Dr. V. MANIMARAN
@srmist.edu.in
Associate Professor, Medicine & Health Sciences
SRM COLLEGE OF PHARMACY, SRMIST.
EDUCATION
M. Pharm., P.hD.,
RESEARCH, TEACHING, or OTHER INTERESTS
Pharmaceutical Science, Pharmacy
Scopus Publications
Scholar Citations
Scholar h-index
Scholar i10-index
Scopus Publications
V. Manimaran, R. P. Nivetha, T. Tamilanban, J. Narayanan, Subramaniyan Vetriselvan, Neeraj Kumar Fuloria, Suresh V. Chinni, Mahendran Sekar, Shivkanya Fuloria, Ling Shing Wong,et al.
Frontiers Media SA
Nanogels are highly recognized as adaptable drug delivery systems that significantly contribute to improving various therapies and diagnostic examinations for different human diseases. These three-dimensional, hydrophilic cross-linked polymers have the ability to absorb large amounts of water or biological fluids. Due to the growing demand for enhancing current therapies, nanogels have emerged as the next-generation drug delivery system. They effectively address the limitations of conventional drug therapy, such as poor stability, large particle size, and low drug loading efficiency. Nanogels find extensive use in the controlled delivery of therapeutic agents, reducing adverse drug effects and enabling lower therapeutic doses while maintaining enhanced efficacy and patient compliance. They are considered an innovative drug delivery system that highlights the shortcomings of traditional methods. This article covers several topics, including the involvement of nanogels in the nanomedicine sector, their advantages and limitations, ideal properties like biocompatibility, biodegradability, drug loading capacity, particle size, permeability, non-immunological response, and colloidal stability. Additionally, it provides information on nanogel classification, synthesis, drug release mechanisms, and various biological applications. The article also discusses barriers associated with brain targeting and the progress of nanogels as nanocarriers for delivering therapeutic agents to the central nervous system.
V. Manimaran, Ponnurengam Malliappan Sivakumar, J. Narayanan, Shanmugam Parthasarathi, and Pranav Kumar Prabhakar
Bentham Science Publishers Ltd.
Abstract:: Conventional delivery of antidiabetic drugs faces many problems like poor absorption, low bioavailability, and drug degradation. Nanoemulsion is a unique drug technology, which is very suitable for the delivery of antidiabetic drugs. In recent years, the flaws of delivering anti-hypoglycaemic drugs have been overcome by choosing nanoemulsion drug technology. They are thermodynamically stable and also provide the therapeutic agent for a longer duration. Generally, nanoemulsions are made up of either oil-in-water or water-in-oil and the size of the droplets is from fifty to thousand nanometer. Surfactants are critical substances that are added in the manufacturing of nanoemulsions. Only the surfactants which are approved for human use can be utilized in the manufacturing of nanoemulsions. Generally, the preparation of emulsions includes mixing of the aqueous phase and organic phase and using surfactant with proper agitation. Nanoemulsions are used for antimicrobial drugs, and they are also used in the prophylaxis of cancer. Reduction in the droplet size may cause variation in the elastic and optical behaviour of nanoemulsions.
S. Kalaiselvi, V. Manimaran, and N Damodharan
A and V Publications
Manimaran V and Damodharan N
Innovare Academic Sciences Pvt Ltd
Objective: Amlodipine besylate is a calcium channel blocker used in the treatment of hypertension which is practically insoluble in water. The present study aims to design oral fast-release tablets of amlodipine besylate and to optimize the dissolution of the drug by altering the carrier concentration.Materials and Methods: Poloxamer 407 (P407) and poloxamer 188 (P188) were selected as carriers for the preparation of solid dispersion (SD) by the solvent evaporation method with different drug-polymer ratios. The prepared SDs were evaluated for the physical state, drug:carrier interactions by X-ray diffraction (XRD), infrared spectroscopy, differential scanning calorimetry, and scanning electron microscopy.Results: From the dissolution studies, it is confirmed that all SDs showed increased dissolution rate when compared to pure amlodipine besylate. Among the two polymers used, P407 was found to be better than P188 in enhancing dissolution efficiency. The tablets were prepared using SD of amlodipine besylate containing P407 as a carrier. The results showed that P407 SD-based tablets gave a significantly higher release of amlodipine besylate when compared with control tablets. The infrared spectral studies showed that there was no significant interaction between amlodipine besylate and its formulation with different polymers used in the preparation of SDs. XRD studies revealed that the degree of crystallinity of amlodipine besylate reduced when the concentration of carriers increased, which reveals that the drug is in amorphous nature.Conclusion: The combination of SD technology and using superdisintegrants in the formulation is a promising approach for preparing efficient, fast-dissolving tablet of poorly water-soluble drugs, viz., amlodipine besylate.