Pharmacology (medical), Anatomy, Research and Theory
4
Scopus Publications
69
Scholar Citations
2
Scholar h-index
1
Scholar i10-index
Scopus Publications
Type 2 Diabetes Mellitus and Parkinson's Disease: An Emerging Link Shubham Teli, Mallappa Shalavadi, Chandrashekhar V.M., Lingaraj Anawal Current Signal Transduction Therapy, 2025 Parkinson’s Disease (PD) is a common neurodegenerative disease, characterized by motor deficit. Diabetes Mellitus (DM) is a metabolic condition characterized by high glucose levels in the blood. The prevalence of chronic disorders like PD has significantly risen in recent decades. Emerging research has increasingly linked PD with Type 2 Diabetes Mellitus (T2DM) in recent years. Apart from the β-cells of the pancreas, insulin is secreted by the choroid plexus in the human brain which is essential for neuroprotection which regulates neurogenesis, oxidative stress, synaptic plasticity, neuronal survival, and neuro-inflammation. The abnormalities in the insulin signaling pathway may be responsible for neurodegeneration via insulin dysregulation, from the aggregation of α-synuclein, neuroinflammation, mitochondrial dysfunction, and altered synaptic plasticity. DM or Insulin resistance is considered a risk factor for the development of PD. Due to the lack of treatment options for PD, consistent research is going on to find a potential drug as a treatment option for PD, and due to its molecular links, the antidiabetic drugs are considered as potential candidates for PD. This review will discuss the potential cellular mechanisms shared between T2DM and PD as well as the role of antidiabetics in this disease and clinical manifestations such as its severity and prognosis.
Nephroprotective effect of Cansjera rheedii on Gentamicin induced Renal toxicity in Wistar albino rats Naveen Maled, V M Chandrashekar, Mallappa Shalavadi, G S Hiremath, Lingaraj Anawal, Shubham Teli, Sushma Kagawade, Sunilkumar Meti, Bhushan Khombare, Veeresh Sadashivanavar Research Journal of Pharmacy and Technology, 2024 Purpose: To examine the effect of Cansjera rheedii in gentamicin induced kidney damage in rats. Material and Method: In this current study, rats in group 1 were used as the normal group and were given physiological saline. Rats of group 2 were injected with gentamicin [100mg/kg] via intraperitoneal injection. Group 3 was given gentamicin (100mg/kg, IP) together with oral selenium [2mg/kg]. Hydroalcoholic extract (HECR) of Cansjera rheedii leaves was administered orally to groups 4 and 5 in low dose of 200mg/kg and high dose of 400 mg/kg, respectively. Above treatments were given to rats over eight days. Blood serum and urine were collected on the 8th day to evaluate blood and urine biochemical parameters. Antioxidant parameters were evaluated using renal homogenates. Kidney sections were used for histopathological examination. Result: The renoprotective effect of HECR plant extract was evident at both low and high dose [200mg/kg and 400mg/kg]. This action maintains structural and functional integrity by preventing damage caused by gentamicin. This protection is attributed to the antioxidant properties of the extract.
Nephroprotective Activity of Manilkara Zapota Nano Suspension Formulation on Gentamicin Induced Nephrotoxicity in Rat Model MS Sahana Shailesh Vajramatti, Salma Bhanu, Marigouda Patil, Lingaraj Anawal ... International Journal of Medical and Pharmaceutical Sciences 1 (3), 369-382 , 2026 2026
Pharmacological and Phytochemical Perspectives of Cansjera rheedei: An Underexplored Member of Opiliaceae with Therapeutic Potential CVM Marigouda Patil, Salma Banu, Sanjay Havaragi, Lingaraj Anawal, Mallappa ... International Journal of Pharmaceutical Sciences 4 (1), 2216-2231 , 2026 2026
Type 2 Diabetes Mellitus and Parkinson's Disease: An Emerging Link S Teli, M Shalavadi, VM Chandrashekhar, L Anawal Current Signal Transduction Therapy 20 (2), E15743624334102 , 2025 2025 Citations: 1
Beverage combination of pomegranate juice and Quinoa extract ameliorates lipid profile in rat study K KN, B G, G VM, C VM, G Goudar, L Amawal, R DL, A G. Nanjappanavar, ... Plant Foods for Human Nutrition 80 (1), 14 , 2025 2025 Citations: 2
Neuroprotective activity of Hibiscus abelmoschus Linn. against 6-OHDA induced Parkinson’s disease in rats K Akki, M Shalavadi, VM Chandrashekhar, S Teli, L Anawal, B Khombare Pharmacological Research-Natural Products 3, 100027 , 2024 2024
ANTI-EPILEPTIC ACTIVITY OF MENTHA CORDIFOLIA AGAINST PTZ INDUCED EPILEPSY IN SWISS ALBINO MICE M SHALAVADI, A HOSOOR, M MUGALI, R KINNAL, S PATIL, CH VM, ... ASIAN JOURNAL OF PHARMACY AND PHARMACOLOGY 10 (2), 59-63 , 2024 2024 Citations: 1
Anti-epileptic activity of against PTZ induced epilepsy in Swiss Mentha cordifolia Albino mice M Shalavadi, A Hosoor, MM Devraj, R Kinnal, S Patil, VM Chandrashekar, ... Asian Journal of Pharmacy and Pharmacology 10 (2), 59-63 , 2024 2024
Nephroprotective effect of Cansjera rheedii on Gentamicin induced Renal toxicity in Wistar albino rats N Maled, VM Chandrashekar, M Shalavadi, GS Hiremath, L Anawal, ... Research Journal of Pharmacy and Technology 17 (8), 3863-3868 , 2024 2024 Citations: 1
Neuroprotective Activity of Polyherbal Formulation on Colchicine Induced Alzheimer’s Disease in Rat Model PH Lingaraj Anawal*, Chandrashekar V M, Mallappa Shalavadi, Shubham Teli ... Asian Journal of Pharmacy and Technology 14 (3), 199-207 , 2024 2024 Citations: 3
Neuroprotective activity of Phoenix sylvestris against colchicine induced neuroinflammation and cognitive deficits in rat P Suryvanshi, VM Chandrashekhar, B Lalasangi, M Shalavadi, L Anawal, ... Journal of Chemical Health Risks 14 (1), 405-424 , 2023 2023
Neuroprotective activity of michelia champaca against ALZHEIMER’S disease in rat model L Anawal Jr, CV M, M Shalavadi, CV M Alzheimer's & Dementia 19, e073074 , 2023 2023 Citations: 1
EVALUTION OF ANTIOXIDANT, ANALGESIC AND ANTI- INFLAMMATORY ACTIVITY OF POLYHERBAL FORMULATION IN ANIMAL SCREERING MODELS LA Shubham Teli, Mallappa Shalavadi, Chandrashekhar V.M Bulletin For Technology And History Journal 23 (6), 101-110 , 2023 2023
Neuroprotective activity of Acanthus maderaspatensis L. against colchicine induced Alzheimer’s disease rat model L Anawal, M Shalavadi, C VM Alzheimer's & Dementia 19, e060408 , 2023 2023 Citations: 1
Neuroprotective Activity of Blepharis maderaspatensis Against Colchicine Induced Alzheimer’s Disease Rat Model SMTS Anawal Lingaraj, V M Chandrashekhar* The Natural Products Journal 13 (8), 1-15 , 2023 2023
Neuroprotective activity of Valerianan offcinalis against colchicine induced Alzheimer's disease A Lingaraj, C V M, M Shalavadi 52nd Annual Conference of Indian Pharmacological Society , 2023 2023
ALZHEIMER’S DISEASE: A REVIEW OF PATHOPHYSIOLOGY AND TYPES OF DEMENTIA L Anawal 2022
Questionnaire-Based Survey on COVID-19 vaccination among healthcare students and workers LA SANDEEP CHANDAKAVATE*, SHARANAGOUD BIRADAR, SHRADDHA DESAI, PRASHANT ... International Journal of Creative Research Thoughts 9 (6), e475-e480 , 2021 2021
A COMPREHENSIVE REVIEW ON ALZHEIMER'S DISEASE MKT Lingaraj Anawal, Sandeep Chandakavate, S Lalitha WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 10 (7), 1170-1185 , 2021 2021 Citations: 59
MOST CITED SCHOLAR PUBLICATIONS
A COMPREHENSIVE REVIEW ON ALZHEIMER'S DISEASE MKT Lingaraj Anawal, Sandeep Chandakavate, S Lalitha WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES 10 (7), 1170-1185 , 2021 2021 Citations: 59
Neuroprotective Activity of Polyherbal Formulation on Colchicine Induced Alzheimer’s Disease in Rat Model PH Lingaraj Anawal*, Chandrashekar V M, Mallappa Shalavadi, Shubham Teli ... Asian Journal of Pharmacy and Technology 14 (3), 199-207 , 2024 2024 Citations: 3
Beverage combination of pomegranate juice and Quinoa extract ameliorates lipid profile in rat study K KN, B G, G VM, C VM, G Goudar, L Amawal, R DL, A G. Nanjappanavar, ... Plant Foods for Human Nutrition 80 (1), 14 , 2025 2025 Citations: 2
Type 2 Diabetes Mellitus and Parkinson's Disease: An Emerging Link S Teli, M Shalavadi, VM Chandrashekhar, L Anawal Current Signal Transduction Therapy 20 (2), E15743624334102 , 2025 2025 Citations: 1
ANTI-EPILEPTIC ACTIVITY OF MENTHA CORDIFOLIA AGAINST PTZ INDUCED EPILEPSY IN SWISS ALBINO MICE M SHALAVADI, A HOSOOR, M MUGALI, R KINNAL, S PATIL, CH VM, ... ASIAN JOURNAL OF PHARMACY AND PHARMACOLOGY 10 (2), 59-63 , 2024 2024 Citations: 1
Nephroprotective effect of Cansjera rheedii on Gentamicin induced Renal toxicity in Wistar albino rats N Maled, VM Chandrashekar, M Shalavadi, GS Hiremath, L Anawal, ... Research Journal of Pharmacy and Technology 17 (8), 3863-3868 , 2024 2024 Citations: 1
Neuroprotective activity of michelia champaca against ALZHEIMER’S disease in rat model L Anawal Jr, CV M, M Shalavadi, CV M Alzheimer's & Dementia 19, e073074 , 2023 2023 Citations: 1
Neuroprotective activity of Acanthus maderaspatensis L. against colchicine induced Alzheimer’s disease rat model L Anawal, M Shalavadi, C VM Alzheimer's & Dementia 19, e060408 , 2023 2023 Citations: 1
Nephroprotective Activity of Manilkara Zapota Nano Suspension Formulation on Gentamicin Induced Nephrotoxicity in Rat Model MS Sahana Shailesh Vajramatti, Salma Bhanu, Marigouda Patil, Lingaraj Anawal ... International Journal of Medical and Pharmaceutical Sciences 1 (3), 369-382 , 2026 2026
Pharmacological and Phytochemical Perspectives of Cansjera rheedei: An Underexplored Member of Opiliaceae with Therapeutic Potential CVM Marigouda Patil, Salma Banu, Sanjay Havaragi, Lingaraj Anawal, Mallappa ... International Journal of Pharmaceutical Sciences 4 (1), 2216-2231 , 2026 2026
Neuroprotective activity of Hibiscus abelmoschus Linn. against 6-OHDA induced Parkinson’s disease in rats K Akki, M Shalavadi, VM Chandrashekhar, S Teli, L Anawal, B Khombare Pharmacological Research-Natural Products 3, 100027 , 2024 2024
Anti-epileptic activity of against PTZ induced epilepsy in Swiss Mentha cordifolia Albino mice M Shalavadi, A Hosoor, MM Devraj, R Kinnal, S Patil, VM Chandrashekar, ... Asian Journal of Pharmacy and Pharmacology 10 (2), 59-63 , 2024 2024
Neuroprotective activity of Phoenix sylvestris against colchicine induced neuroinflammation and cognitive deficits in rat P Suryvanshi, VM Chandrashekhar, B Lalasangi, M Shalavadi, L Anawal, ... Journal of Chemical Health Risks 14 (1), 405-424 , 2023 2023
EVALUTION OF ANTIOXIDANT, ANALGESIC AND ANTI- INFLAMMATORY ACTIVITY OF POLYHERBAL FORMULATION IN ANIMAL SCREERING MODELS LA Shubham Teli, Mallappa Shalavadi, Chandrashekhar V.M Bulletin For Technology And History Journal 23 (6), 101-110 , 2023 2023
Neuroprotective Activity of Blepharis maderaspatensis Against Colchicine Induced Alzheimer’s Disease Rat Model SMTS Anawal Lingaraj, V M Chandrashekhar* The Natural Products Journal 13 (8), 1-15 , 2023 2023
Neuroprotective activity of Valerianan offcinalis against colchicine induced Alzheimer's disease A Lingaraj, C V M, M Shalavadi 52nd Annual Conference of Indian Pharmacological Society , 2023 2023
ALZHEIMER’S DISEASE: A REVIEW OF PATHOPHYSIOLOGY AND TYPES OF DEMENTIA L Anawal 2022
Questionnaire-Based Survey on COVID-19 vaccination among healthcare students and workers LA SANDEEP CHANDAKAVATE*, SHARANAGOUD BIRADAR, SHRADDHA DESAI, PRASHANT ... International Journal of Creative Research Thoughts 9 (6), e475-e480 , 2021 2021