Kumud Joshi
@dituniversity.edu.in
Assistant Professor
DIT University
RESEARCH INTERESTS
Frostbite, Wound Healing
Scopus Publications
Scopus Publications
Kumud Joshi, Bhaskar Mazumder, Pronobesh Chattopadhyay, Danswrang Goyary, Madhubanti Das, and Sanjai Kumar Dwivedi
Informa UK Limited
OBJECTIVE
Development of Frostbite healing hydrogel of manuka honey and hyaluronic acid.
SIGNIFICANCE
Frostbite is a cold-induced ischemic vascular injury non-responsive to most of the wound healing products. Thrombus induced ischemia is main cause of frostbite related necrosis. Hyaluronic acid is known to possess significant antithrombotic and wound healing activity. Moreover Manuka Honey is also rich in flavonoids and polyphenols with potential antithrombotic activity. These two agents were together utilized to develop a frostbite healing formulation.
METHODS
In Silico antithrombotic efficacy of major phytoconstituents of manuka honey was evaluated using in silico- docking studies against Tissue plasminogen activator and Cyclooxigenase-1 protein. Further in-vivo frostbite healing evaluation was carried out in wistar rat, by inducing frostbite with super cooled rod.
RESULTS
The results indicate that major leptosin and other major phytoconstituent of manuka honey has significant antithrombotic property. The hydrogel formulation of HA and MH possess significant antimicrobial efficacy. The wound contraction studies and histopathological evaluation reveals that the hydrogel also has a good frostbite healing activity showing complete wound healing within 18 day period. The findings of the western blotting studies suggest that the hydrogel acts by VEGF- NRF-2 pathway.
CONCLUSION
This result implies that the prepared hydrogel can serve as an effective frostbite healing formulation.
Kumud Joshi, Danswrang Goyary, Bhaskar Mazumder, Pronobesh Chattopadhyay, Reshmi Chakraborty, Y.D. Bhutia, Sanjeev Karmakar, and Sanjai Kumar Dwivedi
Elsevier BV
Kumud Joshi, Danswrang Goyary, Bhaskar Mazumder, Sumit Kishor, Piyali Dey, Yangchen Doma Bhutia, Sanjeev Karmakar, Pronobesh Chattopadhyay, and Sanjai Kumar Dwivedi
Defence Scientific Information and Documentation Centre
Frostbite is a cold induced injury which occurs due to exposure of a particular site of body to sub-zero temperature. One of the primary reasons for lack of proper studies about the underlying mechanism of frostbite injury is due to non-availability of any reliable animal model and method for inflicting frostbite. In our current research, a device was designed and standardised to inflict frostbite wound in wistar rat. A formulation comprising different combination of essential oils was also developed and its activity was assessed and found effective in the treatment of frostbite wound.
Kumud Joshi, Bhaskar Mazumder, Pronobesh Chattopadhyay, Nilutpal Sharma Bora, Danswrang Goyary, and Sanjeev Karmakar
Bentham Science Publishers Ltd.
Graphene in nano form has proven to be one of the most remarkable materials. It has a single atom thick molecular structure and it possesses exceptional physical strength, electrical and electronic properties. Applications of the Graphene Family of Nanomaterials (GFNs) in different fields of therapy have emerged, including for targeted drug delivery in cancer, gene delivery, antimicrobial therapy, tissue engineering and more recently in more diseases including HIV. This review seeks to analyze current advances of potential applications of graphene and its family of nano-materials for drug delivery and other major biomedical purposes. Moreover, safety and toxicity are the major roadblocks preventing the use of GFNs in therapeutics. This review intends to analyze the safety and biocompatibility of GFNs along with the discussion on the latest techniques developed for toxicity reduction and biocompatibility enhancement of GFNs. This review seeks to evaluate how GFNs in future will serve as biocompatible and useful biomaterials in therapeutics.
Sanjay Dey, Kumud Joshi, and Bhaskar Mazumder
Springer Singapore
Pharmacogenomics is receiving a lot of attention for its potential clinical applications in preventive as well as personalized medicine. Pharmacogenomics provides a tool to determine the genetic makeup of individuals and help in establishing relevant genotype-phenotype correlation. This knowledge may uncover the predisposition of patients toward specific disease conditions like diabetes and cardiovascular diseases. It can also be used to gauge the possibility of toxicities of specific drugs in patients and, consequently, assist in the modification of therapy for such patients to improve clinical outcome. In this chapter, we study the current status of pharmacogenomics and its future prospects of how it will impact the current clinical practices for better therapy.