KEWAL KUMAR MAHAPATRA

RESEARCH, TEACHING, or OTHER INTERESTS

Animal Science and Zoology, Cancer Research, Cell Biology, Molecular Biology

Scopus Publications

• PPA2 activates MTFP1-DNM1L fission signaling to govern mitochondrial proliferation and mitophagy
  Soumya Ranjan Mishra, Priyadarshini Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Gajanan Kendre, et al.
  Autophagy, 2026
• Intricate role of DRP1 and associated mitochondrial fission signaling in carcinogenesis and cancer progression
  Soumya Ranjan Mishra, Priyadarshini Mishra, Prakash Kumar Senapati, Kewal Kumar Mahapatra, Sujit Kumar Bhutia
  Biochimica Et Biophysica Acta Reviews on Cancer, 2025
• Autophagy paradox: Genetic and epigenetic control of autophagy in cancer progression
  Chandra Sekhar Bhol, Prakash Kumar Senapati, Rakesh Kumar Kar, Grace Chew, Kewal Kumar Mahapatra, et al.
  Cancer Letters, 2025
• Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy
  Bishnu Prasad Behera, Soumya Ranjan Mishra, Srimanta Patra, Kewal Kumar Mahapatra, Chandra Sekhar Bhol, et al.
  Cytokine and Growth Factor Reviews, 2025
• mTOR inhibitors in targeting autophagy and autophagy-associated signaling for cancer cell death and therapy
  Prakash Kumar Senapati, Kewal Kumar Mahapatra, Amruta Singh, Sujit Kumar Bhutia
  Biochimica Et Biophysica Acta Reviews on Cancer, 2025
• Sublethal urea exposure in Nile tilapia: Morphological, behavioural, and histological alteration
  Trishnarani Jena, Suraj Kumar Chhatoi, Swati Saurabini Khandai, Rutusmita Mishra, Abhipsa Mohanty, et al.
  Chemosphere, 2025
• Prolonged glutamine starvation reactivates mTOR to inhibit autophagy and initiate autophagic lysosome reformation to maintain cell viability
  Amruta Singh, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Srimanta Patra, Soumya Ranjan Mishra, et al.
  International Journal of Biochemistry and Cell Biology, 2024
• SIRT1-activating butein inhibits arecoline-induced mitochondrial dysfunction through PGC1α and MTP18 in oral cancer
  Bishnu Prasad Behera, Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Shankargouda Patil, Thomas Efferth, et al.
  Phytomedicine, 2024
• Recent advancement of autophagy in polyploid giant cancer cells and its interconnection with senescence and stemness for therapeutic opportunities
  Srimanta Patra, Prajna Paramita Naik, Kewal Kumar Mahapatra, Moureq Rashed Alotaibi, Shankargouda Patil, et al.
  Cancer Letters, 2024
• Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma
  Soumya Ranjan Mishra, Bishnu Prasad Behera, Vineet Kumar Singh, Kewal Kumar Mahapatra, Deepak Mundkinajeddu, et al.
  Phytomedicine, 2024
• Stonin 2 activates lysosomal-mTOR axis for cell survival in oral cancer
  Kewal Kumar Mahapatra, Soumya Ranjan Mishra, Rohan Dhiman, Sujit Kumar Bhutia
  Toxicology in Vitro, 2023
• Autophagic lysosome reformation: The beginning from the end
  Kewal Kumar Mahapatra, Sujit Kumar Bhutia
  Autophagy Processes and Mechanisms, 2023
• Autophagy for secretory protein: Therapeutic targets in cancer
  Kewal Kumar Mahapatra, Srimanta Patra, Soumya Ranjan Mishra, Bishnu Prasad Behera, Shankargouda Patil, et al.
  Advances in Protein Chemistry and Structural Biology, 2023
• Recent progress of autophagy signaling in tumor microenvironment and its targeting for possible cancer therapeutics
  Subhadip Mukhopadhyay, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Shankargouda Patil, Sujit Kumar Bhutia
  Seminars in Cancer Biology, 2022
• Inflammasomes in cancer: Effect of epigenetic and autophagic modulations
  Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Chandra Sekhar Bhol, Prakash Priyadarshi Praharaj, et al.
  Seminars in Cancer Biology, 2022
• Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives
  Srimanta Patra, Soumya R. Mishra, Bishnu P. Behera, Kewal K. Mahapatra, Debasna P. Panigrahi, et al.
  Seminars in Cancer Biology, 2022
• The lysosome as an imperative regulator of autophagy and cell death
  Kewal Kumar Mahapatra, Soumya Ranjan Mishra, Bishnu Prasad Behera, Shankargouda Patil, David A. Gewirtz, et al.
  Cellular and Molecular Life Sciences, 2021
• Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
  Soumya Ranjan Mishra, Kewal Kumar Mahapatra, Bishnu Prasad Behera, Srimanta Patra, Chandra Sekhar Bhol, et al.
  International Journal of Biochemistry and Cell Biology, 2021
• Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate
  Srimanta Patra, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, et al.
  Mitochondrion, 2021
• Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: A potential target for anti-CSC cancer therapy
  Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, Srimanta Patra, Soumya Ranjan Mishra, et al.
  Cancer Letters, 2021
• Secretory clusterin promotes oral cancer cell survival via inhibiting apoptosis by activation of autophagy in AMPK/mTOR/ULK1 dependent pathway
  Prajna Paramita Naik, Subhadip Mukhopadhyay, Prakash Priyadarshi Praharaj, Chandra Sekhar Bhol, Debasna Pritimanjari Panigrahi, et al.
  Life Sciences, 2021
• Epigenetic modifications of autophagy in cancer and cancer therapeutics
  Chandra S. Bhol, Debasna P. Panigrahi, Prakash P. Praharaj, Kewal K. Mahapatra, Srimanta Patra, et al.
  Seminars in Cancer Biology, 2020
• The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics
  Debasna P. Panigrahi, Prakash P. Praharaj, Chandra S. Bhol, Kewal K. Mahapatra, Srimanta Patra, et al.
  Seminars in Cancer Biology, 2020
• Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways
  Srimanta Patra, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Biswajit Panda, Chandra Sekhar Bhol, et al.
  Molecular Biology Reports, 2020
• Bacopa monnieri inhibits apoptosis and senescence through mitophagy in human astrocytes
  Sarbari Saha, Kewal Kumar Mahapatra, Soumya Ranjan Mishra, Swarupa Mallick, Vidya Devi Negi, et al.
  Food and Chemical Toxicology, 2020
• Terminalia bellirica extract induces anticancer activity through modulation of apoptosis and autophagy in oral squamous cell carcinoma
  Srimanta Patra, Prashanta Kumar Panda, Prajna Paramita Naik, Debasna Pritimanjari Panigrahi, Prakash Priyadarshi Praharaj, et al.
  Food and Chemical Toxicology, 2020
• Mechanistic Insights into Autophagosome-Lysosome Fusion in Cancer Therapeutics
  Kewal Kumar Mahapatra, Soumya Ranjan Mishra, Bishnu Prasad Behera, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, et al.
  Autophagy in Tumor and Tumor Microenvironment, 2020
• Mitochondrial Biogenesis, Mitophagy, and Mitophagic Cell Death in Cancer Regulation: A Comprehensive Review
  Prakash Priyadarshi Praharaj, Bishnu Prasad Behera, Soumya Ranjan Mishra, Srimanta Patra, Kewal Kumar Mahapatra, et al.
  Autophagy in Tumor and Tumor Microenvironment, 2020
• Autophagy: An Agonist and Antagonist with an Interlink of Apoptosis in Cancer
  Vanishri Chandrashekhar Haragannavar, Roopa S. Rao, Kewal Kumar Mahapatra, Srimanta Patra, Bishnu Prasad Behera, et al.
  Autophagy in Tumor and Tumor Microenvironment, 2020
• Dysregulation of histone deacetylases in carcinogenesis and tumor progression: a possible link to apoptosis and autophagy
  Srimanta Patra, Debasna P. Panigrahi, Prakash P. Praharaj, Chandra S. Bhol, Kewal K. Mahapatra, et al.
  Cellular and Molecular Life Sciences, 2019
• Molecular interplay of autophagy and endocytosis in human health and diseases
  Kewal K. Mahapatra, Debasna P. Panigrahi, Prakash P. Praharaj, Chandra S. Bhol, Srimanta Patra, et al.
  Biological Reviews, 2019
• Plant lectins in cancer therapeutics: Targeting apoptosis and autophagy-dependent cell death
  Sujit K. Bhutia, Prashanta K. Panda, Niharika Sinha, Prakash P. Praharaj, Chandra S. Bhol, et al.
  Pharmacological Research, 2019
• Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics
  Prakash P. Praharaj, Prajna P. Naik, Debasna P. Panigrahi, Chandra S. Bhol, Kewal K. Mahapatra, et al.
  Cellular and Molecular Life Sciences, 2019
• Identification and characterization of stem cells in oral cancer
  Sujit K. Bhutia, Prajna P. Naik, Prakash P. Praharaj, Debasna P. Panigrahi, Chandra S. Bhol, et al.
  Methods in Molecular Biology, 2019
• Mitochondrial Heterogeneity in Stem Cells
  Prajna Paramita Naik, Prakash P. Praharaj, Chandra S. Bhol, Debasna P. Panigrahi, Kewal K. Mahapatra, et al.
  Advances in Experimental Medicine and Biology, 2019
• Monitoring and measuring mammalian autophagy
  Sujit K. Bhutia, Prakash P. Praharaj, Chandra S. Bhol, Debasna P. Panigrahi, Kewal K. Mahapatra, et al.
  Methods in Molecular Biology, 2019

RECENT SCHOLAR PUBLICATIONS

• Chebulagic acid limits mTOR activity leading to TFEB-driven autophagy and lysosomal biogenesis to suppress the arecoline-induced NLRP3-mediated inflammasome axis in OSCC
  PK Senapati, A Singh, RK Kar, KK Mahapatra, S Maiti, M Jena, SK Bhutia
  Available at SSRN 6189047 , 2026
  2026
• PPA2 activates MTFP1-DNM1L fission signaling to govern mitochondrial proliferation and mitophagy
  SR Mishra, P Mishra, KK Mahapatra, BP Behera, G Kendre, MR Alotaibi, ...
  Autophagy 22 (1), 121-144 , 2026
  2026
  Citations: 5
• Intricate role of DRP1 and associated mitochondrial fission signaling in carcinogenesis and cancer progression
  SR Mishra, P Mishra, PK Senapati, KK Mahapatra, SK Bhutia
  Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 189453 , 2025
  2025
  Citations: 4
• Autophagy paradox: Genetic and epigenetic control of autophagy in cancer progression
  CS Bhol, PK Senapati, RK Kar, G Chew, KK Mahapatra, EHC Lee, ...
  Cancer letters, 217909 , 2025
  2025
  Citations: 14
• mTOR inhibitors in targeting autophagy and autophagy-associated signaling for cancer cell death and therapy
  PK Senapati, KK Mahapatra, A Singh, SK Bhutia
  Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1880 (3), 189342 , 2025
  2025
  Citations: 29
• Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy
  BP Behera, SR Mishra, S Patra, KK Mahapatra, CS Bhol, DP Panigrahi, ...
  Cytokine & growth factor reviews , 2025
  2025
  Citations: 18
• Prolonged glutamine starvation reactivates mTOR to inhibit autophagy and initiate autophagic lysosome reformation to maintain cell viability
  A Singh, KK Mahapatra, PP Praharaj, S Patra, SR Mishra, S Patil, ...
  The International Journal of Biochemistry & Cell Biology 177, 106694 , 2024
  2024
  Citations: 8
• Original SIRT1-activating butein inhibits arecoline-induced mitochondrial dysfunction through PGC1 alpha and MTP18 in oral cancer
  BP Behera, SR Mishra, KK Mahapatra, S Patil, T Efferth, SK Bhutia
  Phytomedicine 129 , 2024
  2024
  Citations: 1
• SIRT1-activating butein inhibits arecoline-induced mitochondrial dysfunction through PGC1α and MTP18 in oral cancer
  BP Behera, SR Mishra, KK Mahapatra, S Patil, T Efferth, SK Bhutia
  Phytomedicine 129, 155511 , 2024
  2024
  Citations: 13
• Recent advancement of autophagy in polyploid giant cancer cells and its interconnection with senescence and stemness for therapeutic opportunities
  S Patra, PP Naik, KK Mahapatra, MR Alotaibi, S Patil, BS Patro, G Sethi, ...
  Cancer Letters 590, 216843 , 2024
  2024
  Citations: 16
• Anticancer activity of Bacopa monnieri through apoptosis induction and mitophagy-dependent NLRP3 inflammasome inhibition in oral squamous cell carcinoma
  SR Mishra, BP Behera, VK Singh, KK Mahapatra, D Mundkinajeddu, ...
  Phytomedicine 123, 155157 , 2024
  2024
  Citations: 13
• Autophagic lysosome reformation: The beginning from the end
  KK Mahapatra, SK Bhutia
  Autophagy Processes and Mechanisms, 153 , 2023
  2023
• Stonin 2 activates lysosomal-mTOR axis for cell survival in oral cancer
  KK Mahapatra, SR Mishra, R Dhiman, SK Bhutia
  Toxicology in Vitro 88, 105561 , 2023
  2023
  Citations: 5
• Deciphering The Role Of Stonin 2 In Autophagy and Autophagic Lysosome Reformation to Control Cell Survival in Oral Squamous Cell Carcinoma
  KK Mahapatra
  2023
• Autophagy for secretory protein: Therapeutic targets in cancer
  KK Mahapatra, S Patra, SR Mishra, BP Behera, S Patil, SK Bhutia
  Advances in Protein Chemistry and Structural Biology 133, 159-180 , 2023
  2023
  Citations: 8
• Recent progress of autophagy signaling in tumor microenvironment and its targeting for possible cancer therapeutics
  S Mukhopadhyay, KK Mahapatra, PP Praharaj, S Patil, SK Bhutia
  Seminars in cancer biology 85, 196-208 , 2022
  2022
  Citations: 76
• Inflammasomes in cancer: Effect of epigenetic and autophagic modulations
  SR Mishra, KK Mahapatra, BP Behera, CS Bhol, PP Praharaj, ...
  Seminars in Cancer Biology 83, 399-412 , 2022
  2022
  Citations: 28
• Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives
  S Patra, SR Mishra, BP Behera, KK Mahapatra, DP Panigrahi, CS Bhol, ...
  Seminars in cancer biology 80, 205-217 , 2022
  2022
  Citations: 141
• The lysosome as an imperative regulator of autophagy and cell death
  KK Mahapatra, SR Mishra, BP Behera, S Patil, DA Gewirtz, SK Bhutia
  Cellular and Molecular Life Sciences 78 (23), 7435-7449 , 2021
  2021
  Citations: 227
• Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
  SR Mishra, KK Mahapatra, BP Behera, S Patra, CS Bhol, DP Panigrahi, ...
  The international journal of biochemistry & cell biology 136, 106013 , 2021
  2021
  Citations: 192

MOST CITED SCHOLAR PUBLICATIONS

• The emerging, multifaceted role of mitophagy in cancer and cancer therapeutics
  DP Panigrahi, PP Praharaj, CS Bhol, KK Mahapatra, S Patra, BP Behera, ...
  Seminars in cancer biology 66, 45-58 , 2020
  2020
  Citations: 348
• The lysosome as an imperative regulator of autophagy and cell death
  KK Mahapatra, SR Mishra, BP Behera, S Patil, DA Gewirtz, SK Bhutia
  Cellular and Molecular Life Sciences 78 (23), 7435-7449 , 2021
  2021
  Citations: 227
• Mitochondrial dysfunction as a driver of NLRP3 inflammasome activation and its modulation through mitophagy for potential therapeutics
  SR Mishra, KK Mahapatra, BP Behera, S Patra, CS Bhol, DP Panigrahi, ...
  The international journal of biochemistry & cell biology 136, 106013 , 2021
  2021
  Citations: 192
• Plant lectins in cancer therapeutics: Targeting apoptosis and autophagy-dependent cell death
  SK Bhutia, PK Panda, N Sinha, PP Praharaj, CS Bhol, DP Panigrahi, ...
  Pharmacological research 144, 8-18 , 2019
  2019
  Citations: 165
• Autophagy-modulating phytochemicals in cancer therapeutics: Current evidences and future perspectives
  S Patra, SR Mishra, BP Behera, KK Mahapatra, DP Panigrahi, CS Bhol, ...
  Seminars in cancer biology 80, 205-217 , 2022
  2022
  Citations: 141
• Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics
  PP Praharaj, PP Naik, DP Panigrahi, CS Bhol, KK Mahapatra, S Patra, ...
  Cellular and Molecular Life Sciences 76 (9), 1641-1652 , 2019
  2019
  Citations: 111
• Mitochondrial rewiring through mitophagy and mitochondrial biogenesis in cancer stem cells: A potential target for anti-CSC cancer therapy
  PP Praharaj, DP Panigrahi, CS Bhol, S Patra, SR Mishra, KK Mahapatra, ...
  Cancer letters 498, 217-228 , 2021
  2021
  Citations: 78
• Recent progress of autophagy signaling in tumor microenvironment and its targeting for possible cancer therapeutics
  S Mukhopadhyay, KK Mahapatra, PP Praharaj, S Patil, SK Bhutia
  Seminars in cancer biology 85, 196-208 , 2022
  2022
  Citations: 76
• Epigenetic modifications of autophagy in cancer and cancer therapeutics
  CS Bhol, DP Panigrahi, PP Praharaj, KK Mahapatra, S Patra, SR Mishra, ...
  Seminars in cancer biology 66, 22-33 , 2020
  2020
  Citations: 75
• Terminalia bellirica extract induces anticancer activity through modulation of apoptosis and autophagy in oral squamous cell carcinoma
  S Patra, PK Panda, PP Naik, DP Panigrahi, PP Praharaj, CS Bhol, ...
  Food and Chemical Toxicology 136, 111073 , 2020
  2020
  Citations: 73
• Dysregulation of histone deacetylases in carcinogenesis and tumor progression: a possible link to apoptosis and autophagy
  S Patra, DP Panigrahi, PP Praharaj, CS Bhol, KK Mahapatra, SR Mishra, ...
  Cellular and molecular life sciences: CMLS 76 (17), 3263 , 2019
  2019
  Citations: 63
• Secretory clusterin promotes oral cancer cell survival via inhibiting apoptosis by activation of autophagy in AMPK/mTOR/ULK1 dependent pathway
  PP Naik, S Mukhopadhyay, PP Praharaj, CS Bhol, DP Panigrahi, ...
  Life Sciences 264, 118722 , 2021
  2021
  Citations: 52
• Bioactive compounds from marine invertebrates as potent anticancer drugs: the possible pharmacophores modulating cell death pathways
  S Patra, PP Praharaj, DP Panigrahi, B Panda, CS Bhol, KK Mahapatra, ...
  Molecular biology reports 47 (9), 7209-7228 , 2020
  2020
  Citations: 45
• Molecular interplay of autophagy and endocytosis in human health and diseases
  KK Mahapatra, DP Panigrahi, PP Praharaj, CS Bhol, S Patra, SR Mishra, ...
  Biological Reviews 94 (4), 1576-1590 , 2019
  2019
  Citations: 45
• Monitoring and measuring mammalian autophagy
  SK Bhutia, PP Praharaj, CS Bhol, DP Panigrahi, KK Mahapatra, S Patra, ...
  Autophagy in Differentiation and Tissue Maintenance: Methods and Protocols … , 2018
  2018
  Citations: 39
• Bacopa monnieri inhibits apoptosis and senescence through mitophagy in human astrocytes
  S Saha, KK Mahapatra, SR Mishra, S Mallick, VD Negi, I Sarangi, S Patil, ...
  Food and Chemical Toxicology 141, 111367 , 2020
  2020
  Citations: 31
• mTOR inhibitors in targeting autophagy and autophagy-associated signaling for cancer cell death and therapy
  PK Senapati, KK Mahapatra, A Singh, SK Bhutia
  Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1880 (3), 189342 , 2025
  2025
  Citations: 29
• Inflammasomes in cancer: Effect of epigenetic and autophagic modulations
  SR Mishra, KK Mahapatra, BP Behera, CS Bhol, PP Praharaj, ...
  Seminars in Cancer Biology 83, 399-412 , 2022
  2022
  Citations: 28
• Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate
  S Patra, KK Mahapatra, PP Praharaj, DP Panigrahi, CS Bhol, SR Mishra, ...
  Mitochondrion 57, 230-240 , 2021
  2021
  Citations: 20
• Molecular regulation of mitophagy signaling in tumor microenvironment and its targeting for cancer therapy
  BP Behera, SR Mishra, S Patra, KK Mahapatra, CS Bhol, DP Panigrahi, ...
  Cytokine & growth factor reviews , 2025
  2025
  Citations: 18