Graduated in Chemistry Bachelor's degree from the Federal University of Rio Grande do Norte (1992) and PhD in Physical-Chemistry from the University of São Paulo (1997). He did a postdoc in the United States, 1997-1998 at Boston College and was a visiting researcher between 2010-2011 at the National Cancer Institute / NIH / United States. He was director of the inorganic chemistry division of the Brazilian Chemical Society (2012-2014), adjunct secretary (2018-2020), and current vice president of SBQ. He was coordinator of the Graduate Programs in Inorganic Chemistry (2003-2008) and in Chemistry (2009-2010; 2015-2020). He is currently a full professor at the Federal University of Ceará. Associate Editor of the journal Química Nova. Member of the BASis / INEP evaluator bank. He has experience in the area of Chemistry, with an emphasis on Bio-Inorganic Chemistry, working mainly on the following topics: NO-releasing mechanics, sGC activators, metallic mechanical anti-tuberculostatic agents, etc.
EDUCATION
Ph.D. in Chemistry university of São Paulo, Brazil, March 1997, Thesis “Reactivity trans- Ru(NH3)4P(OEt)3NO](PF6)3“ (with honors)
B.Sc. in Chemistry Federal University of Rio Grande do Norte, Brazil, 1991.
Minimal Functionalization of Ruthenium Compounds with Enhanced Photoreactivity against Hard-to-Treat Cancer Cells and Resistant Bacteria Geângela de Fátima Sousa Oliveira, Florencio Sousa Gouveia, Alexandre Lopes Andrade, Mayron Alves de Vasconcelos, Edson Holanda Teixeira, et al. Inorganic Chemistry, 2024 Metallocompounds have emerged as promising new anticancer agents, which can also exhibit properties to be used in photodynamic therapy. Here, we prepared two ruthenium-based compounds with a 2,2'-bipyridine ligand conjugated to an anthracenyl moiety. These compounds coded GRBA and GRPA contain 2,2'-bipyridine or 1,10-phenathroline as auxiliary ligands, respectively, which provide quite a distinct behavior. Notably, compound GRPA exhibited remarkably high photoproduction of singlet oxygen even in water (ϕΔ = 0.96), almost twice that of GRBA (ϕΔ = 0.52). On the other hand, this latter produced twice more superoxide and hydroxyl radical species than GRPA, which may be due to the modulation of their excited state. Interestingly, GRPA exhibited a modest binding to DNA (Kb = 4.51 × 104), while GRBA did not show a measurable interaction only noticed by circular dichroism measurements. Studies with bacteria showed a great antimicrobial effect, including a synergistic effect in combination with commercial antibiotics. Besides that, GRBA showed very low or no cytotoxicity against four mammalian cells, including a hard-to-treat MDA-MB-231, triple-negative human breast cancer. Potent activities were measured for GRBA upon blue light irradiation, where IC50 of 43 and 13 nmol L-1 were seen against hard-to-treat triple-negative human breast cancer (MDA-MB-231) and ovarian cancer cells (A2780), respectively. These promising results are an interesting case of a simple modification with expressive enhancement of biological activity that deserves further biological studies.
Novel Ruthenium-based Nitrosyl Complexes: NO Donation and Vasorelaxant Potentials for Cardiovascular Therapeutics Florêncio S. Gouveia Júnior, Allandeiverson S. de Sousa, Renally B. da Silva, Danilo G. Rocha, Edson H. Teixeira, et al. European Journal of Inorganic Chemistry, 2024 Nitrosyl ruthenium complexes have emerged as promising platforms for the controlled delivery of nitric oxide (NO) and nitroxyl (HNO), both of which possess significant therapeutic implications. Considering this scenario, we synthesized and characterized the metal complex cis‐[RuNO(phen)2(2MIM)]3+ and its precursors, where phen and 2MIM correspond to 1,10‐phenantroline and 2‐methylimidazole, respectively. Comprehensive structural elucidation was undertaken using a combination of spectroscopic and electrochemical methodologies, including XANES/EXAFS experiments. This structural data was further validated through DFT computational analyses. We demonstrated that such compound can release NO and HNO in the presence of thiol‐based substrates. Not only this, but the same metal complex can also delivery nitric oxide under irradiation with visible light (λ=460 nm). The nitrosyl complex and its derivatives displayed marked vasodilatory capabilities as evidenced in assays involving isolated rat aorta rings. They also exhibited commendable antioxidant activity in free radical scavenging assays. Collectively, based on these data, this nitrosyl ruthenium compound is a potential therapeutic candidate, especially in the field of cardiovascular pathology like atherosclerosis, thereby deserving further in‐depth investigations.
Circular dichroism: A possible route to shed light on signal transduction processes of heme-based gas-sensor proteins WG Guimarães, JB da Silva Lobão, MSP Carepo, ACS Gondim, ... Journal of Inorganic Biochemistry, 113311 , 2026 2026
Photoactivatable diazafluorenone-based ruthenium compounds as a new strategy to combat microbial resistance FMS de Alencar, FS Gouveia Jr, GFS Oliveira, FH de Souza Gomes, ... Journal of Inorganic Biochemistry, 113301 , 2026 2026
Circular dichroism WG Guimarães, JBS Lobão, MSP Carepo, A Gondim, LGF Lopes, ... 2026
Novel phenanthroline-based ruthenium complex as a promising antimicrobial agent PLN Teixeira, ACS Gondim, TF Paulo, EHS Sousa, LGF Lopes, AP Ayala, ... JBIC Journal of Biological Inorganic Chemistry 30 (6), 485-497 , 2025 2025 Citations: 1
The effect of ancillary ligands on vasodilatory activity of nitrosyl ruthenium complexes IA Paz, CDS Silva, EM Carvalho, CS Meira, MBP Soares, ICN Diógenes, ... Journal of Inorganic Biochemistry, 113144 , 2025 2025
Enhanced antimicrobial and antibiofilm activities of ruthenium complexes with fluorine-and bromine-substituted ligands against staphylococcal strains AL Andrade, MA Vasconcelos, IMF Azevedo, TG Silva, PV Soares, ... Biofouling 41 (9), 916-934 , 2025 2025 Citations: 4
Lipid nanoformulations as a platform for antihypertensive applications of a ruthenium nitrosyl compound ACSS Rodrigues, IA Paz, NRF do Nascimento, GFS Oliveira, ... International Journal of Pharmaceutics 678, 125695 , 2025 2025
Synthesis, characterization and incorporation of two phosphine-based ruthenium (II) complexes into lipid nanocarriers as potential antimicrobial agents FWP Santana, ACS Silva, AP Ayala, EA Malveira, EHS Sousa, ... Polyhedron 267, 117340 , 2025 2025 Citations: 2
Terpyridine-based ruthenium complexes containing a 4, 5-diazafluoren-9-one ligand with light-driven enhancement of biological activity FMS de Alencar, FS Gouveia, GFS de Oliveira, AL Andrade, ... Dalton Transactions 54 (5), 1850-1870 , 2025 2025 Citations: 7
Pharmacological evaluation of a new nanoformulation in the erectile tissue of rabbits and humans IA Paz, PM Silva Filho, ASL Junior, TO Pessoa, RO Santiago, ... European Journal of Pharmacology 985, 177071 , 2024 2024
Thiobenzamide-based ruthenium complexes: chemical reactivity and promising biological investigations against Leukemia cancer cells PGF Azevedo, LV Pacheco, FEM Carneiro, GC Fernandes, DS de Sá, ... Transition Metal Chemistry 49 (6), 453-464 , 2024 2024 Citations: 2
Minimal functionalization of ruthenium compounds with enhanced photoreactivity against hard-to-treat cancer cells and resistant bacteria GFS Oliveira, FS Gouveia Jr, AL Andrade, MA de Vasconcelos, ... Inorganic chemistry 63 (31), 14673-14690 , 2024 2024 Citations: 11
Novel Ruthenium‐based Nitrosyl Complexes: NO Donation and Vasorelaxant Potentials for Cardiovascular Therapeutics FS Gouveia Júnior, AS de Sousa, RB da Silva, DG Rocha, EH Teixeira, ... European Journal of Inorganic Chemistry 27 (14), e202300758 , 2024 2024 Citations: 4
SÍNTESE, FOTORREATIVIDADE E INTERAÇÃO COM DNA DE UM NOVO COMPLEXO DE RUTÊNIO PROTÓTIPO PARA O DESENVOLVIMENTO DE AGENTES FOTOQUIMIOTERAPÊUTICOS WG Pereira, PHR Martins, PEC Martins Filho, TF Paulo, ICN Diógenes, ... Química Nova 47 (6), e-20240008 , 2024 2024
Redox-Activated NO Release in Monolayer Regime MP Ferreira, WG Pereira, VS Dibo, DS Abreu, LGF Lopes, ICN Diógenes, ... Journal of the Brazilian Chemical Society 35 (4), e-20230153 , 2024 2024
Investigating the reactivity and cellular interactions of indazole-based ruthenium (ii) complexes in cancer and leishmania cells DKS Sales, GC Fernandes, CDS da Silva, IS Cezar, DKC Silva, ... New Journal of Chemistry 48 (34), 15105-15111 , 2024 2024 Citations: 3
Anti-bacterial, anti-biofilm and synergistic effects of phenazine-based ruthenium (II) complexes PHR Martins, AIB Romo, FS Gouveia Jr, IA Paz, NRF Nascimento, ... Dalton Transactions 53 (30), 12627-12640 , 2024 2024 Citations: 6
Synthesis, photoreactivity and interaction with DNA of a new prototype ruthenium complex for the development of photochemotherapeutic agents WG Pereira, PHR Martins, PEC Martins Filho, TF Paulo, ICN Diogenes, ... 2024
Photochemical behavior of new sulfito complexes of cis-[Ru (phen) 2 (SO3) L] 0/2-, where L= CO, H2O or SO32 FWP Santana, IPL Xavier, AP Ayala, EHS Sousa, LGF Lopes, ... Polyhedron 245, 116660 , 2023 2023 Citations: 3
Redox-responsive fluorescence emission output of a synthetic phenazine derivative LF Bezerra, TF Paulo, IMM de Carvalho, FSG Júnior, LGF Lopes, ... Dyes and Pigments 216, 111375 , 2023 2023 Citations: 6
MOST CITED SCHOLAR PUBLICATIONS
A controlled NO-releasing compound: synthesis, molecular structure, spectroscopy, electrochemistry, and chemical reactivity of R, R, S, S-trans-[RuCl (NO)(cyclam)] 2+(1, 4, 8 … DR Lang, JA Davis, LGF Lopes, AA Ferro, LCG Vasconcellos, DW Franco, ... Inorganic chemistry 39 (11), 2294-2300 , 2000 2000 Citations: 181
Nitric oxide as a central molecule in hypertension: focus on the vasorelaxant activity of new nitric oxide donors GM da Silva, MC da Silva, DVG Nascimento, EM Lima Silva, FFF Gouvêa, ... Biology 10 (10), 1041 , 2021 2021 Citations: 125
Novel ruthenium complexes as potential drugs for Chagas's disease: enzyme inhibition and in vitro / in vivo trypanocidal activity JJN Silva, PMM Guedes, A Zottis, TL Balliano, FO Nascimento Silva, ... British journal of pharmacology 160 (2), 260-269 , 2010 2010 Citations: 119
Cis-and trans-nitrosyltetraammineruthenium (II). Spectral and electrochemical properties and reactivity MG Gomes, CU Davanzo, SC Silva, LGF Lopes, PS Santos, DW Franco Journal of the Chemical Society, Dalton Transactions, 601-608 , 1998 1998 Citations: 98
An inorganic iron complex that inhibits wild-type and an isoniazid-resistant mutant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis JS Oliveira, EHS Sousa, LA Basso, M Palaci, R Dietze, DS Santos, ... Chemical communications, 312-313 , 2004 2004 Citations: 96
The trans-labilization of nitric oxide in RuII complexes by C-bound imidazoles LGF Lopes, A Wieraszko, Y El-Sherif, MJ Clarke Inorganica Chimica Acta 312 (1-2), 15-22 , 2001 2001 Citations: 85
Aryl-substituted ruthenium (II) complexes: a strategy for enhanced photocleavage and efficient DNA binding FD Abreu, TF Paulo, MH Gehlen, RA Ando, LGF Lopes, ACS Gondim, ... Inorganic Chemistry 56 (15), 9084-9096 , 2017 2017 Citations: 69
Thiol-activated HNO release from a ruthenium antiangiogenesis complex and HIF-1α inhibition for cancer therapy EH Silva Sousa, LA Ridnour, FS Gouveia Jr, CD Silva da Silva, DA Wink, ... ACS Chemical Biology 11 (7), 2057-2065 , 2016 2016 Citations: 62
Reactivity of trans-[Ru (NH3) 4P (OEt) 3NO] X3 (X= PF6-, CF3COO-): modulation of the release of NO by the trans-effect LGF Lopes, EE Castellano, AG Ferreira, CU Davanzo, MJ Clarke, ... Inorganica Chimica Acta 358 (10), 2883-2890 , 2005 2005 Citations: 62
Release of NO by a nitrosyl complex upon activation by the mitochondrial reducing power JC Toledo Jr, LG de França Lopes, AA Alves, LP da Silva, DW Franco Journal of inorganic biochemistry 89 (3-4), 267-271 , 2002 2002 Citations: 60
Isoniazid metal complex reactivity and insights for a novel anti-tuberculosis drug design EHS Sousa, LA Basso, DS Santos, ICN Diógenes, E Longhinotti, ... JBIC Journal of Biological Inorganic Chemistry 17 (2), 275-283 , 2012 2012 Citations: 58
Synthesis, Characterization, and NO Release Study of the cis ‐ and trans ‐[Ru(Bpy) 2 (SO 3 )(NO)] + Complexes FON Silva, SXB Araújo, AKM Holanda, E Meyer, FAM Sales, ... European Journal of Inorganic Chemistry 2006 (10), 2020-2026 , 2006 2006 Citations: 52
Mechanism and biological implications of the NO release of cis-[Ru (bpy) 2L (NO)] n+ complexes: A key role of physiological thiols FON Silva, MCL Cândido, AKM Holanda, ICN Diógenes, EHS Sousa, ... Journal of Inorganic Biochemistry 105 (5), 624-629 , 2011 2011 Citations: 48
The influence of NO-containing ruthenium complexes on mouse hippocampal evoked potentials in vitro A Wieraszko, MJ Clarke, DR Lang, LGF Lopes, DW Franco Life Sciences 68 (13), 1535-1544 , 2001 2001 Citations: 48
Nitro-imidazole-based ruthenium complexes with antioxidant and anti-inflammatory activities GL Sasahara, FSG Júnior, R de Oliveira Rodrigues, DS Zampieri, ... Journal of Inorganic Biochemistry 206, 111048 , 2020 2020 Citations: 46
Nitric oxide and Brazilian propolis combined accelerates tissue repair by modulating cell migration, cytokine production and collagen deposition in experimental leishmaniasis MM Miranda, C Panis, AHD Cataneo, SS da Silva, NY Kawakami, ... PLoS One 10 (5), e0125101 , 2015 2015 Citations: 46
A biphosphinic ruthenium complex with potent anti-bacterial and anti-cancer activity JM da Silveira Carvalho, AH de Morais Batista, NAP Nogueira, ... New Journal of Chemistry 41 (21), 13085-13095 , 2017 2017 Citations: 42
The nitric oxide donor cis-[Ru (bpy) 2 (SO3) NO](PF6) increases gastric mucosa protection in mice–Involvement of the soluble guanylate cyclase/KATP pathway APM Santana, BM Tavares, LT Lucetti, FS Gouveia Jr, RA Ribeiro, ... Nitric Oxide 45, 35-42 , 2015 2015 Citations: 42
Preconditioning with a novel metallopharmaceutical NO donor in anesthetized rats subjected to brain ischemia/reperfusion MWS Campelo, RB Oriá, LG de França Lopes, GAC Brito, AA dos Santos, ... Neurochemical research 37 (4), 749-758 , 2012 2012 Citations: 42
In vitro and in vivo leishmanicidal activity of a ruthenium nitrosyl complex against Leishmania (Viannia) braziliensis NRF do Nascimento, FLN de Aguiar, CF Santos, AML Costa, ... Acta Tropica 192, 61-65 , 2019 2019 Citations: 40