Md Kamaruz Zaman
@dibru.ac.in
Assistant Professor, Department of Pharmaceutical Sciences
Dibrugarh University
Dr. Md Kamaruz Zaman is presently working as Assistant Professor in the Department of Pharmaceutical Sciences, Dibrugarh University. He has more than 18 years of experience in teaching and research. He has published 89 research and review papers in various peer reviewed national and international journals. He is also credited with two edited books and three book chapters published by reputed international publishers. He also delivered invited lectures and presented research papers in various national and international Seminers/ Conferences. Recently he has carried out three months Post doctoral research at University of South Florida, Tampa, USA under DBT Overseas Associateship Programme (01March – 31May 2019). He has guided 5 research scholars for the award of Ph.D under Dibrugarh University.
EDUCATION
M. Pharm., Ph.D.
RESEARCH INTERESTS
Herbal Drug Development, Pharmacology, Toxicology, Safety-efficacy assessment, and Quality control of Herbal Drugs
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Arpita Paul, Madhusmita Gogoi, and Kamaruz Zaman
Wiley
Gireesh Kumar Singh, Bindu Kumari, Nirupam Das, Kamaruz Zaman, Pratibha Prasad, and Ravi Bhushan Singh
Springer Science and Business Media LLC
Arpita Paul, Neelutpal Gogoi, Dipak Chetia, and Md. Kamaruz Zaman
Springer Science and Business Media LLC
Farak Ali, Shahnaz Alom, Nilayan Guha, Arpita Paul, and Md. Kamaruz Zaman
CRC Press
Mohit Kumar, Md. Kamaruz Zaman, Sanghita Das, Danswrang Goyary, Manash Pratim Pathak, and Pronobesh Chattopadhyay
Elsevier BV
Kamaruz Zaman, Pompy Patowary, Arpita Paul, Nilayan Guha, and Madhusmita Gogoi
CRC Press
Shahnaz Alom, Farak Ali, Dimpee Choudhury, Apurba Gohain, Abdul Baquee Ahmed, and Md Kamaruz Zaman
Springer International Publishing
Nilayan Guha and Md. Kamaruz Zaman
Springer International Publishing
Hemanga Hazarika, Harshita Krishnatreyya, Bedanta Bhattacharjee, Damanbhalang Rynjah, Dharmajit Gogoi, Abdul Baquee Ahmed, and Kamaruz Zaman
Springer International Publishing
Neelutpal Gogoi and Md. Kamaruz Zaman
Springer International Publishing
Arpita Paul, James H. Zothantluanga, Gourav Rakshit, Ismail Celik, Mithun Rudrapal, and Md. Kamaruz Zaman
Informa UK Limited
Sameeran Gam, Suman Kumar, Susankar Kushari, Rajat Subhra Dutta, Himangshu Sarma, Arpita Paul, and Md Kamaruz Zaman
Springer Science and Business Media LLC
Nilayan Guha and Md. Kamaruz Zaman
CRC Press
Arpita Paul and Md. Kamaruz Zaman
CRC Press
Arpita Paul, Mohit Kumar, Parikshit Das, Nilayan Guha, Mithun Rudrapal, and Md. Kamaruz Zaman
Elsevier BV
Hemanga Hazarika, Harshita Krishnatreyya, Varun Tyagi, Johirul Islam, Neelutpal Gogoi, Danswrang Goyary, Pronobesh Chattopadhyay, and Kamaruz Zaman
Springer Science and Business Media LLC
AbstractMosquito-borne infections like dengue, malaria, chikungunya, etc. are a nuisance and can cause profound discomfort to people. Due to the objectional side effects and toxicity associated with synthetic pyrethroids, N,N-diethyl-3-methylbenzamide (DEET), N,N-diethyl phenylacetamide (DEPA), and N,N-di ethyl benzamide (DEBA) based mosquito repellent products, we developed an essential oil (EO) based mosquito repellent cream (EO-MRC) using clove, citronella and lemongrass oil. Subsequently, a formulation characterization, bio-efficacy, and safety study of EO-MRC were carried out. Expression of Anti-OBP2A and TRPV1 proteins on mosquito head parts were studied by western blotting. In-silico screening was also conducted for the specific proteins. An FT-IR study confirmed the chemical compatibility of the EOs and excipients used in EO-MRC. The thermal behaviour of the best EOs and their mixture was characterized by thermogravimetric analysis (TGA). GC–MS examination revealed various chemical components present in EOs. Efficacy of EO-MRC was correlated with 12% N,N-diethyl benzamide (DEBA) based marketed cream (DBMC). Complete protection time (CPT) of EO-MRC was determined as 228 min. Cytotoxicity study on L-132 cell line confirmed the non-toxic nature of EO-MRC upon inhalation. Acute dermal irritation study, acute dermal dose toxicity study, and acute eye irritation study revealed the non-toxic nature of EO-MRC. Non-target toxicity study on Danio rerio confirmed EO-MRC as safer for aquatic non-target animals. A decrease in the concentration of acetylcholinesterase (AChE) was observed in transfluthrin (TNSF) exposed Wistar rats. While EO-MRC did not alter the AChE concentrations in the exposed animals. Results from western blotting confirmed that Anti-OBP2A and TRPV1 proteins were inhibited in TNSF exposed mosquitoes. Mosquitoes exposed to EO-MRC showed a similar expression pattern for Anti-OBP2A and TRPV1 as the control group. In silico study revealed eight identified compounds of the EOs play significant roles in the overall repellency property of the developed product. The study emphasizes the mosquito repellent activity of EO-MRC, which could be an effective, eco-friendly, and safer alternative to the existing synthetic repellents for personal protection against mosquitoes during field conditions.
This study aimed to investigate hepatoprotective and anti-inflammatory activities of the hydro-alcoholic extract of Oxalis debilis (ODHE) leaves. Acute oral toxicity evaluated ODHE in graded oral doses (100, 500, 1000, 3000, and 5000 mg/kg body weight) in rats. The hepatoprotective activity was evaluated in CCl4 intoxicated rats at 200 and 400 mg/kg body weight doses of ODHE, while anti-inflammatory activity was determined by carrageenan-induced paw edema in rats at 200, 400, 800 mg/kg body weight doses of ODHE. The ODHE was safe at the highest dose of 5000 mg/kg in experimental rats. In hepatoprotective activity, ODHE significantly reduced the serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TB) levels as compared to the CCl4control group. On the other hand, ODHE showed an anti-inflammatory effect similar to that of the control group in the carrageenan-induced paw edema model. The histopathological findings showed a significant difference between the ODHE (400 mg/kg) and CCl4 groups. The present experiment showed that ODHE has significant hepatoprotective and anti-inflammatory activities. Results confirm the use of O. debilis in folk medicine in the treatment of hepatotoxicity and inflammation.
Arpita Paul, Nilayan Guha, and Md Kamaruz Zaman
Wiley
Arpita Paul and Md. Kamaruz Zaman
Elsevier BV
Nilayan Guha, Arpita Paul, Johirul Islam, Malay K. Das, and Md. Kamaruz Zaman
Elsevier
Julfikar Ali Junejo, Kamaruz Zaman, Mithun Rudrapal, Ismail Celik, and Emmanuel Ifeanyi Attah
Elsevier BV
Farak Ali, Shahnaz Alom, and Md Kamaruz Zaman
Asian Journal of Chemistry
The isoquinoline compounds from alkaloidal class have been excellent source of important phytoconstituents having wide range of pharmacological activities. Berberine is a protoberberine alkaloidal compound obtained from Berberis genus plants which belongs to family Barberidaceae. Due to its unique structural properties, berberine and its derivatives has been exploited extensively for its potential uses in various pharmacological targets such as cancer, inflammation, diabetes, gastrointestinal disorder, viral and microbial infections, neurological disorder like Alzheimer, anxiety, schizophrenia, depression, etc. This review illustrates the updated information on berberine with respect to its isolation, biosynthesis, chemical synthesis, structural modification and pharmacological activities. An extensive literature search were carried out in various search engine like PubMed, Google Scholars, Research Gate and SCOPUS by using keywords like Berberine, protoberberine alkaloids, isoquinoline derivatives, pharmacological effects, etc. Prephenic acid is the starting material for biosynthesis of berberine. Structural modifications lead to generation of various potential derivatives, which earn patents by researchers. Besides toxicities, the complications of low solubility and bioavailability should be eliminated. To improve its safety, efficacy and selectivity the berberine should be carefully derivatized.
Julfikar Ali Junejo, Mithun Rudrapal, and Kamaruz Zaman
Springer Singapore
Arpita Paul, Monami Rajiung, Kamaruz Zaman, Sushil K. Chaudhary, Hans R. Bhat, and Anshul Shakya
Bentham Science Publishers Ltd.
Background: Morus alba Linn. commonly known as white mulberry, belongs to the family Moraceae, and is a promising traditional medicine. In Asia, besides its use in the preparation of delicacies, every part of this plant is utilized in traditional medicine. Over the past decade, studies related to the identification and isolation of biologically active compounds, with flavonoids as the major class of phytoconstituents, from this plant have been reported. These phytoconstituents are not only found to be beneficial for the maintenance of general health but also are associated with a range of potential pharmacological activities such as antioxidant, anti-inflammatory, anti- diabetic, anticancer, hepatoprotective, cardioprotective, neuroprotective to name a few. Objective: This review aims to provide upgraded and comprehensive information regarding the phytochemical, ethnomedicinal use and pharmacological profile of the plant Morus alba Linn. Method: The significant information has been collected through various databases viz. PubMed, Scopus, Web of Science, Science Direct based on the recent findings, using different terms of Morus alba. Results: The outcome of the study suggests that Morus alba is a multifunctional plant with numerous phytochemicals, and possesses a range of pharmacological activities. Conclusion: The data assembled on Morus alba will be beneficial to trigger research in various fields of pharmaceutical and allied sciences to explore the medicinal importance of this unique plant.
Pompy Patowary, Manash Pratim Pathak, Sumit Kishor, Probin Kumar Roy, Sanghita Das, Pronobesh Chattopadhyay, and Kamaruz Zaman
Elsevier BV
Cardiopulmonary functions such as respiratory depression, severe irritation, inflamed respiratory tract, hyperventilation and, tachycardia are the most affected ones when it comes to the riot control agent oleoresin capsicum (OC) exposure. However, no studies have been done to elucidate the mechanism underlying deterioration of the combined cardiopulmonary functions. Parameters such as acute respiratory, cardiac, parameters and ultrasonography (USG) measurements were investigated in an in vivo setup using Wistar rats at 1 h and 24 h post inhalation exposure to 2%, 6% and 10% OC, whereas, cell migration in rat peritoneal mast cells (RPMCs), metabolomics and eosinophil peroxidase (EPO) activity in bronchoalveolar lavage fluid (BALF) were investigated in an in vitro setup. Results obtained from electrophysiological recording indicated that OC exposure produces apnea and decrease in mean arterial pressure (MAP) was obtained from hemodynamic parameters whereas cardiac parameters assessment revealed increase in the level of cardiac output (CO) and decrease in stroke volume (SV) with recovery towards the post-exposure period. A decrease in the percentage area of certain fatty acid pathway metabolites in BALF appropriately linked the lung injury following OC exposure which was further cemented by increasing concentration of EPO. Histopathology and SEM also proved to be favorable techniques for the detection of OC induced physiological cardiac and pulmonary modifications respectively. Furthermore, Boyden chamber experiment established the chemoattractant property of OC. It may be concluded from the above studies that these newly reported facets may be utilized pharmacologically to mitigate cardiopulmonary adverse effects owing to OC exposure.