maria.grano

Scopus Publications

Impact of mechanical unloading on the irisin precursor, FNDC5, in skeletal muscle of sheep as a large animal experimental model
Clelia Suriano, Onofrio Daniele Terrevoli, Francesco Staffieri, Luca Lacitignola, Antonio Crovace, Luisa Pellicani, Michela Taurino, Silvia Colucci, Maria Grano, Alberto Maria Crovace, Graziana Colaianni
Jbmr Plus, 2026
Scientific evidence has demonstrated the involvement of irisin, a molecule produced by muscle contraction, in preventing the onset of musculoskeletal decline. We previously demonstrated that the expression of irisin and its muscle-derived precursor FNDC5 is affected by unloading in skeletal muscle of hindlimb-unloaded (HU) mice. Studies in the HU mouse model showed that treatment with irisin prevents muscle wasting and atrophy. In parallel, human studies documented a strong association between irisin/FNDC5 and muscle function. Therefore, the scientific community is committed to determining whether irisin may represent a promising clinical strategy for preventing and treating disorders caused by muscle inactivity, such as those affecting bedridden or elderly patients. In translational research from mice to humans, there are very few in vivo studies conducted on large animals. The sheep model is an excellent model for studying the musculoskeletal system due to its anatomical characteristics, which share similarities with humans, allowing for the reproduction of mechanical load distribution on the limbs. To provide translational knowledge on the progression of muscle atrophy, we evaluated the impact of unloading on the expression of FNDC5 and functional proteins of skeletal muscle in sheep. Our findings revealed a reduction of FNDC5 in the quadriceps muscle after 2 wk of immobilization. The FNDC5 decrease is accompanied by a reduction of myosin isoforms MyHC1 and MyHC2x, and an increase in muscle fibrosis. Importantly, FNDC5 expression positively correlated with expression of myosins, implying that the irisin/FNDC5 system is a driving force for muscle function in this large animal model.
Behavioral and Neurobiological Correlates of Resilience in the Hindlimb Unloading Mouse Model: A Longitudinal Ethogram with Neurotrophin Profile
Arianna Racca, Patrizia Pignataro, Roberta Zerlotin, Graziana Esposito, Bijorn Omar Balzamino, Alessandra Micera, Maria Grano, Daniela Santucci
Life, 2026
Among ground-based paradigms used to reproduce altered gravity exposure, the hindlimb unloading (HU) model is widely employed to simulate microgravity conditions by removing gravitational loading from the hindlimbs. Despite its extensive use, behavioral adjustments during suspension remain poorly characterized, although they may provide valuable indicators of animal welfare and individual susceptibility. Here, we comprehensively characterized the behavioral profile of mice during and after HU using a dedicated ethogram, with the aim of identifying behavioral markers associated with individual coping strategies. Several exploratory and postural behaviors showed marked time-dependent modulation, with baseline exploratory activity predicting a more adaptive behavioral trajectory during suspension, possibly indicative of greater resilience. In parallel, brain levels of the neurotrophins NGF and BDNF were measured to explore their relationship with behavioral outcomes. Although no significant group differences were detected, suspended mice displayed a progressive reduction in both neurotrophins over time, which paralleled behavioral adaptation. Together, these findings indicate that specific exploratory behaviors represent reliable predictors of resilience to HU, while NGF and BDNF may reflect ongoing neuroplastic processes associated with prolonged suspension.
Cerebrospinal fluid sclerostin levels in the early Alzheimer's disease stages
Manuela Dicarlo, Patrizia Pignataro, Daniele Urso, Chiara Zecca, Maria Teresa Dell'Abate, Francesco Borlizzi, Valentina Gnoni, Alessia Giugno, Angela Oranger, Graziana Colaianni, Roberta Zerlotin, Clelia Suriano, Silvia Colucci, Giancarlo Logroscino, Maria Grano
Alzheimer S and Dementia Diagnosis Assessment and Disease Monitoring, 2026
INTRODUCTION Sclerostin, a negative regulator of bone formation, has been involved in memory impairment in Alzheimer's disease (AD) mouse models and is increased in elderly people at risk of AD. Here, we investigated sclerostin's role across the clinical stages of AD. METHODS We evaluated cerebrospinal fluid (CSF) sclerostin levels in patients with dementia due to AD, mild cognitive impairment, and subjective memory complaints, biologically characterized via the amyloid/tau/neurodegeneration classification. Results were correlated with AD biomarkers, amyloid beta (Aβ) 42, phosphorylated tau (p‐tau), and total tau (t‐tau), and clinical parameters of dementia severity. RESULTS CSF sclerostin increased in patients with dementia due to AD and correlated negatively with Aβ42 and positively with p‐tau, t‐tau, and dementia severity. DISCUSSION The association of CSF sclerostin with Aβ42, tau pathology, and dementia severity in the early disease stages is of great clinical relevance for the identification of sclerostin as a promising biomarker in early AD stages.
Comparative psychological well-being evaluation among CKD patients on conservative therapy, dialysis, or kidney transplantation: a cross-sectional study
Patrizia Pignataro, Simona Simone, Manuela Dicarlo, Federica Cassone, Gianvito Caggiano, Raffaella Guido, Fausta Piancone, Carmen Sivo, Anna Maria Dipalma, Roberto Russo, Marco Spilotros, Pasquale Di Tonno, Silvia Colucci, Graziana Colaianni, Paola Pontrelli, Maria Grano, Loreto Gesualdo
Frontiers in Psychology, 2026
Background Chronic kidney disease (CKD) has a significant impact on psychological well-being. Here, the psychological evaluation of patients with CKD undergoing replacement treatment (dialysis or kidney transplantation) and conservative therapy (preemptive patients, who are waiting list for kidney transplantation) was analyzed. In addition, serum irisin levels, a protein displaying anxiolytic and antidepressant effects in mice, were measured in dialysis patients. Methods Dialysis ( N = 57), non-dialysis (preemptive, N = 31) and kidney transplant patients ( N = 33) were enrolled. All participants underwent psychometric tests including State–Trait Anxiety Inventory (STAI-Y 1 and 2 form), Psychological General Well-Being Index (PGWBI), Symptom Checklist-90-R (SCL-90-R), etc. Serum irisin levels in dialyzed patients were measured by ELISA assay. Results Dialysis patient group scored worse on all tests performed than both preemptive and kidney transplant patients. Indeed, dialysis patients displayed the lowest PGWBI score, and higher scores of BDI, and STAY-1 and STAY-2, compared with preemptive and kidney transplant patients. We also found that about 40% of dialysis patients showed significant psychological distress with higher clinical attention values in the somatization, obsessive-compulsive, depression, and anxiety domains assessed by SCL-90. Furthermore, the stratification of all patients into groups younger and older than 50 years showed that the older group of transplanted patients displayed better outcomes than the younger ones. Finally, stratification of dialysis patients according to irisin levels revealed that only those with higher serum irisin levels had better psychological conditions in tests. Conclusions Kidney transplantation as well as conservative therapy were related to a lower prevalence of depressive symptoms and other psychological disorders than dialysis. Furthermore, all transplanted patients over 50 years of age showed better outcomes than the younger ones. However, dialyzed patients with high levels of circulating irisin displayed better psychological conditions. Overall, our findings supported the importance to provide timely access to transplantation and to improve psychological support for dialysis patients.
Cortical Bone Loss and Fragility in a 2-Month Triple Transgenic Mouse Model of Alzheimer’s Disease
Giuseppina Storlino, Francesca Posa, Teresa Stefania Dell'Endice, Federica Piccolo, Graziana Colaianni, Tommaso Cassano, Maria Grano, Giorgio Mori
Cells, 2025
Alzheimer’s disease (AD) and osteoporosis frequently co-occur in the elderly; however, the pathophysiological link between these two diseases remains unclear. This study investigates skeletal alterations in a triple transgenic 3xTg-AD mouse model of AD (3xTg-AD), which harbors mutations in β-amyloid precursor protein (βAPPSwe), presenilin-1 (PS1M146V), and tauP301L, and recapitulates key aspects of AD pathology, including age-dependent β-amyloid plaque accumulation and cognitive decline. To assess early skeletal changes, we analyzed femurs and tibiae of 2-month-old male non-Tg and 3xTg-AD mice (n = 9/group) using micro-CT. Despite the absence of β-amyloid plaques at this stage, 3xTg-AD mice showed significant cortical bone loss, with reduced bone surface, periosteal and endosteal perimeters, total and cortical cross-sectional area, and polar moment of inertia. The 3-point-bending test confirmed compromised mechanical properties, including reduced maximum load-to-fracture and stiffness. Histological analyses highlighted an increased number of Empty Osteocyte Lacunae, reduced TRAP+ osteocytes, and an elevated number of osteoclasts; such evidence indicates impaired osteocyte function and increased bone resorption. These findings indicate that cortical bone loss and compromised mechanical properties occur before detectable neuropathological hallmarks in this AD model.
Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia
Patrizia Pignataro, Manuela Dicarlo, Chiara Zecca, Daniele Urso, Maria Teresa Dell'Abate, Davide Vilella, Francesco Borlizzi, Roberta Zerlotin, Angela Oranger, Graziana Colaianni, Silvia Colucci, Maria Grano, Giancarlo Logroscino
Annals of Clinical and Translational Neurology, 2025
ObjectiveThe myokine irisin, a recent positive mediator of exercise in the brain, shows neuroprotective functions against Alzheimer's disease (AD). The association between irisin and cognition has never been explored in a biologically defined cohort of patients. Thus, in the present study, we investigated the association of irisin with multidomain cognition in patients showing dementia‐related symptomatology.MethodsCerebrospinal fluid (CSF) and serum irisin levels were evaluated using enzyme‐linked immunoassays in a cohort of subjects with a confirmed biomarker evidence of AD, including AD (n = 82), mild cognitive impairment (MCI, n = 44), and subjective memory complaint (SMC, n = 20) patients. The results of this analysis were correlated with global cognitive efficiency assessed by Mini‐Mental State Examination, and multidomain cognition evaluated by a battery of psychometric tests.ResultsDecreased CSF and serum irisin levels were observed in AD and MCI patients compared to SMC. A significant correlation has been found between irisin in the CSF and global cognitive efficiency, as well as with specific cognitive domains such as memory, executive functions, attention, visuospatial abilities, and language. For serum irisin, the correlation analysis evidenced similar results to those observed for the CSF.InterpretationOur results highlight the key involvement of irisin in multidomain cognition, indicating its potential role as a cognitive biomarker of AD progression.
Irisin Prevents the Effects of Simulated Microgravity on Bone and Muscle Differentiation Markers
Lorenzo Sanesi, Roberta Zerlotin, Alessio Campiolo, Angela Oranger, Manuela Dicarlo, et al.
FASEB Bioadvances, 2025
Microgravity exposure affects both tissues and cells, and, in this regard, one of the most affected targets is the skeletal muscle system due to the significant loss of bone and muscle mass leading to osteoporosis and sarcopenia, respectively. Several efforts are underway to counteract the effects of microgravity, and recent studies on irisin, a myokine with anabolic effects on the musculoskeletal system, have shown promising results. Due to the practical challenges of conducting experiments in actual microgravity, different devices generating a simulated microgravity condition on Earth have been developed. Here, we exposed myoblasts, osteoblasts, osteocytes to a random position machine (RPM) for five days to assess microgravity effect on the expression of key differentiation factors in cells untreated or treated with irisin. In myoblasts (C2C12), exposure to RPM led to increased expression of early myogenesis maker genes Pax7 ( p = 0.0016), Myf5 ( p = 0.0005) and MyoD ( p = 0.0009). Irisin treatment in the last 8 h of RPM cultures prevented these increases by returning Pax7 ( p = 0.0008) and MyoD ( p = 0.01) to control values, and only partially Myf5 . In bone cells, exposure to RPM for 5 days showed no effect in osteoblasts (MC3T3) but decreased the expression of Pdpn ( p = 0.0285) and Dmp‐1 ( p = 0.0423) genes in osteocytes (MLO‐Y4). Irisin treatment completely prevented the decline in Pdpn ( p = 0.293) and Dmp‐1 ( p = 0.0339) levels. Overall, our data showed that the impact of RPM exposure keeps myoblasts and osteocytes in a proliferative state, and irisin treatment restores them to their baseline biological condition, suggesting that irisin can counteract the changes induced by simulated microgravity.
Influence of Non-Cross-Linking AGEs on Mechanical Properties and Morphological Features of Tropocollagen Peptides: A Molecular Dynamics Study
Yu-Bai Xiao, Linda Ravazzano, Maria Grano, Graziana Colaianni, Clair Baldock, Flavia Libonati, Anna Tarakanova
ACS Biomaterials Science and Engineering, 2025
Collagen, a protein known for its long lifespan, is susceptible to accumulation of advanced glycation end products (AGEs) with age. These AGEs are considered markers that indicate the aging severity and influence the mechanics of tissues, leading to fragile bones and hardened skin. While many cross-linking AGEs have been widely studied for their ability to reduce the elasticity of biological tissues, contributing to skin hardening and fragile bones, through strong covalent bonds, non-cross-linking AGEs, or AGE adducts, are typically investigated as indicators of aging or as signaling factors in pathological conditions. However, recent experimental findings have revealed that the number of AGE adducts in aged bone is comparable to enzymatic cross-links, which are significantly more abundant than cross-linking AGEs. Based on these observations, we consider one of the most abundant AGE adducts - carboxymethyllysine (CML) - and employ molecular dynamics simulations to explore its direct impact on the mechanical and conformational properties of single tropocollagen molecules. Our models demonstrate that tropocollagen peptides, constructed based on sequences experimentally identified with sites of CML modifications in type I collagen derived from human cortical bone, exhibit heterogeneous behaviors under tensile testing. Still, most of these modified peptides display compromised structural stability, reduction in structural strength, and diminished energy dissipation ability when tension is applied. This study highlights the potential impact of non-cross-linking AGEs on collagen behavior at molecular scale and provides insights into the mechanisms underlying these modifications. Gaining a deeper understanding of the role of AGE adducts and their contribution to the aging process may pave the way for future solutions in antiaging research.
Reference Intervals (RIs) of the Bone Turnover Markers (BTMs) in Children and Adolescents: A Proposal for Effective Use
Vincenzo Brescia, Roberto Lovero, Antonietta Fontana, Roberta Zerlotin, Silvia Concetta Colucci, Maria Grano, Angela Pia Cazzolla, Francesca Di Serio, Vito Crincoli, Maria Felicia Faienza
Biomedicines, 2025
Background/Objectives: Bone turnover markers (BTMs) can provide information on the bone growth of apparently healthy children and adolescents or useful results in the diagnosis and monitoring of the disease condition, comparing them with appropriate reference intervals (RIs). The aim of this study was to establish the RI for the BTM [specific bone alkaline phosphatase (BALP), carboxy-terminal cross-linked collagen type I telopeptide (CTX), N-terminal propeptide pro-collagen type I (PINP), osteocalcin (OC), resistant to acid tartrate phosphatase isoform 5b (TRAcP-5b)] on serum samples from children and adolescents. Method: 202 samples from children and adolescents (ages 1–18 years) (51.48% male), considered apparently healthy. The biomarker was analyzed on automatic immunometric equipment (TGSTA Technogenetics) and the IDS-iSYS automated system kits The RI of the studied parameters was calculated according to CLSI Guideline C28-A3 with stratification by age and sex. Evaluation of the distribution of values and the meaning of the biomarker concentrations were used to calculate general and specific RI for an age group. Results: BTM concentrations vary with pubertal growth. The pattern of change differs for each bone marker. General and age-specific RI were calculated: 1–14 years, 15–18 years for BALP and CTX; 1–13 years, 14–18 years for Oc and PINP and 1–12 years, 13–18 years for TRAcP. Discussion and Conclusions: Concentrations for biomarker studied vary with age and gender. The proof of concentrations with insignificant changes until puberty led to identification of two groups of RI relating to the covariables (age and sex) for each biomarker.
Alteration of vasopressin-aquaporin system in hindlimb unloading mice
Marianna Ranieri, Maria Venneri, Giuseppina Storlino, Angela Ferrulli, Mariagrazia D’Agostino, Mariangela Centrone, Annarita Di Mise, Roberta Zerlotin, Grazia Tamma, Maria Grano, Giovanna Valenti
Frontiers in Physiology, 2025
Murine hindlimb unloading (HU) is considered a model of choice for simulating the physiological effects of microgravity on several functions, including fluid and electrolyte homeostasis. Microgravity causes changes in blood redistribution, modulating vasopressin secretion, a major hormone controlling water reabsorption through the vasopressin-sensitive water channel AQP2. In this study, mice were hindlimb suspended over 4 weeks or rested in the ground as controls, and vasopressin levels, along with renal aquaporins expression were investigated. Copeptin, a stable precursor of the hormone vasopressin, significantly increased as early as 1 week of unloading which correlated with a significant increase in AQP2 total protein expression and decrease in serum osmolality, suggesting early activation of the vasopressin/AQP2 axis in this model. Conversely, in 4 weeks HU suspended mice, copeptin decreased significantly and both AQP2 mRNA and AQP2 total protein expression were significantly reduced. Consistent with a downregulation of the vasopressin/AQP2 axis an increase in serum osmolality was observed at 4 weeks HU. The basolateral water channels AQP3 and AQP4 were, on the other hand, unaffected. Immunolocalization studies confirmed reduced expression of AQP2 in renal collecting ducts of HU mice at 4 weeks. A significantly increased amount of the expressed AQP2 was found phosphorylated at Ser261, a site regulating AQP2 protein stability and degradation. In line, p38-MAPK, committed to phosphorylate Ser261 and to increase miR137 expression, an AQP2 mRNA-targeted microRNA, was significantly increased in HU, suggesting that reduced AQP2 expression was mainly due to increased protein degradation and downregulation of AQP2-mRNA translation. Our results suggest that vasopressin/AQP2 axis is upregulated as early as 1 week and may be involved in the antidiuretic response also observed in early spaceflight period in astronauts. Contrariwise, the vasopressin-AQP2 system is downregulated after 4 weeks HU, likely to counteract the persistent central venous pressure due to cephalic shift of fluids.
Irisin and Metastatic Melanoma: Selective Anti-Invasiveness Activity in BRAF Wild-Type Cells
Simona Serratì, Roberta Zerlotin, Michele Manganelli, Roberta Di Fonte, Manuela Dicarlo, Angela Oranger, Graziana Colaianni, Letizia Porcelli, Amalia Azzariti, Stefania Guida, Maria Grano, Silvia Concetta Colucci, Gabriella Guida
International Journal of Molecular Sciences, 2025
Multiscale and multidisciplinary analysis of aging processes in bone
Linda Ravazzano, Graziana Colaianni, Anna Tarakanova, Yu-Bai Xiao, Maria Grano, Flavia Libonati
Npj Aging, 2024
How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?
Craig R. G. Willis, Marco Calvaruso, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Eugénie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Chouker, Francesca Cialdai, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl’Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Raúl Herranz, Christine Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Petra Rettberg, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Chiara Risaliti, Daniela Santucci, Matthias Sperl, Kevin Tabury, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Monica Monici, Nathaniel J. Szewczyk
Npj Microgravity, 2024
How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?
Trent Davis, Kevin Tabury, Shouan Zhu, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Marco Calvaruso, Eugénie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Choukér, Francesca Cialdai, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl’Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Christiane Hahn, Jason Hatton, Raúl Herranz, Christine E. Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack J.W.A. van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Angelique van Ombergen, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Christopher Puhl, Petra Rettberg, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Daniela Santucci, Matthias Sperl, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Nathaniel Szewczyk, Monica Monici
Npj Microgravity, 2024
Rationale and Protocol of the ETERNITY-ITA Study: Use of Etelcalcetide for Preserving Vitamin K-Dependent Protein Activity—An Italian Study
Maria Fusaro, Andrea Aghi, Carmela Marino, Francesca Mallamaci, Mario Plebani, Martina Zaninotto, Maria Grano, Silvia Colucci, Maurizio Gallieni, Thomas L. Nickolas, Sandro Giannini, Stefania Sella, Paolo Simioni, Alberto Bazzocchi, Giuseppe Guglielmi, Fulvia Taddei, Enrico Schileo, Maria Carmela Versace, Giovanni Tripepi
Journal of Clinical Medicine, 2024
Irisin prevents trabecular bone damage and tumor invasion in a mouse model of multiple myeloma
Roberta Zerlotin, Angela Oranger, Patrizia Pignataro, Manuela Dicarlo, Lorenzo Sanesi, Clelia Suriano, Giuseppina Storlino, Rita Rizzi, Anna Mestice, Sante Di Gioia, Giorgio Mori, Maria Grano, Graziana Colaianni, Silvia Colucci
Jbmr Plus, 2024
Irisin Levels in Cerebrospinal Fluid Correlate with Biomarkers and Clinical Dementia Scores in Alzheimer Disease
Manuela Dicarlo, Patrizia Pignataro, Chiara Zecca, Maria Teresa Dell'Abate, Daniele Urso, Valentina Gnoni, Alessia Giugno, Francesco Borlizzi, Roberta Zerlotin, Angela Oranger, Graziana Colaianni, Silvia Colucci, Giancarlo Logroscino, Maria Grano
Annals of Neurology, 2024
Exploring the Role of Circular RNA in Bone Biology: A Comprehensive Review
Maria Teresa Valenti, Roberta Zerlotin, Mattia Cominacini, Silvia Bolognin, Maria Grano, Luca Dalle Carbonare
Cells, 2024
LIGHT/TNFSF14 Affects Adipose Tissue Phenotype
Angela Oranger, Graziana Colaianni, Giuseppe Ingravallo, Vincenza Sara Scarcella, Maria Felicia Faienza, Maria Grano, Silvia Colucci, Giacomina Brunetti
International Journal of Molecular Sciences, 2024
Time-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis
Lorenzo Sanesi, Giuseppina Storlino, Manuela Dicarlo, Angela Oranger, Roberta Zerlotin, Patrizia Pignataro, Clelia Suriano, Gabriella Guida, Maria Grano, Graziana Colaianni, Silvia Concetta Colucci
Npj Microgravity, 2023
How do gravity alterations affect animal and human systems at a cellular/tissue level?
Francesca Cialdai, Austin M. Brown, Cory W. Baumann, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Marco Calvaruso, Eugénie Carnero-Diaz, Sara Castiglioni, Duccio Cavalieri, Gabriele Ceccarelli, Alexander Choukér, Gianni Ciofani, Giuseppe Coppola, Gabriella Cusella, Andrea Degl’Innocenti, Jean-Francois Desaphy, Jean-Pol Frippiat, Michael Gelinsky, Giada Genchi, Maria Grano, Daniela Grimm, Alain Guignandon, Christiane Hahn, Jason Hatton, Raúl Herranz, Christine E. Hellweg, Carlo Saverio Iorio, Thodoris Karapantsios, Jack van Loon, Matteo Lulli, Jeanette Maier, Jos Malda, Emina Mamaca, Lucia Morbidelli, Angelique van Ombergen, Andreas Osterman, Aleksandr Ovsianikov, Francesco Pampaloni, Elizabeth Pavezlorie, Veronica Pereda-Campos, Cyrille Przybyla, Christopher Puhl, Petra Rettberg, Chiara Risaliti, Angela Maria Rizzo, Kate Robson-Brown, Leonardo Rossi, Giorgio Russo, Alessandra Salvetti, Daniela Santucci, Matthias Sperl, Felice Strollo, Kevin Tabury, Sara Tavella, Christiane Thielemann, Ronnie Willaert, Nathaniel J. Szewczyk, Monica Monici
Npj Microgravity, 2023
High levels of LIGHT/TNFSF14 in patients with Prader–Willi syndrome
M. Faienza, G. Brunetti, D. Fintini, G. Grugni, M. Wasniewska, A. Crinò, G. D’amato, L. Piacente, A. Oranger, M. Dicarlo, S. Colucci, M. Grano
Journal of Endocrinological Investigation, 2023
Short-Term Irisin Treatment Enhanced Neurotrophin Expression Differently in the Hippocampus and the Prefrontal Cortex of Young Mice
Manuela Dicarlo, Patrizia Pignataro, Roberta Zerlotin, Clelia Suriano, Chiara Zecca, Maria Teresa Dell’Abate, Giuseppina Storlino, Angela Oranger, Lorenzo Sanesi, Giorgio Mori, Maria Grano, Graziana Colaianni, Silvia Colucci
International Journal of Molecular Sciences, 2023
Irisin Protects against Loss of Trabecular Bone Mass and Strength in Adult Ovariectomized Mice by Stimulating Osteoblast Activity
Giuseppina Storlino, Manuela Dicarlo, Roberta Zerlotin, Patrizia Pignataro, Lorenzo Sanesi, Clelia Suriano, Angela Oranger, Giorgio Mori, Giovanni Passeri, Silvia Colucci, Maria Grano, Graziana Colaianni
International Journal of Molecular Sciences, 2023
Once-Daily Subcutaneous Irisin Administration Mitigates Depression- and Anxiety-like Behavior in Young Mice
Patrizia Pignataro, Manuela Dicarlo, Clelia Suriano, Lorenzo Sanesi, Roberta Zerlotin, Giuseppina Storlino, Angela Oranger, Chiara Zecca, Maria Teresa Dell’Abate, Giorgio Mori, Maria Grano, Silvia Colucci, Graziana Colaianni
International Journal of Molecular Sciences, 2023
Tumor Necrosis Factor Family Members and Myocardial Ischemia-Reperfusion Injury: State of the Art and Therapeutic Implications
Antonella Galeone, Maria Grano, Giacomina Brunetti
International Journal of Molecular Sciences, 2023
Elevated Expression of ADAM10 in Skeletal Muscle of Patients with Idiopathic Inflammatory Myopathies Could Be Responsible for FNDC5/Irisin Unbalance
Roberta Zerlotin, Marco Fornaro, Mariella Errede, Patrizia Pignataro, Clelia Suriano, Maddalena Ruggieri, Silvia Colucci, Florenzo Iannone, Maria Grano, Graziana Colaianni
International Journal of Molecular Sciences, 2023
Irisin Role in Chondrocyte 3D Culture Differentiation and Its Possible Applications
Francesca Posa, Roberta Zerlotin, Anastasia Ariano, Michele Di Cosola, Graziana Colaianni, Aldo Di Fazio, Silvia Colucci, Maria Grano, Giorgio Mori
Pharmaceutics, 2023
Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing
Angela Oranger, Roberta Zerlotin, Cinzia Buccoliero, Lorenzo Sanesi, Giuseppina Storlino, Ernestina Schipani, Kenneth Michael Kozloff, Giorgio Mori, Graziana Colaianni, Silvia Colucci, Maria Grano
International Journal of Molecular Sciences, 2023
Vitamin D Increases Irisin Serum Levels and the Expression of Its Precursor in Skeletal Muscle
Lorenzo Sanesi, Manuela Dicarlo, Patrizia Pignataro, Roberta Zerlotin, Flavia Pugliese, Carla Columbu, Vincenzo Carnevale, Silvia Tunnera, Alfredo Scillitani, Maria Grano, Graziana Colaianni, Silvia Colucci
International Journal of Molecular Sciences, 2023
Impact of 10-day bed rest on serum levels of irisin and markers of musculoskeletal metabolism
Angela Oranger, Giuseppina Storlino, Manuela Dicarlo, Roberta Zerlotin, Patrizia Pignataro, Lorenzo Sanesi, Marco Narici, Rado Pišot, Bostjan Simunič, Graziana Colaianni, Maria Grano, Silvia Colucci
FASEB Journal, 2023
Circulating Irisin Levels in Patients with Chronic Plaque Psoriasis
Francesca Ambrogio, Lorenzo Sanesi, Angela Oranger, Chiara Barlusconi, Manuela Dicarlo, Patrizia Pignataro, Roberta Zerlotin, Paolo Romita, Elvira Favoino, Gerardo Cazzato, Nicoletta Cassano, Gino Antonio Vena, Caterina Foti, Maria Grano
Biomolecules, 2022
Antidepressant Effect of Intermittent Long‐Term Systemic Administration of Irisin in Mice
Patrizia Pignataro, Manuela Dicarlo, Roberta Zerlotin, Giuseppina Storlino, Angela Oranger, Lorenzo Sanesi, Roberto Lovero, Cinzia Buccoliero, Giorgio Mori, Graziana Colaianni, Silvia Colucci, Maria Grano
International Journal of Molecular Sciences, 2022
Irisin Serum Levels and Skeletal Muscle Assessment in a Cohort of Charcot-Marie-Tooth Patients
Graziana Colaianni, Angela Oranger, Manuela Dicarlo, Roberto Lovero, Giuseppina Storlino, Patrizia Pignataro, Antonietta Fontana, Francesca Di Serio, Angelica Ingravallo, Giuseppe Caputo, Alfredo Di Leo, Michele Barone, Maria Grano
Frontiers in Endocrinology, 2022
Antibody Treatment and Osteoporosis: Clinical Perspective
Giacomina Brunetti, Sara Todisco, Maria Grano
Springer Series in Biomaterials Science and Engineering, 2022
Irisin and Secondary Osteoporosis in Humans
Roberta Zerlotin, Angela Oranger, Patrizia Pignataro, Manuela Dicarlo, Filippo Maselli, Giorgio Mori, Silvia Concetta Colucci, Maria Grano, Graziana Colaianni
International Journal of Molecular Sciences, 2022
The genetic background and vitamin D supplementation can affect irisin levels in Prader–Willi syndrome
M. F. Faienza, G. Brunetti, G. Grugni, D. Fintini, A. Convertino, P. Pignataro, A. Crinò, S. Colucci, M. Grano
Journal of Endocrinological Investigation, 2021
Systemic administration of recombinant irisin accelerates fracture healing in mice
Silvia Concetta Colucci, Cinzia Buccoliero, Lorenzo Sanesi, Mariella Errede, Graziana Colaianni, Tiziana Annese, Mohd Parvez Khan, Roberta Zerlotin, Manuela Dicarlo, Ernestina Schipani, Kenneth M. Kozloff, Maria Grano
International Journal of Molecular Sciences, 2021
In Reply to the Letter to the Editor: Involvement of Irisin in Age-Related Osteoporosis and Its Inhibitory Effect on the Senescent Marker p21 in Osteoblasts
Graziana Colaianni, Mariella Errede, Lorenzo Sanesi, Angela Notarnicola, Monica Celi, Roberta Zerlotin, Giuseppina Storlino, Patrizia Pignataro, Angela Oranger, Vito Pesce, Umberto Tarantino, Biagio Moretti, Maria Grano
Journal of Bone and Mineral Research, 2021
The myokine irisin promotes osteogenic differentiation of dental bud-derived mscs
Francesca Posa, Graziana Colaianni, Michele Di Cosola, Manuela Dicarlo, Francesco Gaccione, Silvia Colucci, Maria Grano, Giorgio Mori
Biology, 2021
FNDC5/irisin is expressed and regulated differently in human periodontal ligament cells, dental pulp stem cells and osteoblasts
Yang Yang, Helen Pullisaar, Maria A. Landin, Catherine Anne Heyward, Maria Schröder, Tianxiang Geng, Maria Grano, Janne Elin Reseland
Archives of Oral Biology, 2021
Fndc5/irisin system in neuroinflammation and neurodegenerative diseases: Update and novel perspective
Patrizia Pignataro, Manuela Dicarlo, Roberta Zerlotin, Chiara Zecca, Maria Teresa Dell’Abate, Cinzia Buccoliero, Giancarlo Logroscino, Silvia Colucci, Maria Grano
International Journal of Molecular Sciences, 2021
The effect of Irisin on bone cells in vivo and in vitro
Cinzia Buccoliero, Angela Oranger, Graziana Colaianni, Patrizia Pignataro, Roberta Zerlotin, Roberto Lovero, Mariella Errede, Maria Grano
Biochemical Society Transactions, 2021
Irisin Correlates Positively With BMD in a Cohort of Older Adult Patients and Downregulates the Senescent Marker p21 in Osteoblasts
Graziana Colaianni, Mariella Errede, Lorenzo Sanesi, Angela Notarnicola, Monica Celi, Roberta Zerlotin, Giuseppina Storlino, Patrizia Pignataro, Angela Oranger, Vito Pesce, Umberto Tarantino, Biagio Moretti, Maria Grano
Journal of Bone and Mineral Research, 2021
In Vivo and In Vitro Models for the Study of Bone Remodeling and the Role of Immune Cells
Giacomina Brunetti, Maria Grano
Methods in Molecular Biology, 2021
Capsid-like biodegradable poly-glycolic acid nanoparticles for a long-time release of nucleic acid molecules
Clara Guido, Mariangela Testini, Stefania D’Amone, Barbara Cortese, Maria Grano, Giuseppe Gigli, Ilaria E. Palamà
Materials Advances, 2021
The novel role of PGC1α in bone metabolism
Cinzia Buccoliero, Manuela Dicarlo, Patrizia Pignataro, Francesco Gaccione, Silvia Colucci, Graziana Colaianni, Maria Grano
International Journal of Molecular Sciences, 2021
Myokines and Osteokines in the Pathogenesis of Muscle and Bone Diseases
G. Colaianni, G. Storlino, L. Sanesi, S. Colucci, Maria Grano
Current Osteoporosis Reports, 2020
Irisin prevents microgravity-induced impairment of osteoblast differentiation in vitro during the space flight CRS-14 mission
Silvia Colucci, Graziana Colaianni, Giacomina Brunetti, Francesca Ferranti, Gabriele Mascetti, Giorgio Mori, Maria Grano
FASEB Journal, 2020
Shedding “light” on the link between bone and fat in obese children and adolescents
Giacomina Brunetti, Maria Felicia Faienza, Laura Piacente, Giuseppina Storlino, Angela Oranger, Gabriele D'Amato, Gianpaolo De Filippo, Silvia Colucci, Maria Grano
International Journal of Molecular Sciences, 2020
Muscle-derived soluble mediators regulating bone
Maria Grano, Graziana Colaianni
Encyclopedia of Bone Biology, 2020
Novel insights in health-promoting properties of sweet cherries
Maria Felicia Faienza, Filomena Corbo, Alessia Carocci, Alessia Catalano, Maria Lisa Clodoveo, Maria Grano, David Q.-H. Wang, Gabriele D'Amato, Marilena Muraglia, Carlo Franchini, Giacomina Brunetti, Piero Portincasa
Journal of Functional Foods, 2020
Irisin Prevents Disuse-Induced Osteocyte Apoptosis
Giuseppina Storlino, Graziana Colaianni, Lorenzo Sanesi, Luciana Lippo, Giacomina Brunetti, Mariella Errede, Silvia Colucci, Giovanni Passeri, Maria Grano
Journal of Bone and Mineral Research, 2020
LIGHT/TNFSF14 regulates estrogen deficiency-induced bone loss
Giacomina Brunetti, Giuseppina Storlino, Angela Oranger, Graziana Colaianni, Maria F Faienza, Giuseppe Ingravallo, Mariasevera Di Comite, Janne E Reseland, Monica Celi, Umberto Tarantino, Giovanni Passeri, Carl F Ware, Maria Grano, Silvia Colucci
Journal of Pathology, 2020
LIGHT/TNFSF14 Promotes Osteolytic Bone Metastases in Non-small Cell Lung Cancer Patients
Giacomina Brunetti, Dimas C Belisario, Sara Bortolotti, Giuseppina Storlino, Graziana Colaianni, Maria F Faienza, Lorenzo Sanesi, Valentina Alliod, Lucio Buffoni, Elisa Centini, Claudia Voena, Roberta Pulito, Silvia Novello, Giuseppe Ingravallo, Rita Rizzi, Giorgio Mori, Janne E Reseland, Carl F Ware, Silvia Colucci, Riccardo Ferracini, Maria Grano, Ilaria Roato
Journal of Bone and Mineral Research, 2020
Irisin promotes growth, migration and matrix formation in human periodontal ligament cells
Helen Pullisaar, Graziana Colaianni, Aina-Mari Lian, Vaska Vandevska-Radunovic, Maria Grano, Janne Elin Reseland
Archives of Oral Biology, 2020
Muscle-Derived Soluble Mediators Regulating Bone
Maria Grano, Graziana Colaianni
Encyclopedia of Bone Biology, 2020
Anatomy and Histology of Male Skeletal Tissue: Gender Differences
Maria Grano, Giacomina Brunetti, Graziana Colaianni, Silvia C. Colucci
Trends in Andrology and Sexual Medicine, 2020
A Novel Interplay between Irisin and PTH: From Basic Studies to Clinical Evidence in Hyperparathyroidism
Andrea Palermo, Lorenzo Sanesi, Graziana Colaianni, Gaia Tabacco, Anda Mihaela Naciu, Roberto Cesareo, Claudio Pedone, Diana Lelli, Giacomina Brunetti, Giorgio Mori, Silvia Colucci, Silvia Manfrini, Nicola Napoli, Maria Grano
Journal of Clinical Endocrinology and Metabolism, 2019
Irisin and bone: From preclinical studies to the evaluation of its circulating levels in different populations of human subjects
Graziana Colaianni, Lorenzo Sanesi, Giuseppina Storlino, Giacomina Brunetti, Silvia Colucci, Maria Grano
Cells, 2019
Effects of sweet cherry polyphenols on enhanced osteoclastogenesis associated with childhood obesity
Filomena Corbo, Giacomina Brunetti, Pasquale Crupi, Sara Bortolotti, Giuseppina Storlino, Laura Piacente, Alessia Carocci, Alessia Catalano, Gualtiero Milani, Graziana Colaianni, Silvia Colucci, Maria Grano, Carlo Franchini, Maria Lisa Clodoveo, Gabriele D'Amato, Maria Felicia Faienza
Frontiers in Immunology, 2019
Irisin serum levels are positively correlated with bone mineral status in a population of healthy children
Graziana Colaianni, Maria F. Faienza, Lorenzo Sanesi, Giacomina Brunetti, Patrizia Pignataro, Luciana Lippo, Sara Bortolotti, Giuseppina Storlino, Laura Piacente, Gabriele D’Amato, Silvia Colucci, Maria Grano
Pediatric Research, 2019
An update on the role of RANKL–RANK/osteoprotegerin and WNT-ß-catenin signaling pathways in pediatric diseases
Giacomina Brunetti, Gabriele D’Amato, Mariangela Chiarito, Apollonia Tullo, Graziana Colaianni, Silvia Colucci, Maria Grano, Maria Felicia Faienza
World Journal of Pediatrics, 2019
Metabolic bone disease of prematurity: Diagnosis and management
Maria Felicia Faienza, Elena D'Amato, Maria Pia Natale, Maria Grano, Mariangela Chiarito, Giacomina Brunetti, Gabriele D'Amato
Frontiers in Pediatrics, 2019
Mechanisms involved in childhood obesity-related bone fragility
Maria Felicia Faienza, Gabriele D'Amato, Mariangela Chiarito, Graziana Colaianni, Silvia Colucci, Maria Grano, Filomena Corbo, Giacomina Brunetti
Frontiers in Endocrinology, 2019
Stemness genes expression in naïve vs. osteodifferentiated human dental-derived stem cells
Andrea Ballini, A. Di Benedetto, Danila De Vito, Antônio Scarano, Salvatore Scacco, et al.
European Review for Medical and Pharmacological Sciences, 2019
Deletion of the Transcription Factor PGC-1α in Mice Negatively Regulates Bone Mass
Graziana Colaianni, Luciana Lippo, Lorenzo Sanesi, Giacomina Brunetti, Monica Celi, Nunzio Cirulli, Giovanni Passeri, Janne Reseland, Ernestina Schipani, Maria Felicia Faienza, Umberto Tarantino, Silvia Colucci, Maria Grano
Calcified Tissue International, 2018
LIGHT/TNFSF14 as a new biomarker of bone disease in multiple myeloma patients experiencing therapeutic regimens
Giacomina Brunetti, Rita Rizzi, Giuseppina Storlino, Sara Bortolotti, Graziana Colaianni, Lorenzo Sanesi, Luciana Lippo, Maria Felicia Faienza, Anna Mestice, Paola Curci, Giorgina Specchia, Maria Grano, Silvia Colucci
Frontiers in Immunology, 2018
Anatomy and physiology of skeletal tissue: The bone cells
Giacomina Brunetti, Graziana Colaianni, Silvia Colucci, Maria Grano
Multidisciplinary Approach to Osteoporosis from Assessment to Treatment, 2018
High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes
Maria Felicia Faienza, Giacomina Brunetti, Lorenzo Sanesi, Graziana Colaianni, Monica Celi, Laura Piacente, Gabriele D'Amato, Ernestina Schipani, Silvia Colucci, Maria Grano
Diabetes Research and Clinical Practice, 2018
Irisin serum levels in metabolic syndrome patients treated with three different diets: A post-hoc analysis from a randomized controlled clinical trial
Alberto R. Osella, Graziana Colaianni, Mario Correale, Pasqua L. Pesole, Irene Bruno, Claudia Buongiorno, Valentina Deflorio, Carla M. Leone, Silvia Concetta Colucci, Maria Grano, Gianluigi Giannelli
Nutrients, 2018
Polydatin, natural precursor of resveratrol, promotes osteogenic differentiation of mesenchymal stem cells
Adriana Di Benedetto, Francesca Posa, Salvatore De Maria, Giampietro Ravagnan, Andrea Ballini, Chiara Porro, Teresa Trotta, Maria Grano, Lorenzo Lo Muzio, Giorgio Mori
International Journal of Medical Sciences, 2018
Analysis of Circulating Mediators of Bone Remodeling in Prader–Willi Syndrome
G. Brunetti, G. Grugni, L. Piacente, M. Delvecchio, A. Ventura, P. Giordano, M. Grano, G. D’Amato, D. Laforgia, A. Crinò, M. F. Faienza
Calcified Tissue International, 2018
High expression of TRAIL by osteoblastic differentiated dental pulp stem cells affects myeloma cell viability
Giacomina Brunetti, Adriana Di Benedetto, Francesca Posa, Graziana Colaianni, Maria Felicia Faienza, Andrea Ballini, Silvia Colucci, Giovanni Passeri, Lorenzo Lo Muzio, Maria Grano, Giorgio Mori
Oncology Reports, 2018
Mechanisms of Enhanced Osteoclastogenesis in Alkaptonuria
Giacomina Brunetti, Albina Tummolo, Gabriele D'Amato, Alberto Gaeta, Federica Ortolani, Laura Piacente, Paola Giordano, Silvia Colucci, Maria Grano, Francesco Papadia, Maria F. Faienza
American Journal of Pathology, 2018
Impairment of Bone Remodeling in LIGHT/TNFSF14-Deficient Mice
Giacomina Brunetti, Maria Felicia Faienza, Graziana Colaianni, Isabella Gigante, Angela Oranger, Paolo Pignataro, Giuseppe Ingravallo, Adriana Di Benedetto, Sara Bortolotti, Mariasevera Di Comite, Giuseppina Storlino, Luciana Lippo, Lindsay Ward-Kavanagh, Giorgio Mori, Janne E Reseland, Giovanni Passeri, Ernestina Schipani, Koji Tamada, Carl F Ware, Silvia Colucci, Maria Grano
Journal of Bone and Mineral Research, 2018
Myokine—Irisin—and Its Effects Linking Bone and Muscle Function
Graziana Colaianni, Giacomina Brunetti, Silvia C. Colucci, Maria Grano
Clinical Reviews in Bone and Mineral Metabolism, 2018
Vitamin D promotes MSC osteogenic differentiation stimulating cell adhesion and αVβ3 expression
Francesca Posa, Adriana Di Benedetto, Elisabetta A. Cavalcanti-Adam, Graziana Colaianni, Chiara Porro, Teresa Trotta, Giacomina Brunetti, Lorenzo Lo Muzio, Maria Grano, Giorgio Mori
Stem Cells International, 2018
Monoclonal antibodies for treating osteoporosis
Maria Felicia Faienza, Mariangela Chiarito, Gabriele D’amato, Graziana Colaianni, Silvia Colucci, Maria Grano, Giacomina Brunetti
Expert Opinion on Biological Therapy, 2018
Erratum: Vitamin D promotes MSC osteogenic differentiation stimulating cell adhesion and avß3 expression (Stem Cells International (2018) 2018 (6958713) DOI: 10.1155/2018/6958713)
Francesca Posa, Adriana Di Benedetto, Elisabetta A. Cavalcanti-Adam, Graziana Colaianni, Chiara Porro, Teresa Trotta, Giacomina Brunetti, Lorenzo Lo Muzio, Maria Grano, Giorgio Mori
Stem Cells International, 2018
Inflammation induces osteoclast differentiation from peripheral mononuclear cells in chronic kidney disease patients: Crosstalk between the immune and bone systems
Cesira Cafiero, Margherita Gigante, Giacomina Brunetti, Simona Simone, Nada Chaoul, Angela Oranger, Elena Ranieri, Silvia Colucci, Giovanni B Pertosa, Maria Grano, Loreto Gesualdo
Nephrology Dialysis Transplantation, 2018
Mechanisms of Altered Bone Remodeling in Multiple Myeloma
Giacomina Brunetti, Maria Felicia Faienza, Graziana Colaianni, Maria Grano, Silvia Colucci
Clinical Reviews in Bone and Mineral Metabolism, 2017
Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice
Graziana Colaianni, Teresa Mongelli, Concetta Cuscito, Paolo Pignataro, Luciana Lippo, Giovanna Spiro, Angela Notarnicola, Ilenia Severi, Giovanni Passeri, Giorgio Mori, Giacomina Brunetti, Biagio Moretti, Umberto Tarantino, Silvia C. Colucci, Janne E. Reseland, Roberto Vettor, Saverio Cinti, Maria Grano
Scientific Reports, 2017
Irisin levels correlate with bone mineral density in soccer players
Journal of Biological Regulators and Homeostatic Agents, 2017
Sclerostin stimulates angiogenesis in human endothelial cells
Angela Oranger, Giacomina Brunetti, Graziana Colaianni, Roberto Tamma, Claudia Carbone, Luciana Lippo, Giorgio Mori, Paolo Pignataro, Nunzio Cirulli, Roberta Zerlotin, Biagio Moretti, Angela Notarnicola, Domenico Ribatti, Maria Grano, Silvia Colucci
Bone, 2017
High sclerostin and dickkopf-1 (DKK-1) serum levels in children and adolescents with type 1 diabetes mellitus
Maria Felicia Faienza, Annamaria Ventura, Maurizio Delvecchio, Anna Fusillo, Laura Piacente, Gabriella Aceto, Graziana Colaianni, Silvia Colucci, Luciano Cavallo, Maria Grano, Giacomina Brunetti
Journal of Clinical Endocrinology and Metabolism, 2017
Irisin and musculoskeletal health
Graziana Colaianni, Saverio Cinti, Silvia Colucci, Maria Grano
Annals of the New York Academy of Sciences, 2017
NURR1 downregulation favors osteoblastic differentiation of MSCs
Adriana Di Benedetto, Francesca Posa, Claudia Carbone, Stefania Cantore, Giacomina Brunetti, Matteo Centonze, Maria Grano, Lorenzo Lo Muzio, Elisabetta A. Cavalcanti-Adam, Giorgio Mori
Stem Cells International, 2017
Bone Regeneration Induced by Bone Porcine Block with Bone Marrow Stromal Stem Cells in a Minipig Model of Mandibular "Critical Size" Defect
Antonio Scarano, Vito Crincoli, Adriana Di Benedetto, Valerio Cozzolino, Felice Lorusso, Michele Podaliri Vulpiani, Maria Grano, Zamira Kalemaj, Giorgio Mori, Felice Roberto Grassi
Stem Cells International, 2017
Crosstalk Between Muscle and Bone Via the Muscle-Myokine Irisin
G. Colaianni, T. Mongelli, S. Colucci, S. Cinti, Maria Grano
Current Osteoporosis Reports, 2016
Impaired bone remodeling in children with osteogenesis imperfecta treated and untreated with bisphosphonates: the role of DKK1, RANKL, and TNF-α
G. Brunetti, F. Papadia, A. Tummolo, R. Fischetto, F. Nicastro, L. Piacente, A. Ventura, G. Mori, A. Oranger, I. Gigante, S. Colucci, M. Ciccarelli, M. Grano, L. Cavallo, M. Delvecchio, M. F. Faienza
Osteoporosis International, 2016
The effects of bone pâté on human osteoblasts cell cultures
Nicola Quaranta, Cinzia Buccoliero, Concetta De Luca, Giorgio Mori, Giacomina Brunetti, Silvia Colucci, Graziana Colaianni, Maria Grano
European Archives of Oto Rhino Laryngology, 2016
Bone fragility in turner syndrome: Mechanisms and prevention strategies
Maria Felicia Faienza, Annamaria Ventura, Silvia Colucci, Luciano Cavallo, Maria Grano, Giacomina Brunetti
Frontiers in Endocrinology, 2016
Functions of vasopressin and oxytocin in bone mass regulation
Li Sun, Roberto Tamma, Tony Yuen, Graziana Colaianni, Yaoting Ji, Concetta Cuscito, Jack Bailey, Samarth Dhawan, Ping Lu, Cosima D. Calvano, Ling-Ling Zhu, Carlo G. Zambonin, Adriana Di Benedetto, Agnes Stachnik, Peng Liu, Maria Grano, Silvia Colucci, Terry F. Davies, Maria I. New, Alberta Zallone, Mone Zaidi
Proceedings of the National Academy of Sciences of the United States of America, 2016
The myokine Irisin recapitulates the effect of physical activity on bone and muscle tissues
Journal of Gerontology and Geriatrics, 2016
Vitamin D effects on osteoblastic differentiation of mesenchymal stem cells from dental tissues
Francesca Posa, Adriana Di Benedetto, Graziana Colaianni, Elisabetta A. Cavalcanti-Adam, Giacomina Brunetti, Chiara Porro, Teresa Trotta, Maria Grano, Giorgio Mori
Stem Cells International, 2016
High serum sclerostin levels in children with haemophilia A
Paola Giordano, Giacomina Brunetti, Giuseppe Lassandro, Lucia D. Notarangelo, Matteo Luciani, Rosa M. Mura, Ilaria Lazzareschi, Elena Santagostino, Laura Piacente, Annamaria Ventura, Luciano Cavallo, Maria Grano, Maria F. Faienza
British Journal of Haematology, 2016
Mechanisms of enhanced osteoclastogenesis in girls and young women with Turner's Syndrome
Maria Felicia Faienza, Giacomina Brunetti, Annamaria Ventura, Laura Piacente, Maria Francesca Messina, Filippo De Luca, Maria Ciccarelli, Angela Oranger, Giorgio Mori, Maria Pia Natale, Margherita Gigante, Elena Ranieri, Loreto Gesualdo, Silvia Colucci, Luciano Cavallo, Maria Grano
Bone, 2015
Osteogenic differentiation of mesenchymal stem cells from dental bud: Role of integrins and cadherins
Adriana Di Benedetto, Giacomina Brunetti, Francesca Posa, Andrea Ballini, Felice Roberto Grassi, Graziana Colaianni, Silvia Colucci, Enzo Rossi, Elisabetta A. Cavalcanti-Adam, Lorenzo Lo Muzio, Maria Grano, Giorgio Mori
Stem Cell Research, 2015
Erratum: The myokine irisin increases cortical bone mass(Proceedings of the National Academy of Sciences of the United States of America (2015) 112 (12157-12162) 10.1073/pnas.1516622112)
Graziana Colaianni, Concetta Cuscito, Teresa Mongelli, Paolo Pignataro, Cinzia Buccoliero, et al.
Proceedings of the National Academy of Sciences of the United States of America, 2015
The myokine irisin increases cortical bone mass
Graziana Colaianni, Concetta Cuscito, Teresa Mongelli, Paolo Pignataro, Cinzia Buccoliero, Peng Liu, Ping Lu, Loris Sartini, Mariasevera Di Comite, Giorgio Mori, Adriana Di Benedetto, Giacomina Brunetti, Tony Yuen, Li Sun, Janne E. Reseland, Silvia Colucci, Maria I. New, Mone Zaidi, Saverio Cinti, Maria Grano
Proceedings of the National Academy of Sciences of the United States of America, 2015
Metabolic syndrome in childhood leukemia survivors: a meta-analysis
Maria Felicia Faienza, Maurizio Delvecchio, Paola Giordano, Luciano Cavallo, Maria Grano, Giacomina Brunetti, Annamaria Ventura
Endocrine, 2015
Evaluation of impact of steroid replacement treatment on bone health in children with 21-hydroxylase deficiency
M. Delvecchio, L. Soldano, A. Lonero, A. Ventura, P. Giordano, L. Cavallo, M. Grano, G. Brunetti, M. F. Faienza
Endocrine, 2015
Human Osteoclast-Like Cells from Giant Cell Tumors of Bone: A New Tool for Investigating Bone Resorption and Osteoclast Biology
A. Zambonin Zallone, M. Grano, S. Colucci, P. Zigrino, M. De Bellis, G. Zambonin, M. Serra
Calcified Tissue International, 2015
A natomy and physiology of adipose tissue
Graziana Colaianni, Silvia Colucci, Maria Grano
Multidisciplinary Approach to Obesity from Assessment to Treatment, 2015
Cellular mechanisms of bone regeneration: Role of WNT-1 in bone-muscle interaction during physical activity
Journal of Biological Regulators and Homeostatic Agents, 2015
Skeleton and glucose metabolism: A bone-pancreas loop
Maria Felicia Faienza, Vincenza Luce, Annamaria Ventura, Graziana Colaianni, Silvia Colucci, Luciano Cavallo, Maria Grano, Giacomina Brunetti
International Journal of Endocrinology, 2015
Human myeloma cell lines induce osteoblast downregulation of CD99 which is involved in osteoblast formation and activity
Angela Oranger, Giacomina Brunetti, Claudia Carbone, Graziana Colaianni, Teresa Mongelli, Isabella Gigante, Roberto Tamma, Giorgio Mori, Adriana Di Benedetto, Marika Sciandra, Selena Ventura, Katia Scotlandi, Silvia Colucci, Maria Grano
Journal of Immunology Research, 2015
Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor
Adriana Di Benedetto, Li Sun, Carlo G. Zambonin, Roberto Tamma, Beatrice Nico, Cosima D. Calvano, Graziana Colaianni, Yaoting Ji, Giorgio Mori, Maria Grano, Ping Lu, Silvia Colucci, Tony Yuen, Maria I. New, Alberta Zallone, Mone Zaidi
Proceedings of the National Academy of Sciences of the United States of America, 2014
Erratum: Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia (Proceedings of the National Academy of Sciences of the United States of America (2013) 110 (18644-18649) DOI: 10.1073/pnas.1318257110)
Tamma R., Sun L., Cuscito C., Lu P., Corcelli M., et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014
Irisin enhances osteoblast differentiation in vitro
Graziana Colaianni, Concetta Cuscito, Teresa Mongelli, Angela Oranger, Giorgio Mori, Giacomina Brunetti, Silvia Colucci, Saverio Cinti, Maria Grano
International Journal of Endocrinology, 2014
Osteoclastogenic potential of peripheral blood mononuclear cells in cleidocranial dysplasia
Maria Felicia Faienza, Annamaria Ventura, Laura Piacente, Maria Ciccarelli, Margherita Gigante, Loreto Gesualdo, Silvia Colucci, Luciano Cavallo, Maria Grano, Giacomina Brunetti
International Journal of Medical Sciences, 2014
Bone cells
Angela Oranger, Graziana Colaianni, Maria Grano
Imaging of Prosthetic Joints A Combined Radiological and Clinical Perspective, 2014
Experimental Model for Studying the Involvement of Regulatory Cytotoxic T Cells in Bone Resorption
Giacomina Brunetti, Angela Oranger, Silvia Colucci, Maria Grano
Methods in Molecular Biology, 2014
Osteoporosis and obesity: Role of Wnt pathway in human and murine models
Graziana Colaianni
World Journal of Orthopedics, 2014
Treatment of osteoporosis in children with glucocorticoid-treated diseases
Maria Felicia Faienza, Vincenza Luce, Antonella Lonero, Annamaria Ventura, Graziana Colaianni, Silvia Colucci, Luciano Cavallo, Maria Grano, Giacomina Brunetti
Expert Review of Endocrinology and Metabolism, 2014
CD99 drives terminal differentiation of osteosarcoma cells by acting as a spatial regulator of ERK 1/2
Marika Sciandra, Maria Teresa Marino, Maria Cristina Manara, Clara Guerzoni, Maria Grano, Angela Oranger, Enrico Lucarelli, Pier-Luigi Lollini, Barbara Dozza, Loredana Pratelli, Maria Flavia Di Renzo, Mario Paolo Colombo, Piero Picci, Katia Scotlandi
Journal of Bone and Mineral Research, 2014
LIGHT/TNFSF14 increases osteoclastogenesis and decreases osteoblastogenesis in multiple myeloma-bone disease
Giacomina Brunetti, Rita Rizzi, Angela Oranger, Isabella Gigante, Giorgio Mori, Grazia Taurino, Teresa Mongelli, Graziana Colaianni, Adriana Di Benedetto, Roberto Tamma, Giuseppe Ingravallo, Anna Napoli, Maria Felicia Faienza, Anna Mestice, Paola Curci, Giorgina Specchia, Silvia Colucci, Maria Grano
Oncotarget, 2014
Introduction
Maria Grano, Graziana Colaianni
Clinical Reviews in Bone and Mineral Metabolism, 2013
Osteotropic cancers: From primary tumor to bone
Giacomina Brunetti, Graziana Colaianni, Maria Felicia Faienza, Silvia Colucci, Maria Grano
Clinical Reviews in Bone and Mineral Metabolism, 2013
Osteoblasts Display Different Responsiveness to TRAIL-Induced Apoptosis During Their Differentiation Process
Giacomina Brunetti, Angela Oranger, Claudia Carbone, Giorgio Mori, Francesca Rita Sardone, Claudio Mori, Monica Celi, Maria Felicia Faienza, Umberto Tarantino, Alberta Zallone, Maria Grano, Silvia Colucci
Cell Biochemistry and Biophysics, 2013
Aortic valvular interstitial cells apoptosis and calcification are mediated by TNF-related apoptosis-inducing ligand
Antonella Galeone, Giacomina Brunetti, Angela Oranger, Giovanni Greco, Adriana Di Benedetto, Giorgio Mori, Silvia Colucci, Alberta Zallone, Domenico Paparella, Maria Grano
International Journal of Cardiology, 2013
Regulation of bone remodeling by vasopressin explains the bone loss in hyponatremia
Roberto Tamma, Li Sun, Concetta Cuscito, Ping Lu, Michelangelo Corcelli, Jianhua Li, Graziana Colaianni, Surinder S. Moonga, Adriana Di Benedetto, Maria Grano, Silvia Colucci, Tony Yuen, Maria I. New, Alberta Zallone, Mone Zaidi
Proceedings of the National Academy of Sciences of the United States of America, 2013
Activation of the receptor activator of the nuclear factor-κB ligand pathway during coronary bypass surgery: Comparison between on- and off-pump coronary artery bypass surgery procedures
A. Galeone, G. Brunetti, C. Rotunno, A. Oranger, S. Colucci, L. de Luca Tupputi Schinosa, A. Zallone, M. Grano, D. Paparella
European Journal of Cardio Thoracic Surgery, 2013
Cellular mechanisms of multiple myeloma bone disease
Angela Oranger, Claudia Carbone, Maddalena Izzo, Maria Grano
Clinical and Developmental Immunology, 2013
Periodontal disease: Linking the primary inflammation to bone loss
Adriana Di Benedetto, Isabella Gigante, Silvia Colucci, Maria Grano
Clinical and Developmental Immunology, 2013
Glucocorticoid-induced osteoporosis in children with 21-hydroxylase deficiency
Annamaria Ventura, Giacomina Brunetti, Silvia Colucci, Angela Oranger, Filomena Ladisa, Luciano Cavallo, Maria Grano, Maria Felicia Faienza
Biomed Research International, 2013
High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment
Giacomina Brunetti, Maria Felicia Faienza, Laura Piacente, Annamaria Ventura, Angela Oranger, Claudia Carbone, Adriana Di Benedetto, Graziana Colaianni, Margherita Gigante, Giorgio Mori, Loreto Gesualdo, Silvia Colucci, Luciano Cavallo, Maria Grano
American Journal of Physiology Endocrinology and Metabolism, 2013
Biological characteristics of dental stem cells for tissue engineering
G. Mori, G. Brunetti, A. Ballini, A. Di Benedetto, U. Tarantino, S. Colucci, M. Grano
Key Engineering Materials, 2013
The role of TNF- α and TNF superfamily members in the pathogenesis of calcific aortic valvular disease
Antonella Galeone, Domenico Paparella, Silvia Colucci, Maria Grano, Giacomina Brunetti
Scientific World Journal, 2013
Osteogenic differentiation of dental follicle stem cells
Giorgio Mori, Andrea Ballini, Claudia Carbone, Angela Oranger, Giacomina Brunetti, Adriana Di Benedetto, Biagio Rapone, Stefania Cantore, Mariasevera Di Comite, Silvia Colucci, Maria Grano, Felice R. Grassi
International Journal of Medical Sciences, 2012
Bone marrow oxytocin mediates the anabolic action of estrogen on the skeleton
Graziana Colaianni, Li Sun, Adriana Di Benedetto, Roberto Tamma, Ling-Ling Zhu, Jay Cao, Maria Grano, Tony Yuen, Sylvia Colucci, Concetta Cuscito, Lucia Mancini, Jianhua Li, Katsuhiko Nishimori, Itai Bab, Heon-Jin Lee, Jameel Iqbal, W.Scott Young, Clifford Rosen, Alberta Zallone, Mone Zaidi
Journal of Biological Chemistry, 2012
Genotype-phenotype correlation in Juvenile Paget disease: Role of molecular alterations of the TNFRSF11B gene
Giacomina Brunetti, Flaviana Marzano, Silvia Colucci, Annamaria Ventura, Luciano Cavallo, Maria Grano, Maria Felicia Faienza
Endocrine, 2012
FT-IR microscopic analysis on human dental pulp stem cells
Elisabetta Giorgini, Carla Conti, Paolo Ferraris, Simona Sabbatini, Giorgio Tosi, Matteo Centonze, Maria Grano, Giorgio Mori
Vibrational Spectroscopy, 2011
Osteoclastogenesis and arthritis
Nicola Maruotti, Maria Grano, Silvia Colucci, Francesca d’Onofrio, Francesco Paolo Cantatore
Clinical and Experimental Medicine, 2011
Regulated production of the pituitary hormone oxytocin from murine and human osteoblasts
Graziana Colaianni, Adriana Di Benedetto, Ling-Ling Zhu, Roberto Tamma, Jianhua Li, Giovanni Greco, Yuanzhen Peng, Stefania Dell’Endice, Guangyu Zhu, Concetta Cuscito, Maria Grano, Silvia Colucci, Jameel Iqbal, Tony Yuen, Li Sun, Mone Zaidi, Alberta Zallone
Biochemical and Biophysical Research Communications, 2011
TRAIL effect on osteoclast formation in physiological and pathological conditions
Frontiers in Bioscience Elite, 2011
Myeloma cells suppress osteoblasts through sclerostin secretion
S Colucci, G Brunetti, A Oranger, G Mori, F Sardone, G Specchia, E Rinaldi, P Curci, V Liso, G Passeri, A Zallone, R Rizzi, M Grano
Blood Cancer Journal, 2011
Sclerostin is overexpressed by plasma cells from multiple myeloma patients
Giacomina Brunetti, Angela Oranger, Giorgio Mori, Giorgina Specchia, Erminia Rinaldi, Paola Curci, Alberta Zallone, Rita Rizzi, Maria Grano, Silvia Colucci
Annals of the New York Academy of Sciences, 2011
Dental pulp stem cells: Osteogenic differentiation and gene expression
Giorgio Mori, Giacomina Brunetti, Angela Oranger, Claudia Carbone, Andrea Ballini, Lorenzo Lo Muzio, Silvia Colucci, Claudio Mori, Felice Roberto Grassi, Maria Grano
Annals of the New York Academy of Sciences, 2011
Immunoregulation of osteoclast differentiation in multiple myeloma bone disease
Maria Grano, Giacomina Brunetti, Silvia Colucci
Bone Cancer, 2010
Osteogenic properties of human dental pulp stem cells
Journal of Biological Regulators and Homeostatic Agents, 2010
The formation of osteoclasts in multiple myeloma bone disease patients involves the secretion of soluble decoy receptor 3
Giacomina Brunetti, Angela Oranger, Giorgio Mori, Matteo Centonze, Graziana Colaianni, Rita Rizzi, Vincenzo Liso, Alberta Zallone, Maria Grano, Silvia Colucci
Annals of the New York Academy of Sciences, 2010
Immunomodulation of Multiple Myeloma Bone Disease
Maria Grano, Giacomina Brunetti, Silvia Colucci
Clinical Reviews in Bone and Mineral Metabolism, 2009
Microgravity during spaceflight directly affects in vitro osteoclastogenesis and bone resorption
Roberto Tamma, Graziana Colaianni, Claudia Camerino, Adriana Di Benedetto, Giovanni Greco, Maurizio Strippoli, Rosaria Vergari, Antonella Grano, Lucia Mancini, Giorgio Mori, Silvia Colucci, Maria Grano, Alberta Zallone
FASEB Journal, 2009
Oxytocin is an anabolic bone hormone
Roberto Tamma, Graziana Colaianni, Ling-ling Zhu, Adriana DiBenedetto, Giovanni Greco, Gabriella Montemurro, Nicola Patano, Maurizio Strippoli, Rosaria Vergari, Lucia Mancini, Silvia Colucci, Maria Grano, Roberta Faccio, Xuan Liu, Jianhua Li, Sabah Usmani, Marilyn Bachar, Itai Bab, Katsuhiko Nishimori, Larry J. Young, Christoph Buettner, Jameel Iqbal, Li Sun, Mone Zaidi, Alberta Zallone
Proceedings of the National Academy of Sciences of the United States of America, 2009
Chlamydia pneumoniae and atherosclerosis: The role of mast cells
Journal of Biological Regulators and Homeostatic Agents, 2009
Normal and osteoporotic human osteoblast behaviour after 1,25-dihydroxy-vitamin D3 stimulation
N. Maruotti, A. Corrado, M. Grano, S. Colucci, F. P. Cantatore
Rheumatology International, 2009
Osteoclastogenesis in children with 21-hydroxylase deficiency on long-term glucocorticoid therapy: The role of receptor activator of nuclear factor-κB ligand/osteoprotegerin imbalance
Maria Felicia Faienza, Giacomina Brunetti, Silvia Colucci, Laura Piacente, Maria Ciccarelli, Lucia Giordani, Giovanni Carlo Del Vecchio, Massimo D'Amore, Livia Albanese, Luciano Cavallo, Maria Grano
Journal of Clinical Endocrinology and Metabolism, 2009
Soluble decoy receptor 3 modulates the survival and formation of osteoclasts from multiple myeloma bone disease patients
S Colucci, G Brunetti, G Mori, A Oranger, M Centonze, C Mori, F P Cantatore, R Tamma, R Rizzi, V Liso, A Zallone, M Grano
Leukemia, 2009
Osteoblast apoptosis in periodontal disease: Role of TNF-related apoptosis-inducing ligand
G. Mori, G. Brunetti, S. Colucci, A. Oranger, E Ciccolella, F. Sardone, P. Pignataro, C. Mori, V. Karapanou, A. Ballini, F. Mastrangelo, S. Tetè, F. R. Grassi, M. Grano
International Journal of Immunopathology and Pharmacology, 2009
L-carnitine fumarate and isovaleryl-L-carnitine fumarate accelerate the recovery of bone volume/total volume ratio after experimetally induced osteoporosis in pregnant mice
N. Patano, L. Mancini, M. P. Settanni, M. Strippoli, G. Brunetti, G. Greco, R. Tamma, R. Vergari, F. Sardelli, A. Koverech, S. Colucci, A. Zallone, M. Grano
Calcified Tissue International, 2008
Alteration of activity and survival of osteoblasts obtained from human periodontitis patients: Role of TRAIL
Journal of Biological Regulators and Homeostatic Agents, 2007
The death receptor DR5 is involved in TRAIL-mediated human osteoclast apoptosis
Silvia Colucci, Giacomina Brunetti, Francesco Paolo Cantatore, Angela Oranger, Giorgio Mori, Paolo Pignataro, Roberto Tamma, Felice Roberto Grassi, Alberta Zallone, Maria Grano
Apoptosis, 2007
Lymphocytes and synovial fluid fibroblasts support osteoclastogenesis through RANKL, TNFα, and IL-7 in an in vitro model derived from human psoriatic arthritis
S Colucci, G Brunetti, FP Cantatore, A Oranger, G Mori, L Quarta, N Cirulli, L Mancini, A Corrado, FR Grassi, M Grano
Journal of Pathology, 2007
IL-7 modulates osteoclastogenesis in patients affected by solid tumors
ILARIA ROATO, EVA GORASSINI, GIACOMINA BRUNETTI, MARIA GRANO, LIBERO CIUFFREDA, ANTONIO MUSSA, RICCARDO FERRACINI
Annals of the New York Academy of Sciences, 2007
In vitro stem cell cultures from human dental pulp and periodontal ligament: New prospects in dentistry
A. Ballini, G. De Frenza, S. Cantore, F. Papa, M. Grano, F. Mastrangelo, S. Tetè, F.R. Grassi
International Journal of Immunopathology and Pharmacology, 2007
Synovial fluid fibroblasts and lymphocytes support the osteoclastogenesis in human psoriatic arthritis
GIORGIO MORI, FRANCESCO P. CANTATORE, GIACOMINA BRUNETTI, ANGELA ORANGER, GRAZIANA COLAIANNI, LAURA QUARTA, ADDOLORATA CORRADO, SILVIA COLUCCI, MARIA GRANO
Annals of the New York Academy of Sciences, 2007
TRAIL is involved in human osteoclast apoptosis
GIACOMINA BRUNETTI, ANGELA ORANGER, GIORGIO MORI, ROBERTO TAMMA, ADRIANA DI BENEDETTO, PAOLO PIGNATARO, FELICE R. GRASSI, ALBERTA ZALLONE, MARIA GRANO, SILVIA COLUCCI
Annals of the New York Academy of Sciences, 2007
IL-7 up-regulates TNF-α-dependent osteoclastogenesis in patients affected by solid tumor
Ilaria Roato, Giacomina Brunetti, Eva Gorassini, Maria Grano, Silvia Colucci, Lisa Bonello, Lucio Buffoni, Roberto Manfredi, Enrico Ruffini, Davide Ottaviani, Libero Ciuffreda, Antonio Mussa, Riccardo Ferracini
Plos One, 2006
Gorham-stout syndrome: A monocyte-mediated cytokine propelled disease
Silvia Colucci, Giulia Taraboletti, Luca Primo, Andrea Viale, Cristina Roca, Donatella Valdembri, Massimo Geuna, Marco Pagano, Maria Grano, Anthony M Pogrel, Adrian L Harris, Nicholas N Athanasou, Alberto Mantovani, Alberta Zallone, Federico Bussolino
Journal of Bone and Mineral Research, 2006
The role of OPG/TRAIL complex in multiple myeloma
GIACOMINA BRUNETTI, SILVIA COLUCCI, RITA RIZZI, GIORGIO MORI, GRAZIANA COLAIANNI, ANGELA ORANGER, ALBERTA ZALLONE, VINCENZO LISO, MARIA GRANO
Annals of the New York Academy of Sciences, 2006
Neridronate and human osteoblasts in normal, osteoporotic and osteoarthritic subjects
Addolorata Corrado, Francesco Paolo Cantatore, Maria Grano, Silvia Colucci
Clinical Rheumatology, 2005
T cells support osteoclastogenesis in an in vitro model derived from human periodontitis patients
G. Brunetti, S. Colucci, P. Pignataro, M. Coricciati, G. Mori, N. Cirulli, A. Zallone, F.R. Grassi, M. Grano
Journal of Periodontology, 2005
L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitro
S. Colucci, G. Mori, S. Vaira, G. Brunetti, G. Greco, L. Mancini, G. M. Simone, F. Sardelli, A. Koverech, A. Zallone, M. Grano
Calcified Tissue International, 2005
Mechanisms of spontaneous osteoclastogenesis in cancer with bone involvement
Ilaria Roato, Maria Grano, Giacomina Brunetti, Silvia Colucci, Antonio Mussa, Oscar Bertetto, Riccardo Ferracini
FASEB Journal, 2005
Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
Nicola Giuliani, Simona Colla, Francesca Morandi, Mirca Lazzaretti, Roberto Sala, Sabrina Bonomini, Maria Grano, Silvia Colucci, Mirija Svaldi, Vittorio Rizzoli
Blood, 2005
Interleukin-7 production by B lymphocytes affects the T cell-dependent osteoclast formation in an in vitro model derived from human periodontitis patients.
International Journal of Immunopathology and Pharmacology, 2005
Osteocalcin synthesis by human osteoblasts from normal and osteoarthritic bone after vitamin D3 stimulation
Francesco Paolo Cantatore, Addolorata Corrado, Maria Grano, Laura Quarta, Silvia Colucci, Nadia Melillo
Clinical Rheumatology, 2004
T cells support osteoclastogenesis in an in vitro model derived from human multiple myeloma bone disease: The role of the OPG/TRAIL interaction
Silvia Colucci, Giacomina Brunetti, Rita Rizzi, Antonia Zonno, Giorgio Mori, Graziana Colaianni, Davide Del Prete, Roberta Faccio, Arcangelo Liso, Silvana Capalbo, Vincenzo Liso, Alberta Zallone, Maria Grano
Blood, 2004
Proteolytic imbalance is reversed after therapeutic surgery in breast cancer patients
Gianluigi Giannelli, Roberta Erriquez, Emilia Fransvea, Antonella Daniele, Paolo Trerotoli, Francesco Schittulli, Maria Grano, Michele Quaranta, Salvatore Antonaci
International Journal of Cancer, 2004
Dehydroepiandrosterone Stimulates Glucose Uptake in Human and Murine Adipocytes by Inducing GLUT1 and GLUT4 Translocation to the Plasma Membrane
Sebastio Perrini, Annalisa Natalicchio, Luigi Laviola, Gaetana Belsanti, Carmela Montrone, Angelo Cignarelli, Vincenza Minielli, Maria Grano, Giovanni De Pergola, Riccardo Giorgino, Francesco Giorgino
Diabetes, 2004
Human osteoclasts express oxytocin receptor
Silvia Colucci, Graziana Colaianni, Giorgio Mori, Maria Grano, Alberta Zallone
Biochemical and Biophysical Research Communications, 2002
Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts
Roberta Faccio, Maria Grano, Silvia Colucci, Antonello Villa, Gianluigi Giannelli, Vito Quaranta, Alberta Zallone
Journal of Cell Science, 2002
Rat hindlimb unloading by tail suspension reduces osteoblast differentiation, induces IL-6 secretion, and increases bone resorption in ex vivo cultures
M. Grano, G. Mori, V. Minielli, O. Barou, S. Colucci, G Giannelli, C. Alexandre, A.Z. Zallone, L. Vico
Calcified Tissue International, 2002
HGF and M-CSF modulate adhesion of MDA-231 breast cancer cell by increasing osteopontin secretion
Journal of Biological Regulators and Homeostatic Agents, 2002
Breast cancer cell line MDA-231 stimulates osteoclastogenesis and bone resorption in human osteoclasts
Maria Grano, Giorgio Mori, Vincenza Minielli, Francesco P. Cantatore, Silvia Colucci, Alberta Zambonin Zallone
Biochemical and Biophysical Research Communications, 2000
Hydroxyapatite coated with hepatocyte growth factor (HGF) stimulates human osteoblasts in vitro
G. Zambonin, C. Camerino, G. Greco, V. Patella, B. Moretti, M. Grano
Journal of Bone and Joint Surgery Series B, 2000
Expression of estrogen receptor-alpha in cells of the osteoclastic lineage
R. O. C. Oreffo, V. Kusec, A. S. Virdi, A. M. Flanagan, M. Grano, A. Zambonin-Zallone, J. T. Triffitt
Histochemistry and Cell Biology, 1999
Hydroxyapatite coated with insulin-like growth factor 1 (IGF1) stimulates human osteoblast activity in vitro
Giovanni Zambonin, Maria Grano, Giovanni Greco, Richard O C Oreffo, James T Triffit
Acta Orthopaedica Scandinavica, 1999
The Osteoclast Cytoskeleton
Alberta Zambonin Zallone, Maria Grano, Silvia Colucci
Advances in Organ Biology, 1998
Alendronate reduces adhesion of human osteoclast-like cells to bone and bone protein-coated surfaces
S. Colucci, V. Minielli, G. Zambonin, N. Cirulli, G. Mori, M. Serra, V. Patella, A. Zambonin Zallone, M. Grano
Calcified Tissue International, 1998
Activation of α(v)β3 integrin on human osteoclast-like cells stimulates adhesion and migration in response to osteopontin
R. Faccio, M. Grano, S. Colucci, A.Zambonin Zallone, V. Quaranta, A.J. Pelletier
Biochemical and Biophysical Research Communications, 1998
In vitro toxicity of N3-methyl-5'-deoxy-5-fluorouridine, a novel metabolite of doxifluridine: A bioanalytical investigation
Carlo Giorgio Zambonin, Antonella Aresta, Maria Grano
Journal of Pharmaceutical and Biomedical Analysis, 1998
Response of human osteoblasts to polymethylmetacrylate in vitro
G. Zambonin, S. Colucci, F. Cantatore, M. Grano
Calcified Tissue International, 1998
Retinoic acid induces cell proliferation and modulates gelatinases activity in human osteoclast-like cell lines
S. Colucci, M. Grano, G. Mori, K. Scotlandi, M. Mastrogiacomo, C. Mori, A.Zambonin Zallone
Biochemical and Biophysical Research Communications, 1996
Hepatocyte growth factor is a coupling factor for osteoclasts and osteoblasts in vitro
M Grano, F Galimi, G Zambonin, S Colucci, E Cottone, A Z Zallone, P M Comoglio
Proceedings of the National Academy of Sciences of the United States of America, 1996
Human osteoclast-like cells selectively recognize laminin isoforms, an event that induces migration and activates Ca2+ mediated signals
Journal of Cell Science, 1996
Etidronate inhibits osteoclast adhesion to bone surfaces but does not interfere with their specific recognition of single bone proteins
Italian Journal of Mineral and Electrolyte Metabolism, 1995
Biomaterials in orthopaedic surgery: effects of different hydroxyapatites and demineralized bone matrix on proliferation rate and bone matrix synthesis by human osteoblasts
Giovanni Zambonin, Maria Grano
Biomaterials, 1995
Extracellular Ca2+ sensing is modulated by pH in human osteoclast-like cells in vitro
M. Grano, R. Faccio, S. Colucci, R. Paniccia, N. Baldini, A. Z. Zallone, A. Teti
American Journal of Physiology Cell Physiology, 1994
Adhesion properties and integrin expression of cultured human osteoclast-like cells
Maria Grano, Paola Zigrino, Silvia Colucci, Giovanni Zambonin, Livio Trusolino, Massimo Serra, Nicola Baldini, Anna Teti, Pier Carlo Marchisio, Alberta Zambonin Zallone
Experimental Cell Research, 1994
Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells
Journal of Cell Biology, 1994
New model for bone resorption study in vitro: Human osteoclast‐like cells from giant cell tumors of bone
Maria Grano, Silvia Colucci, Michele De Bellis, Paola Zigrino, Luigi Argentino, Giovanni Zambonin, Massimo Serra, Katia Scotlandi, Anna Teti, Alberta Zambonin Prof. Zallone
Journal of Bone and Mineral Research, 1994
Immediate cell signal by bone-related peptides in human osteoclast-like cells
R. Paniccia, S. Colucci, M. Grano, M. Serra, A. Z. Zallone, A. Teti
American Journal of Physiology Cell Physiology, 1993
Human osteoclast-like cells recognize laminin via an RGD independent mechanism.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1993
Binding of osteopontin to the osteoclast integrin αvβ3
A. Miyauchi, J. Alvarez, E. M. Greenfield, A. Teti, M. Grano, S. Colucci, A. Zambonin-Zallone, F. P. Ross, S. L. Teitelbaum, D. Cheresh, K. A. Hruska
Osteoporosis International, 1993
Osteoblastic control of osteoclast bone resorption in a serum-free co-culture system. Lack of effect of parathyroid hormone.
Journal of Endocrinological Investigation, 1992
Protein kinase C affects microfilaments, bone resorption, and [Ca2+](o) sensing in cultured osteoclasts
A. Teti, S. Colucci, M. Grano, L. Argentino, A. Zambonin Zallone
American Journal of Physiology Cell Physiology, 1992
Cells from human bone giant cell tumors show a [Ca2+]o-sensing.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1992
Protein kinase C-dependent phosphorylation regulates osteoclast calcium-sensing.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1992
Integrin expression and adhesion property of osteoclast-like cells from giant cell tumours of bone.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1992
Functional and biochemical characterization of osteoclast-like cells derived from giant cell tumours of bone.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1992
Osteoblast-osteoclast relationships in bone resorption: Osteoblasts enhance osteoclast activity in a serum-free co-culture system
Anna Teti, Maria Grano, Silvia Colucci, Francesco P. Cantatore, Maria C. Loperfido, Alberta Zambonin Zallone
Biochemical and Biophysical Research Communications, 1991
Effects of Calcium-phosphate-based Materials on Proliferation and Alkaline Phosphatase Activity of Newborn Rat Periosteal Cells in vitro
A. Teti, A. Tarquilio, M. Grano, S. Colucci, A. Laforgia, F. Mangini, A. Zambonin Zallone
Journal of Dental Research, 1991
Recognition of osteopontin and related peptides by an αvβ3 integrin stimulates immediate cell signals in osteoclasts
A. Miyauchi, J. Alvarez, E.M. Greenfield, A. Teti, M. Grano, S. Colucci, A. Zambonin-Zallone, F.P. Ross, S.L. Teitelbaum, D. Cheresh
Journal of Biological Chemistry, 1991
Osteoblast-osteoclast interaction in bone resorption. Preliminary results.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1990
Osteoclast bone resorption is enhanced in the presence of osteoblasts.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1990
The role of protein kinase C in the osteoclast activity.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1990
Cytosolic free calcium dependent regulation of osteoclast bone resorbing activity.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1990
Voltage dependent calcium channel expression in isolated osteoclasts.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1989
Immunolocalization of beta 3 subunit of integrins in osteoclast membrane.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1989
Podosome expression in osteoclasts: influence of high extracellular calcium concentration.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1989
Intracellular acidification induces decrease of cytosolic calcium in isolated osteoclasts.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1989
Regulation of podosomes by intracellular pH in avian osteoclasts.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1989
Cytoplasmic pH is regulated in isolated avian osteoclasts by a Cl-/HCO3- exchanger.
Bollettino Della Societa Italiana Di Biologia Sperimentale, 1989
Immunocytochemical distribution of extracellular matrix receptors in human osteoclasts: A β3 integrin is colocalized with vinculin and talin in the podosomes of osteoclastoma giant cells
Alberta Zambonin-Zallone, Anna Teti, M. Grano, Alessandro Rubinacci, Marzia Abbadini, Mirella Gaboli, Pier Carlo Marchisio
Experimental Cell Research, 1989
Extracellular protons acidify osteoclasts, reduce cytosolic calcium, and promote expression of cell-matrix attachment structures
A Teti, H C Blair, P Schlesinger, M Grano, A Zambonin-Zallone, A J Kahn, S L Teitelbaum, K A Hruska
Journal of Clinical Investigation, 1989

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