LALCHAND DAYANAND DEVHARE
@manwatkarcop.com
Principal in Pharmacy Department
Manwatkar College of Pharmacy, Ghodpeth, Chandrapur
D. Devhare graduated from Sharad Powar college of Pharmacy Nagpur in 2013 with a B. Pharm in Pharmaceutical Sciences and Post graduated from same college in 2015 with a M. Pharm in Quality Assurance and Doctorate from Oriental University Indore in 2023 with Ph. D.
The author also has a qualification such as DNYS, PGDBM, PGDFSQM and BEMS. At present the author is working as Principal at Manwatkar College of Pharmacy, Ghodpeth, Chandrapur, Maharashtra, India. He has more than 30 publication in various reputed national and international journals, attained more than 25 conferences worldwide, Grant 11 patent in different country, Life member in different association and Award received “Bharat Gaurav Puraskar”, “ Ambedkar Manavi Hakk Puraskar” “India Proud Book of Records” & “Best Paper Award”. As well as he is an author of another 11 books.
EDUCATION
Graduated from Sharad Powar College of Pharmacy Nagpur in 2013 with a B. Pharm in Pharmaceutical Sciences and Post graduated from the same college in 2015 with an M. Pharm in Quality Assurance and Doctorate from Oriental University Indore in 2023 with Ph. D.
The author also qualifies such as DNYS, PGDBM, PGDFSQM, and BEMS.
RESEARCH, TEACHING, or OTHER INTERESTS
Medicine, Multidisciplinary, Health Informatics, General Medicine
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
M Gnana Ruba Priya, Lal Prasanth ML, Lalchand D Devhare, Shaik K Yazdan, and Sachinkumar Gunjal
Dr. Yashwant Research Labs Pvt. Ltd.
In a research study, a metal-based complex demonstrated anticancer properties. The process involved the synthesis of a compound called 7-chloro-N-[5-(diethylamino)pentan-2-yl]-N-[sulfanyl(carbonothioyl)]quinolyn-4-amine, which incorporated a primaquine-based dithiocarbamate ligand. This synthesis method utilized sodium hydroxide and carbon disulfide at temperatures of 0 to 5℃. Nickel(II), copper(II), and zinc(II) ions were employed as the metal-complexed ligands through various chromatographic and spectroscopic techniques that enhanced their purity. Metal compounds, such as cisplatin and its analogs, were widely used to treat different cancer types. Presently, researchers are exploring alternative metal-based complexes as potential agents against cancer, aiming to mitigate toxic effects linked to medications made of platinum. Investigations conducted in-silico revealed that the ligand preferred interacting with DNA’s minor groove, assembling a single hydrogen bond between an adenine hydrogen atom and the oxygen element of the carbonyl compound in the pyrrolidinone unit. Compared to cisplatin, copper complexes can overcome drug resistance by lowering their toxicity. The findings indicate that these primaquine analogs have the potential to lay the foundation for a novel and efficacious category of cancer chemotherapeutics.
Bobde K Shriram, Lalchand D Devhare, Archana Mehrotra, Savita S Deokar, and Surya P Singh
Dr. Yashwant Research Labs Pvt. Ltd.
Most of mosquito-repellent products and devices are made up of synthetic materials presenting market which causes various harmful effects on human beings. The resistance can be developed by the mosquito due to continuous exposure at high doses. Hence, the present research work represents the development and evaluation of mosquito repellent sticks with the help of various herbal products such as starch powder, wood powder, charcoal powder, eucalyptus oil, coconut oil, lavender oil, lemongrass and cinnamon oil, peppermint and citronella, neem oil making them ozone-friendly, financial effective, non-harmful.
Anil K. Adimulapu, Lalchand D. Devhare, Anasuya Patil, Nilesh O. Chachda, and G. Dharmamoorthy
Dr. Yashwant Research Labs Pvt. Ltd.
Objectives: The purpose of the investigation was to extend and evaluate the novel mini tablet cap for treating cardiovascular disease at a desired combinational therapeutic activity and to improve patient compliance. A cheap four-in-one pill can guard against heart attacks and stroke. Methods and Materials: The drug product was manufactured by mini tablet cap technology. The technology was designed to initially use hydrochlorothiazide, simvastatin immediate release, metoprolol succinate, and asprin sustained release to reach the therapeutic levels at prolonged therapy. The two mini-bilayer tablets were prepared by wet granulation method and compression coated with a hydrophobic and hydrophilic polymer like ethyl cellulose and super disintegrating agents to release simvastatin and hydrochlorothiazide immediately. Results: Fourier transformer infrared spectroscopy (FTIR) studied the interaction studies of four chosen drugs. The mini tablet cap technology was designed as two mini bi-layer tablets in a capsule. The quantitative detection of four individual drugs was determined by using the RP-HPLC method. It was found that RP-HPLC is sensitive, reproducible, and valid for determining the mini tablet cap. The in-vitro drug release studies found that simvastatin and hydrochlorothiazide release 90% immediately within 20 minutes. Metoprolol and aspirin controlled the release for up to 24 hours, and drug release kinetics found that the drug release behavior of the optimized formulation followed first-order kinetics. Conclusion: The mini tablet cap is one of the best dosage forms to treat cardiovascular diseases. Because it was reported, the combination of these four drugs reduces mortality by 83% in high-risk patients with heart diseases, hypertension, diabetes, and obesity. The novel mini tablet cap approach data revealed a promising formula for improved relief of patient complaints during treatment or prevention of cardiovascular diseases
Gnana R. Priya M, Lalchand D. Devhare, G. Dharmamoorthy, Mahendra V. Khairnar, and R. Prasidha
Dr. Yashwant Research Labs Pvt. Ltd.
Novel (2-anilino-N-(4,6-dimethyl-1,3-Benzosulfonazol-2-yl) ethanamide derivatives were synthesized and characterized by spectroscopy methods. All the compounds assessed for in-vitro antimicrobial activities on three strains are S. aureus, S. epidermis and E. coli by using disc plate method (25 μg/mL). Compounds 5a-5j showed good to excellent antimicrobial activity for three different strains compared to standard ciprofloxacin. Further screened by in-vitro cytotoxic activity against MCF-7 cell lines. Some compounds were 5i, 5c, 5b,5d and 5i showed high cytotoxic activities of IC50 values 73, 53,37,32 and 24 μg/mL, reference drug as Gefitinib against MCF-7 cell lines and MCF-12A. Further carried out docking studies using Schrodinger software to analyze the orientations, interactions and binding modes of these derivatives at the adenine -5-triphosphate binding site of EGFR (PDB ID: 2ITY), which indicated that the ligands show good interactions with active site residues in this structural benzothiazole class, and are considered lead compounds for further development as anti-breast cancer drugs
Amit Chawla, Lalchand Devhare, G. Dharmamoorthy, Ritika ., and Sachin Tyagi
Dr. Yashwant Research Labs Pvt. Ltd.
The development of novel antitumor agents is paramount in the fight against drug resistance and its associated cardiotoxicity. The present study carried out a thorough anticancer evaluation of N- (4-oxo-2-(4-((5-aryl-1,3,4 thiadiazole-2yl) amino) phenyl thiazolidine-3-yl) benzamide (TH08) in Ehrlich ascites carcinoma (EAC) in Swiss albino mice. Our assessment included the measurement of tumor weight, the duration of survival for mice with tumors, and tumor cell growth inhibition. Additionally, we analyzed hematological parameters, like white and red blood cells and hemoglobin levels. The results we obtained clearly demonstrate that TH08 is a potent anticancer agent that exerts a positive effect on EAC cells. To determine TH08's effectiveness, We compared our findings to those achieved by using the standard medication, bleomycin. Our findings provide compelling evidence that TH08 has significant potential as a novel antitumor agent.
Minal Sonule, Lalchand D Devhare, M Niranjan Babu, Sachinkumar D Gunjal, and S Varalaxmi
Dr. Yashwant Research Labs Pvt. Ltd.
Aim was to prepare hydrogel containing diclofenac sodium using Lipidium sativum as a gelling agent within a micro emulsion-based system. The oil phase consisted of soybean oil, while surfactants, namely Span 80 and Tween 20, were employed in the formulation. Absolute ethanol was used as a co-surfactant and were characterized by a phase diagram. The in-vitro permeation information is derived from the Franz diffusion. Different microemulsion was designed by screening of various components by performing pseudo-ternary phase diagram and then a solubility study. From this psudo-ternary phase diagram was constructed. In-vitro permeation data was screened from these results the topical delivery of diclofenac sodium microemulsion was clearly confirmed as being by means of w/o microemulsion systems. The optimized formulation of the microemulsion consist of soya bean oil 1.25 mL, span:Tween 20 : 2.5 mL, ethanol 1-mL, water 0.2 mL, L. sativum mucilage and it is compared with the marketed preparation. So, the micro emulsion-based hydrogel of diclofenac using L. sativum mucilage can be used as a gelling agent for a topical drug delivery system.
Lalchand D. Devhare and Niharika Gokhale
A and V Publications
Aim: The fundamental objective and goal of the current research is to determine the effectiveness of Cassia tora in the treatment of gastric ulcers in order to produce an anti-ulcer medication of natural origin. Method: The plant material was successively extracted by the Soxhlet extraction technique with chloroform, methanol, butanol and water. The antioxidant activity of the plant extracts and the standard drugs were based on consideration of the radical scavenging influence of the stable "1,1-diphenyl-2-picrylhydrazyl" (DPPH) free radical action and hydrogen peroxide process. Two models, and non-steroidal anti-inflammatory induced ulcer and pyloric ligation, were analysed for methanolic extract of Cassia tora for its antiulcer activity. Results: Among all the extract, the percent of DPPH inhibition at 200 μg mL-1 for MECT extracts (Cassia tora methanolic extract) was 58.67±1.95. The overall scavenging potential for the H2O2 process was 68.23±0.19 at 200 μg mL-1 by MECT extract. Hence MECT extract was undertaken for the antiulcer property. Compared with control, there was a significant (p<0.05) decrease in free acidity, gastric volume, and total acidity in the extract-treated classes and ranitidine (standard). The Cassia tora methanolic extract demonstrated significant (p<0.05) inhibition activity, i.e. 59.42 and 69.59 percent at 500 mg mL-1 with the PL (Pylorus ligation) and NSAID (Non-steroidal anti-inflammatory drugs) process respectively. Conclusion: The findings of present study provide the scientific evidence to Cassia tora as a strong antiulcer and antioxidant agent.
Vaibhav P Uplanchiwar
Medic Scientific
In a study, the potential of hydroalcoholic and petroleum ether extract of Gloriosa superba Linn (GS) tubers in the mitigation of antisecretory and antiulcer was studied. Both extracts were tested at 100, 200, and 400 mg/kg/p.o. using ethanol, and cold stress as toxicants. Both the extracts showed significant ulcer protection at the highest dose of 400mg/kg as compared to standard drug lansoprazole. To support its antiulcer potential, the plant was examined for radical - scavenging capability by lipid peroxidation. The extracts showed a comparative significant result. The flavonoids & polyphenols in the extracts verify the antioxidant potential. From the results, it was concluded that both hydroalcoholic and petroleum ether extracts of tubers of Gloriosa superba are having gastric ulcer protective activity.