I graduated with a degree in developmental neurobiology from the Carlos Chagas Filho Institute of Biophysics at the Federal University of Rio de Janeiro in 1998. I completed postdoctoral training in developmental biology at UCLA, CA, USA, as a Latin American PEW Fellow from 1999 to 2002. Since 2012, I have been a Full Professor at the Institute of Biomedical Sciences of the Federal University of Rio de Janeiro. I serve as a lecturer, researcher, and advisor for Master's and Ph.D. students in the Graduate Program in Morphological Sciences. I was the Director of the Institute of Biomedical Sciences from 2019 to 2023 and coordinated outreach projects that focused on basic education, science, and practical developmental biology classes for low-income students in public schools. I have published more than 80 peer-reviewed articles and have received over 6,000 citations, achieving an H index of 36. I have been awarded as a Scientist of the Rio de Janeiro State scholar.
EDUCATION
• 1993 – 1998 – Ph.D. in Science - Universidade Federal do Rio de Janeiro, UFRJ, Rio De Janeiro, Brazil. Thesis Title: The role of astroglial extracellular matrix in neuritogenesis: Cell interactions in the midbrain midline, Year of degree: 1998, Advisor: Vivaldo Moura Neto e Leny Alves Cavalcante. Sponsor: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).
• 1991 – 1993 – M.Sc. in Science - Universidade Federal do Rio de Janeiro, UFRJ, Rio De Janeiro, Brazil. Dissertation Title: Regionally-specific properties of midbrain glia, Year of degree: 1993, Advisor: Vivaldo Moura Netto e Leny Alves Calvacante. Sponsor: CAPES.
• 1986 – 1990 – B.S. in Biology - Faculdade de Humanidades Pedro II, FAHUPE, Brazil.
Cell division during Xenopus gastrulation influences neuroectoderm patterning I Velloso, R Araujo, M Horb, JG Abreu Frontiers in Cell and Developmental Biology 14, 1798565 , 2026 2026
Membrane potential mediates the cellular response to mechanical pressure A Mukherjee, Y Huang, J Elgeti, S Oh, JG Abreu, L Ammar, AR Neliat, ... Cell 189 (1), 143-160. e22 , 2026 2026 Citations: 15
Exploring the Impact of 3- O -Methylquercetin on Wnt/β-Catenin Pathway Activity and Its Potential in Neural Processes K Leichtweis, D Predes, MC Mangelli, H Mauricio, BSM De Jesus, ... Pharmaceuticals 18 (11), 1680 , 2025 2025 Citations: 1
Sperm derived H2AK119ub1 is required for embryonic development in Xenopus laevis V Francois--Campion, F Berger, M Oikawa, M Goumeidane, N Mouniée, ... Nature Communications 16 (1), 3268 , 2025 2025 Citations: 4
α-Aryl-α-tetralone Derivatives and Fluorinated Analogs: Synthesis and Antiproliferative Evaluation on Colorectal Cancer via Inhibition of Wnt/β-Catenin Signaling LG de Souza, LFS Oliveira, D Predes, MN Renno, JG Abreu, PRR Costa Journal of Molecular Structure, 142251 , 2025 2025
Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb FJ Varella, FAC Xavier, G Zanirati, JIB Gonçalves, TTR Previato, ... Scientific Reports 15 (1), 8049 , 2025 2025 Citations: 1
On X-ray Sensitivity in Xenopus Embryogenesis H Mauricio, JG Abreu, L Peshkin bioRxiv, 2025.03. 25.645254 , 2025 2025
Lysosomes accumulate at the perinuclear region of muscle cells during chick myogenesis KM Bagri, MG Pereira, KS Leichtweis, JG Abreu, ML Costa, ... Cell Biology International 48 (11), 1625-1636 , 2024 2024 Citations: 1
Increased activation of the WNT pathway in brain tissue from patients with cortical dysplasia type IIb: genetics and functional aspects FJ Varella, FAC Xavier, G Zanirati, JIB Gonçalves, TTR Previato, ... 2024
Membrane potential as master regulator of cellular mechano-transduction A Mukherjee, Y Huang, J Elgeti, S Oh, JG Abreu, AR Neliat, J Schüttler, ... bioRxiv, 2023.11. 02.565386 , 2023 2023 Citations: 4
WNT pathway in focal cortical dysplasia compared to perilesional nonlesional tissue in refractory epilepsies DR Marinowic, GG Zanirati, FAC Xavier, FJ Varella, SPC Azevedo, ... BMC neurology 23 (1), 338 , 2023 2023 Citations: 7
The role of Wnt signaling in Xenopus neural induction I Velloso, W Han, X He, JG Abreu Wnt Signaling in Development and Disease 153, 229 , 2023 2023
The Wnt/beta-catenin pathway and cytoskeletal filaments are involved in the positioning, size, and function of lysosomes during chick myogenesis KM Bagri, LF Oliveira, MG Pereira, JG Abreu, C Mermelstein Cells 11 (21), 3402 , 2022 2022 Citations: 5
The flavonol quercitrin hinders GSK3 activity and potentiates the Wnt/β-catenin signaling pathway D Predes, LA Maia, I Matias, HPM Araujo, C Soares, FGQ Barros-Aragão, ... International Journal of Molecular Sciences 23 (20), 12078 , 2022 2022 Citations: 30
Therapeutic potential of naturally occurring small molecules to target the wnt/β-catenin signaling pathway in colorectal cancer LFS Oliveira, D Predes, HL Borges, JG Abreu Cancers 14 (2), 403 , 2022 2022 Citations: 40
5-Fluorouracil disrupts ovarian preantral follicles in young C57BL6J mice JZ Almeida, LF Lima, LA Vieira, C Maside, ACA Ferreira, VR Araújo, ... Cancer Chemotherapy and Pharmacology 87 (4), 567-578 , 2021 2021 Citations: 15
WNT pathway alteration is related to dysplastic cortical tissue and not to adjacent tissue of patients with FCD and refractory epilepsy J Abreu 2021
Establishing embryonic territories in the context of Wnt signaling I Velloso, LA Maia, NG Amado, AH Reis, X He, JG Abreu Int. J. Dev. Biol 65, 227-233 , 2021 2021 Citations: 1
UNESCO Chair of Developmental Biology: how an initiative that fostered careers in Developmental Biology impacted Brazilian Science JG Abreu The International Journal of Developmental Biology 65 (1-2-3), 23-28 , 2021 2021
Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis N Pentagna, TP da Costa, FS dos Santos Cardoso, FM de Almeida, ... Developmental & Comparative Immunology 114, 103840 , 2021 2021 Citations: 10
MOST CITED SCHOLAR PUBLICATIONS
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β JG Abreu, NI Ketpura, B Reversade, EM De Robertis Nature cell biology 4 (8), 599-604 , 2002 2002 Citations: 1235
Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development Y Xu, C Xu, A Kato, W Tempel, JG Abreu, C Bian, Y Hu, D Hu, B Zhao, ... Cell 151 (6), 1200-1213 , 2012 2012 Citations: 342
Amyloid-β binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/β-catenin signaling MH Magdesian, MMVF Carvalho, FA Mendes, LM Saraiva, MA Juliano, ... Journal of Biological Chemistry 283 (14), 9359-9368 , 2008 2008 Citations: 336
Inhibition of GSK3 phosphorylation of β-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6 G Wu, H Huang, JG Abreu, X He PloS one 4 (3), e4926 , 2009 2009 Citations: 296
Wnt stabilization of β-catenin reveals principles for morphogen receptor-scaffold assemblies SE Kim, H Huang, M Zhao, X Zhang, A Zhang, MV Semonov, ... Science 340 (6134), 867-870 , 2013 2013 Citations: 273
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Aβ oligomerization FG De Felice, MNN Vieira, LM Saraiva, JD Figueroa‐Villar, ... The FASEB Journal 18 (12), 1366-1372 , 2004 2004 Citations: 237
Complementary hydropathy identifies a cellular prion protein receptor VR Martins, E Graner, J Garcia-Abreu, SJ De Souza, AF Mercadante, ... Nature medicine 3 (12), 1376-1382 , 1997 1997 Citations: 229
Chordin-like CR domains and the regulation of evolutionarily conserved extracellular signaling systems JG Abreu, C Coffinier, J Larraın, M Oelgeschläger, EM De Robertis Gene 287 (1-2), 39-47 , 2002 2002 Citations: 213
Gap-junctional coupling between neurons and astrocytes in primary central nervous system cultures MM FROes, AHP Correia, J Garcia-Abreu, DC Spray, ... Proceedings of the National Academy of Sciences 96 (13), 7541-7546 , 1999 1999 Citations: 210
Notum is required for neural and head induction via Wnt deacylation, oxidation, and inactivation X Zhang, SM Cheong, NG Amado, AH Reis, BT MacDonald, M Zebisch, ... Developmental cell 32 (6), 719-730 , 2015 2015 Citations: 207
Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation X Zhang, JG Abreu, C Yokota, BT MacDonald, S Singh, KLA Coburn, ... Cell 149 (7), 1565-1577 , 2012 2012 Citations: 167
Inhibition of Alzheimer's disease β‐amyloid aggregation, neurotoxicity, and in vivo deposition by nitrophenols: implications for Alzheimer's therapy FG De Felice, JC Houzel, J Garcia-Abreu, PRF Louzada Jr, RC Afonso, ... The FASEB Journal 15 (7), 1297-1299 , 2001 2001 Citations: 164
Flavonoids: potential Wnt/beta-catenin signaling modulators in cancer NG Amado, BF Fonseca, DM Cerqueira, VM Neto, JG Abreu Life sciences 89 (15-16), 545-554 , 2011 2011 Citations: 155
Isoquercitrin suppresses colon cancer cell growth in vitro by targeting the Wnt/β-catenin signaling pathway NG Amado, D Predes, BF Fonseca, DM Cerqueira, AH Reis, ... Journal of Biological Chemistry 289 (51), 35456-35467 , 2014 2014 Citations: 130
Piperine suppresses the Wnt/β-catenin pathway and has anti-cancer effects on colorectal cancer cells GC de Almeida, LFS Oliveira, D Predes, HH Fokoue, RM Kuster, ... Scientific reports 10 (1), 11681 , 2020 2020 Citations: 117
Isoquercitrin isolated from Hyptis fasciculata reduces glioblastoma cell proliferation and changes β-catenin cellular localization NG Amado, DM Cerqueira, FS Menezes, JFM da Silva, VM Neto, ... Anti-cancer drugs 20 (7), 543-552 , 2009 2009 Citations: 114
Blocking the Wnt pathway, a unifying mechanism for an angiogenic inhibitor in the serine proteinase inhibitor family B Zhang, JG Abreu, K Zhou, Y Chen, Y Hu, T Zhou, X He, J Ma Proceedings of the National Academy of Sciences 107 (15), 6900-6905 , 2010 2010 Citations: 101
Flavonoids and Wnt/β-catenin signaling: potential role in colorectal cancer therapies NG Amado, D Predes, MM Moreno, IO Carvalho, FA Mendes, JG Abreu International journal of molecular sciences 15 (7), 12094-12106 , 2014 2014 Citations: 97
Neurons induce GFAP gene promoter of cultured astrocytes from transgenic mice F Carvalho, A Gomes, J Garcia‐Abreu, M Galou, D Paulin, V Moura Neto Glia 26 (2), 97-108 , 1999 1999 Citations: 96
Complexity of the Wnt/β‑catenin pathway: Searching for an activation model GG Tortelote, RR Reis, F de Almeida Mendes, JG Abreu Cellular Signalling 40, 30-43 , 2017 2017 Citations: 95