Lina Adwan

@birzeit.edu

Pharmacy/Faculty of Pharmacy Nursing and Health Professions
Birzeit University

Lina Adwan


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https://researchid.co/linaadwan

EDUCATION

PhD in Pharmacology

RESEARCH, TEACHING, or OTHER INTERESTS

Pharmacology (medical)
18

Scopus Publications

659

Scholar Citations

11

Scholar h-index

12

Scholar i10-index

Scopus Publications

  • Assessment of the rational use of the most commonly prescribed antibiotics at the Department of Health of Ramallah in Palestine
    Omar Al-Taweel, Costa Shubeita, Fairouz Zayed, Doaa Al-Hamed, Doaa Al-Tarifi, et al.
    Journal of Infection in Developing Countries, 2024
    Introduction: Appropriate antibiotic use requires using the right antibiotic, at the right dose, for the right duration, and at the right time. Drug-resistant diseases cause numerous deaths globally a year, and antibiotic stewardship is a cornerstone in fighting antibiotic resistance. This study focuses on tracking the antibiotic prescribing practices in Palestine and improving future antibiotic prescribing. Methodology: Data from prescriptions of the most commonly prescribed antibiotics was collected from the Health Department of Ramallah and Al-Bireh clinics between January 1 to March 31, 2020. The prescriptions were divided into three categories according to the diagnosis status: unwritten, unspecific, and precise diagnosis. The precise prescriptions were further divided into two categories: appropriate or inappropriate indication. Only appropriate prescriptions were candidates for the assessment of dose and duration appropriateness. Results: The percentages of the three categories of diagnosis precise, unspecific, and unwritten were 23.4%, 20.4%, and 56.2%, respectively. The percentage of appropriate prescriptions was 16.2%. Azithromycin was the most over-utilized antibiotic, followed by co-amoxiclav (amoxicillin/clavulanic acid). Amoxicillin and co-trimoxazole (trimethoprim/sulfamethoxazole) were under-prescribed. All the prescriptions indicated for urinary tract infections (UTIs) were inappropriate. Conclusions: Most prescriptions were not candidates for analysis due to missing diagnosis. Amoxicillin, co-amoxiclav, cefuroxime, azithromycin, and ciprofloxacin were the most commonly prescribed antibiotics and were mostly indicated for pharyngitis. The duration of all sinusitis regimens was inappropriate. More rational antibiotic use in the Department of Health could be achieved by improving documentation, following updated guidelines, choosing cost-effective agents, and keeping track of local resistance patterns and antibiograms.
  • Alarmingly high prevalence of high-risk drug use among palestinian males: a cross-sectional study
    Salwa Massad, Hadil Dalloul, Lina Adwan, Khalid Abu Saman, Rawan Kafri, et al.
    BMC Psychiatry, 2023
    Background The unique socioeconomic context in Palestine, characterized by political and economic tensions, creates conditions that facilitate the spread of illicit drug use among Palestinians. This paper presents findings from a 2017 survey of high-risk drug use (HRDU) among males in four regions in Palestine: the West Bank (north, middle, and south) and the Gaza Strip. These findings are essential for developing effective policies to respond to the increasing use of drugs among Palestinians. Methods Eligible participants were males aged 15 years and above who used at least one drug other than non-synthetic hashish or marijuana during the previous week. Participants underwent a face-to-face interview and had their drug use verified by urinalysis. Data were collected using respondent-driven sampling and data were analyzed using the successive sampling estimator. Multivariate regression analysis was conducted to examine factors associated with ever seeking rehabilitation services for illicit drug use in the West Bank and the Gaza Strip. Results A total of 400 males who use drugs were sampled in Gaza, plus 299 in the south, 300 in the north, and 299 in the middle region of the West Bank. It is estimated that there are 26,500 male HRDUs in Palestine comprising 1.8% of the male population aged 15 and above. Findings indicate that polydrug use is a serious issue in Palestine, especially in the West Bank, and that synthetic marijuana is prevalent among teenagers and young adults. Conclusions Palestine must strengthen its national efforts to scale up harm reduction and treatment and care options for people suffering from drug use disorders, especially those involved in polydrug use. Additional measures are needed to prevent substance use among children and youth, support the families of people who use drugs, and ensure the continuity of HRDU services during emergencies.
  • Israel’s spatial and a-spatial strategy of dispossessing the Jordan Valley’s Palestinian Inhabitants
    Ghazi Falah, Salwa Massad, Lina Adwan, Rawan Kafri, Hadil Dalloul, et al.
    Geojournal, 2023
  • Clinical outcomes of COVID-19 in hemodialysis patients
    Lina Adwan, Tala Al-Sadi, Shorouq Shawakha, Ni’meh A. Al-Shami
    Frontiers in Medicine, 2023
    BackgroundThe coronavirus disease 2019 (COVID-19) is known for its effects on the respiratory system. Three years after the pandemic morbid and mortal consequences, growing evidence is showing that the disease also has adverse outcomes and complications on additional organs including the kidneys. This study aims at investigating the effects of COVID-19 on hemodialysis patients receiving services at Palestine Medical Complex (PMC) kidney dialysis department, and to identify mortality related risk factors.MethodsIn April 2022, data was collected using the electronic medical records system for the dialysis department at PMC. The study included all PMC hemodialysis patients that were infected with COVID-19 between January 2020–April 2022. The collected data included patient demographics, clinical features, laboratory tests, dialysis frequency and the disease outcome.ResultsThe results showed that the patients’ outcomes and dialysis frequency were impacted by their blood urea nitrogen (BUN), serum creatinine (SCr) and calcium levels. About one third of the study population died after being infected with COVID-19. The frequency of dialysis was also affected by the presence of comorbidities like hypertension, diabetes mellitus (DM) and myocardial infarction (MI).ConclusionThis study found that there was a high mortality rate within the hemodialysis patients infected with COVID-19. Having comorbidities affected the frequency of dialysis following COVID-19 infection. Dialysis patients should be protected from infections such as COVID-19 and their comorbidities should be monitored and kept under control as much as possible.
  • Jordan Valley Under Israeli Ihtilal: A Palestinian Story of Stark Oppression
    Arab World Geographer, 2022
  • Health Informatics in the Arab World
    C. El Jabari, L. Adwan
    Handbook of Healthcare in the Arab World, 2021
  • Composition, Anticholinesterase and Antipedicular Activities of Satureja capitata L. Volatile Oil
    Nidal Jaradat, Lina Adwan, Abdel Naser Zaid, Shadi K’aibni, Mohammad Arar
    Open Life Sciences, 2020
    The emergence of resistance for antipedicular agents and the need of potent acetylcholinesterase (AChE) therapeutics for the treatment of a neurodegenerative disorder such as Alzheimer disease has led researchers to the exploration of new therapeutic alternatives such as natural volatile oils. Therefore, the current investigation aimed to identify the components of Satureja capitata L. volatile oil (VO), and examine the VO anticholinesterase, and antipedicular activities. The plant phytoconstituents were identified using Gas chromatography mass spectrometry (GC-MS) method, while the anticholinesterase activity was determined against butyryl- and acetyl-cholinesterase using Ellman’s method. In addition, antipedicular activity was established using the diffusion method. The obtained GC-MS results identified 16 compounds in S. capitata VO with the major constituents being carvacrol, γ-terpinene, and p-cymene. Anticholinesterase analysis showed a marked inhibition potential against acetyl- and butyryl-cholinesterase enzymes with half maximal inhibitory concentration (IC50) values of 28.24±0.97 μg/ml and 92.31±1.22 μg/ml, respectively in comparison with the reference compound galantamine, which has IC50 values against the same enzymes of 5.21±0.07 μg/ml and 10.33±0.37 μg/ml, respectively. In addition, the VO, at a concentration of 20%, was effective against head lice, similar to benzyl benzoate, which resulted in 100% mortality. In addition, the VO completely inhibited the emergence of lice nits after 6 and 14 days. On the basis of the obtained results, S. capitata VO is a promising natural alternative to synthetic antipedicular and anticholinesterase drugs, which can be employed in drug development, and may lead to new candidates against head lice and neurodegenerative diseases.
  • Screening of Antioxidant and Antimicrobial Activity of Micromeria fruticosa serpyllifolia Volatile Oils: A Comparative Study of Plants Collected from Different Regions of West Bank, Palestine
    Nihaya Salameh, Naser Shraim, Nidal Jaradat, Motasem El Masri, Lina Adwan, et al.
    Biomed Research International, 2020
    Background. The investigation of volatile oils used in traditional medicine is vital to enhance the quality of healthcare. This study is aimed at screening the antioxidant and antimicrobial properties of Micromeria fruticosa serpyllifolia volatile oils from three different regions in Palestine (north, middle, and south). Methods. Volatile oils of three samples of M. fruticosa serpyllifolia were extracted using the microwave-ultrasonic apparatus. The antioxidant activity of the volatile oils was assessed by inhibition of DPPH free radical. The antimicrobial activity was examined using the broth microdilution method. Assessment of antifungal activity was achieved using the agar dilution method. Results. Screening the biological activity of plant extracts revealed that the sample from Ramallah (middle region) possessed the most potent antioxidant activity with an IC50 value of 0.45 μg/mL. The three samples exhibited broad antimicrobial activity and showed potential antifungal activity. The sample from the southern region showed the highest potency against Shigella sonnei with the lowest reported MIC; the sample from the northern region demonstrated the least potency against clinical isolate of Staphylococcus aureus and “methicillin”-resistant Staphylococcus aureus. Conclusions. The study showed that Micromeria fruticosa serpyllifolia volatile oil samples from different regions in Palestine possess different potential antioxidant and antimicrobial activities that were in line with traditional uses of the plant extracts.
  • Variability of chemical compositions and antimicrobial and antioxidant activities of ruta chalepensis leaf essential oils from three palestinian regions
    Nidal Jaradat, Lina Adwan, Shadi K’aibni, Abdel Naser Zaid, Munqez J. Y. Shtaya, et al.
    Biomed Research International, 2017
    Introduction. Interest in essential oils was recently revived with their popularity increasing in medicine, pharmacy, and aromatherapy. This study was performed to identify the chemical compositions of the essential oil of Ruta chalepensis growing wildly in three regions in Palestine and to assess and compare their antimicrobial and antioxidant activities. Methods. Identification of the essential oil was performed by gas chromatography coupled with mass spectrometry (GC-MS). Antimicrobial activity was tested against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Methicillin-Resistant Staphylococcus aureus, and Candida albicans by using minimum inhibitory concentration (MIC) assay, while antioxidant activity was analyzed by using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. Results. The essential oils of R. chalepensis from Jerusalem and Hebron regions have almost identical components; the major compounds identified were linalyl acetate and β-linalool; these essential oils exerted potential antioxidant and antibacterial activities. On the other hand, the major components of the plant essential oil from Jenin region were 2-undecanone and 2-nonanone, which exhibited potential antifungal activity. Conclusions. The phytoconstituents and antioxidant and antimicrobial properties of the essential oil of R. chalepensis from different regions in Palestine were established in this study. The obtained results indicate possible applications for R. chalepensis in the treatment of various infectious and noninfectious diseases.
  • Chemical composition, anthelmintic, antibacterial and antioxidant effects of Thymus bovei essential oil
    Nidal Jaradat, Lina Adwan, Shadi K’aibni, Naser Shraim, Abdel Naser Zaid
    BMC Complementary and Alternative Medicine, 2016
  • Tolfenamic acid reduces tau and CDK5 levels: Implications for dementia and tauopathies
    Lina Adwan, Gehad M. Subaiea, Riyaz Basha, Nasser H. Zawia
    Journal of Neurochemistry, 2015
  • Reduction of amyloid-β deposition and attenuation of memory deficits by tolfenamic acid
    Gehad M. Subaiea, Aseef H. Ahmed, Lina I. Adwan, Nasser H. Zawia
    Journal of Alzheimer S Disease, 2015
  • Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers
    Lina Adwan, Gehad M. Subaiea, Nasser H. Zawia
    Neuropharmacology, 2014
  • Short-term treatment with tolfenamic acid improves cognitive functions in alzheimer's disease mice
    Gehad M. Subaiea, Lina I. Adwan, Aseef H. Ahmed, Karen E. Stevens, Nasser H. Zawia
    Neurobiology of Aging, 2013
  • Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease
    Lina Adwan, Nasser H. Zawia
    Pharmacology and Therapeutics, 2013
  • Cellular and organismal toxicity of the anti-cancer small molecule, tolfenamic acid: A pre-clinical evaluation
    Umesh T. Sankpal, Chris M. Lee, Sarah F. Connelly, Omer Kayaleh, Don Eslin, et al.
    Cellular Physiology and Biochemistry, 2013
  • Tolfenamic Acid Interrupts the De Novo Synthesis of the β-Amyloid Precursor Protein and Lowers Amyloid Beta Via a Transcriptional Pathway
    L. I. Adwan, R. Basha, M. Abdelrahim, G. M. Subaiea, N. H. Zawia
    Current Alzheimer Research, 2011
  • Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice
    Remi Dosunmu, Jinfang Wu, Lina Adwan, Bryan Maloney, Md. Riyaz Basha, et al.
    Journal of Alzheimer S Disease, 2009

RECENT SCHOLAR PUBLICATIONS

  • Assessment of the rational use of the most commonly prescribed antibiotics at the Department of Health of Ramallah in Palestine
    O Al-Taweel, C Shubeita, F Zayed, D Al-Hamed, D Al-Tarifi, M Alnadi, ...
    The Journal of Infection in Developing Countries 18 (12), 1909-1915 , 2024
    2024
    Citations: 3
  • Clinical outcomes of COVID-19 in hemodialysis patients
    L Adwan, T Al-Sadi, S Shawakha, N Al-Shami
    Frontiers in Medicine 10 , 2023
    2023
    Citations: 10
  • Alarmingly high prevalence of high-risk drug use among palestinian males: a cross-sectional study
    S Massad, H Dalloul, L Adwan, KA Saman, R Kafri, WA Alia, M Tucktuck, ...
    BMC psychiatry 23 (1), 700 , 2023
    2023
    Citations: 6
  • Israel’s spatial and a-spatial strategy of dispossessing the Jordan Valley’s Palestinian Inhabitants
    G Falah, S Massad, L Adwan, R Kafri, H Dalloul, A Rhodes
    GeoJournal 88 (4), 4505-4521 , 2023
    2023
    Citations: 2
  • Jordan Valley Under Israeli Ihtilal : A Palestinian Story of Stark Oppression
    GW Falah, S Massad, L Adwan
    The Arab World Geographer 25 (1), 1-17 , 2022
    2022
    Citations: 3
  • Health informatics in the Arab world
    C El Jabari, L Adwan
    Handbook of Healthcare in the Arab World, 1681-1692 , 2021
    2021
    Citations: 6
  • Composition, anticholinesterase and antipedicular activities of Satureja capitata L. volatile oil
    N Jaradat, L Adwan, AN Zaid, S K’aibni, M Arar
    Open Life Sciences 15 (1), 60-67 , 2020
    2020
    Citations: 7
  • Screening of Antioxidant and Antimicrobial Activity of Micromeria fruticosa serpyllifolia Volatile Oils: A Comparative Study of Plants Collected from Different Regions …
    N Salameh, N Shraim, N Jaradat, M El Masri, L Adwan, S K’aibni, ...
    BioMed research international 2020 (1), 4851879 , 2020
    2020
    Citations: 23
  • Variability of Chemical Compositions and Antimicrobial and Antioxidant Activities of Ruta chalepensis Leaf Essential Oils from Three Palestinian Regions
    N Jaradat, L Adwan, S K’aibni, AN Zaid, MJY Shtaya, N Shraim, M Assali
    BioMed research international 2017 (1), 2672689 , 2017
    2017
    Citations: 77
  • Chemical composition, anthelmintic, antibacterial and antioxidant effects of Thymus bovei essential oil
    N Jaradat, L Adwan, S K’aibni, N Shraim, AN Zaid
    BMC Complementary and Alternative Medicine 16, 1-7 , 2016
    2016
    Citations: 72
  • Reduction of Amyloid-β Deposition and Attenuation of Memory Deficits by Tolfenamic Acid
    GM Subaiea, AH Ahmed, LI Adwan, NH Zawia
    Journal of Alzheimer's Disease 43 (2), 425-433 , 2015
    2015
    Citations: 25
  • Tolfenamic Acid Reduces Tau and CDK5 Levels: Implications for Dementia and Tauopathies.
    L Adwan, GM Subaiea, R Basha, NH Zawia
    Journal of neurochemistry 133 (2), 266-272 , 2014
    2014
    Citations: 46
  • Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers
    L Adwan, GM Subaiea, NH Zawia
    Neuropharmacology 79, 596-602 , 2014
    2014
    Citations: 47
  • Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice
    GM Subaiea, LI Adwan, AH Ahmed, KE Stevens, NH Zawia
    Neurobiology of aging 34 (10), 2421-2430 , 2013
    2013
    Citations: 60
  • Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease
    L Adwan, NH Zawia
    Pharmacology & therapeutics 139 (1), 41-50 , 2013
    2013
    Citations: 163
  • Cellular and organismal toxicity of the anti-cancer small molecule, tolfenamic acid: a pre-clinical evaluation
    UT Sankpal, CM Lee, SF Connelly, O Kayaleh, D Eslin, R Sutphin, ...
    Cellular Physiology and Biochemistry 32 (3), 675-686 , 2013
    2013
    Citations: 33
  • Pharmacodynamic Mechanisms of Tolfenamic Acid Induced SP1 Degradation Relative to Alzheimer's Disease Pathology
    LI Adwan
    2013
  • A novel approach for lowering multiple targets in Alzheimer's disease
    L Adwan, N Zawia
    Alzheimer's & Dementia 8 (4), P716 , 2012
    2012
  • Tolfenamic acid interrupts the de novo synthesis of the β-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway
    LI Adwan, R Basha, M Abdelrahim, GM Subaiea
    Bentham Science , 2011
    2011
    Citations: 42
  • Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice
    R Dosunmu, J Wu, L Adwan, B Maloney, MR Basha, CA McPherson, ...
    Journal of Alzheimer's Disease 18 (1), 211-230 , 2009
    2009
    Citations: 34

MOST CITED SCHOLAR PUBLICATIONS

  • Epigenetics: A novel therapeutic approach for the treatment of Alzheimer's disease
    L Adwan, NH Zawia
    Pharmacology & therapeutics 139 (1), 41-50 , 2013
    2013
    Citations: 163
  • Variability of Chemical Compositions and Antimicrobial and Antioxidant Activities of Ruta chalepensis Leaf Essential Oils from Three Palestinian Regions
    N Jaradat, L Adwan, S K’aibni, AN Zaid, MJY Shtaya, N Shraim, M Assali
    BioMed research international 2017 (1), 2672689 , 2017
    2017
    Citations: 77
  • Chemical composition, anthelmintic, antibacterial and antioxidant effects of Thymus bovei essential oil
    N Jaradat, L Adwan, S K’aibni, N Shraim, AN Zaid
    BMC Complementary and Alternative Medicine 16, 1-7 , 2016
    2016
    Citations: 72
  • Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer's disease mice
    GM Subaiea, LI Adwan, AH Ahmed, KE Stevens, NH Zawia
    Neurobiology of aging 34 (10), 2421-2430 , 2013
    2013
    Citations: 60
  • Tolfenamic acid downregulates BACE1 and protects against lead-induced upregulation of Alzheimer's disease related biomarkers
    L Adwan, GM Subaiea, NH Zawia
    Neuropharmacology 79, 596-602 , 2014
    2014
    Citations: 47
  • Tolfenamic Acid Reduces Tau and CDK5 Levels: Implications for Dementia and Tauopathies.
    L Adwan, GM Subaiea, R Basha, NH Zawia
    Journal of neurochemistry 133 (2), 266-272 , 2014
    2014
    Citations: 46
  • Tolfenamic acid interrupts the de novo synthesis of the β-amyloid precursor protein and lowers amyloid beta via a transcriptional pathway
    LI Adwan, R Basha, M Abdelrahim, GM Subaiea
    Bentham Science , 2011
    2011
    Citations: 42
  • Lifespan profiles of Alzheimer's disease-associated genes and products in monkeys and mice
    R Dosunmu, J Wu, L Adwan, B Maloney, MR Basha, CA McPherson, ...
    Journal of Alzheimer's Disease 18 (1), 211-230 , 2009
    2009
    Citations: 34
  • Cellular and organismal toxicity of the anti-cancer small molecule, tolfenamic acid: a pre-clinical evaluation
    UT Sankpal, CM Lee, SF Connelly, O Kayaleh, D Eslin, R Sutphin, ...
    Cellular Physiology and Biochemistry 32 (3), 675-686 , 2013
    2013
    Citations: 33
  • Reduction of Amyloid-β Deposition and Attenuation of Memory Deficits by Tolfenamic Acid
    GM Subaiea, AH Ahmed, LI Adwan, NH Zawia
    Journal of Alzheimer's Disease 43 (2), 425-433 , 2015
    2015
    Citations: 25
  • Screening of Antioxidant and Antimicrobial Activity of Micromeria fruticosa serpyllifolia Volatile Oils: A Comparative Study of Plants Collected from Different Regions …
    N Salameh, N Shraim, N Jaradat, M El Masri, L Adwan, S K’aibni, ...
    BioMed research international 2020 (1), 4851879 , 2020
    2020
    Citations: 23
  • Clinical outcomes of COVID-19 in hemodialysis patients
    L Adwan, T Al-Sadi, S Shawakha, N Al-Shami
    Frontiers in Medicine 10 , 2023
    2023
    Citations: 10
  • Composition, anticholinesterase and antipedicular activities of Satureja capitata L. volatile oil
    N Jaradat, L Adwan, AN Zaid, S K’aibni, M Arar
    Open Life Sciences 15 (1), 60-67 , 2020
    2020
    Citations: 7
  • Alarmingly high prevalence of high-risk drug use among palestinian males: a cross-sectional study
    S Massad, H Dalloul, L Adwan, KA Saman, R Kafri, WA Alia, M Tucktuck, ...
    BMC psychiatry 23 (1), 700 , 2023
    2023
    Citations: 6
  • Health informatics in the Arab world
    C El Jabari, L Adwan
    Handbook of Healthcare in the Arab World, 1681-1692 , 2021
    2021
    Citations: 6
  • Assessment of the rational use of the most commonly prescribed antibiotics at the Department of Health of Ramallah in Palestine
    O Al-Taweel, C Shubeita, F Zayed, D Al-Hamed, D Al-Tarifi, M Alnadi, ...
    The Journal of Infection in Developing Countries 18 (12), 1909-1915 , 2024
    2024
    Citations: 3
  • Jordan Valley Under Israeli Ihtilal : A Palestinian Story of Stark Oppression
    GW Falah, S Massad, L Adwan
    The Arab World Geographer 25 (1), 1-17 , 2022
    2022
    Citations: 3
  • Israel’s spatial and a-spatial strategy of dispossessing the Jordan Valley’s Palestinian Inhabitants
    G Falah, S Massad, L Adwan, R Kafri, H Dalloul, A Rhodes
    GeoJournal 88 (4), 4505-4521 , 2023
    2023
    Citations: 2
  • Pharmacodynamic Mechanisms of Tolfenamic Acid Induced SP1 Degradation Relative to Alzheimer's Disease Pathology
    LI Adwan
    2013
  • A novel approach for lowering multiple targets in Alzheimer's disease
    L Adwan, N Zawia
    Alzheimer's & Dementia 8 (4), P716 , 2012
    2012