Isaeva Iuliia

RESEARCH, TEACHING, or OTHER INTERESTS

Chemistry, Biochemistry, Organic Chemistry

Scopus Publications

Nanoparticles of Push-Pull Triphenylamine-Based Molecules for Light-Controlled Stimulation of Neuronal Activity
Yuriy N. Luponosov, Alexander N. Solodukhin, Nikolay A. Aseyev, Tatyana I. Rokitskaya, Darya E. Kolotova, Elena A. Kotova, Tikhon S. Kurkin, Liya A. Poletavkina, Yulia A. Isaeva, Yuri N. Antonenko,et al.
American Chemical Society (ACS)
Organic semiconductor materials with a unique set of properties are very attractive for interfacing biological objects and can be used for noninvasive therapy or detection of biological signals. Here, we describe the synthesis and investigation of a novel series of organic push-pull conjugated molecules with the star-shaped architecture, consisting of triphenylamine as a branching electron donor core linked through the thiophene π-spacer to electron-withdrawing alkyl-dicyanovinyl groups. The molecules could form stable aqueous dispersions of nanoparticles (NPs) without the addition of any surfactants or amphiphilic polymer matrixes with the average size distribution varying from 40 to 120 nm and absorption spectra very similar to those of human eye retina pigments such as rods and green cones. Variation of the terminal alkyl chain length of the molecules forming NPs from 1 to 12 carbon atoms was found to be an efficient tool to modulate their lipophilic and biological properties. Possibilities of using the NPs as light nanoactuators in biological systems or as artificial pigments for therapy of degenerative retinal diseases were studied both on the model planar bilayer lipid membranes and on the rat cortical neurons. In the planar bilayer system, the photodynamic activity of these NPs led to photoinactivation of ion channels formed by pentadecapeptide gramicidin A. Treatment of rat cortical neurons with the NPs caused depolarization of cell membranes upon light irradiation, which could also be due to the photodynamic activity of the NPs. The results of the work gave more insight into the mechanisms of light-controlled stimulation of neuronal activity and for the first time showed that fine-tuning of the lipophilic affinity of NPs based on organic conjugated molecules is of high importance for creating a bioelectronic interface for biomedical applications.


Synthesis, structure, and PDE inhibiting activity of the anionic DNIC with 5-(3-pyridyl)-4H-1,2,4-triazole-3-thiolyl, the nitric oxide donor
Natalia A. Sanina, Yuliya A. Isaeva, Andrey N. Utenyshev, Pavel V. Dorovatovskii, Nickolai S. Ovanesyan, Nina S. Emel'yanova, Olesya V. Pokidova, Liliya V. Tat'yanenko, Il'ya V. Sulimenkov, Alexandr I. Kotel'nikov,et al.
Elsevier BV