Lokman Hizmali
@tip.ahievran.edu.tr
Assistant Professor, MD./ Ahi Evran University Faculty Of Medicine, Department Of İnfection Diseases And Clinical Microbiology
Ahi Evran University Faculty Of Medicine
RESEARCH INTERESTS
İnfection Disease İmmunology
HİV
Viral Hepatitis
İnfectious Diseases
Bacterial Diseases
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
Semiha Çelik Ekinci, E. Yenilmez, Gülfem Akengin Öcal, M. Ç. Sönmezer, Arzu Tarakçı, Cemanur Aygün, Damla Akdağ, D. Seyman, Cansu Aşık, E. Zerdali,et al.
Background: Surgical antimicrobial prophylaxis (SAP) is the peri-operative administration of antimicrobial agents. Compliance rates vary worldwide from 15% to 84.3%, with studies in Turkey not exceeding 35%. The aim of this multicenter study was to determine the rate of appropriate antibiotic class, timing, and duration as well as discharge prescriptions in Turkey. Thus, we aimed to determine the rate of full compliance with SAP procedures in our country Patients and Methods: This multicenter, prospective, observational, descriptive study was conducted in 47 hospitals from 28 provinces in seven different regions of Turkey. Patients over 18 years of age in all surgical units between June 6, 2022, and June 10, 2022, were included in the study. Results: Of the 7,978 patients included in the study, 332 were excluded from further analyses because of pre-existing infection, and SAP compliance analyses were performed on the remaining 7,646 cases. The antibiotic most commonly used for SAP was cefazolin (n = 4,701; 61.5%), followed by third-generation cephalosporins (n = 596; 7.8%). The most common time to start SAP was within 30 minutes before surgery (n = 2,252; 32.5%), followed by 30 to 60 minutes before surgery (n = 1,638; 23.6%). Surgical antimicrobial prophylaxis duration was <24 hours in 3,516 (50.7%) patients and prolonged until discharge in 1,505 (21.7%) patients. Finally, the actual proportion of patients compliant with SAP was 19% (n = 1,452) after omitting 4,458 (58.3%) patients who were prescribed oral antibiotic agents at discharge as part of a prolonged SAP. Conclusions: Surgical antimicrobial prophylaxis compliance rates are still very low in Turkey. Prolonged duration of SAP and especially high rate of antibiotic prescription at discharge are the main reasons for non-compliance with SAP.
Burc Esra Sahin, Asuman Celikbilek, Yusuf Kocak, Aydan Koysuren, and Lokman Hizmali
Scientific Scholar
Objectives: Data are limited regarding the relationship of neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), and platelet/ lymphocyte ratio (PLR) with neurological symptoms (NS) in COVID-19 patients. This study is the first to assess the utility of the NLR, MLR, and PLR for predicting COVID-19 severity in infected patients with NS. Materials and Methods: Consecutive 192 PCR-positive COVID-19 patients with NS were included in this cross-sectional and prospective study. The patients were classified into the non-severe and severe groups. We analyzed routinely complete blood count in these groups in terms of COVID-19 disease severity. Results: Advanced age, a higher body mass index, and comorbidities were significantly more common in the severe group (P < 0.001). Among the NS, anosmia (P = 0.001) and memory loss (P = 0.041) were significantly more common in the non-severe group. In the severe group, the lymphocytes and monocyte counts and the hemoglobin level were significantly lower, while the neutrophil count, NLR, and PLR were significantly higher (all P < 0.001). In the multivariate model, advanced age and a higher neutrophil count were independently associated with severe disease (both P < 0.001) but the NLR and PLR were not (both P > 0.05). Conclusion: We found positive associations of COVID-19 severity with the NLR and PLR in infected patients with NS. Further research is required to shed more light on the role of neurological involvement in disease prognosis and outcomes.
Burcu KAMASAK, Tufan ULCAY, Mehtap NISARI, Ozkan GORGULU, Veysel AKCA, Muhammet ALPASLAN, Aysu YETIS, Lokman HIZMALI, Mustafa Kasim KARAHOCAGIL, and Kenan AYCAN
AEPress, s.r.o.
OBJECTIVE
COVID-19 is caused by SARS-CoV-2 virus and turned into a pandemic in a short time, affects many organs and systems, especially the nervous system. In the present study, it was aimed to determine the morphological and volumetric changes in cortical and subcortical structures in recovered COVID-19 patients.
BACKGROUND
We think that COVID-19 has a long-term effect on cortical and subcortical structures.
METHODS
In our study, 50 post-COVID-19 patients and 50 healthy volunteers participated. In both groups, brain parcellations were made with Voxel-Based Morphometry (VBM) and regions showing density changes in the brain and cerebellum were determined. Gray matter (GM), white matter, cerebrospinal fluid and total intracranial volume were calculated.
RESULTS
Neurological symptoms developed in 80% of COVID-19 patients. In post-COVID-19 patients, a decrease in GM density was detected in pons, gyrus frontalis inferior, gyri orbitales, gyrus rectus, gyrus cinguli, lobus parietalis, gyrus supramarginalis, gyrus angularis, hippocampus, lobulus semilunaris superior of cerebellum, declive, and Brodmann area 7-11-39-40. There was a significant decrease in GM density in these regions and an increase in GM density in amygdala (p<0.001). The GM volume of post-COVID-19 group was found to be less than in the healthy group.
CONCLUSIONS
As a result, it was seen that COVID-19 negatively affected many structures related to the nervous system. This study is a pioneering study to determine the consequences of COVID-19, especially in the nervous system, and to determine the etiology of these possible problems (Tab. 4, Fig. 5, Ref. 25). Text in PDF www.elis.sk Keywords: COVID-19, pandemic, Voxel-based morphometry (VBM), brain, magnetic resonance imaging (MRI).
Burc E. Sahin, Asuman Celikbilek, Yusuf Kocak, Bilal Ilanbey, Gamze T. Saltoglu, Naime M. Konar, and Lokman Hizmali
Wiley
OBJECTIVE
A wide spectrum of neurological symptoms (NS) has been described in patients with COVID-19. We examined the plasma levels of neuron spesific enolase (NSE) and neurofilament light chain (NFL) together, as neuronal damage markers, and their relationships with clinical severity in patients with NS at acute COVID-19.
METHODS
A total of 20 healthy controls and 59 patients with confirmed COVID-19 were enrolled in this pilot prospective study. Serum NSE and NFL levels were measured by using enzymle linked immunoassay method from serum samples.
RESULTS
Serum NSE levels were found to be significantly higher in the severe group than in the non-severe group (p=0.034). However, serum NFL levels were similar between control and disease groups (p>0.05). For mild group, serum NFL levels were significantly higher in patients with the sampling time ≥ 5 days than in those with the sampling time < 5 days (p=0.019). However, no significant results for NSE and NFL were obtained in patients with either single or multiple NS across the groups (p>0.05).
CONCLUSIONS
Increased serum NSE levels were associated with disease severity regardless of accompanied NS in patients with acute COVID-19 infection. However, serum NFL levels may have a role at the subacute phase of COVID-19. This article is protected by copyright. All rights reserved.
B.E. Sahin, A. Celikbilek, Y. Kocak, G.T. Saltoglu, N.M. Konar, and L. Hizmali
Elsevier BV
BE. Sahin, A. Celikbilek, Y. Kocak, and L. Hizmali
Elsevier BV
Özkan Kocamış, Emine Temel, Lokman Hızmalı, Nazife Aşıkgarip, Kemal Örnek, and Fikriye Milletli Sezgin
GN1 Genesis Network
PURPOSE
To assess choroidal changes using enhanced depth imaging optical coherence tomography in coronavirus disease (COVID-19).
METHODS
Thirty-two patients with moderate COVID-19 and 34 healthy subjects were included in the study. Choroidal thickness was measured at 3 points as follows: at the subfovea, 1500 mm nasal to the fovea, and 1500 mm temporal to the fovea. The total choroidal area, luminal area, stromal area, and choroidal vascular index were measured with Image-J. All the measurements were performed during the disease and at 4 months after remission.
RESULTS
In the patient group, the subfoveal, nasal, and temporal choroidal thicknesses were decreased as compared with those in the controls, but without statistically significant differences (p=0.534, p=0.437, and p=0.077, respectively). The mean total choroidal, stromal, and luminal areas and choroidal vascular index were statistically significantly decreased in the patient group (p<0.001, p=0.001, p=0.001, and p=0.003; respectively). At 4 months after remission, the choroidal structural parameters and choroidal vascular index revealed statistically significant increases as compared with the baseline measurements in the patients with COVID-19 (all p<0.001 and p=0.047, respectively).
CONCLUSION
The choroidal vascular and stromal parameters showed significant transient decreases during the disease course of COVID-19.
Özkan Kocamış, Kemal Örnek, Nazife Aşıkgarip, Lokman Hızmalı, Fikriye Milletli Sezgin, and Yahya Şahin
Informa UK Limited
ABSTRACT Purpose To evaluate the results of conjunctival and nasopharyngeal swab tests in patients with confirmed COVID-19. Methods This prospective study included 45 patients who were hospitalized for confirmed COVID-19. Nasopharyngeal swab samples were obtained from the patients before hospitalization. Only one eye of each patient was randomly selected for-conjunctival sampling. All participants underwent a complete slit-lamp examination. Conjunctival and nasopharyngeal swab samples were analyzed by reversetranscriptase-polymerase-chain reaction (RT-PCR). Results Twenty seven (60%) of the patients were male and 18 (40%) were female. Conjunctival swab was positive in only one (2.22%) patient. None of the COVID-19 patients showed ocular changes and symptoms. There were no abnormalities of the ocular surface, anterior chamber or posterior segment at slit-lamp examination. Conclusions The RT-PCR was not high positive in the conjunctiva as in nasopharyngeal swabs. Ocular changes were not common in COVID-19 patients.
Kemal Örnek, Emine Temel, Özkan Kocamış, Nazife Aşıkgarip, and Lokman Hızmalı
GN1 Genesis Network
Nazife Aşıkgarip, Emine Temel, Lokman Hızmalı, Kemal Örnek, and Fikriye Milletli Sezgin
Informa UK Limited
ABSTRACT Purpose: To evaluate the longitudinal changes in retinal vessel diameters in patients with coronavirus disease 2019 (COVID-19). Methods: This study included 25 patients with COVID-19 (Group 1) and 25 healthy subjects (Group 2). The diameters of peripapillary temporal and nasal retinal arteries and veins were measured at baseline and at 4 months after remission. Results: The baseline diameters of the inferior temporal vein and the artery were increased in group 1 compared to controls (p = .007 and p = .041, respectively). There was also an increase in the diameters of the inferior and superior nasal veins and arteries in group 1 at baseline (p = .001, p = .019, p = .037, and p = .008, respectively). Retinal vessel diameters decreased after remission in all quadrants in comparison to baseline measurements (all p < .05). Conclusion: Increased retinal vessel diameters were measured in COVID-19 patients during the disease. Measurement of retinal vessel diameters may be a noninvasive method of estimating the vascular risk.
Serap Şimşek-Yavuz
Turkish Society of Cardiology
Serap Simsek-Yavuz, , Ahmet Ruchan Akar, Sinan Aydogdu, Denef Berzeg-Deniz, Hakan Demir, Tuncay Hazirolan, Mehmet Ali Ozatik, Necla Ozer, Murat Sargin,et al.
Doc Design and Informatics Co. Ltd.
Although infective endocarditis (IE) is rare, it is still important as an infectious disease because of the resulting morbidity and substantial mortality rates. Epidemiological studies in developed countries have shown that the incidence of IE has been approximately 6/100 000 in recent years and it is on the fourth rank among the most life-threatening infectious diseases after sepsis, pneumonia and intraabdominal infections. Although IE is not a Özet İnfektif endokardit (İE) nadir görülmesine karşın, yol açtığı morbiditeler ve yüksek mortalite hızı nedeniyle halen önemini koruyan bir infeksiyon hastalığıdır. Son yıllarda gelişmiş ülkelerde yapılmış epidemiyolojik çalışmalarda İE sıklığının yaklaşık 6/100 000 olduğu ve İE’nin, sepsis, pnömoni ve intraabdominal infeksiyonlardan sonra yaşamı en çok tehdit eden dördüncü infeksiyon hastalığı olduğu görülmüştür. Türkiye’de İE’nin bildirimi Uzlaşı Raporu / Consensus Report