Eulerian–Lagrangian and thin film modeling of drug delivery under physiologically varying breathing in a realistic lung model Sameer Kumar Verma, Saurabh Bhardwaj, Kishore Singh Patel, B. Kiran Naik Physics of Fluids, 2026 This work presents a computational approach to investigate antiviral aerosol deposition in anatomically realistic human airways under various physiological inhalation conditions. Antiviral drugs are represented as fine droplets that form a thin coating on airway surfaces, primarily targeting early infection sites. The suggested method combines an Eulerian–Lagrangian discrete phase model (DPM) to track droplet motion and an Eulerian wall film (EWF) model to mimic the evolution of deposited liquid films. This combination effectively addresses the shortcomings of previous studies that employed DPM exclusively, which ignored the post-deposition redistribution dynamics of liquid drugs on airway surfaces. To the best of our knowledge, this is the first study to integrate a DPM–EWF framework within a realistic airway model under both healthy and disease-specific inhalation conditions to predict drug delivery. The study assesses airflow parameters, film thickness, deposition efficiency, and surface area coverage for aerosol particles from 1 to 10 μm. Results reveal that distressed breathing patterns of chronic obstructive pulmonary disease patients significantly alter the deposition preferences between the upper (∼5.28%) and lower lobes (∼2.52%) compared to the equivalent ideal (upper: ∼3.31%, lower: ∼4.32%) and realistic healthy (upper: ∼3.80%, lower: ∼6.79%) inhalations. Moreover, the distressed breathing also limits the drug penetration into deeper generations, as the highest surface coverage is observed at the carinal region rather than the usual left lower lobe found in ideal and realistic healthy breathing cases. Such deposition contrasts highlight the importance of optimizing inhalation therapy and device designs for individuals with obstructive airway diseases.
Coupled Discrete Phase and Eulerian Wall Film Models for Drug Deposition Efficacy Analysis in Human Respiratory Airways Sameer Kumar Verma, Kishore Singh Patel, B. Kiran Naik Molecular Pharmaceutics, 2024 The current study explores the effectiveness of drug particle deposition into human respiratory airways to cure various pulmonary-bound ailments. It has been assumed that drug solutions are inhaled in the form of tiny droplets or mist, which after striking create a thin layer along the inner surface of airways where the virus initially resides to infect the human body. A coupled Eulerian wall film (EWF) and discrete phase model (DPM) based simulation approach is used to capture these dynamics. Here, the Lagrangian DPM technique tracks the dynamics of tiny droplets, while the liquid layer formation after striking is captured using the Eulerian thin film approximations or the EWF model. Previous studies in this field primarily employed only the DPM method, which is inadequate to predict the poststriking dynamics of drug layer deposition and their spread to neutralize the respiratory virus. The drug delivery effectiveness is characterized by three different particle sizes, 1, 5, and 10 μm at the inhalation rates of 15, 30, and 60 L per minute (LPM). It has been found that the size of the drug particles significantly influences drug delivery effectiveness. The film thickness increases monotonically with particle sizes and inhalation rates. However, this increase in averaged film thickness is prominent in the range 5 to 10 μm (≈60%) compared to 1 to 5 μm (≈10%) droplet sizes at generation level 4 (G4). The other deposition parameters, e.g., deposition fraction, deposition density, and area coverage) roughly show similar behavior with the increase in droplet sizes. Therefore, it is recommended to vary the droplet sizes between 5 and 10 μm for better deposition effectiveness. The sizes of more than 10 μm mostly stuck into the oral cavity and cannot reach the targeted generations. In contrast, less than 5 μm may reach much deeper generations than the targeted one.
Numerical investigations of superconducting material cooling using buoyancy-driven heat transport in cryogenic nanofluids S Nayak, A Bhattad, KS Patel Heat Transfer Engineering 47 (4-5), 412-427 , 2026 2026 Citations: 5
Eulerian–Lagrangian and thin film modeling of drug delivery under physiologically varying breathing in a realistic lung model SK Verma, S Bhardwaj, KS Patel, BK Naik Physics of Fluids 38 (2) , 2026 2026
Realistic Second-Order Analysis of Two-Stage Stirling Cryocooler with Real Gas Modeling and Enhanced Regenerator Method SR Mohanty, D Sahu, KS Patel, BK Naik, S Chandorkar 2026
Performance and feasibility analyses of evacuated U-tube solar collector driven humidification-condensation based wastewater recovery system M Sonkar, R Nayak, BK Naik, KS Patel Water-Energy Nexus 8, 255-280 , 2025 2025 Citations: 1
Single-Stage Stirling Cryocooler Performance Analysis Using the Regenerator Temperature Corrected Second Order Method SR Mohanty, S Ghosh, KS Patel, BK Naik Heat Transfer Engineering, 1-18 , 2025 2025
Sustainable Solar Thermal-Driven and Hydrophobic Membrane Type Freshwater Extraction System from Wastewater: Performance and Feasibility Analyses M Sonkar, R Nayak, BK Naik, KS Patel Water Conservation Science and Engineering 10 (2), 52 , 2025 2025 Citations: 2
A combined Eulerian-Lagrangian and thin film approximation model to investigate the disease-specific drug delivery efficacy on realistic lung geometry and breathing profiles SK Verma, S Bhardwaj, KS Patel, BK Naik bioRxiv, 2025.07. 01.662688 , 2025 2025
Holistic geometrical optimization and magnetic field orientation of single crystal tungsten-based magnetoresistive heat switch Y Bhausaheb Desale, SK Rathore, G Ranjan, BK Naik, KS Patel, ... Heat Transfer Engineering 46 (7), 627-644 , 2025 2025 Citations: 3
Optimized Multi-Response Enhanced CRO PUFs: Addressing Process Variation for Robust Hardware Security. BB Naik, JD Reddy, KS Patel International Journal on Communications Antenna & Propagation 15 (2), 122 , 2025 2025
Unveiling Aerosol Deposition Dynamics in a Disease-Specific Lung Model Under Realistic Breathing Pattern SK Verma, S Mitra, KS Patel, BK Naik 2025
Stirling Cryocooler Modeling Using Regenerator Temperature Corrected Second-Order Analysis SR Mohanty, KS Patel, BK Naik, S Chandorkar 2025
A Micro-Orifice Throttle Valve Design for The Joule-Thomson Cryocooler A Palatasingh, SR Mohanty, KS Patel, S Chandorkar 2025
Texture-based computations for processing volumetric dental image SK Verma, KS Patel, BK Naik, BC Neelapu Advances in Computers 136, 453-492 , 2025 2025
Sustainable wastewater recovery system employing geothermal energy–Performance and feasibility study M Sonkar, SK Pati, BK Naik, KS Patel Desalination and Water Treatment 320, 100674 , 2024 2024 Citations: 2
Coupled discrete phase and Eulerian Wall Film Models for drug deposition efficacy analysis in human respiratory airways SK Verma, KS Patel, BK Naik Molecular Pharmaceutics 21 (10), 5071-5087 , 2024 2024 Citations: 4
Performance Analysis of Compact Joule-Thomson Cryocooler Using Aspen-HYSYS Optimization Tool A Palatasingh, SR Mohanty, KS Patel, S Chandorkar Indian Journal of Cryogenics 49 (1), 83-88 , 2024 2024
Second-order Study of Micro-Stirling Cryocooler with Corrected Regenerator Temperature: Performance and Loss Analysis SR Mohanty, A Palatasing, KS Patel, BK Naik, S Chandorkar 2024
Pressurized Metered Dose Inhaler-Based Analysis of Pulmonary Drug Delivery Using the Coupled Discrete Phase and Eulerian Wall Film Model SK Verma, KS Patel, BK Naik 2024
Superconducting Material Cooling Using Buoyancy Driven Heat Transport in Cryogenic Nanofluids S Nayak, A Bhattad, KS Patel 2024 Citations: 1
Inhaler-based Human Pulmonary Drug Delivery Analysis using the Combined Discrete Phase and Eulerian Wall Film Models SK Verma, KS Patel, BK Naik Conference on Fluid Mechanics and Fluid Power, 193-207 , 2023 2023
MOST CITED SCHOLAR PUBLICATIONS
Computational study on metal hydride based three-stage hydrogen compressor P Muthukumar, KS Patel, P Sachan, N Singhal International Journal of Hydrogen Energy 37 (4), 3797-3806 , 2012 2012 Citations: 50
A critical review on mechanical heat switches for engineering and space applications BR Ram, V Malik, BK Naik, KS Patel Heat Transfer Engineering 44 (19), 1789-1802 , 2023 2023 Citations: 13
Performance analysis of diesel engine using madhuca longifolia blended biodiesel with nano-additive for variable parameters A Bhattad, KS Patel International Journal of Ambient Energy, 1-46 , 2023 2023 Citations: 11
Perceptions about oral liquid medication dosing devices and dosing errors by caregivers of hospitalized children MD Buddhadev, KS Patel, VJ Patel, SP Bhatt, SS Deshpande J Pharm Res 10 (12), 810-813 , 2016 2016 Citations: 7
Numerical investigations of superconducting material cooling using buoyancy-driven heat transport in cryogenic nanofluids S Nayak, A Bhattad, KS Patel Heat Transfer Engineering 47 (4-5), 412-427 , 2026 2026 Citations: 5
Coupled discrete phase and Eulerian Wall Film Models for drug deposition efficacy analysis in human respiratory airways SK Verma, KS Patel, BK Naik Molecular Pharmaceutics 21 (10), 5071-5087 , 2024 2024 Citations: 4
Holistic geometrical optimization and magnetic field orientation of single crystal tungsten-based magnetoresistive heat switch Y Bhausaheb Desale, SK Rathore, G Ranjan, BK Naik, KS Patel, ... Heat Transfer Engineering 46 (7), 627-644 , 2025 2025 Citations: 3
Computational investigation of cooling capacity of the cryogen based nanofluids D Bramhaiah, KS Patel, A Bhattad Proceedings of the 28th national symposium on cryogenics and … , 2022 2022 Citations: 3
Sustainable Solar Thermal-Driven and Hydrophobic Membrane Type Freshwater Extraction System from Wastewater: Performance and Feasibility Analyses M Sonkar, R Nayak, BK Naik, KS Patel Water Conservation Science and Engineering 10 (2), 52 , 2025 2025 Citations: 2
Sustainable wastewater recovery system employing geothermal energy–Performance and feasibility study M Sonkar, SK Pati, BK Naik, KS Patel Desalination and Water Treatment 320, 100674 , 2024 2024 Citations: 2
Development of empirical correlations for assessing the CuAlMn based shape memory alloy thermal switch phase transition temperatures BR Ram, V Malik, BK Naik, KS Patel, VK Singh Sādhanā 48 (3), 189 , 2023 2023 Citations: 2
Thermal performance assessment of tungsten based magneto-resistive heat switch at different oblique plane angles for space application G Ranjan, YB Desale, KS Patel, BK Naik, VK Singh Indian J. Cryogen 47 (1), 84-92 , 2022 2022 Citations: 2
Critical Review on Mechanical Heat Switches for Space Applications B Raghu Ram, V Malik, BK Naik, KS Patel 2022 Citations: 2
Numerical simulation of breakup and detachment of an axially stretching Newtonian liquid bridge with a moving contact line phase field method KS Patel, RK Shukla Sādhanā 42 (4), 467-477 , 2017 2017 Citations: 2
Performance and feasibility analyses of evacuated U-tube solar collector driven humidification-condensation based wastewater recovery system M Sonkar, R Nayak, BK Naik, KS Patel Water-Energy Nexus 8, 255-280 , 2025 2025 Citations: 1
Superconducting Material Cooling Using Buoyancy Driven Heat Transport in Cryogenic Nanofluids S Nayak, A Bhattad, KS Patel 2024 Citations: 1
Analysis of inhaler-based pulmonary drug particles depositions using coupled discrete phase and eulerian wall film models SK Verma, KS Patel, BK Naik International Conference on Medical Image Computing and Computer-Assisted … , 2023 2023 Citations: 1
Eulerian–Lagrangian and thin film modeling of drug delivery under physiologically varying breathing in a realistic lung model SK Verma, S Bhardwaj, KS Patel, BK Naik Physics of Fluids 38 (2) , 2026 2026
Realistic Second-Order Analysis of Two-Stage Stirling Cryocooler with Real Gas Modeling and Enhanced Regenerator Method SR Mohanty, D Sahu, KS Patel, BK Naik, S Chandorkar 2026
Single-Stage Stirling Cryocooler Performance Analysis Using the Regenerator Temperature Corrected Second Order Method SR Mohanty, S Ghosh, KS Patel, BK Naik Heat Transfer Engineering, 1-18 , 2025 2025