Leonid Shafran

RESEARCH INTERESTS

hygiene, toxicology, psychophysiology, microelementology, biochemistry

Scopus Publications

Zinc supply of the population of Ukraine: Consequences for health and reproduction




Elements of a systematic approach to hygienic regulation of xenobiotics
B. M. Shtabskiy, M. R. Gzhegotskiy, and Leonid M. Shafran
Federal Scientific Center for Hygiene F.F.Erisman
Hygienic standardization (HS) of chemicals remains to be the one of the effective ways to ensure chemical safety of the population. At that hygienic standards (such as maximum allowable concentrations--MACs) are interrelated and aggregated into the coherent systems. Therefore, the task of the study was in establishment of the logic of inter- standard relations between the existing standards and actualization of legitimate relations of the interrelations such as MACwz/MACatm, (i.e., to systematize standards) and so as CL₅₀/MACwz (reflecting the ratio of reliability). In the suggested systemic approach the benchmark indices of the proposed HS system are the values of the MACwz. Standards for other media, including atmosphere air may be only some compartments of MACwz. The performed studies and calculations allowed to justify and implement the system approach into the practice of HS in Ukraine. There is need for further search for additional solutions in nonreachability of LC₅₀ in the experiment, justification of standards for the population in the absence of MACwz, comparison with the data of normative databases of other countries. It is necessary to introduce the value of permissible deviation from the requirements of the systemness, to embody conditions (1)-(7) into the general principle of the prohibition of greater deviation and to harmonize acting and newly introduced standards within frameworks of modern ideology and methods of HS of harmful substances. This opens up broad prospects for the new phase of HS and a significant increase in the reliability of results obtained by the various methods and in different laboratories.


Hygienic evaluation of working conditions and working process of fire rescue employees




Synthesis and biological activity of 7H-benzo[4,5]indolo[2,3-b]-quinoxaline derivatives
Marina O. Shibinskaya, Alexander S. Karpenko, Sergey A. Lyakhov, Sergey A. Andronati, Nadezhda M. Zholobak, Nikolay Ya. Spivak, Natalia A. Samochina, Lev M. Shafran, Mykhail Ju. Zubritsky, and Valerij F. Galat
Elsevier BV
New 7-(2-aminoethyl)-7H-benzo[4,5]indolo[2,3-b]quinoxalines (13-20) were synthesized with high yields starting from 3H-benzo[e]indole-1,2-dione. These compounds were screened for the cytotoxicity, anti-viral activity, interferon inducing ability and DNA affinity compared with the corresponding 6-(2-aminoethyl)-6H-indolo[2,3-b]quinoxaline derivatives (1-12). It was shown, that compounds 13-20 bind to DNA stronger (lg Кa=6.23-6.87) than compounds 1-12 (lg Кa=5.57-5.89). Anti-viral activity is significantly reduced with annulations of benzene ring in Indoloquinoxaline moiety 13-20.


Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo[1,2-c]quinazolines
Elena A. Lyakhova, Yulia A. Gusyeva, Julia V. Nekhoroshkova, Lev M. Shafran, and Sergey A. Lyakhov
Elsevier BV
Abstract Novel N-(benzoimidazophenyl)dialkylaminoalkylamides and 6-dialkylaminoalkylbenzoimidazo[1,2-c]quinazolines were prepared as potential interferon inducers and antiviral agents. They were screened for the DNA affinity by the ethidium bromide displacement assay. It was shown that the lg K a values of the compounds containing tetracyclic benzoimidazo[1,2-c]quinazoline fragment are approximately one order magnitude greater than those of the corresponding acyclic phenylbenzoimidazole derivatives.


Dangerous Goods as Ecotoxicants in Ukrainian Ports and after an Accident at the Kherson Area




The problem of allergy in ecotoxicology of polymeric materials
B. Kuzminov, V. Turkina, and L. Shafran
Elsevier BV
In the program of initial toxicological test, the estimation of allergenic activity of some names of polymeric compositions, which are used in the polygraphic industry and when painting and decorating dwelling houses and social purpose premises, had been carried out. Most of the investigated compositions have different degrees of allergenicity. In order to unify the works in this field, we suggest the basic circuit of the estimation of allergenicity of polymeric materials, the final stage of which provides for the compiling of register of potentially allergenic polymeric materials.


The information-search system on industrial ecology of transport




Effect of bis(n-tributyltin)-oxide on the brain GABA-ergic system in vitro




Scientific and technical progress and the problems of protecting the health of workers in water transport




Lipid peroxidation and the trace element content of the blood in patients with lichen ruber planus of the oral mucosa




Psycho-hygienic prevention and correction of functional disorders in workers at increased chemical hazard




Toxicological problems in maritime medicine.




Hygienic evaluation of the effectiveness of means for the collective protection of the crews on board gas-carrier ships




Experience with using a cell culture method for assessing the toxicity of anticorrosive materials intended for shipbuilding




Individual-typologic features of the functioning of the sympatho-adrenal system as a prognostic index of the functional state of the body in complex environmental conditions




Hygienic evaluation of the sorption properties of the synthetic materials used in ship building and ship maintenance




Effect of combined exposure to noise, vibration, and high temperatures on sympathico-adrenal system in sailors




Level of Physiological Reserves of the Body of Sailors Working According to the Ten-hour Schedule.




Upper airways affection in sailors of the transport fleet and its prophylaxis during the long navigation




Work capacity of sailors with a changed work and rest regimen




Hygienic studies in the airless spraying of KhV-53-type antifouling paints




Complex physiological and hygienic characteristics of a new work and rest regimen for ship's personnel




Method for the hygienic evaluation of the toxicity of polymeric material combustion products




Lipid peroxidation, peroxidase activity and glutathione antiperoxide systems in rat tissues under conditions of high altitude hypoxia

RECENT SCHOLAR PUBLICATIONS

Основи теорії медицини: монографія
АІ Гоженко, ВС Бірюков, ОА Гоженко, ЛІ Ковальчук, БА Насібуллін, ...
2024



Toxicological-hygienic and ecological aspects of safety of rolling stock braking systems of railway transport
LM Shafran, VL Mazur, DV Bolshoy, OG Pykhtieieva, OV Tretyakova, ...
Part 2, 15-26 2022



КОНЦЕПЦІЯ “TOXICITY TESTING-21” У СУЧАСНІЙ ТОКСИКОЛОГІЇ
ЛМ Шафран, ОВ Третьякова
Актуальні проблеми профілактичної медицини, 8-42 2021



ДИНАМИКА УРОВНЕЙ ЦИНКА В БИОСУБСТРАТАХ НАСЕЛЕНИЯ УКРАИНЫ В ПЕРИОД 2008-2021 гг
ЛМ Шафран, ЕГ Пыхтеева, ДВ Большой, ЕД Пыхтеева
2021



Zinc supply of the population of Ukraine: consequences for health and reproduction
EG Pykhtieieva, DV Bolshoy, AD Melenevsky, OM Chaika, ...
2021



Анестезиологическое обследование при хирургическом лечении холецистита (обзор литературы и собственные данные)
ЕН Салех, ЛМ Шафран
Актуальні проблеми транспортної медицини: навколишнє середовище; професійне 2020



Анестезиологическое обеспечение при хирургическом лечении холецистита (обзор литературы и собственные данные)
ЕН Салех, ЛМ Шафран
2020



Побудова нової концепції безпечного застосування полімерів у світі вимог міжнародного проекту" Токсикологічні випробування–ХХІ століття"
ОВ Третьякова, ЛМ Шафран
XVIII–і читання ВВ Підвисоцького: Бюлетень матеріалів науково-практичної 2019



Бионеорганическая химия с основами медицинской элементологии: учебник
ТП Максимчук, АВ Скальный, ИВ Радыш, ЛМ Шафран, МГ Скальная, ...
М.: Российский ун-т дружбы народов 624 2019



Гигиеническая регламентация полимеров в XXI веке-новая парадигма
ЛМ Шафран, ЕВ Третьякова
Актуальні проблеми транспортної медицини: навколишнє середовище; професійне 2019



ВНУТРИВЕННЫЕ АНЕСТЕТИКИ С ПОЗИЦИЙ ХИМИЧЕСКОЙ БЕЗОПАСНОСТИ В ХИРУРГИИ
ЕН САЛЕХ, ЛМ ШАФРАН
Likarska Sprava 2019 2018



Тяжелые металлы: система биологического транспорта
ЛМ Шафран, ЕГ Пыхтеева, ДВ Большой
Монография. Одесса 320, 68 2018



Seafarer's health savings competencies: goals, professional features, formation and development
LM Shafran, VV Golikova
Visnyk Mors' koi'Medycyny 80 (3), 4-12 2018



УРОКИ МИНАМАТСКОЙ ТРАГЕДИИ И АКТУАЛЬНЫЕ ПРОБЛЕМЫ СОВРЕМЕННОЙ МИКРОЭЛЕМЕНТОЛОГИИ
ЛМ Шафран
Микроэлементы в медицине 19 (4), 63-65 2018



Професійна компетентність суднових операторів як предиктор хімічної безпеки у морському перевезенні небезпечних вантажів
ЛМ Шафран
Актуальні проблеми транспортної медицини: навколишнє середовище; професійне 2018



Энергоэффективность, энергосбеоежение и здоровье
ВЯ Браверман, ВИ Кушнерук, ЕВ Третьякова, ЛМ Шафран
Актуальні проблеми транспортної медицини: навколишнє середовище; професійне 2018



Здоровьесберегающие компетенции моряка: задачи, профессиональные особенности, формирование и развитие
ЛМ Шафран, ВВ Голикова
Вісник морської медицини, 4-12 2018



Virtual screening, synthesis and biological evaluation of DNA intercalating antiviral agents
K Klimenko, S Lyakhov, M Shibinskaya, A Karpenko, G Marcou, ...
Bioorganic & Medicinal Chemistry Letters 27 (16), 3915-3919 2017



Kidney damage phenylhydrazine and methods of its pathogenetic correction
VM Sirman, BA Nasibullin, LM Shafran, W Zukow, AI Gozhenko
Journal of Education, Health and Sport 7 (3), 239-257 2017



ЭНДОТЕЛИАЛЬНАЯ ДИСФУНКЦИЯ КАК ПРОБЛЕМА СОВРЕМЕННОЙ ТОКСИКОЛОГИИ
ЛМ Шафран
Сборник материалов республиканской научно-практической конференции с 2017

MOST CITED SCHOLAR PUBLICATIONS

Общая токсикология
БА Курляндский, ВА Филов, ВС Безель, НМ Василенко, ЛВ Дарьина, ...
Открытое акционерное общество Издательство Медицина 2002
Citations: 240



Synthesis, cytotoxicity, antiviral activity and interferon inducing ability of 6-(2-aminoethyl)-6H-indolo [2, 3-b] quinoxalines
MO Shibinskaya, SA Lyakhov, AV Mazepa, SA Andronati, AV Turov, ...
European journal of medicinal chemistry 45 (3), 1237-1243 2010
Citations: 135



Теория и практика профессионального психофизиологического отбора моряков
ЛМ Шафран, ЭМ Псядло
Одесса: Феникс 2008
Citations: 92



Anti-inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase inhibitor
IA Schepetkin, LN Kirpotina, D Hammaker, I Kochetkova, AI Khlebnikov, ...
The Journal of Pharmacology and Experimental Therapeutics 353 (3), 505-516 2015
Citations: 72



Тиоловые яды
ИМ Трахтенберг, ЛМ Шафран
Общая токсикология/Под редакцией БА Курляндского, ВА Филова–М.: Медицина 2002
Citations: 47



Synthesis and affinity to DNA of phenylbenzoimidazoles and benzoimidazo [1, 2-c] quinazolines
EA Lyakhova, YA Gusyeva, JV Nekhoroshkova, LM Shafran, SA Lyakhov
European journal of medicinal chemistry 44 (8), 3305-3312 2009
Citations: 41



Металлотионеины
ЛМ Шафран, ЕГ Пыхтеева, ДВ Большой
Издательство" Чорномор'я" 2011
Citations: 33



Гигиена обитаемости морских судов
АМ Войтенко, ЛМ Шафран
К.: Здо ров’я 1989
Citations: 32



Biological active acridine derivatives. Part 4: Synthesis and antiviral activity of some bis-acridinylated diamides.
SA Lyakhov, YI Suveyzdis, LA Litvinova, SA Andronati, SL Rybalko, ...
Die Pharmazie 55 (10), 733-736 2000
Citations: 31



Synthesis, DNA-binding, and interferon-inducing properties of isatin and benzoisatin hydrazones
AS Karpenko, MO Shibinskaya, NM Zholobak, ZM Olevinskaya, ...
Pharmaceutical Chemistry Journal 40, 595-602 2006
Citations: 30



Комплексная гигиеническая оценка условий труда и трудового процесса пожарных-спасателей
ЛМ Шафран, ЮВ Нехорошкова
Гигиена и санитария 94 (1), 77-82 2015
Citations: 28



Synthesis and biological activity of 7H-benzo [4, 5] indolo [2, 3-b]-quinoxaline derivatives
MO Shibinskaya, AS Karpenko, SA Lyakhov, SA Andronati, NM Zholobak, ...
European journal of medicinal chemistry 46 (2), 794-798 2011
Citations: 26



Synthesis of 6‐Aminopropyl‐6H‐indolo [2, 3‐b] quinoxaline Derivatives
MO Shibinskaya, NA Kutuzova, AV Mazepa, SA Lyakhov, SA Andronati, ...
Journal of Heterocyclic Chemistry 49 (3), 678-682 2012
Citations: 23



Virtual screening, synthesis and biological evaluation of DNA intercalating antiviral agents
K Klimenko, S Lyakhov, M Shibinskaya, A Karpenko, G Marcou, ...
Bioorganic & Medicinal Chemistry Letters 27 (16), 3915-3919 2017
Citations: 20



К обоснованию гормезиса как фундаментальной биомедицинской парадигмы (обзор литературы и результатов собственных исследований)
ЛМ Шафран, АВ Мокиенко, НФ Петренко, АИ Гоженко, БА Насибуллин
Современные проблемы токсикологии 2 (3), 13-23 2010
Citations: 20



Научно-теоретические проблемы медицины транспорта
ЛМ Шафран
Актуальні проблеми транспортної медицини 2005
Citations: 20



Гармонизация методов оценки токсичности продуктов горения полимеров с международными требованиями
ЛМ Шафран, ИА Харченко
Со врем. проблемы токсикологии, 10 2003
Citations: 20



Роль лизосом в ме ханизме защиты и повреждения клеток при действии тяжелых метал лов
ЛМ Шафран, ДВ Большой, ЕГ Пыхтеева, ЕВ Третьякова
Современные проблемы токсикологии, 17 2004
Citations: 18



Synthesis and liquid crystal properties of 2, 7-dialkoxy-9-fluorenones
AV Ivanov, SA Lyakhov, MY Yarkova, AI Galatina, AV Mazepa
Russian journal of general chemistry 72, 1435-1438 2002
Citations: 18



Токсикология горения: основные задачи и перспективы развития
ЛМ Шафран
Актуальні проблеми транспортної медицини 2006
Citations: 17