Dr Jaya Agnihotri

@hkcp.edu.in

Associate Professor Department of Pharmaceutics H K College of Pharmacy University of Mumbai
H K College of Pharmacy University of Mumbai

Dr Jaya Agnihotri


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https://researchid.co/jaya_agnihotri

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmaceutical Science, Multidisciplinary, Spectroscopy, Animal Science and Zoology
13

Scopus Publications

Scopus Publications

  • Multifunctional nanotheragnostics: design, development and panoramic applications
    Nitesh Gupta, Jaya Agnihotri, Bhupendra Chauhan, Kusum Lata
    Chemical Papers, 2026
  • Redox-Responsive Systems in Gene Editing and CRISPR-Cas9 Delivery
    As Pee Singh, Jeevan Lal Prajapati, Yogita Dhurandhar, Jaya Agnihotri, Kamta Prasad Namdeo
    Redox Responsive Delivery Systems Principles Advances and Applications, 2026
    Lustrous, regularly interspaced short palindromic repeat (CRISPR)–associated protein 9 (Cas9) is a potential gene-editing method for treating genetic illnesses. Nonetheless, the problem of safely and efficiently delivering CRISPR/Cas9 to host cells limits its clinical use. Intracellular redox-triggered release properties are used to encapsulate and deliver all three types of CRISPR-Cas9 editing machinery, namely pDNA, mRNA/sgRNA, and the ribonucleoprotein complex, advancing CRISPR/Cas9-based delivery strategies and facilitating breakthroughs in biomedical research and therapeutics. CRISPR/Cas9 has revolutionized genome editing by allowing for precise and efficient genetic alterations in a variety of biological systems. Despite its rising therapeutic promise, major problems remain in decreasing off-target effects, reducing immunogenicity, and optimizing CRISPR component transport into target cells, emphasizing recent breakthroughs in the utilization of polymeric carriers, hybrid platforms, and lipid nanoparticles. We also focus on a frequently ignored factor: the Cas9 protein’s aggregation behavior. The future of CRISPR/Cas9 gene therapy is dependent on the development of improved and specialized delivery technologies, as well as the improvement of genome editing precision. Recent breakthroughs in nanotechnology, notably the use of LNPs, polymeric carriers, and other nonviral vectors, have improved the safety and effectiveness of CRISPR/Cas9 delivery systems.
  • Design, Synthesis and Anti-Alzheimer’s Activity of Some Hybrid Molecule of Oxymatrine Through TGF-β
    Subhendu Ghosh, Yogita Dhurandhar, Manoj Kumar Sahoo, Durlav Chowdhury, Ashmita Das, Deepshikha Verma, Surendra H. Bodakhe, Jaya Agnihotri, Kamta P. Namdeo
    Current Topics in Medicinal Chemistry, 2026
    Aims: This study aimed to investigate novel therapeutic approaches for Alzheimer's disease (AD) by targeting the Transforming Growth Factor-β (TGF-β) pathway using hybrid compounds derived from oxymatrine and amino acids. Background: AD remains a significant challenge in neurodegenerative disorders, necessitating innovative treatments that can mitigate its devastating effects. The TGF-β pathway has been implicated in AD pathogenesis, making it a promising target for therapeutic intervention. Objective: The objective of this study was to synthesize and evaluate the anti-AD activity of hybrid molecules combining oxymatrine with different amino acids. These compounds were designed to enhance blood-brain barrier permeability and selectively modulate TGF-β signaling. Method: Hybrid compounds were synthesized based on molecular docking studies. Characterization of synthesized compounds was performed using thin-layer chromatography (TLC), infrared spectroscopy (IR), and nuclear magnetic resonance (NMR) spectroscopy. Anti-AD activity was assessed using an AD rat model induced by a high-cholesterol diet, employing behavioral tests (radial arm maze and Hebb’s Williams maze) and biochemical assays to measure Aβ and TGF-β levels. Result: All hybrid molecules exhibited significant anti-AD activity, with compound 3B demonstrating the highest efficacy at a dose of 100 mg/kg. Biochemical analyses revealed modulation of Aβ and TGF-β levels, indicating the compounds' potential therapeutic effects against AD. Conclusion: This study unveils a new class of hybrid compounds derived from oxymatrine and amino acids that effectively target the TGF-β pathway, offering promising therapeutic potential for AD. These compounds demonstrate neuroprotective properties, suggesting they may mitigate ADrelated pathology, including tau deposition, synaptic dysfunction, and cognitive decline.
  • Milestones in the Technology of Modified Starch in Pharmaceutical Formulation
    Jaya Anil Agnihotri
    Natural Products Journal, 2025
    Carbohydrates, the most prevalent class of organic substances in living systems, play a variety of important roles, such as in the creation of energy, the construction of biological structures, and the synthesis of paper and food. More advanced uses of modified starch have been introduced over the past millennium, demonstrating that modified starches are promising excipients in drug delivery, an area in which their role and range of utility continuously increase. Technological advancements in the pharmaceutical field have led to the development of new and highly stable molecules with enhanced properties for novel drug delivery systems. Innovative starches from various sources present exclusive support in the development of novel dosage forms.
  • FABRICATION AND CHARACTERIZATION OF CENTRIFUGAL SPUN CIPROFLOXACIN-LOADED MICROFIBER DRESSING FOR THE TREATMENT OF DIABETIC FOOT ULCERS
    , Mohd Fareed Shaikh, Payaam Vohra, , Jaya Agnihotri, and
    Indian Drugs, 2024
    Diabetic Foot Ulcers (DFUs) are open ulcers or sores on the foot with a bony prominence. They are a frequent manifestation of uncontrolled diabetes mellitus and often increase the risk of infection. DFUs typically take longer to heal, sometimes resulting in severe complications such as amputation. Our study aimed to develop a drug delivery system that could help to manage DFUs. We developed polymerbased fibers that were loaded with ciprofloxacin HCl via centrifugal spinning setup. The optimized polymeric fiber batch demonstrated over 90% drug entrapment, controlled drug release for 72 h, an average fiber diameter of 4.88 μm and porosity above 70%. The drug-loaded fibers showed antibacterial action against gram-negative (E. coli) and gram-positive (S. aureus) pathogens that are often prevalent in DFUs. Additionally, the fibers showed excellent hemocompatibility. Our study’s findings show great potential in managing DFUs, and future studies will explore the potential application of this drug delivery system in treating and managing diabetic foot ulcers.
  • Novel Chewable Gum Sticks for The Treatment of Oral Candidiasis
    Jaya Agnihotri, Poonam Yadav, Anjali Maurya, Akash Vishwakarma
    Research Journal of Pharmacy and Technology, 2023
    Beeswax is used in medicine from ancient times treatment od oral candidacies is possible by formulation of chewable gum sticks consisting natural hydrophobic wax with anti-fungal drug clotrimazole. Gum sticks are smooth and compatible in oral cavity. Develop safe stable and instant release dosage form offers opportunity for treating immune compromised patients and maintaining their good oral health.
  • Biomimetic approaches for targeted nanomedicine: Current status and future perspectives
    Jaya Agnihotri, Priyanka Maurya, Shobhna Singh, Shubhini A. Saraf
    Current Drug Therapy, 2019
    Background: Cytotherapy products can be described as “living drugs”. Cytotherapy is the swiftest growing fields in the treatment of cancer, heart diseases, aging population and neuromuscular ailments. Biomimetic approaches are processes developed by humans such as devices, substances, or systems that mimic nature or natural processes. </P><P> Objective and Method: It aims at developing a base for personalized medicine with allogeneic, autologous and xenogenic therapies where cells are modified for target selection. Such drug delivery methods appear to be complex and challenging. Literature for approximately past two decades was collected and reviewed for the present article. </P><P> Results and Conclusion: The opportunities and challenges in cytotherapy have been classified, discussed and demystified. Various process inputs, materials and process conditions required in bioprocessing and preservation have been discussed at length. The review also focuses on the regulatory requirements in India, Europe and U.S.
  • Macrophage targeted cellular carriers for effective delivery of anti-tubercular drugs
    Jaya Agnihotri, Sobhna Singh, Mohammad Wais, Abhishek Pathak
    Recent Patents on Anti Infective Drug Discovery, 2018
    BACKGROUND Newly developed vaccine VPM1002 confers paradigm swing in the prophylactic treatment of tuberculosis (TB). Multi-drug resistant and latent TB in adults as well as in underprivileged patients is instigating menace over world population if the host is immune-compromised. METHODS One third of the world's population is infected with TB. Recently it is estimated around 9.6 million people around the world became sick with TB disease. There were 1.5 million TB-related deaths worldwide. Therefore with the advent in biotechnology and Nano engineering, newly adapted survival molecular mechanism of Mycobacterium tuberculosis, new targets receptors on alveolar macrophages must be explored out for eradication of TB from the globe. Macrophage acts as a reservoir of phagocytic receptors to execute diverse physiological functions as well as to perform defense mechanism. RESULTS Advances in novel carriers open new era for the treatment of tuberculosis which remains a very substantial global health encumbrance. Different binding receptors especially mannose, folate and scavenger receptors are attractive platform for internalization of therapeutics in alveolar macrophage. Nano-carriers and nano-devices designed after the acquaintance of receptor composition and functioning affords site specific targeting of biodegradable and biocompatible drug delivery systems for the treatment of tuberculosis offering complete cure and patient compliance. CONCLUSION This chapter encompasses recent studies on nanocarriers and new treatment strategies for tuberculosis. In spite of the budding benefits of nano carriers, many limitations still remain to be overcome such as poor oral stability, instability in circulation, inadequate tissue distribution as well as toxicity to normal cells.
  • Nanoemulsion-based transdermal drug delivery system for the treatment of tuberculosis
    Mohammad Wais, Mohammad Aqil, Priyanka Goswami, Jaya Agnihotri, Sayyed Nadeem
    Recent Patents on Anti Infective Drug Discovery, 2017
    BACKGROUND The nanoemulsion based carriers are the most suitable delivery systems for poorly soluble drugs to improve the drugs solubility, permeation of drugs and ultimately increase bioavailability by transdermal therapeutic system. The nanoemulsion for poorly soluble drugs is admirable and offered several advantages over others drug delivery. METHODS For nanoemulsions formulation, they have to deliver the energetic element at the specific organ with nominal uneasiness. Because of the prevention of hepatic first pass uptake transdermal course excel usual crest and trough plasma shape that usually comfort the administration. The antitubercular drugs relate to the formulation of Poly DL-Lactide-Co-Glycolide nanoparticles having an active substance encapsulated within and that the encapsulated substances are stable with respect to each other. CONCLUSION The present study aimed to explore the challenges and methods in order to increase the solubility of poorly aqueous soluble drug for improved bioavailability alongwith relative study of toxicity problems related to anti-tubercular drug.
  • Development and evaluation of anti-malarial bio-conjugates: artesunate-loaded nanoerythrosomes
    Jaya Agnihotri, Shubhini Saraf, Sobhna Singh, Papiya Bigoniya
    Drug Delivery and Translational Research, 2015
  • Biodegradable long circulating cellular carrier for antimalarial drug pyrimethamine
    Jaya Agnihotri, Narendra Kumar Jain
    Artificial Cells Nanomedicine and Biotechnology, 2013
  • Targeting: New potential carriers for targetted drug delivery system
    International Journal of Pharmaceutical Sciences Review and Research, 2011
  • Engineered cellular carrier nanoerythrosomes as potential targeting vectors for anti-malarial drug
    NarendraKumar Jain, Jaya Agnihotri, Virendra Gajbhiye
    Asian Journal of Pharmaceutics, 2010