Khodijah Zulkiflee

@iium.edu.my

Lecturer in Department of Basic Medical Sciences (Medicine)
International Islamic University Malaysia

Khodijah Zulkiflee


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https://researchid.co/khodijah

EDUCATION

Bachelor of Medicine and Bachelor of Surgery (2012)
Master of Medical Sciences (2018)
Doctor of Philosophy (Medical Anatomy) (2024)

RESEARCH, TEACHING, or OTHER INTERESTS

Anatomy, Histology, Physiology (medical), Medicine
2

Scopus Publications

1

Scholar Citations

1

Scholar h-index

Scopus Publications

  • Vascular Ultrastructural Changes in Hypertensive Rodent Models: A 15-Year Scoping Review
    Malaysian Journal of Medicine and Health Sciences, 2025
  • Unaltered Long-Term Maternal Endothelin System in a Gestational Hypertensive Rat Model
    Khodijah Zulkiflee, Yusoff Sharizal Yusoff Azmi Merican, Maizura Mohd. Zainudin, Hidayatul Radziah Ismawi, Fadhilah Zainal Abidin, et al.
    Iium Medical Journal Malaysia, 2024
    INTRODUCTION: Cardiovascular diseases (CVDs) are two to four times more likely to affect women with a history of hypertensive disorders of pregnancy (HDPs). One of the etiologies of CVDs is endothelial dysfunction, which results from an imbalance in the production of endothelin-1 (ET-1) and nitric oxide (NO). Although blood pressure (BP) is normalized postpartum, we hypothesize that a transient increase in BP during HDPs may cause ongoing endothelial dysfunction. We aimed to discover the impact of HDPs in the development of cardiovascular diseases after long-term postpartum changes in endothelin-A receptor (ETAR) and endothelin-B receptor (ETBR) expression and the concentration of ET-1 and NO. MATERIALS AND METHOD: Twenty-four female Sprague-Dawley (SD) rats were assigned into four groups (n = 6), including two treatment and two control groups. All rats were sacrificed on Day 30 postpartum. The NO and ET-1 concentrations were determined by ELISA and the ETAR and ETBR expression of the mesenteric arteries were measured by immunohistochemistry studies. RESULTS: The mean concentrations of ET-1 and NO were not significantly different in all groups. There was no significant difference in the mean immunoreactivity of ETAR and ETBR percentages area in the tunica intima and media in all groups. CONCLUSION: No evidence demonstrates significant changes in the endothelin system of the resistance arteries at the proteomic level in the long-term duration following HDP. Further investigation of its potential chronic effect warrants a deeper analysis at the molecular and ultrastructural levels.

RECENT SCHOLAR PUBLICATIONS

  • Vascular Ultrastructural Changes in Hypertensive Rodent Models: A 15-Year Scoping Review
    HR Ismawi, K Zulkiflee, YSYA Merican, MM Zainudin, A Abd Fuaat, ...
    Malaysian Journal of Medicine and Health Sciences 21 (5), 302-309 , 2025
    2025
  • Endothelial Dysfunction and Pregnancy-Induced Hypertension: A Bibliometric Analysis (2000–2024).
    HR Ismawi, MM Zainudin, K Zulkiflee
    Asian Journal of Medicine & Health Sciences 8 (1) , 2025
    2025
  • Unaltered Long-Term Maternal Endothelin System in a Gestational Hypertensive Rat Model
    K Zulkiflee, YSYA Merican, MM Zainudin, HR Ismawi, FZ Abidin, AA Fuaat
    IIUM Medical Journal Malaysia 23 (01) , 2024
    2024
  • Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in pregnant rat model: An analysis on the effectiveness of administration methods to induce high …
    K Zulkiflee, Y Merican, MM Zainudin, FZ Abidin, HR Ismawi
    International Journal of Cardiology 345, 21 , 2021
    2021
    Citations: 1
  • A METHOD REVIEW OF SURGICALLY INDUCED HYPERTENSION IN PREGNANT RATS MODEL: MODIFIED REDUCED UTERINE PERFUSION PRESSURE (RUPP)
    K Zulkiflee, MM Zainudin, FZ Abidin, HR Ismawi, YSYA Merican
    International Journal of Allied Health Sciences 5 (1), 2161-2161 , 2021
    2021
  • Topographical Changes of Rat's Colonic Mucosal After Chronic Arsenic Exposure-A Scanning Electron Microscopy Study
    K Zulkiflee, Z Buyong, AH Hamdan, S Saharudin, WMSW Salleh
    IIUM Medical Journal Malaysia 17 (1) , 2018
    2018
  • The Illustration of a Rat Large Intestine: A Model for the Effect of Carcinogens
    K Zulkiflee, Z Buyong, AH Hamdan
    IIUM Medical Journal Malaysia 16 (1) , 2017
    2017

MOST CITED SCHOLAR PUBLICATIONS

  • Nω-nitro-L-arginine methyl ester hydrochloride (L-NAME) induced hypertension in pregnant rat model: An analysis on the effectiveness of administration methods to induce high …
    K Zulkiflee, Y Merican, MM Zainudin, FZ Abidin, HR Ismawi
    International Journal of Cardiology 345, 21 , 2021
    2021
    Citations: 1
  • Vascular Ultrastructural Changes in Hypertensive Rodent Models: A 15-Year Scoping Review
    HR Ismawi, K Zulkiflee, YSYA Merican, MM Zainudin, A Abd Fuaat, ...
    Malaysian Journal of Medicine and Health Sciences 21 (5), 302-309 , 2025
    2025
  • Endothelial Dysfunction and Pregnancy-Induced Hypertension: A Bibliometric Analysis (2000–2024).
    HR Ismawi, MM Zainudin, K Zulkiflee
    Asian Journal of Medicine & Health Sciences 8 (1) , 2025
    2025
  • Unaltered Long-Term Maternal Endothelin System in a Gestational Hypertensive Rat Model
    K Zulkiflee, YSYA Merican, MM Zainudin, HR Ismawi, FZ Abidin, AA Fuaat
    IIUM Medical Journal Malaysia 23 (01) , 2024
    2024
  • A METHOD REVIEW OF SURGICALLY INDUCED HYPERTENSION IN PREGNANT RATS MODEL: MODIFIED REDUCED UTERINE PERFUSION PRESSURE (RUPP)
    K Zulkiflee, MM Zainudin, FZ Abidin, HR Ismawi, YSYA Merican
    International Journal of Allied Health Sciences 5 (1), 2161-2161 , 2021
    2021
  • Topographical Changes of Rat's Colonic Mucosal After Chronic Arsenic Exposure-A Scanning Electron Microscopy Study
    K Zulkiflee, Z Buyong, AH Hamdan, S Saharudin, WMSW Salleh
    IIUM Medical Journal Malaysia 17 (1) , 2018
    2018
  • The Illustration of a Rat Large Intestine: A Model for the Effect of Carcinogens
    K Zulkiflee, Z Buyong, AH Hamdan
    IIUM Medical Journal Malaysia 16 (1) , 2017
    2017