pablo Antonio Maia de Farias, Polrat Wilairatana, Henrique Douglas Melo Coutinho
Molecules, 2022
Pharmacological and toxicological activities of α-humulene and its isomers: A systematic review
Giovana Mendes de Lacerda Leite, Maysa de Oliveira Barbosa, Maria Janice Pereira Lopes, Gyllyandeson de Araújo Delmondes, Daniel Souza Bezerra, Isaac Moura Araújo, Cícero Damon Carvalho de Alencar, Henrique Douglas Melo Coutinho, Laisla Rangel Peixoto, José Maria Barbosa-Filho, Cícero Francisco Bezerra Felipe, Roseli Barbosa, Irwin Rose Alencar de Menezes, Marta Regina Kerntof
Trends in Food Science and Technology, 2021
Toxicity of methyl eugenol against Drosophila melanogaster and its myorelaxant activity in bronchioles isolated from Sus scrofa domesticus
Mikael A. de Souza, Luís Pereira-de-Morais, Zildene de S. Silveira, Nair S. Macêdo, Isaac M. Araujo, Luiz J. de L. Neto, Gyllyandeson de A. Delmondes, Roger H. S. da Costa, Lígia C. C. de Oliveira, Henrique D. M. Coutinho, Roseli Barbosa, Hélcio S. dos Santos, Francisco Assis Bezerra da Cunha
Biologia, 2021
Pharmacological screening of the phenolic compound caffeic acid using rat aorta, uterus and ileum smooth muscle
Andressa de Alencar Silva, Luís Pereira-de-Morais, Renata Evaristo Rodrigues da Silva, Débora de Menezes Dantas, Cícera Georgia Brito Milfont, Maria Franciele Gomes, Isaac Moura Araújo, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes, Roseli Barbosa
Chemico Biological Interactions, 2020
Pharmacological applications of farnesol (C15H26O): a patent review
Gyllyandeson De Araújo Delmondes, Izabel Cristina Santiago Lemos, Diógenes De Queiroz Dias, Glacithane Lins Da Cunha, Isaac Moura Araújo, Roseli Barbosa, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, José Maria Barbosa-Filho, Natanael Teles Ramos De Lima, Irwin Rose Alencar De Menezes, Marta Regina Kerntopf
Expert Opinion on Therapeutic Patents, 2020
Toxicological and pharmacologic effects of farnesol (C 15 H 26 O): A descriptive systematic review
Gyllyandeson de Araújo Delmondes, Daniel Souza Bezerra, Diógenes de Queiroz Dias, Alex de Souza Borges, Isaac Moura Araújo, Glacithane Lins da Cunha, Paulo Felipe Ribeiro Bandeira, Roseli Barbosa, Henrique Douglas Melo Coutinho, Cícero Francisco Bezerra Felipe, José Maria Barbosa-Filho, Irwin Rose Alencar de Menezes, Marta Regina Kerntopf
Food and Chemical Toxicology, 2019

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