LUIZ FELIPE DE ABREU GUIMARAES

@ufrj.br

Infectious Disease Physician at Hospital Universitário Clementino Fraga Filho
Universidade Federal do Rio de Janeiro

LUIZ FELIPE DE ABREU GUIMARAES


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https://researchid.co/luizfelipeag

RESEARCH, TEACHING, or OTHER INTERESTS

Infectious Diseases, Transplantation, Microbiology (medical)
8

Scopus Publications

Scopus Publications

  • Molecular Epidemiology of Methicillin-Resistant Staphylococcus aureus Causing Healthcare-Associated Bloodstream Infections in Brazil: Results from A Prospective Countrywide Multicenter Study
    Laura C. Antochevis, Letícia O. Sudbrack, Robson S. Leão, Luiz F. Abreu Guimarães, João Paulo Telles, et al.
    Infectious Diseases and Therapy, 2026
  • Clonal shift and impact of azithromycin use on antimicrobial resistance of Staphylococcus aureus isolated from bloodstream infection during the COVID-19 pandemic
    Carolina de Oliveira Whitaker, Tamara Lopes Rocha de Oliveira, Adriana Lúcia Pires Ferreira, Simone Aranha Nouér, Anna Carla Castiñeiras, et al.
    Scientific Reports, 2025
  • High colonization by multidrug-resistant and virulent Staphylococcus aureus genotypes among critically ill patients in the COVID-19 pandemic in a Brazilian hospital
    Tamara Lopes Rocha De Oliveira, Thaís Campos Macharete, Evellyn Max Guedes, Gabriel Freire Igari, Andryelle Cristina de Sant’Ana, et al.
    BMC Microbiology, 2025
  • Persisting Gaps in Cytomegalovirus Prevention and Management After Solid Organ Transplantation in a Resource-Limited Setting
    Guilherme Santoro‐Lopes, Luiz Felipe Abreu Guimarães, Wanessa Trindade Clemente, Raquel Silveira Bello Stucchi, Edson Abdala, et al.
    Transplant Infectious Disease, 2025
    Background Cytomegalovirus (CMV) infection remains among the leading complications after solid organ transplantation (SOT). Large international surveys mainly focused on high‐income countries, detected considerable variability in the management of this infection after SOT. Limited data are available from resource‐limited settings. Methods A questionnaire‐based cross‐sectional study was performed. All transplant programs (TP) registered at the Brazilian Organ Transplantation Society (ABTO) were invited to participate. Results Sixty‐one TP participated in the study. Of these, 59 (97%) reported using at least 1 preventive strategy (prophylaxis or preemptive therapy [PET]). Prophylaxis was reported by only 39 (64%). PET was used by 52 (85%), predominantly for R+ recipients ( n = 42/61; 70%). CMV monitoring was performed weekly in only 22 of 52 (42%) TP. This was significantly more common in TP reporting turnaround times ≤72 h for quantitative nuclear acid amplification tests ( p < 0.001). Intravenous (IV) ganciclovir was the predominant drug chosen for prophylaxis (21/39 TP; 54%) and for PET (44/52 TP; 77%). Lack of regular access to valganciclovir was significantly associated with the choice of IV ganciclovir for prophylaxis and PET ( p = 0.002 for both comparisons). Only 8 (13%) TP had access to molecular diagnostic tests for ganciclovir resistance, and 14 (23%) had access to effective therapy for highly resistant infections. Conclusion These results suggest that strategies to improve the management of CMV after SOT in such a resource‐limited setting are needed and should include not only targeted educational programs but also initiatives to tackle economic and structural barriers. image
  • Can habits and behaviors predict colonization by community-associated MRSA in patients admitted to a Brazilian hospital?
    Marcos Vinicius de Barros Pinheiro, Fernanda Sampaio Cavalcante, Dennis de Carvalho Ferreira, Ana Carolina Fonseca Guimarães, Adriana Lúcia Pires Ferreira, et al.
    Revista do Instituto De Medicina Tropical De Sao Paulo, 2024
  • Pandemic clone USA300 in a Brazilian hospital: detection of an emergent lineage among methicillin-resistant Staphylococcus aureus isolates from bloodstream infections
    Mariana Fernandes Augusto, Débora Cristina da Silva Fernandes, Tamara Lopes Rocha de Oliveira, Fernanda Sampaio Cavalcante, Raiane Cardoso Chamon, et al.
    Antimicrobial Resistance and Infection Control, 2022
    Background Staphylococcus aureus is one of the leading causes of bloodstream infections (BSI) worldwide. In Brazil, the hospital-acquired methicillin-resistant S. aureus USA100/SCCmecII lineage replaced the previously well-established clones. However, the emergence of community-associated (CA) MRSA lineages among hospitalized patients is an increasing issue. Methods Consecutive S. aureus isolates recovered from BSI episodes of patients admitted between January 2016 and December 2018 in a Brazilian teaching hospital were tested for antimicrobial resistance, their genotypic features were characterized, and the clinical characteristics of the patients were evaluated. Results A total of 123 S. aureus isolates were recovered from 113 patients. All isolates were susceptible to linezolid, teicoplanin and vancomycin and 13.8% were not susceptible to daptomycin. Vancomycin MIC50 and MIC90 of 2 mg/L were found for both MRSA and MSSA isolates. The MRSA isolation rate was 30.1% (37/123), and 51.4% of them carried the SCCmec type II, followed by SCCmecIV (40.5%). Among the 37 MRSA isolates, the main lineages found were USA100/SCCmecII/ST5 and ST105 (53.7%) and USA800/ST5/SCCmecIV (18.9%). Surprisingly, six (16%) CA-MRSA isolates, belonging to USA300/ST8/SCCmecIVa that carried PVL genes and the ACME cassette type I, were detected. These six patients with USA300 BSI had severe comorbidities, including cancer, and most had a Charlson score ≥ 5; furthermore, they were in wards attended by the same health professionals. MRSA isolates were associated with hospital acquired infections (p = 0.02) in more elderly patients (p = 0.03) and those diagnosed with hematologic cancer (p = 0.04). Among patients diagnosed with MRSA BSI, 19 (54.3%) died. Conclusions The pandemic MRSA USA300 was detected for the first time in the Brazilian teaching hospital under study, and its cross-transmission most probably occurred between patients with BSI. This lineage may already be circulating among other Brazilian hospitals, which highlights the importance of carrying out surveillance programs to fight multidrug resistant and hypervirulent isolates.
  • Increased incidence of candidemia in a tertiary care hospital with the COVID-19 pandemic
    Marcio Nucci, Gloria Barreiros, Luiz Felipe Guimarães, Vitor A.S. Deriquehem, Anna Carla Castiñeiras, et al.
    Mycoses, 2021
    BackgroundThe incidence of candidemia in our hospital has been stable over an 18‐year period (1.3 episodes per 1000 admissions). Since March 2020, we have observed an increase in cases of candidemia.MethodsIn March 2020, the hospital was prepared to receive patients with COVID‐19, with cancellation of elective procedures, discharge of less sick patients and the activation of beds for COVID‐19. We compared the incidence of candidemia in 2 periods: from January 2019 to February 2020 (period 1) and from March to September 2020 (period 2).ResultsWe diagnosed 41 episodes of candidemia, 16 in period 1 and 25 in period 2 (9 COVID‐19 patients). Compared with non‐COVID‐19 patients, COVID‐19 patients with candidemia were more likely to be under mechanical ventilation (100% vs. 34.4%, P < .001). The median number of monthly admissions in period 1 and 2 was 723 (interquartile range 655‐836) and 523 (interquartile range 389‐574), respectively. The incidence of candidemia (per 1000 admissions) was 1.54 in period 1 and 7.44 in period 2 (P < .001). In period 2, the incidence of candidemia (per 1000 admissions) was 4.76 if we consider only cases of candidemia in non‐COVID‐19 patients, 2.68 if we consider only cases of candidemia in COVID‐19 patients and 14.80 considering only admissions of patients with COVID‐19.ConclusionsThe increase in the incidence of candidemia in our hospital may be attributed to 2 factors: a reduction in the number of admissions (denominator) and the occurrence of candidemia in COVID‐19 patients.
  • Invasive Fungal Disease in Renal Transplant Recipients at a Brazilian Center: Local Epidemiology Matters
    L.F.A. Guimarães, M. Halpern, A.S. de Lemos, E.F. de Gouvêa, R.T. Gonçalves, et al.
    Transplantation Proceedings, 2016