Jorge Angulo
@unmsm.edu.pe
Departamento de Química Inorgánica/Facultad de Química e Ingeniería Química
UNMSM
Profesor Principal (Catedrático) de la Facultad de Química e Ingeniería Química de la Universidad Nacional Mayor de San Marcos.
Estudios de Química en la Facultad de Química e Ingeniería Química en la Universidad Nacional Mayor de San Marcos de Lima.
Estancias Posdoctorales de Investigación en la Universidad de Leipzig, Instituto de Química y Inorgánica, Facultad de Química y Mineralogía.
Área de Investigación Síntesis Inorgánica, Química Supramolecular, Bioinorgánica,
EDUCATION
Doctor en Ciencias Químicas. Universidad Técnica Eslovaca en Bratislava
Químico. Universidad Nacional Mayor de San Marcos de Lima Perú.
Bachiller en Ciencias Químicas. Universidad Nacional Mayor de San Marcos de Lima
RESEARCH INTERESTS
Síntesis Inorgánica.
Química Supramolecular.
Química de Coordinación
Bioinorgánica.
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Fernando Riesco, Dwight Acosta, Jorge Angulo-Cornejo, and Edgar Nagles
Elsevier BV
Jorge Angulo and Jenny Delgado-Villanueva
Escuela Politecnica Nacional
Se han preparado complejos metálicos de cobre(II), zinc(II), níquel(II) y magnesio(II) con el ligando curcuminato, en la relación molar 2:1 ligando:metal, en etanol como disolvente: [M(curcumina)2] (M = Ni2+, Cu2+, Mg2+ y Zn2+). La relación estequiométrica ligando-metal (2:1) se determinó por el método espectrofotométrico de Job (método de las variaciones continuas). Los complejos fueron caracterizados por análisis elemental, espectrometría de masas, espectroscopia infrarroja, espectroscopia fotoelectrónica de rayos X (XPS) y resonancia magnética nuclear (1H-RMN, 13C-RMN). En el complejo, cada curcuminato se enlaza al metal a través de dos átomos de oxígeno (C=O y C-O-) formando anillos quelatos de 6 miembros que actúan como un ligando bidentado. Los resultados del estudio antibacteriano de los complejos preparados frente a Staphylococcus aureus (grampositivo) y Escherichia coli (gramnegativo), a través el método Kirby-Bauer (método de difusión en Agar), revelan que todos los complejos presentan importante actividad antibacteriana frente al Staphylococcus aureus, destacándose el complejo de curcumina-zinc que presenta actividad biológica frente a esta bacteria aun a concentraciones bajas.
Carlo Felipe Tovar-Taboada and Jorge Angulo-Cornejo
Universidad Nacional de Colombia
Se han sintetizado los ligandos N-(2-nicotinoilhidrazina-1-carbonotioil)benzamida (H3L1) y su isómero N-(2-isonicotinoilhidrazina-1-carbonotioil)benzamida (H3L2) tipo N, S, O dadores, por reacción del isotiocianato de benzoilo con la hidracida nicotínica y la isoniacida respectivamente. Los ligandos H3L1 y H3L2 fueron caracterizados por 1H-RMN ,13C-RMN, FT-IR y análisis elemental. Se ha realizado el análisis computacional utilizando las funciones de Fukui para determinar las razones por la cuales no se formaron los 1,2,4-triazoles. Se han realizado pruebas preliminares de los ligandos sintetizados frente a Staphylococcus aureus (Gram+) y Escherichia coli (Gram-), habiéndose demostrado importante actividad frente las bacterias mencionadas.
Lothar Hennig, Ketty Ayala-Leon, Jorge Angulo-Cornejo, Rainer Richter, and Lothar Beyer
Elsevier BV
Abstract A series of fluorine substituted benzamides 1–10 was synthesised and investigated by spectroscopic methods (NMR, IR, MS) and X-ray structure analysis. The configuration of these compounds strongly depends on solvent, temperature and substitution pattern. Unexpectedly, some of these compounds form weak intramolecular hydrogen bonds/short N H⋯F C contacts in CDCl3 solution and in the solid state.
Jorge Angulo Cornejo, Ketty Ayala, Rainer Richter, Heinz Böhlig, Lothar Hennig, and Lothar Beyer
Wiley
AbstractHydrogen Bonds in 1,1‐Bis(2‐hydroxyethyl)‐3‐benzoylthiourea and its Nickel(II)‐ and Copper(II)‐Chelate ComplexesThe ligand 1,1‐bis(2‐hydroxyethyl)‐3‐benzoylthiourea HL, (1), yields with nickel(II) and copper(II) ions neutral complexes [NiL2], (2), and [CuL2], (3). By X‐ray structure analysis and IR spectroscopy different intramolecular hydrogen bonds (OH…O) and (OH…N) could be identified in both equally coordinated ligands of the [NiL2] molecule. For comparison X‐ray and IR data were also estimated for 1 and 3.
Gabriel García-Herbosa, Jorge R. Angulo-Cornejo, Arancha Carbayo, Elva Cueva-Talledo, José V. Cuevas, and Asunción Muñoz
Japan Institute of Heterocyclic Chemistry
A phosphorous functionalized isoindole derivative has been formed in the cyclization reaction of 3-chloro-p-tolylmethylene-1,1-diethylthiourea with lithium diphenylphosphide. The reaction involves thiourea desulfuration and C-S to P-S sulfur transfer.
Jorge R. Angulo-Cornejo, Ketty Ayala-León, Gabriel García Herbosa, José V. Cuevas, Virginia Diez, Rainer Richter, Lothar Hennig, and Lothar Beyer
Walter de Gruyter GmbH
The synthesis of N-[4-(2-hydroxyethyl)-1,2,4-oxathiazinan-3-ylidene]-benzamide (2a) and N-[4- (2-hydroxyethyl)-1,2,4-oxathiazinan-3-ylidene]-2-fluorobenzamide (2b) by oxidation of the corresponding 1,1-bis(2-hydroxyethyl)-3-aroylthioureas with potassium iodate in aqueous solution is reported. Variable temperature 1H NMR spectra of 2a prove that the heterocyclic 1,2,4-(O, S,N) sixmembered ring is involved in a dynamic chair-boat conformational interconversion. Molecular mechanic calculations show that the chair conformation is more stable than the boat conformation by 3.0 kcal/mol. The synthesis of the adduct [(2a)·0.5 HgCl2] 3 as well as the X-ray structural characterization of 2a and 3 are also reported.
Uwe Schröder, Lothar Beyer, Rainer Richter, Jorge Angulo-Cornejo, Mary Castillo-Montoya, and Maria Lino-Pacheco
Elsevier BV
N ∩ N -ethylene bridged 3-benzoyl-2-ethyl-1-[2-(3-benzoyl-2-ethyl-isoureido)-ethyl]-isourea 1 and 2-benzoylimino-imidazolidine 2 are easily accessible in good yields and act as N , O donor ligands. After deprotonation 1 and 2 form mononuclear neutral complexes whose molecular structures have been determined by X-ray structure analysis. The metal ions in the 1:1 complexes of 1 with Cu II , Ni II and Co II are coordinated by the two bridging N atoms and the two carbonyl O atoms of one ligand molecule resulting in one five membered and two six membered chelate rings. The coordination geometry is square planar with cis arrangement of the ligator atoms. In comparison to the free ligand 1 the lengths of the CO and CN bonds involved in coordination are changed characteristically. The 2:1 complexes of 2 with Cu II and Ni II are isostructural. One deprotonated imidazolidine N and the carbonyl O atom of each ligand molecule coordinate the metal ion in a square planar trans arrangement. The X-ray structure analysis of 2 shows, besides an intramolecular imidazolidine-NH⋯O hydrogen bridge, two intermolecular hydrogen bonds originating from both imidazolidine N atoms, an NH⋯N and an NH⋯O one, leading to the formation of molecular chains in the crystal structure. 2-Benzoylimino-1,3-diaza-6,9-dioxacycloundecane 3 was synthesized from N -dichloromethylene-benzamide and 1,8-diamino-3,6-dioxaoctane using the dilution principle. The crystal structure of 3 reveals again, besides an intramolecular NH⋯O hydrogen bridge, the formation of molecular chains caused by one intermolecular NH⋯O hydrogen bridge per molecule. The bulky structure of the 1,3-diaza-6,9-dioxacycloundecane ring in 3 seems to prevent any complex formation of 3 with late transition metal ions.
Uwe Schröder, R. Richter, L. Beyer, J. Angulo-Cornejo, M. Lino-Pacheco, and A. Guillen
Wiley
The thiourea derivative N,N-diethyl-N-2-naphthoylthi- ourea (1) and three N-(dialkylaminothiocarbonyl)-N-(1-naphthyl)- arylamidines (2-4) have been synthesized and Cu II -, Ni II - and Pd II - complexes of them have been prepared. According to the X-ray structure analyses 1 with Cu II and Ni II under deprotonation forms neutral bis-chelates of nearly square-planar coordination with a cis arrangement of the O and S ligator atoms. Using their N and S atoms in 1,3 position as ligators, 2-4 in deprotonated form coordi-
Rainer Richter, Uwe Schröder, Lothar Beyer, Jorge Angulo-Cornejo, and Maria Lino-Pacheco
Wiley
Jorge Angulo-Cornejo*, Maria Lino-Pacheco, Rainer Richter, Lothar Hennig, Karl-Heinz Hallmeier, and Lothar Beyer*
Elsevier BV
Abstract The synthesis of the title ligands N-benzothiazol-2-yl-benzamide (1), N-benzoxazol-2-yl-benzamide (2) and N-(1H-benzimidazol-2-yl)-benzamide (3) is described. The molecular structure of 1 confirms the localization of a hydrogen atom at the nitrogen atom of the benzamide group. The ligands form 2:1 metal chelates under deprotonization with CuII, NiII, PdII and ZnII. 3 gives a cationic silver(I) complex. The complexes were characterized by XPS, NMR, and FAB mass spectroscopy. The molecular structure of two complexes was determined.
Lothar Beyer, Rainer Richter, Robert Wolf, Jana Zaumseil, Maria Lino-Pacheco, and Jorge Angulo-Cornejo
Elsevier BV
Abstract Bis(2-benzoylimino-benzimidazolinato)copper(II) (1) as the first neutral chelate of an acylimino-benzimidazoline contains guanidine and amide moieties directly coordinated to a metal atom. The ligands are arranged in trans position. The synthesis of cis-bis(pyridine)bis(N-benzoyl-O-ethyl-N′-m-nitrophenyl-isoureato)nickel(II) (2) is described. The molecular structures of both complexes were determined by X-ray crystal structure analysis.
J. Angulo Cornejo, F. Anaya Melendez, L. Beyer, R. Richter, and J. Sieler
Wiley
RECENT SCHOLAR PUBLICATIONS
MOST CITED SCHOLAR PUBLICATIONS
Publications
M Ceroni-Galloso, JR Angulo-Cornejo, MN Lino-Pacaheco, ..., Synthesis and characterization of silver (I) complex with mixed ligands saccharinate and 2-(2-pyridyl) bezimidazole. Revista Colombiana de Química (2018), 47 (2), 73-78
JR Angulo-Cornejo, M Ceroni-Galloso, MN Lino-Pacheco, ...Síntesis de 3-Nitro-N-(1, 1, 3-Trioxo-1, 3-Dihidro-2H-1λ6, 2-Benzotiazol-2-Carbotioil) benzamida. Revista de la Sociedad Química del Perú, (2017), 83 (3), 348-353
M Ceroni Galloso, JR Angulo Cornejo, MN Lino Pacheco, ...Síntesis de Sacarinatocobre (I). Revista de la Sociedad Química del Perú 83 (3), 341-347.
JR Angulo-Cornejo, CF Tovar. Utilización de la química computacional: Método semiempírico PM3, para elucidar la estructura del complejo bis (1, 5-difenil-1, 2, 4-triazol-3-tionato) plomo (II)(Pb (DTT) 2). Revista de la Sociedad Química del Perú (2014),80 (2), 136-143
L. Beyer, J. Angulo Cornejo, Koordinationschemie: Grundlagen-Synthesen-Anwendungen. Springer-Verlag 2012.
L Hennig, K Ayala-Leon, J Angulo-Cornejo, R Richter, L Beyer. Fluorine hydrogen short contacts and hydrogen bonds in substituted benzamides.
Journal of Fluorine Chemistry (2009),130 (5), 453-460.
U Schröder, R Richter, L Beyer, J Angulo‐Cornejo, M Lino‐Pacheco, ...Metallkomplexe naphthyl‐substituierter Thioharnstoffderivate. Zeitschrift für anorganische und allgemeine Chemie (2003), 629 (6), 1051-1058.