Computer Graphics and Computer-Aided Design, Mechanical Engineering, Bioengineering, Computer Engineering
71
Scopus Publications
868
Scholar Citations
18
Scholar h-index
25
Scholar i10-index
Scopus Publications
Influence of Infill Density on the Degradation and Tribological Performance of FDM-Printed PLA for Biomedical Applications Nebojša Zdravković, Živana Jovanovic Pešić, Dalibor Nikolić, Dragan S. Džunić Lubricants, 2026 This study investigates the influence of physiological body fluids on the mass stability and tribological performance of polylactic acid (PLA) samples produced by Fused Deposition Modeling (FDM) 3D printing. Body fluid exposure was simulated using Dulbecco’s Modified Eagle Medium (DMEM) under controlled conditions. Black PLA filament was printed with three infill densities (15%, 20%, and 90%) and immersed in DMEM for 7 days at 37 ± 1 °C. Mass measurements revealed that lower infill densities resulted in significantly higher mass loss, with the 15% infill samples exhibiting the greatest reduction (5.07%), while the 90% infill samples showed negligible change (0.17%). Tribological testing using a CSM nanotribometer under loads of 5 mN, 500 mN, and 1000 mN demonstrated that infill density critically affects friction and wear behavior. The 90% infill samples exhibited the lowest wear volumes and the most stable tribological response, while the 15% infill samples showed degradation-dominated contact behavior. Although the friction measurements for the 15% infill samples were consistent, their interpretation should be approached with caution due to pronounced surface deterioration and debris-mediated sliding. This behavior is attributed to structural weakening caused by immersion in DMEM, which promoted material degradation and influenced the tribological response. These findings confirm the critical role of structural density in wear resistance. To the best of our knowledge, this is the first study to systematically investigate the combined effect of hydrolytic degradation and tribological behavior of FDM-printed PLA as a function of infill density under simulated physiological conditions. These findings provide a scientific basis for optimizing infill density in the design of PLA-based surgical instrument guides, where both degradation resistance and tribological performance under body fluid exposure are essential. The findings should be interpreted within the limitations of the experimental design.
Machine Learning Model for Prediction of Development of Cancer Stem Cell Subpopulation in Tumurs Subjected to Polystyrene Nanoparticles Amra Ramović Hamzagić, Marina Gazdić Janković, Danijela Cvetković, Dalibor Nikolić, Sandra Nikolić, et al. Toxics, 2024 Cancer stem cells (CSCs) play a key role in tumor progression, as they are often responsible for drug resistance and metastasis. Environmental pollution with polystyrene has a negative impact on human health. We investigated the effect of polystyrene nanoparticles (PSNPs) on cancer cell stemness using flow cytometric analysis of CD24, CD44, ABCG2, ALDH1 and their combinations. This study uses simultaneous in vitro cell lines and an in silico machine learning (ML) model to predict the progression of cancer stem cell (CSC) subpopulations in colon (HCT-116) and breast (MDA-MB-231) cancer cells. Our findings indicate a significant increase in cancer stemness induced by PSNPs. Exposure to polystyrene nanoparticles stimulated the development of less differentiated subpopulations of cells within the tumor, a marker of increased tumor aggressiveness. The experimental results were further used to train an ML model that accurately predicts the development of CSC markers. Machine learning, especially genetic algorithms, may be useful in predicting the development of cancer stem cells over time.
Modeling 5-FU-Induced Chemotherapy Selection of a Drug-Resistant Cancer Stem Cell Subpopulation Amra Ramović Hamzagić, Danijela Cvetković, Marina Gazdić Janković, Nevena Milivojević Dimitrijević, Dalibor Nikolić, et al. Current Oncology, 2024 (1) Background: Cancer stem cells (CSCs) are a subpopulation of cells in a tumor that can self-regenerate and produce different types of cells with the ability to initiate tumor growth and dissemination. Chemotherapy resistance, caused by numerous mechanisms by which tumor tissue manages to overcome the effects of drugs, remains the main problem in cancer treatment. The identification of markers on the cell surface specific to CSCs is important for understanding this phenomenon. (2) Methods: The expression of markers CD24, CD44, ALDH1, and ABCG2 was analyzed on the surface of CSCs in two cancer cell lines, MDA-MB-231 and HCT-116, after treatment with 5-fluorouracil (5-FU) using flow cytometry analysis. A machine learning model (ML)–genetic algorithm (GA) was used for the in silico simulation of drug resistance. (3) Results: As evaluated through the use of flow cytometry, the percentage of CD24-CD44+ MDA-MB-231 and CD44, ALDH1 and ABCG2 HCT-116 in a group treated with 5-FU was significantly increased compared to untreated cells. The CSC population was enriched after treatment with chemotherapy, suggesting that these cells have enhanced drug resistance mechanisms. (4) Conclusions: Each individual GA prediction model achieved high accuracy in estimating the expression rate of CSC markers on cancer cells treated with 5-FU. Artificial intelligence can be used as a powerful tool for predicting drug resistance.
Use Case: Stent Biodegradation Modeling Dalibor D. Nikolić, Nenad Filipović In Silico Clinical Trials for Cardiovascular Disease A Finite Element and Machine Learning Approach, 2024
AI-Driven Optimization of PCL/PEG Electrospun Scaffolds for Enhanced In Vivo Wound Healing Katarina Virijević, Marko N. Živanović, Dalibor Nikolić, Nevena Milivojević, Jelena Pavić, et al. ACS Applied Materials and Interfaces, 2024 Here, an artificial intelligence (AI)-based approach was employed to optimize the production of electrospun scaffolds for in vivo wound healing applications. By combining polycaprolactone (PCL) and poly(ethylene glycol) (PEG) in various concentration ratios, dissolved in chloroform (CHCl3) and dimethylformamide (DMF), 125 different polymer combinations were created. From these polymer combinations, electrospun nanofiber meshes were produced and characterized structurally and mechanically via microscopic techniques, including chemical composition and fiber diameter determination. Subsequently, these data were used to train a neural network, creating an AI model to predict the optimal scaffold production solution. Guided by the predictions and experimental outcomes of the AI model, the most promising scaffold for further in vitro analyses was identified. Moreover, we enriched this selected polymer combination by incorporating antibiotics, aiming to develop electrospun nanofiber scaffolds tailored for in vivo wound healing applications. Our study underscores three noteworthy conclusions: (i) the application of AI is pivotal in the fields of material and biomedical sciences, (ii) our methodology provides an effective blueprint for the initial screening of biomedical materials, and (iii) electrospun PCL/PEG antibiotic-bearing scaffolds exhibit outstanding results in promoting neoangiogenesis and facilitating in vivo wound treatment.
Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—an observational cross-sectional study I. Koncar, D. Nikolic, Z. Milosevic, N. Bogavac-Stanojevic, N. Ilic, et al. Frontiers in Surgery, 2023 ObjectivesThe study aimed to identify differences and compare anatomical and biomechanical features between elective and ruptured abdominal aortic aneurysms (AAAs).MethodsData (clinical, anatomical, and biomechanical) of 98 patients with AAA, 75 (76.53%) asymptomatic (Group aAAA) and 23 (23.46%) ruptured AAA (Group rAAA), were prospectively collected and analyzed. Anatomical, morphological, and biomechanical imaging markers like peak wall stress (PWS) and rupture risk equivalent diameter (RRED), comorbid conditions, and demographics were compared between the groups. Biomechanical features were assessed by analysis of Digital Imaging and Communication in Medicine images by A4clinics (Vascops), and anatomical features were assessed by 3Surgery (Trimensio). Binary and multiple logistic regression analysis were used and adjusted for confounders. Accuracy was assessed using receiving operative characteristic (ROC) curve analysis.ResultsIn a multivariable model, including gender and age as confounder variables, maximal aneurysm diameter [MAD, odds ratio (OR) = 1.063], relative intraluminal thrombus (rILT, OR = 1.039), and total aneurysm volume (TAV, OR = 1.006) continued to be significant predictors of AAA rupture with PWS (OR = 1.010) and RRED (OR = 1.031). Area under the ROC curve values and correct classification (cc) for the same parameters and the model that combines MAD, TAV, and rILT were measured: MAD (0.790, cc = 75%), PWS (0.713, cc = 73%), RRED (0.717, cc = 55%), TAV (0.756, cc = 79%), rILT (0.656, cc = 60%), and MAD + TAV + rILT (0.797, cc = 82%).ConclusionBased on our results, in addition to MAD, other important predictors of rupture that might be used during aneurysm surveillance are TAV and rILT. Biomechanical parameters (PWS, RRED) as valuable predictors should be assessed in prospective clinical trials. Similar studies on AAA smaller than 55 mm in diameter, even difficult to organize, would be of even greater clinical value.
Virtual ankle-brachial index – can the immediate outcome of femorodistal bypass surgery be predicted? Dragan Sekulic, Aleksandar Tomic, Andreja Dimic, Aleksandar Mitrovic, Lazar Davidovic, et al. Vojnosanitetski Pregled, 2023 Background/Aim. The best treatment for the occlusion of the largest artery in the thigh is a femorodistal (FD) bypass. Ankle-brachial index (ABI) and multidetector computed tomographic (MDCT) angiography are the gold standards for diagnosing peripheral arterial occlusive disease. The finite element analysis (FEA) method can help measure the quantity of blood flow and arterial pressure in the arteries in the leg. The aim of this study was to examine the possibility of using the FEA method in predicting the outcome of FD bypass surgery. Methods. The study involved 45 patients indicated for FD arterial reconstruction from December 1, 2021, to March 31, 2023. Each patient underwent pre- and postoperative MDCT angiography of the arteries of the lower extremities, on the basis of which, with the use of FEA, models were made for measuring ABI. All patients had their ABI measured pre-operatively and postoperatively using the Doppler ultrasound and sphygmomanometer. Based on the findings of the preoperative MDCT angiography, postoperative virtual surgical models were created using the FEA method, on which ABI were also measured. The values of ABI were divided into five groups: ABI measured preoperatively (ABI pre-op), ABI measured postoperatively (ABI post-op), ABI measured on FEA models based on the MDCT findings [ABI (sim) pre-op], ABI sim post-op, and ABI measured on virtual surgery model [ABI sim post-op (virtual)]. The ABI of the models were statistically compared with preoperative and postoperative measurements done on patients. Results. The values based on the virtual ABI model did not show significant differences compared to the values obtained on patients and values obtained with the FEA method using MDCT angiography (p < 0.001). A strong statistically significant correlation was shown between the virtual ABI and the values obtained by the other two methods, measured on the postoperative MDCT angiography model and virtual postoperative model (p < 0.001). Conclusion. Virtual simulation based on the MDCT angiography parameters of peripheral blood vessels can be successfully used to predict the immediate outcome of the FD bypass surgery.
Hemodynamics of Femoro-Popliteal 'Bi-Pass' Surgery using FEA Methods Dalibor D. Nikolic, Dragan B. Sekulic, Danko Z. Milasinovic, Dragana S. Paunovic, Igor M. SekuliC, et al. Bibe 2021 21st IEEE International Conference on Bioinformatics and Bioengineering Proceedings, 2021
Prediction of coronary plaque progression using data driven approach Bojana Andjelkovic Cirkovic, Velibor Isailovic, Dalibor Nikolic, Igor Saveljic, Oberdan Parodi, et al. Lecture Notes of the Institute for Computer Sciences Social Informatics and Telecommunications Engineering Lnicst, 2018
Biomechanical model for detection of vertigo disease Nenad Filipovic, Zarko Milosevic, Igor Saveljic, Dalibor Nikolic, Nebojsa Zdravkovic, et al. Proceedings 2016 International Conference on Identification Information and Knowledge in the Internet of Things Iiki 2016, 2016
Finite element coiled cochlea model Velibor Isailovic, Milica Nikolic, Zarko Milosevic, Igor Saveljic, Dalibor Nikolic, et al. Aip Conference Proceedings, 2015
Using of finite element method for modeling of active cochlea Velibor M. Isailovic, Milica M. Nikolic, Dalibor D. Nikolic, Igor B. Saveljic, Nenad D. Filipovic 2015 IEEE 15th International Conference on Bioinformatics and Bioengineering Bibe 2015, 2015
SIFEM project: Finite element modeling of the cochlea Velibor M. Isailovic, Milica Obradovic, Dalibor Nikolic, Igor Saveljic, Nenad D. Filipovic 13th IEEE International Conference on Bioinformatics and Bioengineering IEEE Bibe 2013, 2013
Computer modeling of restenosis and heating stent thermal effects in the coronary artery Journal of the Serbian Society for Computational Mechanics, 2013
Computer modeling of atherosclerosis Nenad Filipovic, Milos Radovic, Velibor Isailovic, Zarko Milosevic, Dalibor Nikolic, et al. Computational Medicine in Data Mining and Modeling, 2013
Software tools for image-based modeling of fluid-solid interaction in coronary arteries fusing ivus and angiography modalities Journal of the Serbian Society for Computational Mechanics, 2012
Plaque formation and stent deployment with heating thermal effects in arteries Journal of the Serbian Society for Computational Mechanics, 2012
The Effect of Dulbecco’s ‘Eagle’Medium on the Mass and Tribological Characteristics of PLA Samples: A Preliminary Study D Nikolic, M Jovanović, D Šeklić, M Pešić, D Dzunic Book of Proceedings International Conference on Chemo and BioInformatics (3 … , 2025 2025
INFLUENCE OF PRESS-FIT DIMENSIONS ON REPEATED ASSEMBLY OF BALL BEARINGS INTO 3D PRINTED HOUSINGS S Milenković, Ž Jovanović, N Petrović, D Nikolic, N Kostic Faculty of Engineering University of Kragujevac , 2025 2025
AI-driven optimization of PCL/PEG electrospun scaffolds for enhanced in vivo wound healing K Virijević, MN Zivanovic, D Nikolic, N Milivojevic, J Pavic, I Moric, ... ACS Applied Materials & Interfaces 16 (18), 22989-23002 , 2024 2024 Citations: 37
Advancements in Intraocular Lenses Design and Manufecturing: Evaluating Optical Clarity and Performance Standards A Mirić, N Milivojević, S Milenković, D Nikolic, V Slavkovic, N Grujovic, ... Institute of Technical Sciences of SASA, Kneza Mihaila 35/IV, 11000 Belgrade … , 2024 2024
Abdominal aortic aneurysm volume and relative intraluminal thrombus volume might be auxiliary predictors of rupture—An observational cross-sectional study I Koncar, D Nikolic, Z Milosevic, N Bogavac-Stanojevic, N Ilic, M Dragas, ... Frontiers in Surgery 10, 1095224 , 2023 2023 Citations: 6
Sistem za hologramsku prezentaciju trodimenzionalnih virtuelnih modela-Holoboks D Nikolic, I Saveljic Matični naučni odbor za elektroniku, telekomunikacije i informacione tehnologije , 2023 2023
Electrospun Poly (Lactic Acid)-Chitosan Nanofibers for Wound Healing Application K Virijevic, B Markovic, J Grujic, M Jovanovic, N Kastratovic, M Živanovic, ... Presented at the 3rd International Electronic Conference on Applied Sciences … , 2022 2022
Simulation of stent mechanical testing D Nikolic, N Filipovic Cardiovascular and Respiratory Bioengineering, 41-65 , 2022 2022 Citations: 4
Controlled drug release from a 3D printed tablet A Mirić, J Pavić, L Benolic, D Nikolic, N Milivojevic, M Zivanovic, ... 1st Serbian International Conference on Applied Artificial Intelligence … , 2022 2022 Citations: 1
Numerical Analysis of the Impact of Vibration on the Lumbar Spine of the Driver I Saveljic, S D Macuzic Saveljic, D Nikolic 2022
InSilc Computational Tool for In Silico Optimization of Drug‐Eluting Bioresorbable Vascular Scaffolds M Milosevic, M Anic, D Nikolic, B Milicevic, M Kojic, N Filipovic Computational and Mathematical Methods in Medicine 2022 (1), 5311208 , 2022 2022 Citations: 8
Application of AR Technology in Bioengineering DD Nikolic, ND Filipovic Computational Modeling and Simulation Examples in Bioengineering, 219-257 , 2021 2021
Numerical simulation of fractional flow reserve in atherosclerotic coronary arteries I Saveljic, T Djukic, D Nikolic, S Djorovic, N Filipovic 2021 IEEE 21st International Conference on Bioinformatics and Bioengineering … , 2021 2021 Citations: 2
Application of in silico Platform for the Development and Optimization of Fully Bioresorbable Vascular Scaffold Designs M Milosevic, M Anic, D Nikolic, V Geroski, B Milicevic, M Kojic, N Filipovic Frontiers in Medical Technology 3, 724062 , 2021 2021 Citations: 9
Virtual ABI: A computationally derived ABI index for noninvasive assessment of femoro-popliteal bypass surgery outcome DZ Milasinovic, DB Sekulic, DD Nikolic, AM Vukicevic, AP Tomic, ... Computer Methods and Programs in Biomedicine 208, 106242 , 2021 2021 Citations: 9
In vitro and in silico testing of partially and fully bioresorbable vascular scaffold N Filipovic, D Nikolic, V Isailovic, M Milosevic, V Geroski, G Karanasiou, ... Journal of Biomechanics 115, 110158 , 2021 2021 Citations: 22
SISTEM ZA KONTROLISANU BALON DILATACIJU U MEDICINI P Arsenijevic, D Nikolic Завод за интелектуалну својину, Београд, Кнегиње Љубице 5, Београд, Србија , 2021 2021
Numerical modeling the motion of otoconia particles in the semicircular canal under whole body vibration I Saveljic, S D Macuzic Saveljic, D Nikolic, V Đukic, S Djorovic, J Lukić, ... Serbian Society of Mechanics, 9/1 Kneza Miloša, 11000 Belgrade, Serbia , 2021 2021
EXPERIMENTAL ELECTROCHEMOTHERAPY USING NOVEL DESIGN SINGLE NEEDLE DEVICE A Cvetković, D Cvetkovic, D Milašinović, N Jovicic, N Miailović, D Nikolic, ... 2021
Haemodynamics of femoropopliteal bypass surgery using finite element analysis method D Sekulić, A Tomić, D Milašinović, D Nikolic, D Paunović, U Miladinović, ... Srpsko lekarsko društvo-Okružna podružnica Kragujevac , 2021 2021 Citations: 1
MOST CITED SCHOLAR PUBLICATIONS
ARTreat project: three-dimensional numerical simulation of plaque formation and development in the arteries N Filipovic, M Rosic, I Tanaskovic, Z Milosevic, D Nikolic, N Zdravkovic, ... IEEE Transactions on Information Technology in Biomedicine 16 (2), 272-278 , 2011 2011 Citations: 80
Patient-specific prediction of coronary plaque growth from CTA angiography: a multiscale model for plaque formation and progression O Parodi, TP Exarchos, P Marraccini, F Vozzi, Z Milosevic, D Nikolic, ... Ieee Transactions on Information Technology in Biomedicine 16 (5), 952-965 , 2012 2012 Citations: 65
Occlusal load distribution through the cortical and trabecular bone of the human mid-facial skeleton in natural dentition: a three-dimensional finite element study A Janovic, I Saveljic, A Vukicevic, D Nikolic, Z Rakocevic, G Jovicic, ... Annals of Anatomy-Anatomischer Anzeiger 197, 16-23 , 2015 2015 Citations: 63
Simulation of hydraulic check valve for forestry equipment N Nedić, D Pršić, C Fragassa, V Stojanović, A Pavlovic International journal of heavy vehicle systems 24 (3), 260-276 , 2017 2017 Citations: 49
Does the presence of an unerupted lower third molar influence the risk of mandibular angle and condylar fractures? S Antic, I Saveljic, D Nikolic, G Jovicic, N Filipovic, Z Rakocevic, M Djuric International Journal of Oral and Maxillofacial Surgery 45 (5), 588-592 , 2016 2016 Citations: 38
AI-driven optimization of PCL/PEG electrospun scaffolds for enhanced in vivo wound healing K Virijević, MN Zivanovic, D Nikolic, N Milivojevic, J Pavic, I Moric, ... ACS Applied Materials & Interfaces 16 (18), 22989-23002 , 2024 2024 Citations: 37
Guiding principles for identification, evaluation and conservation of Vitis vinifera L. subsp. sylvestris T Schreiber Vitis , 2017 2017 Citations: 36
Impact of diagnostics state model to the reliability of motor vehicles N Janjić, Z Adamovic, D Nikolic, A Asonja, B Stojanovic 2015 Citations: 34
Primary surgical treatment of war injuries of the foot D Nikolić, Z Jovanović, R Vulović, M Mladenović Injury 31 (3), 193-197 , 2000 2000 Citations: 31
Aquatic macroinvertebrates of the Sava River A Lucić, M Paunović, J Tomović, S Kovačević, K Zorić, V Simić, ... The Sava River, 335-359 , 2014 2014 Citations: 30
Prediction of coronary plaque location on arteries having myocardial bridge, using finite element models D Nikolić, M Radović, S Aleksandrić, M Tomašević, N Filipović Computer methods and programs in biomedicine 117 (2), 137-144 , 2014 2014 Citations: 29
Potential metallurgical treatment of copper concentrates with high arsenic contents I Mihajlovic, N Strbac, D Nikolic, Z Zivkovic Journal of the Southern African Institute of Mining and Metallurgy 111 (6 … , 2011 2011 Citations: 23
In vitro and in silico testing of partially and fully bioresorbable vascular scaffold N Filipovic, D Nikolic, V Isailovic, M Milosevic, V Geroski, G Karanasiou, ... Journal of Biomechanics 115, 110158 , 2021 2021 Citations: 22
Biomechanical modeling of knee for specific patients with chronic anterior cruciate ligament injury N Filipović, V Isailović, D Nikolić, A Peulić, NV Mijailović, S Petrović, ... Computer Science and Information Systems 10 (1), 525-545 , 2013 2013 Citations: 21
Psychometric evaluation and validation of the Serbian version of “Reading the Mind in the Eyes” test J Đorđević, M Živanović, A Pavlović, G Mihajlović, I Stašević-Karličić, ... Psihologija 50 (4), 483-502 , 2017 2017 Citations: 20
Computer simulation of three-dimensional plaque formation and progression in the coronary artery N Filipovic, D Nikolic, I Saveljic, Z Milosevic, T Exarchos, G Pelosi, ... Computers & Fluids 88, 826-833 , 2013 2013 Citations: 20
Mapping cyclic stretch in the postpneumonectomy murine lung N Filipovic, BC Gibney, M Kojic, D Nikolic, V Isailovic, A Ysasi, ... Journal of applied physiology 115 (9), 1370-1378 , 2013 2013 Citations: 18
Prediction of Al2O3 leaching recovery in the Bayer process using statistical multilinear regresion analysis I Đurić, P Đorđević, I Mihajlović, Đ Nikolić, Ž Živković Journal of Mining and Metallurgy, Section B: Metallurgy 46 (2), 161-169 , 2010 2010 Citations: 18
Microstructural properties of the mid-facial bones in relation to the distribution of occlusal loading A Janovic, P Milovanovic, I Saveljic, D Nikolic, M Hahn, Z Rakocevic, ... Bone 68, 108-114 , 2014 2014 Citations: 16
Computer simulation of thromboexclusion of the complete aorta in the treatment of chronic type B aneurysm N Filipovic, D Nikolic, I Saveljic, T Djukic, O Adjic, P Kovacevic, ... Computer Aided Surgery 18 (1-2), 1-9 , 2013 2013 Citations: 15