Magdy K. Zahran is a professor emeritus in the Department of Chemistry, Faculty of Science, Helwan University.
EDUCATION
Professor Zahran attended Mahala El-Kobra schools for primary and secondary education. He obtained his B.S. degree in chemistry from Tanta University, Egypt, in 1980. He received his M.S. and Ph.D. degrees from Helwan University, Cairo, Egypt, in 1987 and 1991, respectively. Since 2010, he has been a distinguished professor in applied organic chemistry at the University of Helwan, where he was a lecturer and an associate professor in 1991 and 1999, respectively.
RESEARCH INTERESTS
Zahran's research interests include a variety of applied organic chemistry branches.
104
Scopus Publications
3260
Scholar Citations
29
Scholar h-index
55
Scholar i10-index
Scopus Publications
Chemical and mechanical extraction for egyptian safflower bio-oil with a performance and economic analysis for renewable fuel applications Mahmoud A. Kamel, Magdy K. Zahran, Samya El-Sherbiny, Said M. El-Sheikh, Hassan M. M. Mustafa Scientific Reports, 2026 The growing demand for sustainable biofuels has increased interest in efficient methods for extracting oil from non-edible feedstocks such as safflower. This study compares chemical and mechanical extraction techniques, including Soxhlet extraction, maceration, hydraulic pressing, and screw pressing, for biodiesel feedstock production. A Box–Behnken response surface methodology was applied to optimize screw press operating conditions. The optimal parameters were identified at 172.5 °C and a screw press speed of 1400 rpm, with an energy consumption of 3.86 W-hour and a yield of approximately 19% in 29.8 s. The oils extracted using four extraction techniques were characterized using gas chromatography-mass spectrometry and Fourier-transform infrared spectroscopy, confirming their suitability for biodiesel applications. Among the evaluated methods, a screw press proved to be the most energy-efficient and time-saving method, owing to the elimination of solvent use and its lower operational costs compared to conventional chemical methods. These findings highlight the potential of mechanical extraction as a cost-effective and environmentally sustainable approach for biodiesel production. Overall, this study provides a comparative and optimized framework for safflower oil extraction, supporting the transition toward greener and scalable biofuel production technologies.
UPLC-QTOF/MS Profiling of Portulaca Oleracea Extract and Green Biosynthesis of Gold Nanoparticles with Anticancer Potential Nada Tarek El-Bayioumy, Magdy K. Zahran, Hanaa mohamed El-Rafie, Maha I Fatahalla, Mohamed Abdelaziz, et al. Egyptian Journal of Chemistry, 2024 Recently, the nanotechnology sector has opened new avenues for enhancing the therapeutic potential of plant-based compounds. Nanoparticles, especially those synthesized from plant extracts, have shown great promise in improving the delivery and efficacy of anticancer agents. These plant-derived nanoparticles can target cancer cells more precisely, minimizing side effects and maximizing therapeutic outcomes. A chemical profiling study using UPLC-QTOF-MS/MS was conducted to explore the Portulaca oleracea ( P. oleracea ) phytoconstituents that exert the biological activities. Fifty compounds, comprising phenolic acids, organic acids, flavonoids, coumarins, fatty acids, alkaloids and amino acids were recognized via chemical characterization. The Folin.-Ciocalteu technique was utilized to assess the overall phenolics content of the obtained fractions, while the total amount of flavonoid was obtained using AlCl 3 . Moreover, the antioxidant ability was measured by ABTS, FRAP and DPPH techniques. Our findings revealed that the methanolic fraction has the greatest level of flavonoid (121.47 ±1.41 mg RE/g extract) and phenolic amounts (555.15 ± 1.14 mg GAE / g extract) among the examined extracts also the total alkaloid and the total saponin percent of the methanolic extract are 1.79% and 1.28% respectively. Moreover, methanol extract also show the highest antioxidant activity IC 50 = 6.87, 21.31, 20.18µg/mL for ABTS, DPPH and FRAP respectively, this activity could be explained by the extract's high flavonoid and phenolics content. The water extract of P. oleracea was employed in producing gold nanoparticles AuNPs. UV-Vis spectrophotometric analysis and transmittance electron microscope (TEM) were used for analyzing the biosynthesized AuNPs. Additionally, the anti-cancer potential of the water extract and its biosynthesized AuNPs was explored by MTT assay against several cancer cell lines. The findings demonstrated that the the synthesized gold nanoparticles (AuNPs) was active against mammary gland breast cancer MCF-7 with an IC 50 of (29.44±0.5) μ g/mL compared to the reference medication, staurosporine STA with an IC 50 of (12.24±0.68) μ g/mL where in case of hepatocellular carcinoma HepG-2 cell lines the AuNPs has IC 50 of (14.51±1.02) μ g/mL, compared to staurosporine STA IC 50 (5.20±0.87) μ g/mL. The IC 50 valuesofAu-NPs were 31.14±0.87µg/mL for cervical cancer HeLa, 18.11±2.1 µg/mL for colon cancer cell lines Caco-2, 21.0±0.99 µg/mL, for HCT116 and17.47±1.3 µg/mL, for kidney cancer cell line UO-31 cell line. Across all cancer cell lines tested, the synthesized gold nanoparticles (AuNPs) from P. oleracea extract consistently demonstrated lower IC 50 values compared to the crude water extract, indicating that the synthesis of AuNPs enhances the anticancer activity of the plant extract, this can be attributed to several factors, including their small size, which allows for better penetration into cancer cells, and their ability to induce reactive oxygen species (ROS), leading to apoptosis. The combination of plant-based bioactive compounds and nanotechnology provides a promising strategy for developing effective anticancer therapies.
Optimization of Cellulolytic enzymes production from local potent fungi using full factorial design for bioethanol production from MFEX-treated rice straw using Klebsiella oxytoca P2 Bioscience Research, 2018
One-step process for desizing, scouring and bleaching of cotton fabric using a novel eco-friendly bleaching agent Journal of the Textile Association, 2006
Graft copolymerization of methacrylic acid and other vinyl monomers onto cotton fabric using the cellulose thiocarbonate-KMnO "SUB 4" -acid system Cellulose Chemistry and Technology, 1990
Cellulose thiocarbonate-Cr(VI) system induced graft copolymerization of vinyl monomers onto cotton fabric Cellulose Chemistry and Technology, 1990
Grafting of cotton fabric with vinyl monomers using cellulose thiocarbonate/potassium bromate redox system Cellulose Chemistry and Technology, 1989
RECENT SCHOLAR PUBLICATIONS
Augmenting the antimicrobial activity of clindamycin hydrochloride-loaded acrylate polymer/zinc oxide nanocomposites against pathogenic microbes RA Sobh, AS Mohammed, WS Mohamed, MK Zahran, TF Hassanein RSC advances 16 (27), 24947-24963 , 2026 2026
Phytochemical-Assisted Green Synthesis of Antioxidant and Antimicrobial Silver Nanoparticles Using Cichorium Intybus Extract for Enhanced Medical Cotton Fabrics AI Ghiniwa, MK Zahran, H El Rafie, E Ayad, M Abdelaziz, TS Mohamed Egyptian Journal of Chemistry 68 (9), 715-728 , 2025 2025 Citations: 1
Unveiling the Potential of Syzygium aqueum Extracts: Chemical Profiling, Bioactivities and Assessment of ADME Associated Physicochemical Properties S Hussien, AM Abdou, AM Saad, AA Hamed, MK Zahran, MA Ghareeb Egyptian Journal of Chemistry 68 (9), 453-466 , 2025 2025
Tailoring electrochemically-active biofilm activity grown on binder-free hierarchical core-shell CoFe2O4@ NiMoO4 nanocomposite-modified carbon-felt bioanodes for high … Y Ahmed, F El-Gohary, MK Zahran, SK Mohamed, M Mahmoud Journal of Power Sources 648, 237413 , 2025 2025 Citations: 6
Modern designs of electrochemical sensor for accurate drug analysis in pharmaceutical and biological samples: Principles, nanofabrication, and key challenges A Barhoum, A Naseef, YM Ahmed, MK Zahran, Y Alhashemi, ... Materials Chemistry and Physics 337, 130588 , 2025 2025 Citations: 14
Acrylic molecularly imprinted polymer-based electrochemical sensor for precise nanomolar quantification of daclatasvir dihydrochloride in Daclavirdin®, Serum, and Urine A Naseef, FM Abdel-Haleem, MK Zahran, A Barhoum Microchemical Journal 208, 112389 , 2025 2025 Citations: 5
Evaluation of smart bi-functional dressing based on polysaccharide hydrogels and Brassica oleracea extract for wound healing and continuous monitoring AA Arafa, OA Hakeim, AA Nada, MK Zahran, NM Shaffie, AY Ibrahim International Journal of Biological Macromolecules 286, 138339 , 2025 2025 Citations: 4
Kinetic and Isotherm Models For Metal Removal Using Modified Graphene SW Hgag, S Abdel Moniem, M Eid, MK Zahran, A Barhoom, HS Ibrahim Egyptian Journal of Chemistry 67 (12), 245-252 , 2024 2024 Citations: 4
UPLC-QTOF/MS profiling of Portulaca oleracea extract and green biosynthesis of gold nanoparticles with anticancer potential NT El-Bayioumy, MK Zahran, HM El-Rafie, MI Fatahalla, M Abdelaziz, ... Egyptian Journal of Chemistry 67 (12), 347-363 , 2024 2024 Citations: 6
Valorization of paper-mill sludge laden with 2-chlorotoluene using hydroxyapatite@ biochar nanocomposite to enrich methanogenic community: A techno-economic approach RM Hafez, A Tawfik, GK Hassan, MK Zahran, AA Younes, ... Biomass and Bioenergy 190, 107401 , 2024 2024 Citations: 5
Synergism of floated paperboard sludge cake/sewage sludge for maximizing biomethane yield and biochar recovery from digestate: a step towards circular economy RM Hafez, A Tawfik, GK Hassan, MK Zahran, AA Younes, ... Chemosphere 362, 142639 , 2024 2024 Citations: 8
Multicomponent reactions of cyanoacetanilide derivatives: Synthesis of coumarin and quinoline derivative and evaluations of their cytotoxicity RM Mohareb, MK Zahran, HR Maghraby, AEM Abdallah Bulletin of the Chemical Society of Ethiopia 38 (3), 739-750 , 2024 2024 Citations: 4
Alginate-modified surfactants functionalized metal-organic framework-based fluorescent film sensors for detection and adsorption of volatile aldehydes in water ES Bishay, AH Elged, AA Farag, MK Zahran, SM Tawfik International Journal of Biological Macromolecules 259, 129080 , 2024 2024 Citations: 20
Multicomponent reactions of cyanoacetanilide derivatives: Synthesis of coumarin and quinoline derivatives and evaluations of their cytotoxicity AEMA Rafat M. Mohareb , Magdy K. Zahran , Hager R. Maghraby Bulletin of the Chemical Society of Ethiopia 38 (3), 739-750 , 2024 2024
Efficient anticorrosive acrylate water-borne paint based on polyaniline nanocomposite dispersion for carbon steel protection in 3.5% NaCl solution N Elhalawany, M Yehia, AM Abdel-karim, MM Saleeb, MK Zahran Journal of Bio-and Tribo-Corrosion 9 (1), 6 , 2023 2023 Citations: 7
Enhancement of cytotoxic and antioxidant activities of Digenea simplex chloroform extract using the nanosuspension technique HM El-Rafie, EA Hasan, MK Zahran Bioprocess and Biosystems Engineering 46 (2), 279-296 , 2023 2023 Citations: 14
In vitro cytotoxicity against breast cancer using biogenically synthesized gold and iron oxide nanoparticles derived from the hydroethanolic extract of Salvia officinalis L HM El-Rafie, SMA El-Aziz, MK Zahran Chemical Papers 77 (1), 361-373 , 2023 2023 Citations: 15
Synthesis and characterization of emulsion polymerizable surfactant based on ethoxylate alcohol maleate MK Zahran, AI Hamed, A El-Hag Ali Egyptian Journal of Chemistry 65 (132), 1369-1378 , 2022 2022 Citations: 2
Polystyrene sulfonate coated activated graphene aerogel for boosting desalination performance using capacitive deionization AG El-Deen, HK El-kholly, MEM Ali, HS Ibrahim, MK Zahran, MH Helal, ... Separation and Purification Technology 299, 121760 , 2022 2022 Citations: 30
Synthesis and characterization of polymerizable surfactants based on ethoxylate alcohol cinnamate for emulsion polymerization MK Zahran, AI Hamed, AEH Ali Journal of Radiation Research and Applied Sciences 15 (2), 59-66 , 2022 2022 Citations: 7
MOST CITED SCHOLAR PUBLICATIONS
Green synthesis of silver nanoparticles using polysaccharides extracted from marine macro algae HM El-Rafie, MH El-Rafie, MK Zahran Carbohydrate Polymers 96 (2), 403-410 , 2013 2013 Citations: 411
Corrosion inhibition efficiency and surface activity of benzothiazol-3-ium cationic Schiff base derivatives in hydrochloric acid NA Negm, YM Elkholy, MK Zahran, SM Tawfik Corrosion Science 52 (10), 3523-3536 , 2010 2010 Citations: 230
Surface modification of cotton fabrics for antibacterial application by coating with AgNPs–alginate composite MK Zahran, HB Ahmed, MH El-Rafie Carbohydrate polymers 108, 145-152 , 2014 2014 Citations: 175
Characterization of nanosilver coated cotton fabrics and evaluation of its antibacterial efficacy MH El-Rafie, HB Ahmed, MK Zahran Carbohydrate polymers 107, 174-181 , 2014 2014 Citations: 159
Functionalization of medical cotton by direct incorporation of silver nanoparticles HE Emam, NH Saleh, KS Nagy, MK Zahran International journal of biological macromolecules 78, 249-256 , 2015 2015 Citations: 115
Facile size-regulated synthesis of silver nanoparticles using pectin MK Zahran, HB Ahmed, MH El-Rafie Carbohydrate polymers 111, 971-978 , 2014 2014 Citations: 89
Preparation and characterization of smart therapeutic pH-sensitive wound dressing from red cabbage extract and chitosan hydrogel AA Arafa, AA Nada, AY Ibrahim, P Sajkiewicz, MK Zahran, OA Hakeim International journal of biological macromolecules 182, 1820-1831 , 2021 2021 Citations: 88
Multifunctional hydroxyapatite/silver nanoparticles/cotton gauze for antimicrobial and biomedical applications MM Said, M Rehan, SM El-Sheikh, MK Zahran, MS Abdel-Aziz, ... Nanomaterials 11 (2), 429 , 2021 2021 Citations: 87
Generation of biocompatible nanogold using H2O2–starch and their catalytic/antimicrobial activities HE Emam, MK Zahran, HB Ahmed European Polymer Journal 90, 354-367 , 2017 2017 Citations: 86
Instantly AgNPs deposition through facile solventless technique for poly-functional cotton fabrics HE Emam, NH Saleh, KS Nagy, MK Zahran International journal of biological macromolecules 84, 308-318 , 2016 2016 Citations: 86
Ag0 nanoparticles containing cotton fabric: Synthesis, characterization, color data and antibacterial action HE Emam, MK Zahran International journal of biological macromolecules 75, 106-114 , 2015 2015 Citations: 80
Greener therapeutic pH-sensing wound dressing based on Curcuma Longa and cellulose hydrogel AA Arafa, AA Nada, AY Ibrahim, MK Zahran, OA Hakeim European Polymer Journal 159, 110744 , 2021 2021 Citations: 75
Heatless synthesis of well dispersible Au nanoparticles using pectin biopolymer HB Ahmed, MK Zahran, HE Emam International journal of biological macromolecules 91, 208-219 , 2016 2016 Citations: 72
Facile precursor for synthesis of silver nanoparticles using alkali treated maize starch MH El-Rafie, HB Ahmed, MK Zahran International scholarly research notices 2014 (1), 702396 , 2014 2014 Citations: 69
UV-curable encapsulation of surface—Modified organic pigments for inkjet printing of textiles OA Hakeim, AA Arafa, MK Zahran, LAW Abdou Colloids and Surfaces A: Physicochemical and Engineering Aspects 447, 172-182 , 2014 2014 Citations: 68
Room temperature synthesis of metallic nanosilver using acacia to impart durable biocidal effect on cotton fabrics HE Emam, MH El-Rafie, HB Ahmed, MK Zahran Fibers and Polymers 16 (8), 1676-1687 , 2015 2015 Citations: 67
One-step process for enzymatic desizing and bioscouring of cotton fabrics AS Aly, SM Sayed, MK Zahran Journal of Natural Fibers 7 (2), 71-92 , 2010 2010 Citations: 64
Benzothiazol-3-ium cationic Schiff base surfactants: synthesis, surface activity and antimicrobial applications against pathogenic and sulfur reducing bacteria in oil fields NA Negm, YM Elkholy, FM Ghuiba, MK Zahran, SA Mahmoud, SM Tawfik Journal of dispersion science and technology 32 (4), 512-518 , 2011 2011 Citations: 57
A comparative study of the polymerization of acrylic acid with native and hydrolyzed maize starches using a potassium bromate-thiourea dioxide redox initiation system MH El-Rafie, MK Zahran, KF El Tahlawy, A Hebeish Polymer degradation and stability 47 (1), 73-85 , 1995 1995 Citations: 51