Gut Microbiota Based Strategies for the Management of Gastrointestinal Inflammations S. Sowmiya, R. Jasmine, B.N. Selvakumar, H. Deena Priscilla, Rameshkumar Santhanam Gastrointestinal Inflammations and Gut Microbiota Pathophysiology Management and Emerging Therapies, 2025 The gut microbiota is essential for nutrition metabolism and immune function regulating in living organisms. It is well recognized that adaptation is necessary for any self-regulating mechanism that biological systems use to keep themselves stable in order to survive and thrive (homeostasis). Recent studies have indicated that commensal bacteria dysbiosis has a role in the etiology of a variety of disorders, including inflammatory bowel disease (IBD) and obesity. IBD includes two illnesses, Crohn’s disease and Ulcerative colitis, which are caused by persistent inflammation of the gastrointestinal (GI) tract. Presently, the first line of treatment for these conditions includes antibiotics, anti-inflammatory drugs, painkillers, surgery, and restricted diet modification. Microbiome-based therapies are emerging as promising interventions that intend to improve the structure of residential microbial populations. Our entire focus is envisaged upon promoting the beneficial microbiota of the gut to reduce inflammation while maintaining homeostasis and immune function. The role of prebiotics, probiotics, postbiotics, fecal microbiota transplantation (FMT), and exopolysaccharides has been shown to boost the growth of the natural microbiota of the gut. This biotherapeutic approach toward the treatment of gastrointestinal inflammation helps to retain and restore the natural self-defense capabilities within the human system. This approach is safe and does not pose serious health hazards. Thus, the method of natural healing is considered to be the most sought-after therapy for treating mankind. Living with nature is the ultimate aim to cure and combat diseases in the future. This chapter aims to provide possible insights and strategies for the effective management of gastrointestinal inflammation. It stresses the need to harbor and maintain beneficial bacteria to lead a healthy and disease-free life, representing a promising therapy for the future.
Systems biology and human diseases R. Jasmine, Sowmiya Soundararajan, A. Sherlin Rosita, H. Deena Priscilla Systems Biology Approaches Prevention Diagnosis and Understanding Mechanisms of Complex Diseases, 2024
Investigating the modulatory effects of Moringa oleifera on the gut microbiota of chicken model through metagenomic approach Sowmiya Soundararajan, Jasmine Selvakumar, Zion Mercy Maria Joseph, Yuvapriya Gopinath, Vaishali Saravanan, Rameshkumar Santhanam Frontiers in Veterinary Science, 2023 IntroductionThis study aimed to assess the effects of supplementing chicken feed with Moringa oleifera leaf powder, a phytobiotic, on the gastrointestinal microbiota. The objective was to examine the microbial changes induced by the supplementation.MethodsA total of 40, one-day-old chickens were fed their basal diet for 42 days and then divided into two groups: SG1 (basal diet) and SG2 (basal diet + 10 g/kg Moringa oleifera leaf powder). Metagenomics analysis was conducted to analyze operational taxonomic units (OTUs), species annotation, and biodiversity. Additionally, 16S rRNA sequencing was performed for molecular characterization of isolated gut bacteria, identified as Enterococcus faecium. The isolated bacteria were tested for essential metabolites, demonstrating antibacterial, antioxidant, and anticancer activities.Results and discussionThe analysis revealed variations in the microbial composition between the control group (SG1) and the M. oleifera-treated group (SG2). SG2 showed a 47% increase in Bacteroides and a 30% decrease in Firmicutes, Proteobacteria, Actinobacteria, and Tenericutes compared to SG1. TM7 bacteria were observed exclusively in the M. oleifera-treated group. These findings suggest that Moringa oleifera leaf powder acts as a modulator that enhances chicken gut microbiota, promoting the colonization of beneficial bacteria. PICRUSt analysis supported these findings, showing increased carbohydrate and lipid metabolism in the M.oleifera-treated gut microbiota.ConclusionThis study indicates that supplementing chicken feed with Moringa oleifera leaf powder as a phytobiotic enhances the gut microbiota in chicken models, potentially improving overall health. The observed changes in bacterial composition, increased presence of Bacteroides, and exclusive presence of TM7 bacteria suggest a positive modulation of microbial balance. The essential metabolites from isolated Enterococcus faecium bacteria further support the potential benefits of Moringa oleifera supplementation.
A disease-driven approach to medicinal natural products R Jasmine, H Deena Priscilla, S Sowmiya Phytopharmaceuticals and Biotechnology of Herbal Plants, 2022 Nature holds great plausibility and enormous resources for the survival and existence of life on this earth. Since ancient times, natural products have played an important role due to their medicinal properties based on traditional claims. The current scenario has drastically changed owing to advancements in scientific techniques and the availability of essential materials to broaden this area of research, leading to huge developments and raising the standard of living by leading to the development of anti-infective drugs. Owing to their diversified chemical properties, it is the prime resource for drug discovery and development in the future. In general, Food and Drug Administration-approved drugs are natural products. Among the modern drugs, phytobiotics have remained one of the major sources. This field is gaining momentum, and many eco-friendly, cost-effective therapies involved in finding the lead molecule are based on the pharmacokinetic approach and have paved the way to attain the zenith of successful implementation of natural products to treat a particular disease. This chapter also addresses the challenges, opportunities and applications of such novel ideas and supports its growth in an affordable manner to create a breakthrough in the history of scientific research contributing the medicinal value that is obtained from mother nature.
Herbal medicinal compounds and their anti-breast cancer actions: A mechanistic perspective Daniel A. Gideon, Pushparaj Annadurai, Abhinav Parashar, Rachel Grace Murthy, Kandavel Dhandayuthapani, Sriram Srinivasan, R Sivaramakrishnan, R. Jasmine Phytopharmaceuticals and Biotechnology of Herbal Plants, 2022 Next to cardiovascular disease, cancer remains the second leading cause of mortality and morbidity in the world. Breast cancer is the leading cancer type in women. The high rates of cervical and breast cancer burden among women have had a huge impact on health-related quality of life and increased the economic burden of several countries. Mastectomy, chemotherapy, axillary lymph node dissection, hormonal therapy, radiotherapy and targeted therapy are the common breast cancer treatment modalities. Several natural and synthetic drug molecules have been discovered, and the efficacy of these molecules has been assessed in vitro, in animal models as well as in human clinical trials. However, cancer incidence is on the rise, and there is a pressing need to identify novel and more efficient therapeutic approaches to combat the disease. Drug resistance is the most significant limiting problem, which diminishes the efficacy of cancer chemotherapy. Since ancient times, mankind has relied on plants for food and medicine. Plants or bioactive phytocompounds are known to both prevent and treat cancer. In this chapter, the mechanisms of key phytochemicals which bind to several classical targets and exhibit anticancer attributes through induction of beneficial pathways such as autophagy, mitohormesis, cell cycle arrest and apoptosis are summarized. There is a new vigor and interest in phytomedicine for breast cancer, because much like synthetic drugs, phytochemical formulations and isolated compounds possess anticancer properties. However, the advantage of phytochemical-based therapeutics is that these formulations may engender anticancer effects through synergistic mechanisms and thereby prevent the overt toxicity that is seen in routine cancer chemotherapy. Moreover, phytocompounds inhibit cancer-related inflammation, angiogenesis, oxidative stress, metastasis and cell cycle dysregulation. Due to the unique combinations of these effects, plant-based bioactive compounds have either been used directly or have served as effective scaffolds for QSAR-based modifications for the synthesis of novel drug candidates. Apart from summarizing the state of the art in phytomedicine-based cancer therapy, we recapitulate the potential uses of phytochemicals that we have identified from literature and in our own research (through in silico and in vitro studies), which may prevent as well as treat breast cancer. Established mechanisms of phytochemical action must be interpreted in the light of the murburn concept to further improve phytochemical therapy and drug biology/pharmacology. This knowledge can potentially open up new avenues for exploration of nutraceutical formulations which could both prevent and treat breast cancer.
Analysis of the gut microbiota of healthy CARI-Nirbheek (Aseel cross) Chickens: A metagenomic approaches Sowmiya S, Jasmine R, Sivakumar Mohan, Rameshkumar Santhanam, Prathiviraj R, George Seghal Kiran, Joseph Selvin Environmental Advances, 2022 Rising specialized knowledge of the chicken gastrointestinal tract microbiota through culture-independent metagenomic analysis has improved the understanding of the dynamics of bacterial diversity and their involvement in chicken metabolism and health. A metagenomics study was performed with the gut of healthy country chicken scientifically known as CARI- Nirbheek Species. Nucleotide composition analysis of 16S rRNA metagenomics studies was performed using MySeq Illumina Sequencer. In this study, the Polymerase Chain Reaction focused on V3-V4 16S rRNA ribosomal gene. The primary analysis was performed employing Next-generation sequencing data, elimination of short along with chimeric sequences, clustering into OTUs (operational taxonomic units), and biodiversity assessment by calculating ACE, Chao1, and Shannon indices. According to the identity level, 97% show these sequences were dissected through to 393 operational taxonomic units (OTUs). The sequencing findings for the 16S rRNA gene amplicon have been posted in the NCBI biological database at Sequence Read Archive (Accession number: PRJNA761012). The results revealed Firmicutes as the predominant phyla, which accounted for 50% of the gut microbiota, followed by Cyanobacterial (26%), Proteobacteria (17%), and Archaea, which only accounted for 0.14%. Among the isolates from the chicken gut, the predominant genera were Clostridium, Turicibacter, Enterococcus, and Camphylobacter. Species such as Shigella, Bulledia, Atopium were lower in cecal microbiota. Based on our results, Clostridium sp was found to be the most abundant genera in CARI-Nirbheek chicken. In-depth studies on the function and synergies of the gut microbiota could help the research community to develop specific probiotics to achieve the expected breeding goals.
Probing the mechanism of the anti-diabetic potential of a terpenoid from elephantopus scaber L., an Indian ethnomedicinal plant in STZ diabetic rats- in vivo and in silico analysis Indian Journal of Biochemistry and Biophysics, 2018
A review on a few medicinal plants possessing anticancer activity against human breast cancer International Journal of Pharmtech Research, 2016
Role of a few bacterial species on biodegradation of organophosphorous pesticide (methyl parathion): An approach to access the outcome of biodegradation by GC-MS & HPLC Der Pharma Chemica, 2016
Investigating the mode of action of silver nanoparticles stabilized by Adathoda vasica targeted against multidrug resistant [MDR] urinary isolates Der Pharmacia Lettre, 2016
Role of compounds from Terminalia chebula exhibiting anti-cholesterol property International Journal of Pharmtech Research, 2015
The photosynthetic behaviour and biomass as indicators for the resistance and tolerance capacity of the algae as well as its potential use for tannin removal in the tannery effluents Asian Journal of Water Environment and Pollution, 2013
Assessing the curative property of Moringa oleifera and investigating its mechanism of action against urinary tract infection International Journal of Pharmtech Research, 2013
Regeneration of the β-cells in the islets of langerhans by Eugenia jambolana in streptozotocin-diabetic rats Pharmacologyonline, 2011
Harnessing Gut Microbiome and Multi-Omics Integration for Next-Generation Therapeutic Strategies R Jasmine, S Soundararajan, NS Balasingh The Gut Microbiome in Precision Medicine, 367-379 , 2026 2026
AI and emerging technologies for diagnosis. S Soundararajan, J Selvakumar, V Selvakumar, N Baskaran Progress in Brain Research 297, 191-220 , 2025 2025
Gut Microbiota Based Strategies for the Management of Gastrointestinal Inflammations S Sowmiya, R Jasmine, BN Selvakumar, HD Priscilla, R Santhanam Gastrointestinal Inflammations and Gut Microbiota, 197-212 , 2025 2025
Systems Biology and Human Diseases R Jasmine, S Soundararajan, A Sherlin Rosita, H Deena Priscilla Systems Biology Approaches: Prevention, Diagnosis, and Understanding … , 2024 2024 Citations: 1
Investigating the Phytochemical Analysis and Antioxidant Activity of Hedychium flavescens GVA Anandi A A1*, Vathana A1 , Jasmine R2 African Journal of Biological Sciences 6 (5) , 2024 2024
Smart packaging− A pragmatic solution to approach sustainable food waste management K Ganeson, GK Mouriya, K Bhubalan, MR Razifah, R Jasmine, ... Food Packaging and Shelf Life 36, 101044 , 2023 2023 Citations: 113
Analysis of evolutionary imprints among the gut bacteria in phytobiotic supplemented Gallus gallus domesticus RJ Soundararajan Sowmiya, Ragothaman Prathiviraj, Joseph Selvin Animal Gene 29 , 2023 2023 Citations: 5
Investigating the modulatory effects of Moringa oleifera on the gut microbiota of chicken model through metagenomic approach VSRS Sowmiya Soundararajan, Jasmine Selvakumar, Zion Mercy Maria Joseph ... Frontiers in Veterinary Science 10 , 2023 2023 Citations: 24
Interface of ‘meta-omics’ in gut biome remediation to unravel the complications of environmental pollutants AA Margret, S Aishwarya, A Arun, R Jasmine Metagenomics to Bioremediation, 183-206 , 2023 2023 Citations: 2
A Disease-Driven Approach to Medicinal Natural Products R Jasmine, HD Priscilla, S Sowmiya Phytopharmaceuticals and Biotechnology of Herbal Plants, 213-223 , 2022 2022
Herbal Medicinal Compounds and Their Anti–Breast Cancer Actions: A Mechanistic Perspective DA Gideon, P Annadurai, A Parashar, RG Murthy, K Dhandayuthapani, ... Phytopharmaceuticals and Biotechnology of Herbal Plants, 157-184 , 2022 2022 Citations: 1
Analysis of the gut microbiota of healthy CARI-Nirbheek (Aseel cross) chickens: a metagenomic approaches S Sowmiya, R Jasmine, R Prathiviraj Environmental Advances 9, 100304 , 2022 2022 Citations: 8
Probiotic rhodotorula mucilaginosa isolated from fermented food: investigation of pufa production and strategy for health improvement R Jasmine, R Ganesh, S Mohanapriya, R Dharani Asian Journal of Advances in Medical Science 4 (1), 172-178 , 2022 2022 Citations: 3
A MINI REVIEW ON NON-ANTIBIOTIC THERAPIES TO TARGET EMERGING ANTIMICROBIAL RESISTANCE DURING POST COVID ERA R Jasmine, BN Selvakumar Asian Journal of advances in Medical Science 3 (1), 368-373 , 2021 2021
Department of Zoology, Bishop Heber College, Trichy, India. R Jasmine, N Abarna, S Verghese Asian Journal of advances in Medical Science 3 (1), 220-224 , 2021 2021
Anticancer potential of Elephantopus scaber L. leaves against MCF-7 cell lines R Jasmine, N Abarna, S VERGHESE Asian Journal of Advances in Medical Science 3 (1), 220-224 , 2021 2021 Citations: 3
ANTIBACTERIAL AND ANTIOXIDANT ACTIVITY OF PIGMENTS FROM Staphylococcus sp. AND Rhodotorula sp. R Jasmine, S Muhil, M Neelaveni, S Deepa, R Monisha, S Narmatha, ... Asian Journal of Advances in Research 4 (1), 836-843 , 2021 2021 Citations: 1
Regeneration of Beta Cells by Inhibition of pro-Apoptotic Proteins through Phytocompound in STZ Induced Diabetic Albino Wistar Rats: In Vivo and In Silico Approach R Jasmine, A Sherlin Rosita Structure and Health Effects of Natural Products on Diabetes Mellitus, 219-234 , 2021 2021
Exploration of anti-breast cancer effects of Terminalia chebula extract on DMBA induced mammary carcinoma in Sprague Dawley rats ASMA Deena Priscilla Henry, Jasmine Ranjan, Rajesh Kumar Murugan Future Journal of Pharmaceutical Sciences 6 (108) , 2020 2020 Citations: 22
Screening of phytochemicals, antibacterial and antioxidant activities of Elephantopus scaber leaves N Abarna, S Verghese, R Jasmine 2018 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
A novel steroid from Elephantopus scaber L. an ethnomedicinal plant with antidiabetic activity P Daisy, R Jasmine, S Ignacimuthu, E Murugan Phytomedicine 16 (2-3), 252-257 , 2009 2009 Citations: 136
Smart packaging− A pragmatic solution to approach sustainable food waste management K Ganeson, GK Mouriya, K Bhubalan, MR Razifah, R Jasmine, ... Food Packaging and Shelf Life 36, 101044 , 2023 2023 Citations: 113
A review on a few medicinal plants possessing anticancer activity against human breast cancer B Jaikumar, R Jasmine Int J Pharm Tech Res 9, 333-365 , 2016 2016 Citations: 51
Evaluating the antioxidant and anticancer property of Ficus carica fruits R Jasmine, K Manikandan, K Karthikeyan African Journal of Biotechnology 14 (7), 634-641 , 2015 2015 Citations: 50
Investigating the mechanism of action of terpenoids and the effect of interfering substances on an Indian medicinal plant extract demonstrating antibacterial activity R Jasmine, BN Selvakumar, P Daisy Int J Pharm Stud Res 2 (2), 19-24 , 2011 2011 Citations: 38
Hypoglycemic and hepatoprotective activity of Eugenia jambolana in streptozotocin-diabetic rats. R Jasmine, P Daisy 2007 Citations: 37
Antibiotic susceptibility of ESBL-producing urinary isolates at a tertiary care hospital in Tiruchirappalli, South India. BN Selvakumar, R Jasmine 2007 Citations: 33
Probing the mechanism of the anti-diabetic potential of a terpenoid from Elephantopus scaber L., an Indian ethnomedicinal plant in STZ diabetic rats-in vivo and in silico analysis. R Jasmine, GA Kumar, R Rajaram 2018 Citations: 27
Investigating the modulatory effects of Moringa oleifera on the gut microbiota of chicken model through metagenomic approach VSRS Sowmiya Soundararajan, Jasmine Selvakumar, Zion Mercy Maria Joseph ... Frontiers in Veterinary Science 10 , 2023 2023 Citations: 24
Exploration of anti-breast cancer effects of Terminalia chebula extract on DMBA induced mammary carcinoma in Sprague Dawley rats ASMA Deena Priscilla Henry, Jasmine Ranjan, Rajesh Kumar Murugan Future Journal of Pharmaceutical Sciences 6 (108) , 2020 2020 Citations: 22
Hypoglycemic and hypolipidemic activity of Eugenia jambolana in streptozotocin-diabetic rats. R Jasmine, P Daisy 2007 Citations: 20
Therapeutic applications of nanorobots-respirocytes and microbivores PS Shabnashmi, S Naga Kani, V Vithya, B Vijaya Lakshmi, R Jasmine J. Chem. Pharm. Res 8 (5), 605-609 , 2016 2016 Citations: 17
Evaluating the antibacterial activity of Elephantopus scaber extracts on clinical isolates of β-lactamase producing methicillin resistant Staphylococcus aureus from … R Jasmine, P Daisy, BN Selvakumar 2007 Citations: 15
Evaluating the efficiency of Ficus carica fruits against a few drug resistant bacterial pathogens. R Jasmine, K Manikandan, B Brinda, N Niveditha, K Kalaivani, ... 2014 Citations: 14
A novel terpenoid from Elephantopus scaber with antibacterial activity against beta lactamase-producing clinical isolates. R Jasmine, P Daisy, BN Selvakumar 2007 Citations: 14
Effect of crude extract and fractions from Elephantopus scaber on hyperglycemia in streptozotocin-diabetic rats. R Jasmine, P Daisy 2007 Citations: 12
Role of compounds from Terminalia chebula exhibiting Anti-Cholesterol property R Jasmine, H Sakthivel International Journal of PharmTech Research 8 (10), 210-215 , 2015 2015 Citations: 10
Synergistic action of two Indian medicinal plants on clinical isolates of vancomycin resistant Enterococci species R Jasmine, B Selvakumar Pharmacologyonline 3, 1192-1198 , 2011 2011 Citations: 10
Saponins from Eugenia jambolana with antibacterial activity against beta-lactamase producing methicillin resistant Staphylococcus aureus . R Jasmine, BN Selvakumar, P Daisy 2007 Citations: 10
Activity of Eugenia jambolana , an ethnomedical plant, against drug-resistant bacteria R Jasmine, BN Selvakumar, P Daisy, S Ignacimuthu Pharmaceutical Biology 48 (4), 405-410 , 2010 2010 Citations: 9
