Juliano Casonatto

RESEARCH, TEACHING, or OTHER INTERESTS

Physical Therapy, Sports Therapy and Rehabilitation, Health Professions

Scopus Publications

Acute dose-response effect of photobiomodulation therapy on muscle performance in female futsal players: A randomized, double-blind, placebo-controlled, crossover study
Jayne Maria Borim, Sérgio Marques Borghi, Ana Paula do Nascimento, Adriano Valmozino da Silva, Alex Silva Ribeiro, Juliano Casonatto, Cleber Ferraresi, and Andreo Fernando Aguiar
Elsevier BV



Exploring the immediate effects of aerobic exercise on nocturnal blood pressure dip in medication-controlled hypertensive individuals: a randomised controlled trial




Waist circumference and waist-to-height ratio: Exploring the associations for high blood pressure risk in school-age adolescents
Adeluci Moraes, Aline Giselle Nagafuchi, Raphael Testa, Kamila Grandolfi, Andreo Aguiar, and Juliano Casonatto
Elsevier BV



The physical demands and physiological responses to CrossFit®: a scoping review with evidence gap map and meta-correlation
Diogo V. Martinho, André Rebelo, Élvio R. Gouveia, Adam Field, Renato Costa, Alex S. Ribeiro, Juliano Casonatto, Catarina Amorim, and Hugo Sarmento
Springer Science and Business Media LLC



Acute dose-response effect of photobiomodulation therapy on 5-km running performance in trained runners: a randomized, double-blind, placebo-controlled, crossover study
Ana Paula do Nascimento, Giani Alves de Oliveira, João Pedro Beguetto Bressanin, Pablo Aguirra, Alex Silva Ribeiro, Lúcio Flávio Soares Caldeira, Juliano Casonatto, Cleber Ferraresi, and Andreo Fernando Aguiar
Springer Science and Business Media LLC



Effects of a Mat Pilates Exercise Program Associated with Photobiomodulation Therapy in Patients with Chronic Nonspecific Low Back Pain: A Randomized, Double-Blind, Sham-Controlled Trial
Jeanne Karlette Merlo, Adriano Valmozino da Silva, Juliano Casonatto, Alex Silva Ribeiro, Eros de Oliveira Junior, Ana Paula do Nascimento, Raphael Gonçalves de Oliveira, Cosme Franklim Buzzachera, Rubens Alexandre da Silva, and Andreo Fernando Aguiar
MDPI AG
Objective: To investigate the effects of combining a Pilates program with photobiomodulation therapy (PBMT) in patients with chronic nonspecific low back pain (CNLBP). Methods: Thirty-eight adults with CNLBP were randomly assigned to two groups: Pilates exercise + active PBMT (PIL + PBMT) or Pilates exercise + sham PBMT (PIL + SHAM). Both groups performed an 8-week mat Pilates program and received PBMT on their lumbar muscles 10 min before and after each session. The following variables were assessed before and after intervention: peak pain intensity, postural balance (i.e., center of the pressure [A-COP], velocity anteroposterior [Vel AP], and velocity mediolateral [Vel ML]), perceived disability (i.e., Oswestry Disability Index [ODI] and Roland Morris Disability Questionnaire [RMDQ]), and pain-related fear of movement (i.e., Tampa Scale of Kinesiophobia [TSK], Fear Avoidance Beliefs Questionnaire [FABQ], and Pain Catastrophizing Scale [PCS]). Results: Postural balance variables showed no statistically significant differences (p > 0.05) across time or between groups. The groups showed similar (p < 0.05) reductions in peak pain intensity, ODI, RMDQ, and PCS scores, but no statistically significant difference (p > 0.05) in TSK and FABQ scores. Conclusion: The mat Pilates program reduced peak pain intensity, perceived disability, and pain catastrophizing in adults with CNLBP, but PBMT had no additional effect on these variables. Mat Pilates alone or combined with PBMT was not able to improve postural balance.


Inter-individual responses to arginine oral supplementation on post-exercise hypotension in treated hypertensives: A pilot study
J.V. Cavalari, A.F. Aguiar, and J. Casonatto
Elsevier BV



Systematic review and meta-analysis of randomized controlled trials on the effects of exercise interventions on amyloid beta levels in humans
Isabela Mayer Pucci, Andreo F. Aguiar, Rodrigo M. Pucci, Juliano Casonatto, and Sergio Marques Borghi
Springer Science and Business Media LLC



Overweight and Blood Pressure in Pre-Pubertal Children: A Longitudinal Study
Marcelo José Alves, Wésley Torres, Ana Elisa von Ah Morano, Carlos Augusto de Carvalho Filho, Robson Chacon Castoldi, Diego Giulliano Destro Christofaro, Juliano Casonatto, Luiz Carlos Marques Vanderlei, and Rômulo Araújo Fernandes
Springer Science and Business Media LLC



Parent-child associations of sleep quality: is physical activity a confounder? The EPI-FAMILY health study
Gustavo S. Druzian, William R. Tebar, Vitor S. Beretta, Enrique G. Leite, Isabella C. Leocci, Amanda B. Santos, Ewerton P. Antunes, Juliano Casonatto, Gerson Ferrari, Rômulo A. Fernandes,et al.
Elsevier BV



Acute Effects of Citrulline Malate Supplementation on Nocturnal Blood Pressure Dipping After Exercise in Hypertensive Patients: A Randomized, Placebo-Controlled Trial
Veridiana Domingues, João V. Cavalari, Kamila Grandolfi, Andreo F. Aguiar, Sergio M. Borghi, and Juliano Casonatto
Informa UK Limited
BACKGROUND Citrulline malate (CM), especially when used in conjunction with physical exercise, has demonstrated potential as a non-pharmacological adjunct in the management of hypertension. Nevertheless, its impact on nocturnal blood pressure dipping remains unexplored. OBJECTIVE Evaluate the impact of a single dose of CM on nocturnal blood pressure dipping after exercise in hypertensive individuals. METHODS In a double-blind, placebo-controlled, parallel-group clinical trial, twenty hypertensive adults (55 ± 16 years) were randomly assigned to either a CM (6 g) or placebo (6 g of corn starch) group (PLA). Resting blood pressure was measured after a 20-min period of comfortable seating in a calm environment. Both groups underwent 40 min of treadmill running/walking at an intensity of 60-70% of their reserve heart rate, 120 min after ingesting the substances. Ambulatory blood pressure monitoring was employed to measure blood pressure over 24 h. RESULTS No significant differences in systolic blood pressure values were observed between the CM and PLA groups at rest, during wakefulness, sleep, or over a 24-h period. However, CM exhibited a significant reduction in diastolic blood pressure in several metrics: delta 24 h (-14 mmHg vs -6 mmHg, p = 0.047), delta wakefulness (-12 mmHg vs -4 mmHg, p = 0.024), percent delta 24 h (-16% vs -6%, p = 0.024), and percent delta wakefulness (-14% vs -4%, p = 0.013). No significant differences were found between CM and PLA in terms of systolic and diastolic nocturnal absolute reductions (-13 mmHg vs -12 mmHg, p = 0.808, and -13 mmHg vs -8 mmHg, p = 0.273, respectively) or nocturnal percentage decrease (-9.9% vs -9.4%, p = 0.844, and -15.3% vs -11.7%, p = 0.399, respectively). CONCLUSIONS The study found no significant changes in the post-exercise nocturnal blood pressure dip following a single dose of CM supplementation. However, a notable reduction in diastolic blood pressure was observed during the waking period and over the average 24-h monitoring period. CLINICAL TRIAL REGISTRY NUMBER AND WEBSITE ClinicalTrials.gov platform (NCT03378596).


A Meta-Analysis of Randomized Controlled Trials on the Effects of Photobiomodulation Therapy on Running Performance
Ana Paula DO Nascimento, Adriano Valmozino DA Silva, J. Casonatto and A. Aguiar
International Journal of Exercise Science, L.L.C.
Objective To conduct a meta-analysis to investigate the effects of Photobiomodulation (PBM) therapy on running performance. Introduction PBM has recently been advocated as a valuable non-pharmacological ergogenic strategy, however, the efficacy of PBM on running performance remains unproven. Methods A computerized literature search was conducted until June 2023. The databases searched were PubMed/Medline, Embase, Scopus, SPORTDiscus, and Web of Science. Inclusion/exclusion criteria were determined through the PICO process. The running variables analyzed were time-trial or time-to-exhaustion. Results were combined with the standardized mean differences (SMD) and the 95% confidence intervals. Results Twelve studies fulfilled the inclusion criteria. No significant effects in favor of PBM were found (SMD = 0.13; p = 0.11). There was no effect considering the presence (SMD = 0.16; p = 0.38) and absence (SMD = 0.11; p = 0.25) of training, and there was no dose-response effect (p = 0.82). Conclusion Our findings indicate that PBM alone or combined with a training program does not improve running performance in terms of time-trial and time-to-exhaustion testing. More studies involving PBM plus training and doses higher than 1000 J are needed to determine if PBM is effective in improving running performance.


Undernutrition risk is independently associated with worsened indicators of hospital rehabilitation in COVID-19 patients
Vanessa Esquissato Pinheiro, Alex Silva Ribeiro, Carlos Augusto Marçal Camillo, and Juliano Casonatto
Informa UK Limited
OBJECTIVE This study was designed to analyze the association between the risk of undernutrition and indicators of hospital rehabilitation in patients with COVID-19 while controlling for confounding variables. METHODS This was an analytical study conducted by analyzing the medical records of patients with COVID-19. A total of 562 adult patients were eligible for the study. In addition to the risk of undernutrition (independent variable), indicators of hospital rehabilitation (dependent variables) were evaluated. These indicators included the length of hospital stay, clinical outcome (discharge or death), food intake, mobility (bedridden status), the use of mechanical ventilation, and the need for enteral nutrition. Pre-existing comorbidities (confounding/control variables) were grouped into cardiovascular, metabolic/endocrine, neurological, chronic obstructive pulmonary disease, and other categories (neoplasms, multiple sclerosis, and kidney disease). A dichotomization model was applied for data analysis. The Chi-Square test was used to verify the association between the risk of undernutrition and the dependent variables. Associations with a significance level of P < 0.05 were subjected to Poisson regression to identify the prevalence ratio. RESULTS Patients at risk of undernutrition had a 90% higher chance of being bedridden and were 35 times more likely to experience a decrease in food intake. They also had an 89% higher chance of using invasive mechanical ventilation and a 91% higher chance of requiring enteral nutrition. Additionally, individuals at risk of undernutrition had a 73% higher chance of death. Adjustment for comorbidities did not alter these associations, demonstrating that the risk of undernutrition is independently associated with indicators of hospital rehabilitation. CONCLUSION The risk of undernutrition is independently associated with worsened indicators of hospital rehabilitation in patients with COVID-19, including higher prevalence of mortality.


A Single Dosage of l-Arginine Oral Supplementation Induced Post-Aerobic Exercise Hypotension in Hypertensive Patients
Juliano Casonatto and João Vagner Cavalari
Informa UK Limited
Lowering of peripheral vascular resistance is one of the primary processes involved in blood pressure decrease. Nitric oxide plays a significant role in this process and the availability of l-arginine is a crucial element in nitric oxide biosynthesis. Oral l-arginine supplementation may therefore be a potentiating element in post-exercise hypotension, mediated by its vasodilator action. Thus, the purpose of this study was to investigate if a single dose of l-arginine oral supplementation might impact the post-aerobic exercise blood pressure responses in treated hypertensive individuals. A double-blind, randomized, placebo-controlled crossover trial was conducted. The sample included male (4) and female (6) subjects [62 ± 10 years]. The participants were randomized to ingest one sachet containing 8 grams of l-arginine or placebo (corn starch) dissolved in water (100 ml). The substances were self-administered 120 min before the experimental or control session. The exercise was conducted on a treadmill and consisted of: a 5 min warm-up (50-65% HRreserve); 40 min of running/walking at 60-70% HRreserve; and a 5 min progressive cooldown. After the exercise sessions, blood pressure was measured every 10 min for 60 min. The l-arginine supplementation arm led to significant post-exercise systolic hypotension (mean post-exercise) in relation to rest period (117 ± 12 vs 125 ± 15 mmHg - p = 0.004 [l-arginine] and 121 ± 11 vs 125 ± 15 - p = 0.341 [placebo]). In addition, a systolic net effect of -6.9 ± 3.6 mmHg [p = 0.046] was identified for the mean post-exercise values. Therefore, this study showed that a single dosage of l-arginine oral supplementation induced post-aerobic exercise hypotension in hypertensive patients.


Effects of Aquatic Exercise in Post-exercise Hypotension: A Systematic Review and Meta-Analysis
Cristina Oliveira Trindade, Emerson Cruz Oliveira, Daniel Barbosa Coelho, Juliano Casonatto, and Lenice Kappes Becker
Frontiers Media SA
BackgroundPost-exercise hypotension (PEH) can be an important non-pharmacological strategy in the treatment of arterial hypertension. Both aerobic and resistance exercises produce PEH, but it is not clear if the exercise environment can lead to a higher PEH.ObjectiveThis meta-analysis investigated whether a session of aquatic exercise (AE) induces PEH in comparison with control conditions such as land exercise (LE) or rest in hypertensive subjects.MethodsThe present systematic review and meta-analysis was conducted using the following electronic databases: PubMed, Google Scholar, and EMBASE. Ambulatory blood pressure measurements made in randomized clinical trials were pooled to compare PEH induced by AE with LE and rest conditions in hypertensive subjects.ResultsData from four trials were included, which comprised 127 participants (94 women and 33 men). A 24-h analysis did not detect significant differences between AE and LE or rest for either systolic blood pressure (SBP) or diastolic blood pressure (DBP). Monitoring during the night showed that AE induced significant PEH in comparison with LE for SBP [−8.6 (−15.0 to −1.5) mmHg (p = 0.01)]. For DBP, the AE had pronounced PEH during the night in comparison with LE [−3.7 (−4.7 to −2.8) mmHg, p = 0.000] and rest [−1.7 (−1.9 to −0.8) mmHg, p = 0.000]. There were no differences in daytime values.ConclusionAE showed a higher PEH effect than LE sessions and rest conditions. PEH was observed in both SBP and DBP during the night. The number of studies was low, but all studies included in this meta-analysis used 24-h monitoring. The understanding of clinical relevance of AE, inducing a higher PEH, depends on a standardization of exercise protocols plus a rigorous monitoring of blood pressure.Systematic Review RegistrationPROSPERO registration: CRD42021271928.


Effects of Citrulline Malate Supplementation on Muscle Strength in Resistance-Trained Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Andreo F. Aguiar and Juliano Casonatto
Informa UK Limited
Abstract Although the ergogenic mechanisms of supplementation with citrulline malate are well known, unclear findings regarding variables of muscle strength have been recorded. Such misleading findings in the literature illustrate the need for well-conducted meta-analysis research to elucidate the possible ergogenic impact, which could have major practical consequences for athletes and recreational practitioners seeking to optimize gains in muscle strength. The objective of this systematic review was to summarize the existing literature that evaluated the effects of citrulline malate supplementation on muscle strength outcomes from resistance exercise in resistance-trained individuals. A systematic electronic search in Medline and Scientific Electronic Library Online (SciELO) was completed in August 2020 identifying randomized controlled trials investigating the effect of citrulline malate supplementation on muscle strength in resistance-trained adults. A subsequent meta-analysis was performed. The meta-analysis involved four studies and 138 assessments (69 in citrulline-malate and 69 in placebo groups). We did not observe an overall effect favoring citrulline-malate supplementation (SMD95% = 0.13 [−0.21; 0.46]). Considering the lower (SMD95% = 0.06 [−0.47; 0.60]) and upper (SMD95% = 0.17 [−0.26; 0.60]) limbs, a non-significant overall effect was identified. The mean effects were similar for “limbs” (upper vs lower) [p = 0.763]. Accordingly, our findings suggest that citrulline malate supplementation does not improve muscle strength in healthy and resistance-trained individuals (PROSPERO registration number: CRD42020159338).


Effect of Different Sports Practice on Sleep Quality and Quality of Life in Children and Adolescents: Randomized Clinical Trial
Camila Cassemiro Rosa, William Rodrigues Tebar, Crystian Bittencourt Soares Oliveira, Breno Quintella Farah, Juliano Casonatto, Bruna Thamyres Ciccotti Saraiva, and Diego Giulliano Destro Christofaro
Springer Science and Business Media LLC
Abstract Background Sports practice can promote several health benefits in pediatric populations; nonetheless, most of the studies that investigated these benefits are of cross-sectional design. Thus, our objective was to verify the effectiveness of two types of physical activities through sports, judo and ball games (soccer, volleyball, handball, and basketball) on the quality of sleep and life of Brazilian children and adolescents. Methods The study is a randomized clinical trial, conducted with 65 participants of both sexes (6–15 years old) in a philanthropic institution in Brazil. The variables investigated were the quality of sleep and life, using the mini-sleep questionnaire and KidsCreen-52 questionnaires (this instrument has a scale ranging from 0 to 100, where 100 is the best value for each domain), respectively. The interventions carried out during 12 weeks (twice a week) were judo and ball games. In the statistical analysis, analysis of variance (ANOVA) for repeated measures was used and the level of statistical significance used was 5%. Results Judo (P = 0.032) and ball games (P = 0.005) contributed to improving the quality of sleep in the participants. Considering the score of the domains of quality of life, judo and ball games significantly increased the perception of health and physical activity [mean = 6.9 (8.3%) and 8.91 (12.2%) points, respectively], autonomy [mean = 5.81 (7.3%) and 5.00 (6.9%) points], friends and social support (mean = 2.83 (3.8%) and 12.00 (15.9%) points), provocation and bullying [mean = 10.21 (18.1%) and 2.14 (4.1%) points]. Conclusion It is concluded that both judo and ball games brought benefits to the quality of sleep and life of children and adolescents. Health promotion actions should encourage the increase in sports practice in children and adolescents to improve sleep and quality of life.


Post-exercise Hypotension Following a Single Bout of High Intensity Interval Exercise vs. a Single Bout of Moderate Intensity Continuous Exercise in Adults With or Without Hypertension: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Isabela Roque Marçal, Karla Fabiana Goessler, Roselien Buys, Juliano Casonatto, Emmanuel Gomes Ciolac, and Véronique A. Cornelissen
Frontiers in Physiology Frontiers Media SA
Background: Post-exercise hypotension (PEH) is an important tool in the daily management of patients with hypertension. Varying the exercise parameters is likely to change the blood pressure (BP) response following a bout of exercise. In recent years, high-intensity interval exercise (HIIE) has gained significant popularity in exercise-based prevention and rehabilitation of clinical populations. Yet, to date, it is not known whether a single session of HIIE maximizes PEH more than a bout of moderate-intensity continuous exercise (MICE).Objective: To compare the effect of HIIE vs. MICE on PEH by means of a systematic review and meta-analysis.Methods: A systematic search in the electronic databases MEDLINE, Embase, and SPORTDiscus was conducted from the earliest date available until February 24, 2020. Randomized clinical trials comparing the transient effect of a single bout of HIIE to MICE on office and/or ambulatory BP in humans (≥18 years) were included. Data were pooled using random effects models with summary data reported as weighted means and 95% confidence interval (CIs).Results: Data from 14 trials were included, involving 18 comparisons between HIIE and MICE and 276 (193 males) participants. The immediate effects, measured as office BP at 30- and 60-min post-exercise, was similar for a bout of HIIE and MICE (p &amp;gt; 0.05 for systolic and diastolic BP). However, HIIE elicited a more pronounced BP reduction than MICE [(−5.3 mmHg (−7.3 to −3.3)/ −1.63 mmHg (−3.00 to −0.26)] during the subsequent hours of ambulatory daytime monitoring. No differences were observed for ambulatory nighttime BP (p &amp;gt; 0.05).Conclusion: HIIE promoted a larger PEH than MICE on ambulatory daytime BP. However, the number of studies was low, patients were mostly young to middle-aged individuals, and only a few studies included patients with hypertension. Therefore, there is a need for studies that involve older individuals with hypertension and use ambulatory BP monitoring to confirm HIIE's superiority as a safe BP lowering intervention in today's clinical practice.Systematic Review Registration: PROSPERO (registration number: CRD42020171640).


Leucine Supplementation Does Not Improve Muscle Recovery from Resistance Exercise in Young Adults: A Randomized, Double-Blinded, Crossover Study




Post-aerobic-exercise autonomic responses in hypertensives — a randomized controlled trial
Juliano Casonatto, Liane Sardi Oliveira, and Kamila Grandolfi
VM Media SP. zo.o VM Group SK
Background. Heart rate variability (HRV) response to an exercise bout may provide useful insight into autonomic stress reactivity. Considering that cardiovascular responses to a stressor may be predictive of certain diseases, it becomes critical to understand if high blood pressure can influence the autonomic nervous system response to acute exercise. We, therefore, undertook a study to investigate the effect of a single bout of aerobic exercise on autonomic responses in hypertensives. Material and methods. Twenty hypertensives were randomly assigned to one of the two experimental groups [control (CG) or exercise (EG)]. The exercise session was conducted on a treadmill and consisted of 40 min of running/walking at 60–70% HRreserve. In the control session, the participants remained seated in a quiet room for 40 min. After the exercise/control sessions, the HRV was recorded continuously for 60 min. Results. The EG presented an increase with a large effect size for LF [1.0 (post-30) and 1.0 (post-60)] and LF/HF [0.8 (post-30) and 1.1 (post-60)]. Additionally, a reduction with a large effect was observed for HF [–1.0 (post-30) and –1.0 (post-60)]. Conclusion. There is a considerable reduction in post-aerobic-exercise parasympathetic activity and an increase in sympathetic activity. Therefore, a single bout of aerobic exercise is not able to quickly improve the cardiac autonomic regulation.


Is physical activity associated with resting heart rate in boys and girls? A representative study controlled for confounders
Edner F. Zanuto, Raphael M. Ritti-Dias, William R. Tebar, Catarina C. Scarabottolo, Leandro D. Delfino, Juliano Casonatto, Luiz Carlos M. Vanderlei, and Diego Giulliano Destro Christofaro
Elsevier BV



Pilates exercise and postural balance in older adults: A systematic review and meta-analysis of randomized controlled trials
Juliano Casonatto and Cárita Mayume Yamacita
Elsevier BV



Citrulline malate supplementation might potentiate post-exercise hypotension in hypertensives: A 24-hour analysis
J. Casonatto, J.V. Cavalari, K.F. Goessler, D.G.D. Christofaro, M.D. Polito, D.M. Enokida, and K. Grandolfi
Elsevier BV



Inter-individual responses to citrulline malate oral supplementation on post-exercise hypotension in hypertensives: A 24-hour analysis
Juliano Casonatto, Daniel Massaharu Enokida, and Kamila Grandolfi
Sociedade Brasileira de Cardiologia
Background Studies have persuasively demonstrated that citrulline has a key role in the arginine-nitric oxide system, increasing nitric oxide bioavailability, an important mediator of peripheral vasodilation. Objective To analyze the inter-individual post-exercise hypotension responsiveness following acute citrulline supplementation in hypertensives. Methods Forty hypertensives were randomly assigned to one of the four experimental groups (control-placebo, control-citrulline, exercise-placebo, and exercise-citrulline). They ingested placebo or citrulline malate [CM] (6 grams). During the exercise session, individuals performed 40 minutes of walking/running on a treadmill at 60-70% of HR reserve. For the control session, the individuals remained seated at rest for 40 minutes. Office blood pressure (BP) was taken every 10 minutes until completing 60 minutes after the experimental session. The ambulatory BP device was programmed to take the readings every 20 minutes (awake time) and every 30 minutes (sleep time) over the course of 24 hours of monitoring. Statistical significance was defined as p < 0.05. Results Unlike the other experimental groups, there were no “non-responders” in the exercise/citrulline (EC) for “awake” (systolic and diastolic BP) and “24 hours” (diastolic BP). The effect sizes were more consistent in the EC for systolic and diastolic ambulatorial BP response. The effects were “large” (> 0.8) for “awake”, “asleep”, and “24 hours” only in the EC for diastolic BP. Conclusion CM supplementation can increase the post-exercise hypotensive effects in hypertensives. In addition, the prevalence of non-responders is lower when associated with aerobic exercise and CM supplementation.


L-arginine supplementation improves post-exercise hypotension in elderly women
Juliano Casonatto, Daniele Mantovani Zago, Daniel Massaharu Enokida, Kamila Grandolfi, and Andreo Fernando Aguiar
FapUNIFESP (SciELO)
ABSTRACT Introduction: L-Arginine supplementation increases plasma levels of nitric oxide (NO) metabolites, an important mediator of peripheral dilatation. Therefore, L-Arginine supplementation can improve the duration and magnitude of post-exercise hypotension. Objectives: This study investigated the effects of L-Arginine supplementation on post-exercise hypotension, femoral artery area and heart rate variability in elderly women. Methods: Twenty prehypertensive and hypertensive adult female participants were divided (in a random and balanced manner) into two groups (placebo and L-arginine). The participants ingested eight grams of inert substance (placebo group) or eight grams of L-Arginine (L-arginine group), dissolved in water, 90 min prior to the experimental session. The experimental session consisted of an isokinetic maximal strength test. Blood pressure was measured using an oscillometric device (Omron MX3 Plus, Bannockburn, US) every 10 minutes for 60 minutes after the experimental session. Femoral artery area (ultrasound) and heart rate variability were also analyzed. Data underwent repeated measures (ANOVA) analysis and respective assumptions. Results: L-Arginine supplementation associated with exercise produced a significant decrease in systolic blood pressure [placebo vs L-Arginine] (p &lt;0.05) at the “half-life” time point (90 minutes after supplementation) (141±12 vs 130±11 mmHg) and 40 min. (146±13 vs 127±13 mmHg), 50 min. (145±20 vs 127±15 mmHg) and 60 min. (147±19 vs 129±14mmHg) post-exercise. No significant differences were identified in femoral artery area and heart rate variability. Conclusion: Acute L-Arginine supplementation can increase post-exercise hypotension effects in elderly women. Additionally, acute L-Arginine supplementation is not related to either femoral artery area or heart rate variability responses. Level of evidence I; Randomized clinical trial.

RECENT SCHOLAR PUBLICATIONS

Acute dose-response effect of photobiomodulation therapy on muscle performance in female futsal players: A randomized, double-blind, placebo-controlled, crossover study
JM Borim, SM Borghi, AP do Nascimento, AV da Silva, AS Ribeiro, ...
Journal of Bodywork and Movement Therapies 41, 35-43 2025



Associao entre os estgios de mudana de comportamento e a percepo de barreiras para a prtica de atividade fsica em trabalhadores de indstrias
SC de Souza, MV da Costa, J Casonatto, D de Castro Teixeira
Brazilian Journal of Health Review 8 (1), e77368-e77368 2025



Exploring the immediate effects of aerobic exercise on nocturnal blood pressure dip in medication-controlled hypertensive individuals: a randomised controlled trial
EA Lopez, JV Cavalari, K Grandolfi, DGD Christofaro, AF Aguiar, ...
Acta Cardiologica, 1-7 2025



Waist circumference and waist-to-height ratio: Exploring the associations for high blood pressure risk in school-age adolescents
A Moraes, AG Nagafuchi, R Testa, K Grandolfi, A Aguiar, J Casonatto
Obesity Medicine 52, 100562 2024



Acute Effects of Citrulline Malate Supplementation on Nocturnal Blood Pressure Dipping After Exercise in Hypertensive Patients: A Randomized, Placebo-Controlled Trial
V Domingues, JV Cavalari, K Grandolfi, AF Aguiar, SM Borghi, ...
Journal of Dietary Supplements 21 (6), 868-880 2024



The physical demands and physiological responses to CrossFit: A scoping review with evidence gap map and meta-correlation
DV Martinho, A Rebelo, R Gouveia, A Field, R Costa, AS Ribeiro, ...
BMC Sports Science, Medicine and Rehabilitation 16 (1), 196 2024



Effects of a Mat Pilates Exercise Program Associated with Photobiomodulation Therapy in Patients with Chronic Nonspecific Low Back Pain: A Randomized, Double-Blind, Sham
JK Merlo, AV da Silva, J Casonatto, AS Ribeiro, E de Oliveira Junior, ...
Healthcare 12 (14), 1416 2024



Relationship between Habitual Physical Activity and high Blood Pressure Among Adolescents In High Socioeconomic Level School: a Confounder-Controlled Analysis
A Moraes, AG Nagafuchi, RG Testa, JVT Martins, DGD Christofaro, ...
Journal of Health Sciences 26 (2), 100-105 2024



Inter-individual responses to arginine oral supplementation on post-exercise hypotension in treated hypertensives: A pilot study
JV Cavalari, AF Aguiar, J Casonatto
Science & Sports 39 (4), 399-404 2024



Acute dose-response effect of photobiomodulation therapy on 5-km running performance in trained runners: a randomized, double-blind, placebo-controlled, crossover study
AP do Nascimento, GA de Oliveira, JPB Bressanin, P Aguirra, AS Ribeiro, ...
Lasers in Medical Science 39 (1), 145 2024



Systematic review and meta-analysis of randomized controlled trials on the effects of exercise interventions on amyloid beta levels in humans
IM Pucci, AF Aguiar, RM Pucci, J Casonatto, SM Borghi
Experimental Brain Research 242 (5), 1011-1024 2024



Overweight and Blood Pressure in Pre-Pubertal Children: A Longitudinal Study
MJ Alves, W Torres, AE von Ah Morano, CA de Carvalho Filho, ...
Indian Pediatrics 61 (4), 352-356 2024



Parent-child associations of sleep quality: is physical activity a confounder? The EPI-FAMILY health study
GS Druzian, WR Tebar, VS Beretta, EG Leite, IC Leocci, AB Santos, ...
Sleep Medicine 116, 51-55 2024



A Meta-analysis of Randomized controlled trials on the effects of Photobiomodulation Therapy on running performance
AP do Nascimento, AV da Silva, J Casonatto, AF Aguiar
International Journal of Exercise Science 17 (4), 327 2024



The Impact of Undernutrition Risk on Rehabilitation Outcomes in Ischemic Stroke Survivors: A Hospital-Based Study
DFC Pereira, KBP Fernandes, AF Aguiar, J Casonatto
Brain & NeuroRehabilitation 17 (1), e7 2024



The physical demands and physiological responses to CrossFit
DV Martinho, A Rebelo, R Gouveia, A Field, R Costa, AS Ribeiro, ...
2024



Undernutrition risk is independently associated with worsened indicators of hospital rehabilitation in COVID-19 patients
VE Pinheiro, AS Ribeiro, CAM Camillo, J Casonatto
Hospital Practice 51 (5), 267-274 2023



Exerccio Fsico e Hipertenso
JV Cavalari, J Casonatto
Editora Dialtica 2023



A single dosage of L-arginine oral supplementation induced post-aerobic exercise hypotension in hypertensive patients
J Casonatto, JV Cavalari
Journal of Dietary Supplements 20 (5), 735-748 2023



Anlise do equilbrio postural em praticantes de crossfit e pessoas sedentrias
AFM da Silva, E de Oliveira Junior, FD Antunes, AFV Paixo, ...
Brazilian Journal of Development 9 (6), 20024-20036 2023

MOST CITED SCHOLAR PUBLICATIONS

Acute effects of caffeine-containing energy drinks on physical performance: a systematic review and meta-analysis
DB Souza, J Del Coso, J Casonatto, MD Polito
European journal of nutrition 56, 13-27 2017
Citations: 213



The blood pressure-lowering effect of a single bout of resistance exercise: a systematic review and meta-analysis of randomised controlled trials
J Casonatto, KF Goessler, VA Cornelissen, JR Cardoso, MD Polito
European journal of preventive cardiology 23 (16), 1700-1714 2016
Citations: 204



Cardiovascular and autonomic responses after exercise sessions with different intensities and durations
J Casonatto, T Tinucci, AC Dourado, M Polito
Clinics 66 (3), 453-458 2011
Citations: 124



Acute effect of caffeine consumption on isotonic muscular strength and endurance: a systematic review and meta-analysis
MD Polito, DB Souza, J Casonatto, P Farinatti
Science & Sports 31 (3), 119-128 2016
Citations: 105



Hipotenso ps-exerccio aerbio: uma reviso sistemtica
J Casonatto, MD Polito
Revista Brasileira de Medicina do Esporte 15, 151-157 2009
Citations: 105



Prevalence of dyslipidemia in individuals physically active during childhood, adolescence and adult age
RA Fernandes, DGD Christofaro, J Casonatto, JS Codogno, ...
Arquivos brasileiros de cardiologia 97, 317-323 2011
Citations: 93



Relationship between resting heart rate, blood pressure and pulse pressure in adolescents
DGD Christofaro, J Casonatto, LCM Vanderlei, GG Cucato, RMR Dias
Arquivos brasileiros de cardiologia 108 (5), 405-410 2017
Citations: 86



Isolated and combined effects of aerobic and strength exercise on post-exercise blood pressure and cardiac vagal reactivation in normotensive men
RJ Ruiz, R Simo, MG Saccomani, J Casonatto, JL Alexander, M Rhea, ...
The Journal of Strength & Conditioning Research 25 (3), 640-645 2011
Citations: 86



Physical activity is inversely associated with high blood pressure independently of overweight in B razilian adolescents
DGD Christofaro, RM Ritti‐Dias, A Chiolero, RA Fernandes, J Casonatto, ...
Scandinavian journal of medicine & science in sports 23 (3), 317-322 2013
Citations: 83



Cross-sectional association between healthy and unhealthy food habits and leisure physical activity in adolescents
RA Fernandes, DGD Christofaro, J Casonatto, SS Kawaguti, ERV Ronque, ...
Jornal de pediatria 87 (3), 252-256 2011
Citations: 75



Association between health-related physical fitness and body mass index status in children
J Casonatto, RA Fernandes, MB Batista, ES Cyrino, MJ Coelho-e-Silva, ...
Journal of Child Health Care 20 (3), 294-303 2016
Citations: 73



Pilates exercise and postural balance in older adults: A systematic review and meta-analysis of randomized controlled trials
J Casonatto, CM Yamacita
Complementary therapies in medicine 48, 102232 2020
Citations: 72



Riscos para o excesso de peso entre adolescentes de diferentes classes socioeconmicas
RA Fernandes, J Casonatto, DGD Christofaro, ERV Ronque, AR Oliveira, ...
Revista da Associacao Medica Brasileira 54, 334-338 2008
Citations: 66



Prevalncia de dislipidemia em indivduos fisicamente ativos durante a infncia, adolescncia e idade adulta
RA Fernandes, DGD Christofaro, J Casonatto, JS Codogno, ...
Arquivos Brasileiros de Cardiologia 97, 317-323 2011
Citations: 64



Evaluation of the Omron MX3 Plus monitor for blood pressure measurement in adolescents
DGD Christofaro, J Casonatto, MD Polito, JR Cardoso, R Fernandes, ...
European journal of pediatrics 168, 1349-1354 2009
Citations: 61



Atividade fsica: prevalncia, fatores relacionados e associao entre pais e filhos
RA Fernandes, DGD Christofaro, VF Milanez, J Casonatto, JR Cardoso, ...
Revista Paulista de Pediatria 29, 54-59 2011
Citations: 47



Effect of different sports practice on sleep quality and quality of life in children and adolescents: randomized clinical trial
CC Rosa, WR Tebar, CBS Oliveira, BQ Farah, J Casonatto, BTC Saraiva, ...
Sports medicine-open 7, 1-10 2021
Citations: 46



Aptido fsica relacionada prtica esportiva em crianas e adolescentes
A Schubert, RSB Janurio, J Casonatto, CN Sonoo
Revista Brasileira de Medicina do Esporte 22, 142-146 2016
Citations: 43



Blood pressure and autonomic responses following isolated and combined aerobic and resistance exercise in hypertensive older women
PG Anunciao, PTV Farinatti, KF Goessler, J Casonatto, MD Polito
Clinical and experimental hypertension 38 (8), 710-714 2016
Citations: 42



Comparao da aptido fsica relacionada sade de adultos de diferentes faixas etrias
DF Dias, ICB Reis, DA Reis, ES Cyrino, D Ohara, FO Carvalho, ...
Rev Bras Cineantropom Desempenho Hum 10 (2), 123-8 2008
Citations: 42