Lina Nasser Al Tamimi

@zu.edu.jo

Clinical Pharmacy Department/ Faculty of Pharmacy
Zarqa University

Lina Nasser Al Tamimi


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https://researchid.co/ltamimi

RESEARCH INTERESTS

Supplementary Therapy, Clinical Pharmacy, Pharmaceutical Nutritional Support, Drug-Supplement Interaction, Diabetology, Clinical Biochemistry
8

Scopus Publications

151

Scholar Citations

7

Scholar h-index

5

Scholar i10-index

Scopus Publications

  • Exploring the impact of pharmacist involvement in palliative care medication management
    Pharmacy Practice, 2025
  • Pharmacokinetics and Pharmacodynamics: A Comprehensive Analysis of the Absorption, Distribution, Metabolism, and Excretion of Psychiatric Drugs
    Zainab Zakaraya, Mohammad Abu Assab, Lina N. Tamimi, Nida Karameh, Mohammad Hailat, et al.
    Pharmaceuticals, 2024
    The two main classifications of antidepressant medications are selective norepinephrine reuptake inhibitors (SNRIs) and selective serotonin reuptake inhibitors (SSRIs). Out of the available choices, selective serotonin reuptake inhibitors (SSRIs) have emerged as the most commonly prescribed option. The class demonstrates a greater degree of diversity in its structural characteristics in contrast to its neurochemical effects. Nevertheless, it is important to acknowledge that the chemical composition of a drug within this specific class does not carry substantial significance in the selection process. A comprehensive analysis of the pharmacodynamic and pharmacodynamic properties of antidepressant drugs proves advantageous for clinicians and managed care providers responsible for selecting preferred selective serotonin reuptake inhibitors (SSRIs) from a roster of authorized medications. The physicochemical characteristics, which possess considerable significance, are frequently disregarded except during the drug development stage. Pharmacodynamic properties refer to the physiological and biochemical effects that drugs exert on the human body. It is noteworthy that the inclusion of selective serotonin reuptake inhibitors (SSRIs) and serotonin–norepinephrine reuptake inhibitors (SNRIs) in a comprehensive depression management protocol may demonstrate enhanced effectiveness in clinical environments as opposed to controlled trials.
  • Efficacy and Safety of Pharmacist-Managed NSAIDs Deprescribing: A Jordanian Outpatient Study
    Deema Jaber, Abeer Al Shihab, Lina N. Tamimi
    Journal of Clinical Pharmacy and Therapeutics, 2024
    Background. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used to manage pain, including chronic pain conditions. However, their prolonged use is associated with significant risks, particularly gastrointestinal (GI) adverse events. This study aimed to evaluate the effectiveness and safety of a pharmacist-managed deprescribing program for NSAIDs in a Jordanian outpatient population. Methods. A convenience sample of 100 participants who had been using NSAIDs for pain management was recruited. Participants underwent a structured deprescribing intervention in collaboration with physicians. Various effectiveness and safety outcomes were assessed before and after deprescribing. Descriptive statistics and chi-square test were used for data analysis. Results. The majority of participants reported chronic pain conditions, with rheumatoid arthritis (24%) and osteoarthritis (22%) being the most prevalent. Ibuprofen (28%) and diclofenac (22%) were the most commonly used NSAIDs. The deprescribing program was associated with a significant reduction in heartburn, stomach ulcer, kidney problems and fluctuation in blood pressure readings (p<0.05), and pain exacerbation. Notably, the reduction in pain exacerbation was evident (p=0.003) in the 4-month follow-up. Conclusion. A pharmacist-managed NSAIDs deprescribing program demonstrated effectiveness in reducing the risk of GI adverse events and fluctuation in blood pressure readings without causing harm during a short-term follow-up. These findings support the feasibility of implementing such programs in outpatient settings. Further long-term investigations are necessary to confirm these results.
  • Effect of date molasses on levetiracetam pharmacokinetics in healthy rats
    Wael Abu Dayyih, Raghad Layth, Mohammad Hailat, Bayan Alkhawaja, Lina Al Tamimi, et al.
    Scientific Reports, 2023
    Twelve healthy eight-week-old male Wistar rats weighing 200 g were used. Rats were chosen randomly, and their tails were identified and separated into cages/groups. The first group received an oral dose of 11.5 mg of levetiracetam in 5 mL of water, and the second group was given date syrup (250 g mixed with 250 mL water) for seven days, then 11.5 mg LEV in 5 mL water on day 7. One week of preadministered date molasses significantly decreased levetiracetam pharmacokinetic parameters in rats, such as Cmax (72 vs. 14 ng/mL, p = 0.01), Tmax (1.78 vs. 0.44 h, p < 0.001), and AUC (880 vs. 258 ng.h/mL, p < 0.001). This decrease in plasma levetiracetam levels caused by date molasses could be attributed to decreased levetiracetam absorption. On the other hand, the current study discovered that rats given date molasses for a week had a reduced rate and extent of absorption. As a result, date molasses might increase the risk of epileptic seizures in oral LEV-treated ones.
  • Anti-diabetic effect of cotreatment with resveratrol and pioglitazone in diabetic rats
    L. Tamimi, Z. Zakaraya, M. Hailat, W. Abu Dayyih, E. Daoud, et al.
    European Review for Medical and Pharmacological Sciences, 2023
    OBJECTIVE Limitations and side effects associated with current anti-diabetic treatments have necessitated the search for new therapeutic alternatives. This study aimed to explore the combined use of resveratrol (RVT) and established anti-diabetic drug pioglitazone (PGZ) against streptozotocin (STZ)-induced diabetes mellitus (DM). MATERIALS AND METHODS STZ was supplemented daily to Sprague-Dawley rats to induce DM. The synergistic effect of the RVT (20 mg/kg) and PGZ (0.65 mg/kg) on DM complications was evaluated after 8 weeks of treatment. Biochemical analyses were performed to evaluate the effectiveness of our treatment on glucose level, insulin sensitivity, lipid disturbances, oxidative mediators and inflammatory markers. RESULTS STZ induced DM onset that is accompanied with elevated diabetic markers, lipid disturbances, remarkable oxidative damage and hyper-inflammation. The PGZ+RVT combination has the best effect as illustrated by significant (p < 0.05) decreases in fasting blood glucose, insulin, HbA1c and HOMA-IR levels. This combination attenuated (p < 0.05) lipid disturbances and their associated elevated atherogenic biomarkers. At the same time, treatments with PGZ+RVT exhibited an anti-inflammatory effect as it attenuated the increase in inflammatory parameters (CRP, TNF-α, IL-6). Also, it restored total antioxidant capacity and peroxisome proliferator-activated receptor (PPARg) levels that decreased by STZ-DM induction. CONCLUSIONS This study provides PGZ+RVT as promising DM therapeutic alternative. This synergistic combination alleviates most of DM-related complications and insulin resistance.
  • Spectrophotometric analysis of empagliflozin tablets as SGLT2 inhibitors in pharmaceutical samples
    Wael Abu Dayyih, Mohammad Hailat, Tayel A. Al Hujran, Mousa Magharbeh, Zainab Zakaraya, et al.
    Journal of Applied Pharmaceutical Science, 2022
    Azo dyes account for 70% of dye chemistry, and their importance may grow in the future. Empagliflozin is a sodium-glucose co-transporter-2 (SGLT2) inhibitor. SGLT2 transporters are primarily responsible for glucose reabsorption in the kidney. In 2014, empagliflozin was approved for medical use in the United States and the European Union. With over 4 million prescriptions in 2019, it was the 146th most commonly prescribed medication in the United States in 2019. The spectrophotometric determination of empagliflozin is described using coupling agents such as 3-chloro-4-nitroaniline or sulfanilamide. These methods are straightforward and are based on the reaction of empagliflozin with diazotized products of 3-chloro-4-nitroaniline or sulfanilamide to produce colored azo dyes with absorption maxima at 470 and 480 nm. Empagliflozin was linear from 1.2 to 26.6 µgml −1 or 0.8 to 20.4 µgml −1 when combined with diazotized 3-chloro-4-nitroaniline or sulfanilamide, respectively. Empagliflozin’s molar absorptivity and Sandell’s sensitivity to 3-chloro-4-nitroaniline or sulfanilamide azo dyes were 3.179 × 10 4 l mol −1 cm −1 or 4.367 × 10 4 l mol −1 cm −1 and 1.149 × 10 −2 µgcm −2 or 8.368 × 10 −3 µgcm −2 , respectively. The formed colored azo dyes are stable for more than 12 hours. The optimal reaction conditions and other analytical parameters are assessed. Foreign organic compound interference has been studied. The method has been successfully used to determine empagliflozin in pharmaceutical samples.
  • Development and Validation of a Stability-Indicating HPLC-DAD Method for the Determination of Canagliflozin and Metformin Simultaneously in Combination Dosage Form
    Ramadan Al-Shdefat, Israa Al-Ani, Lina Tamimi, Riad Awad, Walid Abu Rayyan, et al.
    Pharmaceutical Chemistry Journal, 2021
  • Saxagliptin levels and its pharmacokinetic application in presence of sucralse in animals serum by HPLC method
    International Journal of Pharmacy and Pharmaceutical Sciences, 2015

RECENT SCHOLAR PUBLICATIONS

  • Predicting infection with COVID-19 disease using logistic regression model in Karak City, Jordan
    A Khaleel, WA Dayyih, L AlTamimi, L Dalaeen, Z Zakaraya, A Ahmad, ...
    F1000Research 12, 126 , 2025
    2025
    Citations: 2
  • Impact of Oxidative Stress on Jordanian Children with Autism Spectrum Disorder.
    A Al-Ramahi, Z Zakaraya, L AlTamimi, M Hailat, MF Hamad, WA Dayyih, ...
    Jordan Journal of Pharmaceutical Sciences 18 (3) , 2025
    2025
  • Exploring the impact of pharmacist involvement in palliative care medication management
    Z Zakaraya, MT Alsaadi, L Tamimi, MA Assab, WA Dayyih, F Lorena, ...
    Pharmacy Practice 23 (2), 1-12 , 2025
    2025
    Citations: 2
  • Pharmacokinetics and pharmacodynamics: a comprehensive analysis of the absorption, distribution, metabolism, and excretion of psychiatric drugs
    Z Zakaraya, M Abu Assab, LN Tamimi, N Karameh, M Hailat, L Al-Omari, ...
    Pharmaceuticals 17 (3), 280 , 2024
    2024
    Citations: 37
  • Efficacy and Safety of Pharmacist‐Managed NSAIDs Deprescribing: A Jordanian Outpatient Study
    D Jaber, A Al Shihab, LN Tamimi
    Journal of Clinical Pharmacy and Therapeutics 2024 (1), 5874686 , 2024
    2024
    Citations: 5
  • Test of insulin resistance in nondiabetic and streptozotocin-induced diabetic rats using glycosylated hemoglobin test and other interventions
    L AlTamimi, ZZ Zakaraya, M Hailat, MN Ahmad, NA Qinna, MF Hamad, ...
    Journal of Advanced Pharmaceutical Technology & Research 15 (1), 1-7 , 2024
    2024
    Citations: 5
  • Determination of five phosphodiesterase-5 inhibitors in multiple honey-based consumer products by chromatographic technique in rat plasma
    W Abu Dayyih, AA Rasras, M Hailat, R Karaki, AA Deeb, I Al-Ani, ...
    Processes 11 (10), 3019 , 2023
    2023
    Citations: 8
  • Effect of date molasses on levetiracetam pharmacokinetics in healthy rats
    W Abu Dayyih, R Layth, M Hailat, B Alkhawaja, L Al Tamimi, Z Zakaraya, ...
    Scientific Reports 13 (1), 758 , 2023
    2023
    Citations: 4
  • The impressive evaluation of selenium yeast role against diabetes mellitus and its comorbidities by streptozotocin-induced diabetes in rats
    LN Tamimi, Z Zakaraya, W Abu Dayyih, TY ALjaraedah, RH Al Omari, ...
    J Popul Ther Clin Pharmacol 30, 85-92 , 2023
    2023
    Citations: 3
  • Anti-diabetic effect of cotreatment with resveratrol and pioglitazone in diabetic rats
    LN Tamimi, Z Zakaraya, M Hailat, W Abu Dayyih, E Daoud, A Abed, ...
    Eur. Rev. Med. Pharmacol. Sci 27, 325-332 , 2023
    2023
    Citations: 16
  • Ameliorative effect of selenium yeast in combination with pioglitazone on diabetes outcomes in streptozotocin-induced.
    ZZ Zakaraya, L AlTamimi, M Hailat, MN Ahmad, NA Qinna, BY Ghanim, ...
    Journal of Population Therapeutics and Clinical Pharmacology= Journal de la … , 2022
    2022
    Citations: 3
  • Spectrophotometric analysis of empagliflozin tablets as SGLT2 inhibitors in pharmaceutical samples
    WA Dayyih, M Hailat, TA Al Hujran, M Magharbeh, Z Zakaraya, ...
    Journal of Applied Pharmaceutical Science 12 (10), 140-146 , 2022
    2022
    Citations: 7
  • Antidiabetic Effect of Aqueous Extract of Orthosiphon Stamineus Benth on Alloxan-Induced Diabetic Rats
    RMA Ali Alsarhan1, *, Naznin Sultana2 , Lee Suan CHUA3 , Ashraf O ...
    Sapporo Medical Journal 56 (6), 1-10 , 2022
    2022
    Citations: 1
  • Fructose-Induced Insulin Resistance: Prospective Biochemical Mechanisms
    LN Tamimi, MN Ahmad, NA Qinna
    Jordan Journal of Agricultural Sciences 17 (4), 441-453 , 2021
    2021
  • Development and validation of a stability-indicating HPLC-DAD method for the determination of canagliflozin and metformin simultaneously in combination dosage form
    R Al-Shdefat, I Al-Ani, L Tamimi, R Awad, WA Rayyan, WA Dayyih
    Pharmaceutical Chemistry Journal 55 (4), 402-409 , 2021
    2021
    Citations: 11
  • Clinical Nutrition in Diabetes Mellitus with Third Degree Burns and Foot Ulcers
    WA Dayyih, Z Zakareia, L Tamimi, R Awad, M Hamad
    Asian Journal of Pharmaceutical Research and Health Care 13 (1), 95-100 , 2021
    2021
    Citations: 1
  • End-Stage Renal Disease Hemodialysis Patients Malnutrition Treatment Using Intradialytic Parenteral Nutrition (IDPN); Prospective Effectiveness and Potential Adverse Effects
    Lina N. Tamimi1, Zainab Z. Zakareia1
    2021
    Citations: 1
  • FOLIC ACID BIOAVAILABILITY: A REVIEW
    ZZ Zakareia, HR Takruri, LN Tamimi, WA Dayyih
    2020
  • HEPATIC UPTAKE, STORAGE AND RELEASE OF VITAMIN A IN HUMANS LINA N. TAMIMI1, HAMED R. TAKRURI1, ZAINAB Z. ZAKARIA1, WAEL ABU DAYYIH2
    LN TAMIMI, HR TAKRURI, ZZ ZAKARIA, W ABU
    2020
  • Effect of smoking and obesity on the serum levels of Vitamin D3 in the central region of Jordan
    M Bustami, W Abudayyih, YS Batarseh, IS Al-Majali, LN Tamimi, A Rahhal, ...
    Int J Biol Pharm Allied Sci 8, 17 , 2019
    2019
    Citations: 2

MOST CITED SCHOLAR PUBLICATIONS

  • Pharmacokinetics and pharmacodynamics: a comprehensive analysis of the absorption, distribution, metabolism, and excretion of psychiatric drugs
    Z Zakaraya, M Abu Assab, LN Tamimi, N Karameh, M Hailat, L Al-Omari, ...
    Pharmaceuticals 17 (3), 280 , 2024
    2024
    Citations: 37
  • Pioglitazone HCl levels and its pharmacokinetic application in presence of sucralose in Animals serum by HPLC method
    L Tamimi, W Abudayyih, E Mallah, T Arafat
    Pharm Anal Acta 5 (318), 2 , 2014
    2014
    Citations: 18
  • Anti-diabetic effect of cotreatment with resveratrol and pioglitazone in diabetic rats
    LN Tamimi, Z Zakaraya, M Hailat, W Abu Dayyih, E Daoud, A Abed, ...
    Eur. Rev. Med. Pharmacol. Sci 27, 325-332 , 2023
    2023
    Citations: 16
  • Saxagliptin levels and its pharmacokinetic application in presence of sucralose in animals serum by HPLC method
    WA Dayyih, L Tamimi, E Mallah, K Mansour, T Arafat, M Bustami
    Int. J. Parm. Pharmac. Sci 7 (9), 243-250 , 2015
    2015
    Citations: 12
  • Development and validation of a stability-indicating HPLC-DAD method for the determination of canagliflozin and metformin simultaneously in combination dosage form
    R Al-Shdefat, I Al-Ani, L Tamimi, R Awad, WA Rayyan, WA Dayyih
    Pharmaceutical Chemistry Journal 55 (4), 402-409 , 2021
    2021
    Citations: 11
  • Determination of five phosphodiesterase-5 inhibitors in multiple honey-based consumer products by chromatographic technique in rat plasma
    W Abu Dayyih, AA Rasras, M Hailat, R Karaki, AA Deeb, I Al-Ani, ...
    Processes 11 (10), 3019 , 2023
    2023
    Citations: 8
  • Spectrophotometric analysis of empagliflozin tablets as SGLT2 inhibitors in pharmaceutical samples
    WA Dayyih, M Hailat, TA Al Hujran, M Magharbeh, Z Zakaraya, ...
    Journal of Applied Pharmaceutical Science 12 (10), 140-146 , 2022
    2022
    Citations: 7
  • Simultaneous determination of Atorvastatin, Glimepiride and Amlodipine in solution and plasma matrix using HPLC/UV method
    WA Dayyih, A Al-fayez, L Tamimi, E Mallah, T Arafat
    Journal of Chemical and Pharmaceutical Research 6 (11), 515-528 , 2014
    2014
    Citations: 7
  • VALIDATION AND DETERMINATION OF PIRACETAM IN RAT PLASMA BY USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY / UV / VIS SPECTROMETRY ( HPLC / UV / VIS ) IN PRESENCE OF POMEGRANATE …
    ANDAT HAMAD M1 , AL-JARIRI R2 , AL TAMIMI L2 , ABU DAYYIH A3 , ABU DAYYIH W2 ...
    International Journal of Biology, Pharmacy and Allied Sciences (IJBPAS) 6 … , 2017
    2017
    Citations: 6
  • Efficacy and Safety of Pharmacist‐Managed NSAIDs Deprescribing: A Jordanian Outpatient Study
    D Jaber, A Al Shihab, LN Tamimi
    Journal of Clinical Pharmacy and Therapeutics 2024 (1), 5874686 , 2024
    2024
    Citations: 5
  • Test of insulin resistance in nondiabetic and streptozotocin-induced diabetic rats using glycosylated hemoglobin test and other interventions
    L AlTamimi, ZZ Zakaraya, M Hailat, MN Ahmad, NA Qinna, MF Hamad, ...
    Journal of Advanced Pharmaceutical Technology & Research 15 (1), 1-7 , 2024
    2024
    Citations: 5
  • Effect of date molasses on levetiracetam pharmacokinetics in healthy rats
    W Abu Dayyih, R Layth, M Hailat, B Alkhawaja, L Al Tamimi, Z Zakaraya, ...
    Scientific Reports 13 (1), 758 , 2023
    2023
    Citations: 4
  • The impressive evaluation of selenium yeast role against diabetes mellitus and its comorbidities by streptozotocin-induced diabetes in rats
    LN Tamimi, Z Zakaraya, W Abu Dayyih, TY ALjaraedah, RH Al Omari, ...
    J Popul Ther Clin Pharmacol 30, 85-92 , 2023
    2023
    Citations: 3
  • Ameliorative effect of selenium yeast in combination with pioglitazone on diabetes outcomes in streptozotocin-induced.
    ZZ Zakaraya, L AlTamimi, M Hailat, MN Ahmad, NA Qinna, BY Ghanim, ...
    Journal of Population Therapeutics and Clinical Pharmacology= Journal de la … , 2022
    2022
    Citations: 3
  • Predicting infection with COVID-19 disease using logistic regression model in Karak City, Jordan
    A Khaleel, WA Dayyih, L AlTamimi, L Dalaeen, Z Zakaraya, A Ahmad, ...
    F1000Research 12, 126 , 2025
    2025
    Citations: 2
  • Exploring the impact of pharmacist involvement in palliative care medication management
    Z Zakaraya, MT Alsaadi, L Tamimi, MA Assab, WA Dayyih, F Lorena, ...
    Pharmacy Practice 23 (2), 1-12 , 2025
    2025
    Citations: 2
  • Effect of smoking and obesity on the serum levels of Vitamin D3 in the central region of Jordan
    M Bustami, W Abudayyih, YS Batarseh, IS Al-Majali, LN Tamimi, A Rahhal, ...
    Int J Biol Pharm Allied Sci 8, 17 , 2019
    2019
    Citations: 2
  • Antidiabetic Effect of Aqueous Extract of Orthosiphon Stamineus Benth on Alloxan-Induced Diabetic Rats
    RMA Ali Alsarhan1, *, Naznin Sultana2 , Lee Suan CHUA3 , Ashraf O ...
    Sapporo Medical Journal 56 (6), 1-10 , 2022
    2022
    Citations: 1
  • Clinical Nutrition in Diabetes Mellitus with Third Degree Burns and Foot Ulcers
    WA Dayyih, Z Zakareia, L Tamimi, R Awad, M Hamad
    Asian Journal of Pharmaceutical Research and Health Care 13 (1), 95-100 , 2021
    2021
    Citations: 1
  • End-Stage Renal Disease Hemodialysis Patients Malnutrition Treatment Using Intradialytic Parenteral Nutrition (IDPN); Prospective Effectiveness and Potential Adverse Effects
    Lina N. Tamimi1, Zainab Z. Zakareia1
    2021
    Citations: 1