LUCA ROMEO received a Ph.D. degree in computer science from the Department of Information Engineering (DII), Università Politecnica delle Marche, in 2018. His Ph.D. thesis was on "applied machine learning for human motion analysis and affective computing". He is currently a Tenure Track Assistant Professor of Computer Science with University of Macerata | UniMC Department Economics and Law. He is also Adjunct Professor of Customer Intelligence & Big Data, at Luiss, Roma and he is affiliated with the Unit of Computational Statistics and Machine Learning, Fondazione Istituto Italiano di Tecnologia Genova. His research topics include the design of novel Machine learning algorithms for solving relevant challenges in different real-world domains.
Machine Learning-Based Clinical Decision Support System for Hepatic Fibrosis Risk Prediction in General Practice Michele Bernardini, Mariachiara di Cosmo, Gaia Barone, Luca Romeo, Emanuele Frontoni ACM Transactions on Computing for Healthcare, 2026 Hepatic steatosis, or non-alcoholic fatty liver disease (NAFLD), affects a significant portion of the global population and can lead to more severe liver conditions, including hepatic fibrosis. Early and accurate risk prediction of fibrosis is crucial for timely intervention. Traditional diagnostic methods are invasive and carry risks, while imaging techniques and blood-based biomarkers have limitations in routine general practice. This study presents a machine learning-based clinical decision support system designed to assess the risk of hepatic fibrosis in patients with NAFLD using routine laboratory tests. The framework is developed using electronic health record data collected over 15 years, initially encompassing 1,272,572 patients from general practice. After applying clinical selection criteria, two cohorts of 12,960 and 25,478 patients were used for model development and evaluation. The proposed approach provides a robust foundation for monitoring fibrosis risk by implementing a novel screening method, which preprocesses predictors by leveraging well-established clinical indicators (e.g., hepatic steatosis index, fibrosis-4 index), alongside a selected minimal number of predictors, making it practical and cost-effective for widespread clinical use. The study’s findings indicate promising results for screening and monitoring fibrosis risk in NAFLD patients, achieving the best AUC of 92.97%, PRAUC of 75.44%, and Sensitivity of 79.63%.
Deep Learning Based Image Steganalysis Alexandr Kuznetsov, Nicolas Luhanko, Emanuele Frontoni, Luca Romeo, Riccardo Rosati 2022 IEEE 9th International Conference on Problems of Infocommunications Science and Technology Pic S and T 2022 Proceedings, 2022
Preface of the 2nd Italian Workshop on Artificial Intelligence and Applications for Business and Industries Ceur Workshop Proceedings, 2022
Deep Learning Based Face Liveliness Detection Aleksandr Kuznetsov, Davyd Kvaratskheliia, Andrea Maranesi, Luca Romeo, Alessandro Muscatello, et al. 2022 IEEE 9th International Conference on Problems of Infocommunications Science and Technology Pic S and T 2022 Proceedings, 2022
A novel spatio-temporal multi-task approach for the prediction of diabetes-related complication: A cardiopathy case of study Ijcai International Joint Conference on Artificial Intelligence, 2020
Machine Learning approach for Predictive Maintenance in Industry 4.0 Marina Paolanti, Luca Romeo, Andrea Felicetti, Adriano Mancini, Emanuele Frontoni, et al. 2018 14th IEEE ASME International Conference on Mechatronic and Embedded Systems and Applications Mesa 2018, 2018
Real-time mental stress detection based on smartwatch Lucio Ciabattoni, Francesco Ferracuti, Sauro Longhi, Lucia Pepa, Luca Romeo, et al. 2017 IEEE International Conference on Consumer Electronics Icce 2017, 2017
Modular design of a novel wireless sensor node for smart environments Massimo Grisostomi, Lucio Ciabattoni, Mariorosario Prist, Luca Romeo, Gianluca Ippoliti, et al. Mesa 2014 10th IEEE ASME International Conference on Mechatronic and Embedded Systems and Applications Conference Proceedings, 2014
RECENT SCHOLAR PUBLICATIONS
A novel multi-task multi-view approach with custom multi-label loss for fault detection in complex industrial apparatus R Rosati, L Pepa, L Romeo Advanced Engineering Informatics 73, 104592 , 2026 2026
Ordinal evolutionary artificial neural networks for predicting diabetic nephropathy progression AM Gómez-Orellana, M Bernardini, R Ayllón-Gavilán, VM Vargas, ... Applied Soft Computing, 115153 , 2026 2026
Machine Learning-Based Clinical Decision Support System for Hepatic Fibrosis Risk Prediction in General Practice M Bernardini, M di Cosmo, G Barone, L Romeo, E Frontoni ACM Transactions on Computing for Healthcare , 2026 2026
Type 2 Diabetes Prediction from Multi-center Electronic Health Records in General Practice Using Machine Learning M Rerisi, M Di Cosmo, M Bernardini, L Romeo International Workshop on Artificial Intelligence for Biomedical Data, 39-46 , 2025 2025
A machine learning algorithm for the prediction of complications incorporated in electronic medical records improves type 2 diabetes care A Nicolucci, G Vespasiani, D Mannino, GT Russo, G Lucisano, MC Rossi, ... Diabetes Research and Clinical Practice, 112900 , 2025 2025 Citations: 2
ML-predicted surgical site infections: An epidemiological study utilizing machine learning on routinely collected healthcare data to predict infection risk D Golinelli, S Rosa, P Rucci, F Sanmarchi, D Tedesco, C Biagetti, A Gili, ... Smart Health 37, 100596 , 2025 2025 Citations: 5
Knee Osteoarthritis Severity Grading Using Soft Labelling and Ordinal Classification F Bérchez-Moreno, VM Vargas, AM Gómez-Orellana, D Guijo-Rubio, ... International Work-Conference on Artificial Neural Networks, 522-533 , 2025 2025 Citations: 1
Single-and multi-task linear models for ATMs fault classification in human-centered predictive maintenance R Rosati, L Romeo, A Mancini Computers & Industrial Engineering 200, 110763 , 2025 2025 Citations: 5
ArtifiAI for Aging Rehabilitation and Intelligent Assisted Living SS Khan, L Romeo, A Abedi 2025
Corrections to “On the Integration of Artificial Intelligence and Blockchain Technology: A Perspective About Security” O Kuznetsov, P Sernani, L Romeo, E Frontoni, A Mancini IEEE Access 12, 162550-162550 , 2024 2024
Neighborhood Component Feature Selection for Multiple Instance Learning Paradigm G Turri, L Romeo Joint European Conference on Machine Learning and Knowledge Discovery in … , 2024 2024
Algor-ethics: charting the ethical path for AI in critical care J Montomoli, MM Bitondo, M Cascella, E Rezoagli, L Romeo, V Bellini, ... Journal of clinical monitoring and computing 38 (4), 931-939 , 2024 2024 Citations: 49
Enhancing copy-move forgery detection through a novel CNN architecture and comprehensive dataset analysis O Kuznetsov, E Frontoni, L Romeo, R Rosati Multimedia Tools and Applications 83 (21), 59783-59817 , 2024 2024 Citations: 29
Image steganalysis using deep learning models A Kuznetsov, N Luhanko, E Frontoni, L Romeo, R Rosati Multimedia Tools and Applications 83 (16), 48607-48630 , 2024 2024 Citations: 22
Learning Ordinal–Hierarchical Constraints for Deep Learning Classifiers R Rosati, L Romeo, VM Vargas, PA Gutiérrez, E Frontoni, ... IEEE Transactions on Neural Networks and Learning Systems , 2024 2024 Citations: 5
On the Integration of Artificial Intelligence and Blockchain Technology: A Perspective About Security (vol 12, pg 3881, 2024) O Kuznetsov, P Sernani, L Romeo, E Frontoni, A Mancini IEEE ACCESS 12, 162550-162550 , 2024 2024
CAlibrazione e SImulazione di un modello macroECOnomico di grandi dimensioni (CASIECO) L Riccetti, L Romeo 2024
METODO PER LA PREDIZIONE DELL'INSORGENZA DI COMPLICANZE A BREVE-MEDIO TERMINE NEL PAZIENTE DIABETICO E DELLA LORO STRATIFICAZIONE TEMPORALE G Vespasiani, M Vespasiani, E Frontoni, L Romeo, M Bernardini, ... 2024
Mitigating Bias in Aesthetic Quality Control Tasks: An Adversarial Learning Approach D Bernovschi, A Giacomini, R Rosati, L Romeo Procedia Computer Science 232, 719-725 , 2024 2024 Citations: 2
Data augmentation strategy for generating realistic samples on defect segmentation task M Martini, R Rosati, L Romeo, A Mancini Procedia Computer Science 232, 1597-1606 , 2024 2024 Citations: 3
MOST CITED SCHOLAR PUBLICATIONS
Machine Learning approach for Predictive Maintenance in Industry 4.0 M Paolanti, L Romeo, A Felicetti, A Mancini, E Frontoni, J Loncarski 2018 14th IEEE/ASME International Conference on Mechatronic and Embedded … , 2018 2018 Citations: 403
From knowledge-based to big data analytic model: a novel IoT and machine learning based decision support system for predictive maintenance in Industry 4.0 R Rosati, L Romeo, G Cecchini, F Tonetto, P Viti, A Mancini, E Frontoni Journal of Intelligent Manufacturing 34 (1), 107-121 , 2023 2023 Citations: 332
A sequential deep learning application for recognising human activities in smart homes D Liciotti, M Bernardini, L Romeo, E Frontoni Neurocomputing 396, 501-513 , 2020 2020 Citations: 253
The KIMORE Dataset: KInematic Assessment of MOvement and Clinical Scores for Remote Monitoring of Physical REhabilitation M Capecci, MG Ceravolo, F Ferracuti, S Iarlori, A Monteriù, L Romeo, ... IEEE Transactions on Neural Systems and Rehabilitation Engineering 27 (7 … , 2019 2019 Citations: 206
On the integration of artificial intelligence and blockchain technology: a perspective about security O Kuznetsov, P Sernani, L Romeo, E Frontoni, A Mancini IEEE Access 12, 3881-3897 , 2024 2024 Citations: 191
SOPHIA: An Event-Based IoT and Machine Learning Architecture for Predictive Maintenance in Industry 4.0 M Calabrese, M Cimmino, F Fiume, M Manfrin, L Romeo, S Ceccacci, ... Information 11 (4), 202 , 2020 2020 Citations: 191
Harnessing the power of smart and connected health to tackle covid-19: Iot, ai, robotics, and blockchain for a better world F Firouzi, B Farahani, M Daneshmand, K Grise, J Song, R Saracco, ... IEEE Internet of Things Journal 8 (16), 12826-12846 , 2021 2021 Citations: 176
Discovering the type 2 diabetes in electronic health records using the sparse balanced support vector machine M Bernardini, L Romeo, P Misericordia, E Frontoni IEEE Journal of Biomedical and Health Informatics 24 (1), 235-246 , 2019 2019 Citations: 152
Real-time mental stress detection based on smartwatch L Ciabattoni, F Ferracuti, S Longhi, L Pepa, L Romeo, F Verdini 2017 IEEE International Conference on Consumer Electronics (ICCE), 110-111 , 2017 2017 Citations: 148
Machine learning-based design support system for the prediction of heterogeneous machine parameters in industry 4.0 L Romeo, J Loncarski, M Paolanti, G Bocchini, A Mancini, E Frontoni Expert Systems with Applications 140, 112869 , 2020 2020 Citations: 121
A Hidden Semi-Markov Model based approach for rehabilitation exercise assessment M Capecci, MG Ceravolo, F Ferracuti, S Iarlori, V Kyrki, A Monteriu, ... Journal of biomedical informatics 78, 1-11 , 2018 2018 Citations: 98
Machine learning using the extreme gradient boosting (XGBoost) algorithm predicts 5-day delta of SOFA score at ICU admission in COVID-19 patients J Montomoli, L Romeo, S Moccia, M Bernardini, L Migliorelli, D Berardini, ... Journal of Intensive Medicine 1 (02), 110-116 , 2021 2021 Citations: 97
A Smart Sensing Architecture for Domestic Monitoring: Methodological Approach and Experimental Validation A Monteriù, M Prist, E Frontoni, S Longhi, F Pietroni, S Casaccia, ... Sensors 18 (7), 2310 , 2018 2018 Citations: 89
Prediction of complications of type 2 Diabetes: A Machine learning approach A Nicolucci, L Romeo, M Bernardini, M Vespasiani, MC Rossi, M Petrelli, ... Diabetes Research and Clinical Practice 190, 110013 , 2022 2022 Citations: 73
Accuracy evaluation of the kinect v2 sensor during dynamic movements in a rehabilitation scenario M Capecci, MG Ceravolo, F Ferracuti, S Iarlori, S Longhi, L Romeo, ... 2016 38th Annual International Conference of the IEEE Engineering in … , 2016 2016 Citations: 72
Multiple instance learning for emotion recognition using physiological signals L Romeo, A Cavallo, L Pepa, N Bianchi-Berthouze, M Pontil IEEE Transactions on Affective Computing 13 (1), 389-407 , 2019 2019 Citations: 68
Robotic retail surveying by deep learning visual and textual data M Paolanti, L Romeo, M Martini, A Mancini, E Frontoni, P Zingaretti Robotics and Autonomous Systems 118, 179-188 , 2019 2019 Citations: 65
Faster R-CNN approach for detection and quantification of DNA damage in comet assay images R Rosati, L Romeo, S Silvestri, F Marcheggiani, L Tiano, E Frontoni Computers in Biology and Medicine 123, 103912 , 2020 2020 Citations: 62
Early temporal prediction of type 2 diabetes risk condition from a general practitioner electronic health record: A multiple instance boosting approach M Bernardini, M Morettini, L Romeo, E Frontoni, L Burattini Artificial Intelligence in Medicine 105, 101847 , 2020 2020 Citations: 61
Predicting Motor and Cognitive Improvement Through Machine Learning Algorithm in Human Subject that Underwent a Rehabilitation Treatment in the Early Stage of Stroke P Sale, G Ferriero, L Ciabattoni, AM Cortese, F Ferracuti, L Romeo, ... Journal of Stroke and Cerebrovascular Diseases 27 (11), 2962-2972 , 2018 2018 Citations: 52