Lupeol as a Potential Inhibitor of NorA Efflux Pumps in Staphylococcus aureus: In Silico and In Vitro Evidence Nara Juliana Santos Araújo, Camila Aparecida Pereira Silva, Vanessa Lima Bezerra, Cicera Datiane Morais Oliveira‐Tintino, Gabriel Gonçalves de Alencar, Maria do Socorro Costa, Ana Raquel Pereira da Silva, Josefa Sayonara dos Santos, Kamila Correa Camara, Heberty diTarso Fernandes Facundo, Lívia Pereira Ferreira, Henrique Douglas Melo Coutinho, José Maria Barbosa Filho, Carolina Bandeira Domiciano, José Bezerra de Araújo‐Neto, Jacqueline Cosmo Andrade‐Pinheiro Chemistryopen, 2025 Antimicrobial resistance remains one of the major challenges to global public health, compromising the effectiveness of treatments and contributing to increased morbidity and mortality associated with bacterial infections. Among the mechanisms involved, efflux pumps—such as NorA, expressed in resistant strains of Staphylococcus aureus —are particularly noteworthy. These transport proteins actively expel antibiotics from the cell, reducing their intracellular concentration. In this context, natural compounds have been explored as potential resistance inhibitors, with a focus on the triterpene lupeol, known for its pharmacological properties. This study evaluates the activity of lupeol against the NorA efflux pump using in vitro assays and in silico modeling. The minimum inhibitory concentration (MIC) is determined by broth microdilution, and pump inhibition is assessed via ethidium bromide‐induced fluorescence. SYTOX Green assays indicated that lupeol does not compromise bacterial membrane integrity. Although lupeol presented a MIC ≥ 1024 μg mL −1 , it demonstrates significant inhibition of NorA activity. Molecular docking reveals a binding energy of –7.112 kcal mol −1 and interactions with key residues of the protein, outperforming the CCCP control. These findings suggest that lupeol acts as a modulator of bacterial resistance, with potential application as a therapeutic adjuvant in the treatment of infections caused by multidrug‐resistant S. aureus.
Chemical Composition and In Vitro Antibiofilm Action of Varronia curassavica Jacq. (Boraginaceae) Essential Oil: A Promising Natural Agent Against Bacterial Infections José Thyálisson da Costa Silva, Gabriel Gonçalves Alencar, Nara Juliana Santos Araújo, Lariza Leisla Leandro Nascimento, Saulo Almeida Menezes, Dhenes Ferreira Antunes, Adrielle Rodrigues Costa, Murilo Felipe Felício, Cicero dos Santos Leandro, Luis Pereira de Morais, Marcos Aurélio Figueirêdo dos Santos, Severino Denicio Gonçalves de Sousa, Julimery Gonçalves Ferreira Macedo, João Pereira da Silva Junior, Ana Carolina Ferreira Araujo, Maísa Freire Cartaxo Pires de Sá, Jacqueline Cosmo Andrade‐Pinheiro, Henrique Douglas Melo Coutinho, José Weverton Almeida‐Bezerra Chemistry and Biodiversity, 2025 Antimicrobial resistance is an increasing threat to public health, with alarming estimates of mortality rates. In this context, the clinical properties of Varronia curassavica Jacq. are highlighted due to its biological and pharmacological activities. This study aims to analyze the phytochemical composition of the essential oil from V. curassavica (EOVC) and its antibiofilm activity against Gram‐positive and Gram‐negative strains. The essential oil was extracted from the leaves using hydrodistillation and analyzed by gas chromatography–mass spectrometry (GC–MS), phytochemical analysis of EOVC identified 97.36% of the total composition, predominantly composed of monoterpenes (α‐pinene at 44.46%) and sesquiterpenes (β‐caryophyllene at 21.82%). Antibiofilm tests were performed on five bacterial strains (both Gram‐positive and Gram‐negative) to evaluate the ability to inhibit and eradicate biofilms, with statistical analysis of the results. Antibiofilm formation tests demonstrated that EOVC exhibited efficacy against Staphylococcus aureus and Staphylococcus epidermidis , with minimum inhibitory concentrations (MIC) of 1.024 and 10.240 µg/mL, respectively, values comparable to those observed for the reference antibiotic. In addition, at high concentrations (10 × MIC), EOVC inhibited biofilm development by Streptococcus mutans and Enterococcus faecalis , achieving performance similar to that of gentamicin. In biofilm eradication assays, EOVC showed effective activity against E. faecalis , S. epidermidis , and S. aureus at concentrations of 10.240 µg/mL, equivalent to gentamicin. However, resistance was found in strains of Pseudomonas aeruginosa and S. mutans , with P. aeruginosa showing the highest level of resistance to EOVC.
LC-MS Analysis and Antimicrobial Activity of Different Extracts of Spondias purpurea L Maria Elenilda Paulino da Silva, Joara Nályda Pereira Carneiro, Carlos Vinicius Barros Oliveira, Antonia Thassya Lucas dos Santos, Rafael Pereira da Cruz, Débora Lima Sales, José Weverton Almeida‐Bezerra, Viviane Bezerra da Silva, Adrielle Rodrigues Costa, Jacqueline Cosmo Andrade‐Pinheiro, Gyllyandeson de Araújo Delmondes, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Catarina Martins Tahim, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais‐Braga Chemistryselect, 2025 Spondias purpurea L. is widely used in folk medicine to treat various pathological conditions. One of its promising activities is antimicrobial. The present work aimed to characterize the composition and evaluate the antifungal and antibacterial effects of aqueous (AESP) and ethanolic (EESP) extracts of leaves. The technique of ultra‐performance liquid chromatography coupled to a quadruple time‐of‐flight system (UPLC‐QTOF) was used for phytochemical qualification. For the antifungal tests, two strains of Candida albicans were used, and for the antibacterial tests, strains of Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus were used. Quercetin, Kaempferol, Quinic Acid, gallo (epi)catechin dimer, dehydroascorbic acid, and quercetin derivative were detected in AESP, and quinic acid, iriflofenone 3‐C‐β D glycopyranoside, chlorogenic acid, and stearidonic acid in EESP. It was found that AESP potentiated the action of amikacin against bacteria, and an antifungal effect of both extracts was observed at a concentration of 8,192 µg/mL for the CA URM 4127 strain. The two evaluated extracts significantly potentiated the effect of fluconazole against CA INCQS 40006. The research showed that the extracts tested alone do not present significant antibacterial or antifungal activities at low concentrations against the tested strains. However, they demonstrated potentiating effect of already standardized drugs.
Evaluation of the susceptibility of planktonic cells and bacterial biofilms to Sarcomphalus joazeiro extracts Camila Aparecida Pereira da Silva, Nara Juliana Santos Araújo, Thiago Sampaio de Freitas, Cicera Datiane de Morais Oliveira-Tintino, Maria do Socorro Costa, Yedda Maria Lobo Soares de Matos, Josefa Sayonara dos Santos, Juliete Bezerra Soares, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Jacqueline Cosmo Andrade-Pinheiro Microbe Netherlands, 2025 ABSTRACT Bacterial biofilms are structured communities of microorganisms embedded in an extracellular matrix, which confer high resistance to antibiotics and complicate the treatment of infections. In this context, the search for new strategies to control bacterial resistance becomes urgent. This study aimed to evaluate the susceptibility of planktonic cells and bacterial biofilms to the hydroethanolic extracts of the bark (HEBSJ) and leaves (HELSJ) of Sarcomphalus joazeiro , as well as to perform their chemical characterization. The extracts were obtained by cold maceration and analyzed using UPLC-ESI-QToF-MS E . Antibacterial activity and biofilm formation/inhibition assays were conducted in 96-well microdilution plates, with quantification performed using the crystal violet method and absorbance readings taken at 570 nm. All tests were performed in triplicate. Chemical analysis revealed the presence of flavonoids, organic acids, and saponins. Regarding biofilm-forming capacity, Staphylococcus aureus and Staphylococcus epidermidis were classified as strong biofilm producers; Enterococcus faecalis , Streptococcus mutans , and Pseudomonas aeruginosa showed moderate biofilm formation, while Escherichia coli was classified as a non-biofilm-producing strain. HELSJ exhibited inhibitory activity only against P. aeruginosa , while it appeared to promote biofilm formation in the remaining strains. In contrast, HEBSJ demonstrated inhibitory activity in all analyzed strains at least at one tested concentration, including complete inhibition of E. faecalis biofilm, outperforming chlorhexidine. In conclusion, the bark extract (HEBSJ) showed superior and consistent antibiofilm activity across all tested strains, with significant results compared to the leaf extract (HELSJ), which exhibited limited efficacy. These findings reinforce the need for further studies to elucidate the mechanisms of action involved and support the development of novel phytotherapeutic agents for the treatment of biofilm-associated infections.
Modifying-antibiotic action of Hecogenin Acetate as an alternative to combat bacterial infections Nara Juliana Santos Araújo, Maria Do Socorro Costa, Ana Raquel Pereira Da Silva, Cícera Laura Roque Paulo, Camila Aparecida Pereira Silva, Franceildo Jorge Felix, José Maria Barbosa Filho, Henrique Douglas Melo Coutinho, Jacqueline Cosmo Andrade-Pinheiro Journal of Steroid Biochemistry and Molecular Biology, 2025
Evaluation of inhibition and eradication of bacterial biofilm by solasodin Ana Raquel Pereira da Silva, Maria do Socorro Costa, Nara Juliana Santos Araújo, Thiago Sampaio de Freitas, Cícera Laura Roque Paulo, Maria Anésia Sousa de Alencar, José Maria Barbosa-Filho, Jacqueline Cosmo Andrade-Pinheiro, Henrique Douglas Melo Coutinho Journal of Steroid Biochemistry and Molecular Biology, 2025
Effect of betulinic acid on MepA efflux pump inhibition in Staphylococcus aureus: Antibacterial and molecular study Camila Aparecida Pereira da Silva, Nara juliana Santos Araújo, Cícera Datiane Morais Oliveira-Tintino, José Maria Barbosa Filho, Gabriel Gonçalves Alencar, José Bezerra de Araújo-Neto, Josefa Sayonara dos Santos, Juliete Bezerra Soares, Carolina Bandeira Domiciano, Davi Antas e Silva, Henrique Douglas Melo Coutinho, Jacqueline Cosmo Andrade-Pinheiro Steroids, 2025
Biofilm Inhibition: The Role of Fixed Oil from Caryocar coriaceum in Fighting Resistant Bacterial Communities José Weverton Almeida-Bezerra, José Thyálisson da Costa Silva, Saulo Almeida Menezes, Gabriel Gonçalves Alencar, Daiany Alves Ribeiro, Bárbara Fernandes Melo, João Pereira da Silva-Junior, Francisca de Fátima Silva de Sousa, Severino Denicio Gonçalves de Sousa, Marcos Aurélio Figueirêdo dos Santos, Dieferson Leandro de Souza, Luiz Neldecílio Alves Vitor, Ademar Maia Filho, Murilo Felipe Felício, Jacqueline Cosmo Andrade-Pinheiro, Viviane Bezerra da Silva, José Jailson Lima Bezerra, Maria Flaviana Bezerra Morais-Braga, Henrique Douglas Melo Coutinho Bacteria, 2025 Biofilms, formed by microbial communities that increase resistance to antibiotics, are responsible for chronic infections, making their combat a therapeutic priority. Taking this into account, the fruit Caryocar coriaceum stands out for its potential in the treatment of infectious diseases. The different parts of this plant can be used, and the fixed oil extracted from its fruit, rich in fatty acids, is indicated as responsible for its biological activities. Thus, the objective of this study was to evaluate the chemical composition of the fixed oil extracted from the fruits of C. coriaceum (FOCC), in addition to analyzing its action in the inhibition and pre-formed biofilm disruption of bacteria. The fixed oil was extracted from the internal mesocarp through exhaustive extraction with n-hexane, resulting in a yield of 38.29%. For antibiofilm evaluation, multidrug-resistant bacterial strains were exposed to the oil, and the antibiofilm activity was verified through biofilm formation and pre-formed biofilm disruption assays. The chemical analysis of the fixed oil of C. coriaceum (FOCC) identified eight fatty acids, representing 98.2% of the total composition, with a predominance of oleic acid (60.1%) and palmitic acid (33.5%). FOCC demonstrated approximately 70% inhibition of Streptococcus mutans biofilm formation at a concentration of 10 mg/mL and approximately 60% inhibition against Staphylococcus aureus and Pseudomonas aeruginosa. In pre-formed biofilm disruption, FOCC showed low efficacy against S. mutans and P. aeruginosa but showed greater activity against Enterococcus faecalis and S. aureus. These results indicate that FOCC has the potential to prevent biofilms, but its pre-formed biofilm disruption capacity is still limited.
Assessment of the potential susceptibility of planktonic cells and bacterial biofilms by diosgenin Maria do Socorro Costa, Ana Raquel Pereira da Silva, Nara Juliana Santos Araújo, Cícera Laura Roque Paulo, Gabriel Gonçalves Alencar, Maria Anesia Sousa de Alencar, Talysson Felismino Moura, Clara Mariana Gonçalves Lima, Thiago Sampaio de Freitas, José Maria Barbosa Filho, Jacqueline Cosmo Andrade-Pinheiro, Henrique Douglas Melo Coutinho Food Bioscience, 2024
Antiparasitary potential of Sarcomphalus joazeiro (Mart.) Hauenschild (Rhamnaceae) Camila Aparecida P. Silva, Nara Juliana S. Araújo, Ana Raquel P. da Silva, Maria do Socorro Costa, Juliete B. Soares, Yedda Maria L.S. de Matos, José Weverton A. Bezerra, Viviane B. da Silva, Erlânio O. de Souza, Maria Celeste V. Gomez, Míriam Rolóm, Cathia Coronel, Jaime Ribeiro-Filho, José Maria Barbosa Filho, Davi Antas e Silva, Lucia Raquel de Lima, Irwin R.A. Menezes, Henrique D.M. Coutinho, Jacqueline C. Andrade-Pinheiro Pharmacological Research Natural Products, 2024
In vitro Evaluation of Fungal Susceptibility and Inhibition of Virulence by Diosgenin Maria do Socorro Costa, Ana Raquel Pereira da Silva, Juliana Santos Araújo, Antonia Thassya Lucas dos Santos, Victor Juno Alencar Fonseca, Gabriel Gonçalves Alencar, Talysson Felismino Moura, Sheila Alves Gonçalves, José Maria Barbosa Filho, Maria Flaviana Bezerra Morais‐Braga, Jacqueline Cosmo Andrade‐Pinheiro, Henrique Douglas Melo Coutinho Chemistry and Biodiversity, 2024
In vitro evaluation of the susceptibility of bacterial biofilms to hecogenin acetate Nara Juliana Santos Araújo, Maria do Socorro Costa, Ana Raquel Pereira da Silva, Cícera Laura Roque Paulo, Camila Aparecida Pereira Silva, Franceildo Jorge Felix, Cicera Datiane de Morais Oliveira-Tintino, José Maria Barbosa Filho, Thiago Sampaio de Freitas, Maria Flaviana Bezerra Morais Braga, Henrique Douglas Melo Coutinho, Jacqueline Cosmo Andrade-Pinheiro Acta Tropica, 2024
Comparative antimicrobial potential of Ocimum basilicum essential oil, estragole and estragole/β-cyclodextrin complex in an infection model on adult zebrafish Francisco Lucas A. Batista, Jacqueline Cosmo Andrade-Pinheiro, Antonia Thassya L. dos Santos, Jessyca Nayara M. Lima, Gabriel Gonçalves Alencar, Gustavo Miguel Siqueira, Ana Raquel Pereira da Silva, Natália Kelly Gomes de Carvalho, Anita Oliveira Brito Pereira B. Martins, Roger Henrique S. da Costa, Lindaiane Bezerra Rodrigues, Henrique Douglas M. Coutinho, José Galberto Martins da Costa, Francisco Ernani A. Magalhães, Irwin Rose Alencar de Menezes Carbohydrate Polymer Technologies and Applications, 2023
Antibacterial activity and antibiotic-modifying action of carvacrol against multidrug-resistant bacteria Ana Raquel Pereira da Silva, Maria do Socorro Costa, Nara Juliana Santos Araújo, Thiago Sampaio de Freitas, Antônia Thassya Lucas dos Santos, Sheila Alves Gonçalves, Viviane Bezerra da Silva, Jacqueline Cosmo Andrade-Pinheiro, Catarina Martins Tahim, Elaine Cristina Pereira Lucetti, Henrique Douglas Melo Coutinho Advances in Sample Preparation, 2023
LC-MS Analysis and Antifungal Activity of Turnera subulata Sm. Jacqueline Cosmo Andrade-Pinheiro, Celestina Elba Sobral de Souza, Daiany Alves Ribeiro, Andressa de Alencar Silva, Viviane Bezerra da Silva, Antonia Thassya Lucas dos Santos, Victor Juno Alencar Fonseca, Delmacia Gonçalves de Macêdo, Rafael Pereira da Cruz, José Weverton Almeida-Bezerra, Antonio Júdson Targino Machado, Thiago Sampaio de Freitas, Edy Sousa de Brito, Paulo Riceli Vasconcelos Ribeiro, José Galberto Martins da Costa, Henrique Douglas Melo Coutinho, Grażyna Kowalska, Rafał Rowiński, Radosław Kowalski, Maria Flaviana Bezerra Morais-Braga Plants, 2023
UPLC-MS-ESI-QTOF Analysis and Antifungal Activity of Aqueous Extracts of Spondias tuberosa Antonia Thassya Lucas dos Santos, Joara Nályda Pereira Carneiro, Rafael Pereira da Cruz, Débora Lima Sales, Jacqueline Cosmo Andrade-Pinheiro, Maria Audilene de Freitas, Marta Regina Kerntopf, Gyllyandeson de Araújo Delmondes, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Francisco Lucas Alves Batista, Francisco Ernani Alves Magalhães, Ivo C. Pita Neto, Maria Flaviana Bezerra Morais-Braga, Radosław Kowalski, Grazyna Kowalska, Aleksandra Szopa, Tomasz Baj, Henrique Douglas Melo Coutinho Molecules, 2023
Antifungal activity of Gracilaria cervicornis (Turner) J. Agardh against Candida spp. Thaís Magda Morais Sampaio, Antonia Thassya Lucas dos Santos, Maria Audilene de Freitas, José Weverton Almeida-Bezerra, Victor Juno Alencar Fonseca, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga, George Emmanuel Cavalcanti de Miranda, Jacqueline Cosmo Andrade-Pinheiro South African Journal of Botany, 2022
GC-MS-FID characterization and antibacterial activity of the essential oil from Achyrocline satureioides (Lam) DC Cícera Natalia Figueiredo Leite Gondim, Joara Nályda Pereira Carneiro, Catarina Pereira Leite, Jacqueline Cosmo Andrade Pinheiro, Wanderlei do Amaral, Cícero Deschamps, Luiz Everson da Silva, Nadghia Figueiredo Leite Sampaio, Gonçalo Emanuel Carvalho Gondim, Henrique Douglas Melo Coutinho Journal of Plant Biochemistry and Biotechnology, 2022
Anti-Candida Properties of Gossypium hirsutum L.: Enhancement of Fungal Growth, Biofilm Production and Antifungal Resistance Luciene Ferreira de Lima, Jacqueline Cosmo Andrade-Pinheiro, Maria Audilene Freitas, Adriely Idalina da Silva, Victor Juno Alencar Fonseca, Taís Gusmão da Silva, Josefa Carolaine Pereira da Silva, Rosilaine Honorato de Lima, Débora Lima Sales, Rejane Pereira Neves, Edy Sousa de Brito, Paulo Riceli Vasconcelos Ribeiro, Kirley Marques Canuto, Henrique Douglas Melo Coutinho, Abolghasem Siyadatpanah, Bonglee Kim, Maria Flaviana Bezerra Morais-Braga Pharmaceutics, 2022
Evaluation of Elaiophylin extracted from Streptomyces hygroscopicus as a potential inhibitor of the NorA efflux protein in Staphylococcus aureus: An in vitro and in silico approach Cristina Rodrigues dos Santos Barbosa, Débora Feitosa Muniz, Pedro Silvino Pereira, Sandrine Maria de Arruda Lima, Cícera Datiane de Morais Oliveira Tintino, Veruska Cintia Alexandrino de Souza, Julia Mariana Assis da Silva, Roger Henrique Sousa da Costa, Jacqueline Cosmo Andrade Pinheiro, Yedda Maria Lobo Soares de Matos, Irwin Rose Alencar Menezes, Teresinha Gonçalves da Silva, Gláucia Manoella de Souza Lima, Tereza Cristina Leal Balbino, José Pinto Siqueira-Júnior, Francisco Assis Bezerra da Cunha, Henrique Douglas Melo Coutinho, Saulo Relison Tintino Bioorganic and Medicinal Chemistry Letters, 2021
FTIR analysis and reduction of the phytotoxic effect of mercury dichloride by rutin Yedda Maria Lobo Soares de Matos, Janaina Esmeraldo Rocha, Celestina Elba Sobral Souza, Tássia Thaís Al Yafawi, José Bezerra de Araújo Neto, Fabia Ferreira Campina, Jacqueline Cosmo Andrade Pinheiro, Thiago Sampaio de Freitas, Amanda Karine Sousa, Saulo Relison Tintino, Maria Flaviana Bezerra Morais Braga, Daniel Linhares Militão Vasconcelos, Antonio César Honorato Barreto, João Hermínio da Silva, Irwin Rose Alencar Menezes, Raimundo Nonato Pereira Teixeira, Juan Carlos Alvarez-Pizarro, Henrique Douglas Melo Coutinho Rhizosphere, 2021
Chemical constituents and biological activities of croton heliotropiifolius kunth Priscilla Augusta de Sousa Fernandes, Josefa Carolaine Pereira da Silva, Débora Lima Sales, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Marta Regina Kerntopf, Gyllyandeson de Araújo Delmondes, Jacqueline Cosmo Andrade Pinheiro, Gerson Javier Torres Salazar, Francisco Lucas Alves Batista, Francisco Ernani Alves Magalhães, Maria Celeste Vega Gomez, Míriam Rolón, Cathia Coronel, Jaime Ribeiro-Filho, José Weverton Almeida-Bezerra, Abolghasem Siyadatpanah, Veeranoot Nissapatorn, Maria de Lourdes Pereira, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga Antibiotics, 2021
Perseaamericana Mill. (Lauraceae): Chemical Composition and Antifungal Effect Advances in Medicine and Biology, 2021
UPLC–MS–QTOF analysis and antifungal activity of Cumaru (Amburana cearensis) Maria Tatiana Alves Oliveira, Marcus Vinícius Oliveira Barros de Alencar, Vicente de Paulo dos Anjos Landim, Geovanna Maria Medeiros Moura, Joelton Igor Oliveira da Cruz, Elizeu Antunes dos Santos, Henrique Douglas Melo Coutinho, Jacqueline Cosmo Andrade, Irwin Rose Alencar de Menezes, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Erlânio Oliveira de Sousa, Adriana Ferreira Uchoa 3 Biotech, 2020
Phytochemical characterization and evaluation of antibacterial potential and modulator of antibiotic resistance of the essential oil of Campomanesia aurea O. Berg Essential Guide to Plant Oils, 2020
Phytochemical characterization and evaluation of the Eupatorium intermediun DC. (Asteraceae) essential oil modulatory and antibacterial activities Essential Guide to Plant Oils, 2020
Phytochemical characterization of the Ziziphus joazeiro Mart. metabolites by UPLC-QTOF and antifungal activity evaluation Jacqueline C. Andrade, Antí´nia T.L. Dos Santos, Ana R.P. Da Silva, Maria A. Freitas, Muhammad Inam Afzal, Maria I.P. Gonçalo, Victor J. A. Fonseca, Maria do S. Costa, Joara N. P. Carneiro, Erlí¢nio O. Sousa, Yedda M. L. S. De Matos, Thiago S. De Freitas, Amanda K. De Sousa, Maria F. B. Morais-Braga, Henrique D. M. Coutinho, Shinawar Waseem Ali, Bahare Salehi, Muhammad Imran, Muhammad Umer, Ehsan Ul-Haque, William N. Setzer, Javad Sharifi-Rad Cellular and Molecular Biology, 2020
UPLC-MS-ESI-QTOF analysis and antifungal activity of the spondias tuberosa arruda leaf and root hydroalcoholic extracts Antonia Thassya Lucas dos Santos, Joara Nályda Pereira Carneiro, Rafael Pereira da Cruz, Débora Lima Sales, Jacqueline Cosmo Andrade, Waltécio de Oliveira Almeida, José Galberto Martins da Costa, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Francisco Lucas Alves Batista, Francisco Ernani Alves Magalhães, Marcello Iriti, Maria Flaviana Bezerra Morais-Braga, Henrique Douglas Melo Coutinho Antibiotics, 2019
Chemical composition, antiparasitic and cytotoxic activities of aqueous extracts of Ziziphus joazeiro Mart. HenriqueDouglas Melo Coutinho, JacquelineCosmo Andrade, AnaRaquel Pereira da Silva, AntôniaThassya Lucas dos Santos, MariaAudilene Freitas, YeddaMaria Lobo Soares de Matos, MariaFlaviana Bezerra Morais Braga, CamilaFonseca Bezerra, MariaIsabeli Pereira Gonçalo, MariaCeleste Vega Gomez, Míriam Rolóm, Cathia Coronel, PauloRiceli Vasconcelos Ribeiro, EdySousa de Brito Asian Pacific Journal of Tropical Biomedicine, 2019
Antibacterial and antibiotic modifying activity evaluation of ruminants’ body fat used as zootherapeutics in ethnoveterinary practices in Northeast Brazil Diógenes de Queiroz Dias, Débora Lima Sales, Jacqueline Cosmo Andrade, Ana Raquel Pereira da Silva, Saulo Relison Tintino, Cícera Datiane de Morais Oliveira-Tintino, Gyllyandeson de Araújo Delmondes, Maysa de Oliveira Barbosa, Henrique Douglas Melo Coutinho, Felipe Silva Ferreira, Marcos Fábio Gadelha Rocha, Daniela Maria do Amaral Ferraz Navarro, Suyana Karolyne Lino da Rocha, José Galberto Martins da Costa, Romulo Romeu da Nóbrega Alves, Waltécio de Oliveira Almeida Journal of Ethnopharmacology, 2019
Antimicrobial, gastroprotective and healing effect of the hydroalcoholic extract of astronium fraxinifolium Anita Oliveira Brito Pereira Bezerra Martins, Ana Luiza Albuquerque Siebra, Cicera Datiane de Morais Oliveira, Gerlania Oliveira Leite, Henrique Douglas Melo Coutinho, Margareth Linde Athayde, Aline Augusti Bolignon, Jacqueline Cosmo Andrade, Larissa Rolim Oliveira, Marta Regina Kerntopf, Roseli Barbosa, Francisco Rafael Alves Santana Cesario, Thales Silva Coutinho, Lucindo Jose Quintans-Junior, Irwin Rose Alencar de Menezes Letters in Drug Design and Discovery, 2018
Additive effect of Lygodium venustum SW. in association with gentamicin Maria F. B. Morais-Braga, Teógenes M. Souza, Karla K. A. Santos, Gláucia M. M. Guedes, Jacqueline C. Andrade, Saulo R. Tintino, Celestina E. Sobral-Souza, José G. M. Costa, Antonio A. F. Saraiva, Henrique D. M. Coutinho Natural Product Research, 2016
Antibacterial, antifungal and antimicrobial modulatory activities of fractions from Lygodium venustum SW Boletin Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromaticas, 2013
