Mariana abrahao Bueno Morais

@cnpem.br

Researcher at Brazilian Biorenewables National Laboratory
Brazilian Center for Research in energy and Materials

https://researchid.co/marianaabm

RESEARCH, TEACHING, or OTHER INTERESTS

Structural Biology, Physical and Theoretical Chemistry, Biotechnology

509

Scholar Citations

Scholar h-index

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

A metagenomic ‘dark matter’enzyme catalyses oxidative cellulose conversion
CA Santos, MAB Morais, F Mandelli, EA Lima, RY Miyamoto, PMR Higasi, ...
Nature, 1-8 2025

Coordinated conformational changes in P450 decarboxylases enable hydrocarbons production from renewable feedstocks
WC Generoso, AHS Alvarenga, IT Simes, RY Miyamoto, RR Melo, ...
Nature Communications 16 (1), 945 2025

A functionally augmented carbohydrate utilization locus from herbivore gut microbiota fueled by dietary β-glucans
F Mandelli, MP Martins, M Chinaglia, EA Lima, MAB Morais, TB Lima, ...
npj Biofilms and Microbiomes 10 (1), 105 2024

Glycosidase mechanisms: Sugar conformations and reactivity in endo-and exo-acting enzymes
MAB Morais, A Nin-Hill, C Rovira
Current Opinion in Chemical Biology 74, 102282 2023

Molecular plasticity of CBM3 ancillary domain leads to conformational changes in the cellulose binding interface
MAB Morais, JH Paiva, MT Murakami
Biochemical and Biophysical Research Communications 645, 71-78 2023

Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum
RL Cordeiro, CR Santos, MN Domingues, TB Lima, RAS Pirolla, ...
Nature Chemical Biology 19 (2), 218-229 2023

State-of-the-art experimental and computational approaches to investigate structure, substrate recognition, and catalytic mechanism of enzymes
CR Santos, CA dos Santos, EA de Araujo, MAB Morais, ...
Polysaccharide Degrading Biocatalysts, 75-107 2023

Glycoside hydrolase subfamily GH5_57 features a highly redesigned catalytic interface to process complex hetero-β-mannans
MP Martins, MAB Morais, GF Persinoti, RH Galinari, L Yu, Y Yoshimi, ...
Acta Crystallographica Section D: Structural Biology 78 (11) 2022

Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides
L Cabral, GF Persinoti, DAA Paixo, MP Martins, MAB Morais, ...
Nature Communications 13 (1), 629 2022

Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides. Nat Commun 13: 629
L Cabral, GF Persinoti, DAA Paixo, MP Martins, MAB Morais, ...
2022

Xyloglucan processing machinery in Xanthomonas pathogens and its role in the transcriptional activation of virulence factors
PS Vieira, IM Bonfim, EA Araujo, RR Melo, AR Lima, MR Fessel, ...
Nature Communications 12 (1), 4049 2021

Gut microbiome of capybara, the Amazon master of the grasses, harbors unprecedented enzymatic strategies for plant glycans breakdown
L Cabral, GF Persinoti, DAA Paixao, MP Martins, M Chinaglia, ...
2021

Two distinct catalytic pathways for GH43 xylanolytic enzymes unveiled by X-ray and QM/MM simulations
MAB Morais, J Coines, MN Domingues, RAS Pirolla, CCC Tonoli, ...
Nature Communications 12 (1), 1-13 2021

A single P115Q mutation modulates specificity in the Corynebacterium pseudotuberculosis arginine repressor
RB Mariutti, JE Hernndez-Gonzlez, AFZ Nascimento, MAB de Morais, ...
Biochimica et Biophysica Acta (BBA)-General Subjects 1864 (7), 129597 2020

Exploring the Molecular Basis for Substrate Affinity and Structural Stability in Bacterial GH39 β-Xylosidases
MAB Morais, CC Polo, MN Domingues, GF Persinoti, RAS Pirolla, ...
Frontiers in Bioengineering and Biotechnology 8, 419 2020

Spatially remote motifs cooperatively affect substrate preference of a ruminal GH26-type endo-β-1, 4-mannanase
F Mandelli, MAB de Morais, EA de Lima, L Oliveira, GF Persinoti, ...
Journal of Biological Chemistry 295 (15), 5012-5021 2020

A rationally identified marine GH1 β‐glucosidase has distinguishing functional features for simultaneous saccharification and fermentation
AS de Sousa, RR de Melo, RY Miyamoto, MAB Morais, LP Andrade, ...
Biofuels, Bioproducts and Biorefining 2020

Structure‐guided design combined with evolutionary diversity led to the discovery of the xylose‐releasing exo‐xylanase activity in the glycoside hydrolase family 43
LM Zanphorlin, MAB de Morais, JA Diogo, MN Domingues, ...
Biotechnology and bioengineering 116 (4), 734-744 2019

An engineered GH1 β-glucosidase displays enhanced glucose tolerance and increased sugar release from lignocellulosic materials
CA Santos, MAB Morais, OM Terrett, JJ Lyczakowski, LM Zanphorlin, ...
Scientific Reports 9 2019

The mechanism by which a distinguishing arabinofuranosidase can cope with internal di-substitutions in arabinoxylans
CR Dos Santos, PO de Giuseppe, FHM de Souza, LM Zanphorlin, ...
Biotechnology for biofuels 11, 1-19 2018

MOST CITED SCHOLAR PUBLICATIONS

How pH Modulates the Dimer-Decamer Interconversion of 2-Cys Peroxiredoxins from the Prx1 Subfamily
MA Morais, PO Giuseppe, TA Souza, TG Alegria, MA Oliveira, LE Netto, ...
Journal of Biological Chemistry 2090, 8582-8590 2015
Citations: 58

Structural basis of exo-β-mannanase activity in the GH2 family
MN Domingues, FHM Souza, PS Vieira, MAB de Morais, LM Zanphorlin, ...
Journal of Biological Chemistry 293 (35), 13636-13649 2018
Citations: 22

A novel β-glucosidase isolated from the microbial metagenome of Lake Poraqu (Amazon, Brazil)
D Toyama, MAB de Morais, FC Ramos, LM Zanphorlin, CCC Tonoli, ...
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1866 (4), 569-579 2018
Citations: 18

How high pressure pre-treatments affect the function and structure of hen egg-white lysozyme
AAL Tribst, MAB de Morais, CY Tominaga, AFZ Nascimento, ...
Innovative Food Science & Emerging Technologies 47, 195-203 2018
Citations: 17

Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum
RL Cordeiro, CR Santos, MN Domingues, TB Lima, RAS Pirolla, ...
Nature Chemical Biology 19 (2), 218-229 2023
Citations: 16

Glycosidase mechanisms: Sugar conformations and reactivity in endo-and exo-acting enzymes
MAB Morais, A Nin-Hill, C Rovira
Current Opinion in Chemical Biology 74, 102282 2023
Citations: 13

Calcium and magnesium ions modulate the oligomeric state and function of mitochondrial 2-Cys peroxiredoxins in Leishmania parasites
MA Morais, PO Giuseppe, TA Souza, H Castro, RV Honorato, ...
Journal of Biological Chemistry 292, 7023–7039 2017
Citations: 13

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the mitochondrial tryparedoxin peroxidase from Leishmania braziliensis
MAB de Morais, TACB de Souza, MT Murakami
Acta Crystallographica Section F: Structural Biology and Crystallization 2013
Citations: 9