Israa M. Al-Bayaa

@uomustansiriyah.edu.iq

Pathology Department
Al-Mustansirya university/college of medicine

Israa M. Al-Bayaa


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https://researchid.co/israa-albayaa

RESEARCH, TEACHING, or OTHER INTERESTS

Medicine, Pathology and Forensic Medicine, Hematology
8

Scopus Publications

28

Scholar Citations

4

Scholar h-index

Scopus Publications

  • Gene therapy for hemophilia: Recent developments and challenges (Review)
    Marwa Ali Abdulnabi, Enass Abdul Kareem Dagher Al‑Saadi, Israa M. Al‑Bayaa
    World Academy of Sciences Journal, 2025
  • Comparative Evaluation of the Immunophenotypic Profile of Acute Lymphoblastic Leukaemia in Adult and Paediatric Age Groups in Iraq
    Enass Abdul Kareem Al-Saadi, Marwa Ali Abdulnabi, Israa M Al-Bayaa
    Shiraz E Medical Journal, 2024
    Background: Immunophenotyping is a primary tool for investigating acute lymphoblastic leukemia (ALL). Acute lymphoblastic leukemia accounts for 75 - 80% of pediatric leukemia cases and 14% of adult leukemia cases. However, the prognostic factors, treatment strategies, and pathogenic pathways differ between these groups. Objectives: This study aims to compare the pattern of antigen expression between adult and pediatric ALL patients in the Iraqi population and to evaluate the frequency of aberrant myeloid antigen expression in both groups. Methods: A total of 131 patients with de-novo ALL were studied from May 2014 to May 2015. The diagnosis of ALL was confirmed by morphology and immunophenotyping of peripheral blood and bone marrow aspirate specimens using a panel of fluorochrome-labeled antibodies in 6 - colored flow cytometry. Results: The B-ALL phenotype was prevalent in 44 (68.7%) of adult patients compared to 51 (76.1%) in the pediatric group. CD10 expression was present in 49 (76.6%) of adults, mostly with B-ALL. The pediatric group had lower CD10 expression in T-ALL (P = 0.039). CD20 expression was significantly lower in adults compared to children. In T-ALL, significant differences between adult and pediatric groups were observed in CD1a and CD2 expression. Aberrant myeloid antigen expression was present in 29 (45.3%) adults and 30 (44.8%) pediatric patients, with CD33 and CD13 being the most prevalent in both groups. Conclusions: There was an increased T-cell lineage and aberrant antigen expression in both adult and pediatric ALL cases in this Iraqi sample. Adults with ALL tend to display higher levels of CD20 and lower levels of CD1a and CD2 compared to children, markers associated with poorer prognoses.
  • A typical lymphocyte cells identification based combination of similarity measurement and affine geometric transformation
    Marwan F. Al-Bayati, Aws Al-Azawi, Israa M. Al-Bayaa, Haider Qasim Hamood
    Aip Conference Proceedings, 2023
  • Evaluation of the Serum Level of Vascular Endothelial Growth Factor in Patients with Beta-Thalassemia Major and Sickle/Beta-Thalassemia, and its Correlation with Clinical and Laboratory Parameters
    Sara Abdul Mohsin, Israa Al-Bayaa, Ihsan Al-Badran
    Journal of Applied Hematology, 2023
    BACKGROUND: The most prevalent inherited disorders of red blood cells are hemoglobinopathies, with thalassemia and sickle cell diseases (SCDs) being the most common. In SCD and thalassemia major, angiogenesis has been identified as a substantial contributor to vascular-mediated tissue damage. Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis. This study aims to assess the circulating level of serum VEGF in beta-thalassemia (β-thal) and sickle β-thal patients and also to explore the correlation with clinical and laboratory data. PATIENTS, MATERIALS AND METHODS: This is a cross-sectional study conducted on 80 individuals, clinical data were gathered, complete blood count, serum ferritin, and serum VEGF tests were done. RESULTS: Patients' age ranged from 1.5 to 17.5 years, males formed (70%). Platelet count was significantly higher in β-thal compared to sickle/β-thal (S/β-thal) patients, with a P = 0.015. Mean serum ferritin in patients was significantly higher in β-thal compared to S/β-thal patients, P < 0.001. Patients' serum VEGF levels were noticeably higher than controls with P = 0.01. Strong positive correlation of serum VEGF with platelet count among the patients (r = 0.603, P < 0.001). A significant positive correlation was observed between serum VEGF and the age of starting chelation therapy in thalassemic patients (r = 0.475, P = 0.006). CONCLUSIONS: Serum VEGF levels were significantly higher in patients compared to healthy controls, and there is a significant positive correlation between serum VEGF levels and the age at which iron chelation therapy was initiated as well as between serum VEGF levels and platelet counts in patients.
  • Assessment of soluble syndecan-1 level in adult patients with de novo acute myeloid leukemia and its correlation with hematological parameters and treatment response
    Riyam Ismael Shaker, Israa M. Al-Bayaa
    Iraqi Journal of Hematology, 2023
    BACKGROUND: Syndecan-1 (CD138) is a member of the transmembrane proteoglycans family that is expressed in various normal and malignant tissues. It attracted the attention because of its possible prognostic role when expressed in different tumors as well as its role as a target for therapy by the monoclonal antibody indatuximab coupled with other cytotoxic agents. In acute myeloid leukemia (AML), syndecan-1 was found to be significantly increased either inside leukocytes or as a soluble form in the plasma and it was correlated with overall survival of AML patients and with more bleeding manifestations and impaired platelet function. AIMS: The aims of this study were to assess the level of soluble syndecan-1 (or CD 138) in adult patients with de novo AML compared to the control group and to explore any possible correlation between the level of syndecan-1 with hematological parameters and response to remission induction therapy. PATIENTS AND METHODS: Cross-sectional study recruited 60 newly diagnosed adult AML patients. Moreover, 25 healthy individuals were included as the control group. The peripheral blood and bone marrow smears were examined at presentation for establishing the diagnosis and after remission induction for assessing the treatment response. Plasma syndecan-1 assay was done by sandwich enzyme-linked immunosorbent assay, which was done to patients at time of diagnosis. RESULTS: Plasma syndecan-1 (SDC-1) level of AML patients at presentation was much higher than that in the control group (P &lt; 0.001); there was also a statistically significant difference in plasma level of syndecan-1 between male and female patients (P = 0.002). There was no significant difference for plasma (SDC-1) level between different AML French American British (FAB) subtypes; however, the highest level was seen among patients with the M3 subtype. No significant difference for plasma (SDC-1) level was seen between the patients who achieved remission status and patients who failed to achieve remission after chemotherapy and also between patients alive and deceased after 6 months of follow-up. Insignificant correlations were demonstrated between soluble (SDC-1) and the presenting complete blood count (CBC) parameters. CONCLUSIONS: Although the high level of plasma syndecan-1 was demonstrated in patients with AML compared to the control group, there was no significant difference with respect to age, FAB subtype, and type of response to treatment nor with the patient outcome, and also no significant association was established with any of the hematological parameters.
  • The impact of JAK2V617F allelic burden on clinical and laboratory parameters in patients with myeloproliferative neoplasms
    Haithem Ahmed Al-Rubaie, Israa M Al-Bayaa, Bassam MS Al-Musawi
    Annals of Tropical Medicine and Public Health, 2020
  • Evaluation of hepatocyte growth factor in iraqi patients with acute myeloid leukemia: Its correlation with clinical parameters and response to induction therapy
    Israa M. Al-Bayaa, Haithem Ahmed Al-Rubaie, Haider Hasan Al-Shammari
    Open Access Macedonian Journal of Medical Sciences, 2020
    BACKGROUND: Hepatocyte growth factor (HGF) is a proangiogenic factor that exerts different effects over stem cell survival growth, apoptosis, and adhesion. Its impact on leukemogenesis has been established by many studies.&#x0D; AIM: This study aimed to determine the effect of plasma HGF activity on acute myeloid leukemia (AML) patients at presentation and after remission.&#x0D; PATIENTS AND METHODS: This was a cross-sectional prospective study of 30 newly-diagnosed, adult, and AML patients. All patients received the 7+3 treatment protocol. Patients’ clinical data were taken at presentation, and patients were followed up for 6 months to evaluate the clinical status. Plasma HGF levels were estimated by ELISA based methods in the patients at two intervals first at diagnosis and the 2nd time after remission of disease. Plasma HGF levels were only measured once in twenty healthy control individuals.&#x0D; RESULTS: A statistically significant lowering in the median levels of HGF after remission induction therapy has been found when compared with those before treatment (p = 0.006) and in the group of patients who achieved complete remission in comparison with those before treatment (p = 0.005). Furthermore, a significant reduction was also demonstrated after treatment in patients presenting with extramedullary involvement (p = 0.003) and in the alive group (p = 0.001).&#x0D; CONCLUSION: Plasma HGF estimation can be a useful parameter in predicting treatment outcomes in patients with AML, and it can add potentially useful information to risk stratification parameters.
  • The value of soluble transferrin receptor and soluble transferrin receptor-ferritin index in discriminating iron deficiency anaemia from anaemia of chronic disease in patients with rheumatoid arthritis
    Haithem A. Al-Rubaie, Israa M. Al-Bayaa, Yassmin A. Al-Amiri
    Open Rheumatology Journal, 2019
    Background:Anaemia is a common extra-articular manifestation of rheumatoid arthritis (RA) where anaemia of chronic disease (ACD) and iron deficiency anaemia (IDA) are the two most frequent types. The distinction between these two types of anaemia has always been challenging requiring sophisticated techniques. Serum transferrin receptor (sTfR) a truncated soluble form of the transferrin receptor is one of the parameters that is influenced by the Iron content and supply to the erythrons and is not affected by inflammatory status and therefore the use of the sTfR/log ferritin (sTfR-F) index can be a reliable indicator of functional iron deficiency.Aim of the study:This study aims to evaluate the usefulness of sTfR and sTfR-F index in discriminating the most common types of anaemia in patients with RA.Patients and methods:The study included 50 patients with RA and 30 healthy subjects as a control group. Complete blood picture, C-reactive protein, serum Iron, unsaturated iron binding capacity, sTfR and serum ferritin were tested.Results and Conclusion:anaemia was present in 34/50 patients; 19 patients had ACD, 9 had ACD/IDA and only 6 patients had IDA. Both the sTfR and the sTfR-F index showed a significant difference between anaemia groups (P values = 0.037 and 0.001, respectively). sTfR-F index has shown to be a very useful parameter that can discriminate efficiently between IDA and ACD and between ACD and ACD/IDA in patients with RA.

RECENT SCHOLAR PUBLICATIONS

  • Soluble CD163 Concentration in Chronic Lymphocytic Leukemia and its Correlation with Prognostic Parameters
    MM Jawad, IMB Al-Bayaa
    Hammurabi Journal of Medical Sciences 2 (3), 14-22 , 2025
    2025.0
  • Gene therapy for hemophilia: Recent developments and challenges
    M Ali Abdulnabi, EAKD Al-Saadi, IM Al-Bayaa
    World Academy of Sciences Journal 7 (3), 41 , 2025
    2025.0
    Citations: 2
  • Prognostic value of soluble CD200 concentration in chronic lymphocytic leukemia and its correlation with clinical and laboratory parameters
    D Fakhri, IM Baqir
    Iraqi Postgraduate Medical Journal 25 (1), 9 , 2025
    2025.0
  • Evaluation of plasma progranulin level in patients with newly diagnosed chronic lymphocytic leukemia and its correlation with clinical stages, hematological parameters, and B2 …
    ZQ Mohammed, IM Al-bayaa
    Iraqi Journal of Hematology 14 (1), 94-100 , 2025
    2025.0
    Citations: 1
  • Comparative Evaluation of the Immunophenotypic Profile of Acute Lymphoblastic Leukaemia in Adult and Paediatric Age Groups in Iraq
    EAK Al-Saadi, MA Abdulnabi, IM Al-Bayaa
    Shiraz E-Medical Journal 25 (25), e153753 , 2024
    2024.0
    Citations: 1
  • Assessment of soluble syndecan-1 level in adult patients with de novo acute myeloid leukemia and its correlation with hematological parameters and treatment response
    RI Shaker, IM Al-Bayaa
    Iraqi Journal of Hematology 12 (2), 123-127 , 2023
    2023.0
    Citations: 2
  • Evaluation of the Serum Level of Vascular Endothelial Growth Factor in Patients with Beta-Thalassemia Major and Sickle/Beta-Thalassemia, and its Correlation with Clinical and …
    SAA Mohsin, IM Al-Bayaa, IM Al-Badran
    Journal of Applied Hematology 14 (2), 115-121 , 2023
    2023.0
  • Plasminogen Activator Inhibitor-1 in Acute Myeloid Leukemia: Is It Useful in Predicting Response to Induction Remission Therapy?
    HHJ Al-Shammari, I Al-Bayaa, HA Al-Rubaie
    Open Access Macedonian Journal of Medical Sciences 10 (B), 1894-1898 , 2022
    2022.0
  • The impact of JAK2V617F allelic burden on clinical and laboratory parameters in patients with myeloproliferative neoplasms
    BMSAM Haithem Ahmed Al-Rubaie1*, Israa M Al-Bayaa2
    Annals of Tropical Medicine & Public Health http://doi.org/10.36295/ASRO … , 2020
    2020.0
  • Evaluation of Hepatocyte Growth Factor in Iraqi Patients with Acute Myeloid Leukemia: Its Correlation with Clinical Parameters and Response to Induction Therapy
    HHAS Israa M. Al-Bayaa1, Haithem Ahmed Al-Rubaie2*
    Open Access Macedonian Journal of Medical Sciences 25 (8(A)), 49-53. , 2020
    2020.0
    Citations: 7
  • The value of soluble transferrin receptor and soluble transferrin receptor-ferritin index in discriminating iron deficiency anaemia from anaemia of chronic disease in patients …
    HA Al-Rubaie, IM Al-Bayaa, YA Al-Amiri
    The Open Rheumatology Journal 13 (1) , 2019
    2019.0
    Citations: 7
  • Immunophenotyic profile of adult acute lymphoblastic leukaemia in Iraq, a one year experience
    IM Al-Bayaa
    Iraqi Journal of Cancer and Medical Genetics 8 (2) , 2015
    2015.0
    Citations: 4
  • Detection of JAK2V617F tyrosine kinase mutation and estimation of serum erythropoietin in blood donors who have high hematocrit
    HA AL-Rubaie, MA Khudeir, IM Al-Bayaa
    Journal of the Faculty of Medicine Baghdad 56 (4), 395-400 , 2014
    2014.0
    Citations: 4
  • The Value of Serum Ferritin in the Prediction of Iron Deficiency in Patients with Lymphoid Neoplasms
    A I Shuk, Y Ali abdul-kareem AL-Amiri, AL Ali abdul-kareem, ...
    Kerbala Journal of Medicine 6 (2), 1668-1674 , 2013
    2013.0
  • Prognostic Value of Soluble CD200 Concentration in Chronic Lymphocytic Leukemia and Its Correlation with Clinical and Laboratory Parameters
    IMBAB Dhuha Fawzi Fakhri1
    Iraqi postgraduate medical journal 26 (1), 54-61 , 0

MOST CITED SCHOLAR PUBLICATIONS

  • Evaluation of Hepatocyte Growth Factor in Iraqi Patients with Acute Myeloid Leukemia: Its Correlation with Clinical Parameters and Response to Induction Therapy
    HHAS Israa M. Al-Bayaa1, Haithem Ahmed Al-Rubaie2*
    Open Access Macedonian Journal of Medical Sciences 25 (8(A)), 49-53. , 2020
    2020.0
    Citations: 7
  • The value of soluble transferrin receptor and soluble transferrin receptor-ferritin index in discriminating iron deficiency anaemia from anaemia of chronic disease in patients …
    HA Al-Rubaie, IM Al-Bayaa, YA Al-Amiri
    The Open Rheumatology Journal 13 (1) , 2019
    2019.0
    Citations: 7
  • Immunophenotyic profile of adult acute lymphoblastic leukaemia in Iraq, a one year experience
    IM Al-Bayaa
    Iraqi Journal of Cancer and Medical Genetics 8 (2) , 2015
    2015.0
    Citations: 4
  • Detection of JAK2V617F tyrosine kinase mutation and estimation of serum erythropoietin in blood donors who have high hematocrit
    HA AL-Rubaie, MA Khudeir, IM Al-Bayaa
    Journal of the Faculty of Medicine Baghdad 56 (4), 395-400 , 2014
    2014.0
    Citations: 4
  • Gene therapy for hemophilia: Recent developments and challenges
    M Ali Abdulnabi, EAKD Al-Saadi, IM Al-Bayaa
    World Academy of Sciences Journal 7 (3), 41 , 2025
    2025.0
    Citations: 2
  • Assessment of soluble syndecan-1 level in adult patients with de novo acute myeloid leukemia and its correlation with hematological parameters and treatment response
    RI Shaker, IM Al-Bayaa
    Iraqi Journal of Hematology 12 (2), 123-127 , 2023
    2023.0
    Citations: 2
  • Evaluation of plasma progranulin level in patients with newly diagnosed chronic lymphocytic leukemia and its correlation with clinical stages, hematological parameters, and B2 …
    ZQ Mohammed, IM Al-bayaa
    Iraqi Journal of Hematology 14 (1), 94-100 , 2025
    2025.0
    Citations: 1
  • Comparative Evaluation of the Immunophenotypic Profile of Acute Lymphoblastic Leukaemia in Adult and Paediatric Age Groups in Iraq
    EAK Al-Saadi, MA Abdulnabi, IM Al-Bayaa
    Shiraz E-Medical Journal 25 (25), e153753 , 2024
    2024.0
    Citations: 1
  • Soluble CD163 Concentration in Chronic Lymphocytic Leukemia and its Correlation with Prognostic Parameters
    MM Jawad, IMB Al-Bayaa
    Hammurabi Journal of Medical Sciences 2 (3), 14-22 , 2025
    2025.0
  • Prognostic value of soluble CD200 concentration in chronic lymphocytic leukemia and its correlation with clinical and laboratory parameters
    D Fakhri, IM Baqir
    Iraqi Postgraduate Medical Journal 25 (1), 9 , 2025
    2025.0
  • Evaluation of the Serum Level of Vascular Endothelial Growth Factor in Patients with Beta-Thalassemia Major and Sickle/Beta-Thalassemia, and its Correlation with Clinical and …
    SAA Mohsin, IM Al-Bayaa, IM Al-Badran
    Journal of Applied Hematology 14 (2), 115-121 , 2023
    2023.0
  • Plasminogen Activator Inhibitor-1 in Acute Myeloid Leukemia: Is It Useful in Predicting Response to Induction Remission Therapy?
    HHJ Al-Shammari, I Al-Bayaa, HA Al-Rubaie
    Open Access Macedonian Journal of Medical Sciences 10 (B), 1894-1898 , 2022
    2022.0
  • The impact of JAK2V617F allelic burden on clinical and laboratory parameters in patients with myeloproliferative neoplasms
    BMSAM Haithem Ahmed Al-Rubaie1*, Israa M Al-Bayaa2
    Annals of Tropical Medicine & Public Health http://doi.org/10.36295/ASRO … , 2020
    2020.0
  • The Value of Serum Ferritin in the Prediction of Iron Deficiency in Patients with Lymphoid Neoplasms
    A I Shuk, Y Ali abdul-kareem AL-Amiri, AL Ali abdul-kareem, ...
    Kerbala Journal of Medicine 6 (2), 1668-1674 , 2013
    2013.0
  • Prognostic Value of Soluble CD200 Concentration in Chronic Lymphocytic Leukemia and Its Correlation with Clinical and Laboratory Parameters
    IMBAB Dhuha Fawzi Fakhri1
    Iraqi postgraduate medical journal 26 (1), 54-61 , 0