Khaled S. Abd-Elrahman

@ucalgary.ca

Smooth Muscle Research Group, Cumming School of Medicine
University of Calgary in Alberta

Khaled S. Abd-Elrahman


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https://researchid.co/kshabdel
61

Scopus Publications

1387

Scholar Citations

23

Scholar h-index

36

Scholar i10-index

Scopus Publications

RECENT SCHOLAR PUBLICATIONS

  • Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Muscarinic Receptor Modulation Revealed by Peptidisc-Enabled DIA-MS
    A Bhattacharya, F Antony, H Aoki, M Babu, SSG Ferguson, ...
    Journal of Proteome Research , 2026
    2026
    Citations: 1
  • An optimized protocol for single-brain isolation of sex-defined pure mouse astrocyte cultures
    S Al-Jaf, EH Ai, JA Wilson, KS Abd-Elrahman
    bioRxiv, 2026.03. 23.713747 , 2026
    2026
  • Role of Endocannabinoid System Perturbation in Organophosphate‐Mediated Metabolic Impairment and Neuroinflammation
    RE Arida, DM Elgameel, W Bassiouni, V Sandilya, SM Abdallah, ...
    Basic & Clinical Pharmacology & Toxicology 138 (3), e70198 , 2026
    2026
  • Neuroglial Function and Hormonal Modulation in Neurodegenerative Diseases: The Influence of Sex Hormones
    MM Alhajeri, Y Abukhaled, RR Alkhanjari, W Bassiouni, H Al-Ali, A Baig, ...
    Cellular and Molecular Neurobiology , 2026
    2026
    Citations: 2
  • Exploring the Sex-Specific Role of Astroglial mGluR5 in Alzheimer's Disease
    S Aljaf, KS Abd-Elrahman
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY 104 , 2026
    2026
  • 阿尔茨海默病治疗前景: 现有疗法和新兴机制的靶向疗法
    E Yang, KS Abd-Elrahman
    中国神经再生研究 (英文版) 20 (12), 3531 , 2025
    2025
  • Alzheimer’s disease treatment landscape: current therapies and emerging mechanism-targeted approaches
    E Yang, KS Abd-Elrahman
    Neural Regeneration Research 20 (12), 3531-3532 , 2025
    2025
    Citations: 5
  • Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production
    AA Kasongo, V Vijithakumar, KS Abd-Elrahman, R Prabhune, L Gharibeh, ...
    Journal of Lipid Research 66 (9) , 2025
    2025
    Citations: 1
  • Positive Allosteric Modulation of M1 mAChRs with VU0486846 Reverses Cognitive Deficits in Male APPswe/PSEN1ΔE9 Alzheimer’s Mice
    KS Ibrahim, TLL Colson, SSG Ferguson, KS Abd-Elrahman
    Neuropharmacology, 110654 , 2025
    2025
    Citations: 2
  • Breaking free from opioids: A turning point in acute pain management
    KS Abd-Elrahman, CD Peterson, ER Gross, B Greenwood-Van Meerveld
    The Journal of Pharmacology and Experimental Therapeutics 392 (8) , 2025
    2025
  • Enhancing remyelination in multiple sclerosis via M1 muscarinic acetylcholine receptor
    K Chen, E Park, KS Abd-Elrahman
    Molecular Pharmacology 107 (4), 100027 , 2025
    2025
    Citations: 14
  • Beyond weight loss: Exploring the neurological ramifications of altered gut microbiota post-bariatric surgery
    RT Almheiri, B Hajjar, SMI Alkhaaldi, N Rabeh, S Aljoudi, ...
    Journal of Translational Medicine 23 (1), 223 , 2025
    2025
    Citations: 13
  • Unveiling the interplay: neurovascular coupling, astrocytes and G Protein-Coupled receptors in alzheimer’s disease
    S Al-Jaf, AY Soliman, AF El-Yazbi, KS Abd-Elrahman
    ACS Pharmacology & Translational Science 8 (2), 271-285 , 2025
    2025
    Citations: 6
  • Minor cannabinoids as an emerging frontier for pain relief
    MJ Ippolito, ER Gross, KS Abd-Elrahman
    The Journal of Pharmacology and Experimental Therapeutics 391 (2), 132 , 2024
    2024
    Citations: 1
  • 大脑中 G 蛋白偶联受体信号传导的两性异形
    S Aljoudi, H Hamdan, KS Abd-Elrahman
    中国神经再生研究 (英文版) 19 (8), 1635 , 2024
    2024
  • 1641 Role of fullerenols derivative 3HFWC in the treatment of Alzheimer’s
    R Gómez-Oliva, P Nunez-Abades, C Castro, H Ohm, S Rey, C Klämbt, ...
    NEURAL REGENERATION RESEARCH 19 (8), 1625 , 2024
    2024
  • Sexual dimorphism of G protein-coupled receptor signaling in the brain
    S Aljoudi, H Hamdan, KS Abd-Elrahman
    Neural Regeneration Research 19 (8), 1635-1636 , 2024
    2024
    Citations: 5
  • A positive allosteric modulator of M1 Acetylcholine receptors improves cognitive deficits in male and female Alzheimer’s mice
    K Abd-Elrahman, TL Colson, S Ferguson
    The Journal of Pharmacology and Experimental Therapeutics 389, 352 , 2024
    2024
  • A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer’s mice
    KS Abd-Elrahman, TLL Colson, S Sarasija, SSG Ferguson
    Biomedicine & Pharmacotherapy 173, 116388 , 2024
    2024
    Citations: 11
  • Emerging insights in glutamate receptor signaling in psychiatric, neurodevelopmental, and neurodegenerative diseases
    KS Abd-Elrahman, JM Beaulieu, SSG Ferguson
    Frontiers in Cell and Developmental Biology 12, 1388514 , 2024
    2024

MOST CITED SCHOLAR PUBLICATIONS

  • Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer’s disease model mice in a sex-selective manner
    KS Abd-Elrahman, A Albaker, JM de Souza, FM Ribeiro, ...
    Science signaling 13 (662), eabd2494 , 2020
    2020
    Citations: 99
  • mGluR5 antagonism increases autophagy and prevents disease progression in the zQ175 mouse model of Huntington’s disease
    KS Abd-Elrahman, A Hamilton, SR Hutchinson, F Liu, RC Russell, ...
    Science signaling 10 (510), eaan6387 , 2017
    2017
    Citations: 92
  • Noncanonical metabotropic glutamate receptor 5 signaling in Alzheimer's disease
    KS Abd-Elrahman, SSG Ferguson
    Annual Review of Pharmacology and Toxicology 62, 235-254 , 2022
    2022
    Citations: 82
  • Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington’s pathology in zQ 175 mice
    KS Abd-Elrahman, SSG Ferguson
    Molecular brain 12 (1), 35 , 2019
    2019
    Citations: 77
  • Stromatoxin‐sensitive, heteromultimeric Kv2. 1/Kv9. 3 channels contribute to myogenic control of cerebral arterial diameter
    XZ Zhong, KS Abd‐Elrahman, CH Liao, AF El‐Yazbi, EJ Walsh, MP Walsh, ...
    The Journal of physiology 588 (22), 4519-4537 , 2010
    2010
    Citations: 76
  • Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models
    KS Abd-Elrahman, A Hamilton, M Vasefi, SSG Ferguson
    Molecular Brain 11 (1), 19 , 2018
    2018
    Citations: 63
  • mGluR5 contribution to neuropathology in Alzheimer mice is disease stage-dependent
    KS Abd-Elrahman, A Hamilton, A Albaker, SSG Ferguson
    ACS pharmacology & translational science 3 (2), 334-344 , 2020
    2020
    Citations: 55
  • Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases
    SH Li, KS Abd-Elrahman, SSG Ferguson
    Pharmacology & therapeutics 239, 108275 , 2022
    2022
    Citations: 50
  • PKC-mediated cerebral vasoconstriction: Role of myosin light chain phosphorylation versus actin cytoskeleton reorganization
    AF El-Yazbi, KS Abd-Elrahman, A Moreno-Dominguez
    Biochemical pharmacology 95 (4), 263-278 , 2015
    2015
    Citations: 49
  • Pioglitazone abrogates cyclosporine-evoked hypertension via rectifying abnormalities in vascular endothelial function
    MM El-Mas, HM El-Gowelli, KS Abd-Elrahman, EI Saad, AGA Abdel-Galil, ...
    Biochemical pharmacology 81 (4), 526-533 , 2011
    2011
    Citations: 49
  • Amelioration of perivascular adipose inflammation reverses vascular dysfunction in a model of nonobese prediabetic metabolic challenge: potential role of antidiabetic drugs
    MAW Elkhatib, A Mroueh, RW Rafeh, F Sleiman, H Fouad, EI Saad, ...
    Translational Research 214, 121-143 , 2019
    2019
    Citations: 48
  • mGluR5 allosteric modulation promotes neurorecovery in a 6-OHDA-toxicant model of Parkinson’s disease
    K Farmer, KS Abd-Elrahman, A Derksen, EM Rowe, AM Thompson, ...
    Molecular Neurobiology 57 (3), 1418-1431 , 2020
    2020
    Citations: 46
  • Podocyte NADPH oxidase 5 promotes renal inflammation regulated by the toll-like receptor pathway
    CE Holterman, NC Boisvert, JF Thibodeau, E Kamto, M Novakovic, ...
    Antioxidants & redox signaling 30 (15), 1817-1830 , 2019
    2019
    Citations: 44
  • The role of neuroglial metabotropic glutamate receptors in Alzheimer’s disease
    KS Abd-Elrahman, S Sarasija, SSG Ferguson
    Current neuropharmacology 21 (2), 273-283 , 2023
    2023
    Citations: 40
  • A positive allosteric modulator for the muscarinic receptor (M1 mAChR) improves pathology and cognitive deficits in female APPswe/PSEN1ΔE9 mice
    KS Abd‐Elrahman, S Sarasija, TLL Colson, SSG Ferguson
    British Journal of Pharmacology 179 (8), 1769-1783 , 2022
    2022
    Citations: 39
  • ROK and arteriolar myogenic tone generation: molecular evidence in health and disease
    AF El-Yazbi, KS Abd-Elrahman
    Frontiers in pharmacology 8, 87 , 2017
    2017
    Citations: 37
  • Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention
    W Fakih, R Zeitoun, I AlZaim, AH Eid, F Kobeissy, KS Abd‐Elrahman, ...
    Obesity 30 (5), 982-993 , 2022
    2022
    Citations: 36
  • mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease
    JM de Souza, KS Abd-Elrahman, FM Ribeiro, SSG Ferguson
    Molecular brain 13 (1), 118 , 2020
    2020
    Citations: 34
  • The pleiotropic effects of antithrombotic drugs in the metabolic–cardiovascular–neurodegenerative disease continuum: impact beyond reduced clotting
    RA Alaaeddine, I AlZaim, SH Hammoud, A Arakji, AH Eid, ...
    Clinical Science 135 (8), 1015-1051 , 2021
    2021
    Citations: 27
  • Targeting vesicular glutamate transporter machinery: implications on metabotropic glutamate receptor 5 signaling and behavior
    KS Ibrahim, KS Abd-Elrahman, S El Mestikawy, SSG Ferguson
    Molecular pharmacology 98 (4), 314-327 , 2020
    2020
    Citations: 26