Pharmaceutical Science, Drug Discovery, Pharmacy, Chemistry
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Scopus Publications
Scopus Publications
Secondary Metabolism in Tissue Cultures with Emphasis on the Production of Medicinal Agents: Precursors and Elicitors on the Production of Secondary Metabolites—Applications and Associated Problems Gajanand Engla, Love Kumar Soni, Mayur Chaurey, Arun Patidar Plant Biotechnology the Medicinal and Phytopharmaceutical Aspects, 2025 Plants serve as the main source of crucial secondary metabolites (SMs), which hold medicinal significance in the advancement of drug discovery. Secondary metabolites are frequently employed by plants for diverse functions, such as resistance to herbivory, interspecies interactions, and various forms of stress. These secondary metabolites serve vital functions in the human body as drugs, pigments, flavors, and medications. The pharmaceutical industry’s significant faith on medicinal plants and their extraction has resulted in the endangerment of these plants. The utilization of plant cell culture technologies is accessible as a reasonable approach to generate and investigate plant SMs. For the enhancement of plant SM production, a variety of in vitro techniques (elicitation, crown gall, hairy root culture system, cell suspension culture system, etc.) have been utilized widely. Although cell suspension culture and elicitation are the most common techniques used to increase SM production, it has been demonstrated that hairy root culture and other organ cultures can also meet the demand for secondary metabolites (Winter & Tang, 2012).
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-UHPLC METHOD FOR THE ESTIMATION OF IMEGLIMIN HYDROCHLORIDE USED FOR THE TREATMENT OF METABOLIC DISORDER DIABETES MELLITUS AVNISH JAIN, LOVE KUMAR SONI, RAJESH SHARMA International Journal of Applied Pharmaceutics, 2023 Objective: The present work was aimed to develop and validate a novel, simple, rapid, consistent, and sensitive stability indicating reverse phase ultra-high-performance liquid chromatographic (RP-UHPLC) method for the determination of oral anti-diabetic drug Imeglimin Hydrochloride in bulk and pharmaceuticals dosage form as per the technical recommendations of International Council for Harmonization guidelines for human use pharmaceutical (ICH-Q2(R1)). Methods: A novel simple, selective, stable and sensitive stability indicating method which used isocratic RP-UHPLC methodology for the quantitative measurement of Imeglimin Hydrochloride was developed. The chromatographic separation of Imeglimin Hydrochloride was achieved on RP-UHPLC equipped with Hypersil gold ODS endcapped column of dimensions (150x4.6 mm, 3micron) using isocratic elution with a mobile phase consisting of water: acetonitrile in a ratio of (15:85% v/v) at a flow rate of 1 ml/min with an injection volume of 20 µl. All measurements are done on 240 nm using eight channels Dionex Ultimate 3000 PDA detector equipped with chromeleon data acquisition system for data integration. Validation of the proposed method was carried out according to the (ICH-Q2 (R1)) guidelines. Results: The retention time of the Imeglimin Hydrochloride was found to be 3.831 with excellent absorbance sensitivity at 240 nm wavelength. The linear regression equation was found to be y = 3199x+1605.5 with a correlation coefficient (R2)>0.999 which shows excellent linear correlation. Specificity, linearity, precision, accuracy robustness, LOD and LOQ were determined for method validation and results were found to be well within recommended limits as per ICH guidelines. Conclusion: The proposed stability indicating reverse phase ultra-high-performance liquid chromatographic (RP-UHPLC) method was found to be fast, affordable, robust, precise and specific for estimation of Imeglimin Hydrochloride in pharmaceutical dosage form.
Development of parenteral formulation of poorly water soluble drugs: The role of novel mixed-solvency concept Asian Journal of Pharmaceutics, 2017
Molecular docking simulation of small diverse chemical molecules based virtual screening for treatment of tuberculosis Mohammad Rizwan Khan, Love Kumar Soni Asian Journal of Chemistry, 2016 Asian Journal of Chemistry, a Multidisciplinary Chemistry Journal is an Peer Reviewed International Journal and publishes from India. The journal has been established since January 1989 on a firm foundation of International Quality Research. This Journal encompasses all branches of chemistry and its sub – disciplines like Pharmaceutical, Biological activities of Synthetic Drugs, Environmental Chemistry, Biochemistry, Polymer Chemistry, Petroleum Chemistry, and Agricultural Chemistry, etc.
Exploring structural requirements for PPARγ modulation of benzoyl 2-methyl indoles using physico-chemical parameters International Journal of Pharmtech Research, 2012
Development and validation of rp-hplc method for simultaneous estimation of metformin hydrochloride and repaglinide in tablet dosage form Love Kumar Soni, Tamanna Narsinghani, Madhavi Jain Journal of Liquid Chromatography and Related Technologies, 2012 A simple, rapid, and specific reversed-phase high performance liquid chromatographic method for simultaneous estimation of Metformin hydrochloride (MET) and Repaglinide (RPG) in a tablet dosage form has been developed and validated. HPLC analysis was performed on a C 18 column with 90:10 (v/v) acetonitrile-water as mobile phase at a flow rate of 1.0 mL min−1. UV detection was performed at 223 nm. Total run time was 10 min; Metformin hydrochloride and Repaglinide were eluted with retention times of 2.72 min and 6.13 min, respectively. The method was validated for accuracy, precision, linearity, specificity, and sensitivity in accordance with ICH guidelines. Validation revealed that the method is specific, rapid, accurate, precise, reliable, and reproducible. The high recovery and low coefficients of variation confirmed the suitability of the method for simultaneous analysis of the two drugs in tablet dosage form.
Classical QSAR modelling of Indole-3-Acetic acids for Cancer therapy International Journal of Chemtech Research, 2012
Development and validation of UV-Spectrophotometric assay protocol for simultaneous estimation of ebastine and phenylephrine hydrochloride in tablet dosage form using simultaneous equation method International Journal of Chemtech Research, 2011
QSAR modeling of benzoxazole derivatives as antimicrobial agents Der Pharmacia Lettre, 2011
Effect of Allium sativum on the pharmacokinetic of Metformin in rat plasma: A herb-drug interaction study Der Pharma Chemica, 2011
HPLC estimation of perindopril erbumine in tablet dosage form Asian Journal of Chemistry, 2011
QSAR modeling of thalidomide analogs as antiangiogenic and prostate cancer inhibitor using AMI calculations Indian Journal of Chemistry Section A Inorganic Physical Theoretical and Analytical Chemistry, 2007
QSAR studies of 2,3-diarylpyrazolo[1,5-b]-pyridazine analogs as cyclooxygenase-2 inhibitors Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2006
QSAR analysis of 5-aryl thiazolidine-2,4-diones as PPAR-α and PPAR-γ agonists Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2006
Development of pharmacophoric model of condensed pyridine and pyrimidine analogs as hydroxymethyl glutaryl coenzyme A reductase inhibitors Indian Journal of Biochemistry and Biophysics, 2006
QSAR analysis of 2,4-diaminopyrido[2,3-d]pyrimidines and 2,4-diaminopyrrolo[2,3-d]pyrimidines as dihydrofolate reductase inhibitors Indian Journal of Biochemistry and Biophysics, 2005
QSAR analysis of analogs of bis[2-(acylamino) phenyl] disulfides, 2-(acylamino)benzenethiols and S-[2-(acylamino) phenyl] alkanethioates as antihyperlipidemic agents Indian Journal of Chemistry Section B Organic and Medicinal Chemistry, 2005
