Anesthetic potential of Cymbopogon citratus essential oil in tambaqui juveniles Colossoma macropomum Jonas da Silva Costa, Lenise Vargas Flores da Silva, Hugo Napoleão Pereira da Silva, Luciano Jensen Vaz, Michelle Midori Sena Fugimura, Laura Giovanna Carvalho, Rosineia de Oliveira Silva, João Paulo Viana Figueira, Paula Raniele Freitas Tavares, Rosa Helena Veras Mourão, Matheus Dellaméa Baldissera, Bernardo Baldisserotto, Lilian Dena dos Santos Aquaculture, 2026
Farnesol modulates seric and splenic purinergic signaling during disseminated sporotrichosis by Sporothrix brasiliensis: improvement of immune response Samanta Chagas Corrêa, Isabela Maraschin Vieira, Marcelo Leite da Veiga, Raquel Tusi Tamiosso, Matheus Dellaméa Baldissera Journal of Toxicology and Environmental Health Part A Current Issues, 2026 Sporotrichosis is an implantation mycosis induced by exposure to thermodimorphic fungi of genus Sporothrix, which affects both humans and animals, resulting in severe inflammatory responses. Purinergic signaling has been implicated in pathogenesis of fungal infections, recognized as a critical system for modulating immune responses and triggering effector mechanisms during sporotrichosis. Natural products have emerged as promising modulators of immune responses, particularly through their influence on purinergic signaling. Among these, farnesol, a sesquiterpene alcohol, demonstrated anti-inflammatory effects during sporotrichosis. However, the pathways involved in farnesol anti-inflammatory effects during S. brasiliensis infection remain to be determined. The aim of this study was to determine whether farnesol exerts a protective effect against S. brasiliensis-induced inflammatory damage via modulation of purinergic enzymes and purinergic molecules. Serum and splenic E-nucleoside triphosphate diphosphohydrolase (E-NTPDase) activity for adenosine triphosphate (ATP) was stimulated in infected rats compared to uninfected rats, while E-adenosine deaminase (E-ADA) activity was reduced. Serum and splenic extracellular levels of ATP and adenosine were elevated in infected rats compared to uninfected, as well as serum levels of interleukin 2 (IL-2) and interleukin-6 (IL-6). Farnesol diminished S. brasiliensis-initiated rise in serum and splenic E-NTPDase and elevation in levels of IL-2 and IL-6. In addition, farnesol blocked fungal-mediated fall in serum and splenic E-ADA activities and decreased alterations on extracellular levels of ATP and adenosine. Farnesol exerted protective effects involved stimulation of purinergic signaling enzyme activities and consequently regulation of purine metabolism, associated with elevated cytokine levels, thereby ameliorating immune response during sporotrichosis.
Rutin prevents memory impairment by reducing brain oxidative stress and fungal burden in a rat model of cryptococcosis Camila Eduarda Justen, Alana Bianca de Moraes Chitolina, Isabela Andres Finamor, Maria Amália Pavanato, Marina Machado Maurente, Isabela Maraschin Vieira, Marcelo Leite da Veiga, Eduarda Saab, Raquel Tusi Tamiosso, Matheus Dellaméa Baldissera Journal of Toxicology and Environmental Health Part A Current Issues, 2026 initiated memory loss via stimulation of the antioxidant defense system protecting the brain against free radical-mediated effects and lipid peroxidation, as well as exerting antifungal action. Thus, rutin may be considered as a potential source for cryptococcosis treatment.
Farnesol attenuates inflammation and protects the liver of rats experimentally infected with Sporothrix brasiliensis Helena Martins Ciliatto, Rúbia Schallenberger da Silva, Cinthia Melazzo de Andrade, Isabela Maraschin Vieira, Carlos Eurico Fernandes, Marcelo Leite da Veiga, Camila Eduarda Justen, Isabela Garcia, Samanta Chagas Corrêa, Raquel Tusi Tamiosso, Matheus Dellaméa Baldissera Journal of Toxicology and Environmental Health Part A Current Issues, 2026 Sporotrichosis, a neglected tropical disease, is an emerging implantation mycosis considered a global public health concern attributed to thermodimorphic fungus of the genus Sporothrix. An important step in controlling sporotrichosis is the implementation of suitable treatments. However, resistance to first-line antifungal therapies represents a growing challenge for sporotrichosis management, reinforcing the need for alternative and effective treatments, such as farnesol. Farnesol is a sesquiterpene alcohol considered a potential compound due to its antifungal activity in vitro and anti-inflammatory and hepatoprotective effects noted in vivo. However, farnesol in-vivo antifungal activity against S. brasiliensis remains to be determined. The aim of this study was to determine whether farnesol exerts antifungal action in rats inoculated with S. brasiliensis, and whether this compound provides protection to hepatic. Farnesol (100 mg/kg daily for 21 days) did not significantly reduce hepatic and renal fungal burden compared to infected rats and those treated with corn oil. Farnesol treatment diminished elevation of total leukocytes, lymphocytes, and eosinophil counts compared to infected and corn oil-treated rats. In infected rats, farnesol reduced increase in activities of aspartate aminotransferase, alanine aminotransferase and levels of creatinine, and urea. Further, farnesol also restored hematological indices related to white blood parameters. Farnesol also improved biomarkers of hepatic and renal functions. Therapeutic use of farnesol may be considered an interesting approach to improve hematological and hepatic consequences during disseminated sporotrichosis.
Role of Microencapsulated Essential Oil and Pepper Resin in the Diet of Cows in the Third Lactation Phase on Immunological Pathways Karoline Wagner Leal, Marta Lizandra do Rego Leal, Gabriel S. Klein, Andrei Lucas R. Brunetto, Guilherme Luiz Deolindo, Camila Eduarda Justen, Matheus Dellaméa Baldissera, Tainara L. Santos, Daniela Zanini, Rafael C. de Araujo, Aleksandro Schafer da Silva Veterinary Sciences, 2025 The objective was to determine whether dairy cows may activate traditional and alternative inflammatory pathways by consuming a combination of a phytogenic diet (essential oil and pepper resin). Twenty pregnant Jersey cows in the final (third) lactation phase (260 days in milk) were divided into two groups: control, with no additive consumption, and test, with the addition of the phytogenic to the concentrate portion of the diet (150 mg/day/kg dry matter). Blood samples were collected on experimental days 1, 7, 14, 21, 28, 35, and 42 by coccygeal vein puncture to assess the complete blood count, serum biochemistry of levels of total protein, albumin, and globulin, as well as carbohydrate metabolism (glucose), lipid metabolism (cholesterol and triglycerides), protein metabolism (urea), activities of hepatic enzymes (gamma-glutamyl transferase (GGT) and aspartate aminotransferase (AST)), cytokine levels (interleukins IL-1β, IL-6, and IL-10), antioxidant response [thiobarbituric acid reactive substances (TBARS), reactive oxygen species (ROS), total thiol (PSH), and non-protein thiol (NPSH), and glutathione S(GST)], cholinergic system [total cholinesterase (ChE) and acetylcholinesterase (AChE)], purinergic signaling [NTPDase, 5′ectonucleotidase and adenosine deaminase (ADA)], and energetic metabolism enzymes [creatine kinase (CK), pyruvate kinase (PK), and adenylate kinase (AK)]. Productive performance was assessed through feed intake and milk production. The results revealed that the use of phytogenic compounds significantly influenced the cholinergic system and purinergic signaling associated with immunology. The reduction in cholinesterase (ChE) activity and the increase in acetylcholinesterase (AChE) activity in lymphocytes suggest the modulation of the cholinergic system, enhancing the immune response. Furthermore, the elevated activity of adenosine deaminase (ADA) in lymphocytes and platelets, together with increased ATP and ADP hydrolysis in platelets, indicates the beneficial regulation of purinergic signaling, potentially contributing to inflammatory modulation. These effects were accompanied by a lower production of pro-inflammatory cytokines (IL-1β and IL-6) and a higher production of IL-10, reinforcing an anti-inflammatory profile. The reduced leukocyte and lymphocyte counts may reflect a lower inflammatory demand, while the increased levels of NPSH and GST antioxidants suggest cellular protection. Despite these physiological changes, productive performance and milk quality remained unaffected. In summary and practical terms, including this additive in the cows’ diet benefits the cow’s health in the final third of gestation when the animal already has a reduced immune response due to advanced gestation.
Organic Zinc and Selenium Supplementation of Late Lactation Dairy Cows: Effects on Milk and Serum Minerals Bioavailability, Animal Health and Milk Quality Gabriel S. Klein, Karoline W. Leal, Camila A. Rodrigues, Taynara M. R. Draszevski, Andrei L. R. Brunetto, Maksuel G. Vitt, Mathias S. Klein, Vitoria H. Cauduro, Erico M. M. Flores, Gilnei B. da Silva, Margarete D. Bagatini, Alana B. de M. Chitolina, Matheus D. Baldissera, Aleksandro S. Da Silva Animals, 2025 This study determined whether organic zinc and selenium supplementation of late lactation dairy cows positively affects immunity, oxidative status, milk quality (especially mineral levels), biochemical and hematologic parameters, and production efficiency. Twenty Jersey cows were divided into three groups: Control (n = 6)—without organic supplementation; Zinc (n = 7)—zinc supplementation (zinc amino acid chelate) and Selenium (n = 7)—selenium supplementation (selenium amino acid complex). The basal diet contained inorganic minerals. Blood and milk samples were collected on days 1, 14 and 28. Serum selenium concentration was higher in the Selenium group, and zinc level in milk was higher in the Zinc group. On day 28, supplementations resulted in higher lymphocyte counts, and lower serum creatine kinase, myeloperoxidase activity, levels of reactive oxygen species, thiobarbituric acid-reactive substances, and iron. In milk, lower somatic cell count was also observed when cows were zinc or selenium supplemented compared to the control. Lower serum cholinesterase activity and higher heavy chain immunoglobulin concentration were observed on days 14 and 28. Selenium supplementation resulted in a higher immunoglobulin A concentration on days 14 and 28, and lower ceruloplasmin concentration on day 28 compared to Control, as well as a lower haptoglobin concentration on day 28. The Selenium group also had lower milk fat content compared to the Control. Supplementations changed the milk fatty acid profile, producing a higher unsaturated fatty acid/saturated fatty acid ratio. There was no effect on lactation persistence. It is concluded that mineral supplementation with selenium and zinc benefits immune, antioxidant, and anti-inflammatory responses. Conversely, milk quality was affected both positively and negatively.
β-Cyclodextrins alter the energy metabolism-related enzyme activities in rats FRANCINE R. IANISKI, AMANDA L. DE OLIVEIRA, NATHANA JAMILLE MEZZOMO, ITIANE D. DE FRANCESCHI, GUILHERME M. DO CARMO, CAMILA R. CREMONESE, MATHEUS D. BALDISSERA, JENIFER P. ZANON, JENIFER KOLLING, JORDANA DANIELA FRIEDERICH, IVANA Z. SILVA, JANICE L. GIONGO, LUCIANE R. FEKSA, RODRIGO A. VAUCHER, CLOVIS MILTON D. WANNMACHER, VIRGINIA C. RECH Anais Da Academia Brasileira De Ciencias, 2023
In vitro and in vivo trypanocidal activity of a benzofuroxan derivative against Trypanosoma cruzi Letícia dos Santos Petry, João Cândido Pillar Mayer, Marjorie de Giacommeti, Dionatan Teixeira de Oliveira, Litiérria Razia Garzon, Ana Martiele Engelmann, Antônio Francisco Igor Magalhães de Matos, Matheus Dellaméa Baldissera, Luciano Dornelles, Cinthia Melazzo de Andrade, Silvia Gonzalez Monteiro Experimental Parasitology, 2021
Evaluation of the in vivo safety of tucumã oil nanocapsules in an experimental model of silver catfish Rhamdia quelen Kátia Nascimento, Matheus Dellaméa Baldissera, Carine de Freitas Souza, Gerson Fernandes de Brum, Andiara Prates Ramos, Roberta Cougo Riéffel, Lauren Pappis, Walter Paixão de Sousa Filho, André Gundel, Alencar Kolinski Machado, Aline Ferreira Ourique, Bernardo Baldisserotto, José Edson Paz da Silva, Michele Rorato Sagrillo Natural Product Research, 2020
Copper oxide and closantel prevent alterations in hepatic energetic metabolism and reduce inflammation in Haemonchus contortus infection. Andressa Salvadori Schafer, Matheus D. Baldissera, Cássia Bagolin da Silva, Juliana Sorraila de Oliveira, Antônio Francisco Igor Magalhães de Matos, Guilherme Lopes Dornelles, Thirssa Helena Grando, Lucas Trevisan Gressler, Simone Stefanello, Eduarda Santi, Alessandro Pelegrine Minho, Daniele Rodrigues, Carine F. Souza, Marta L. R. Leal, Silvia G. Monteiro, Sonia T.A. Lopes, Cinthia Melazzo de Andrade Experimental Parasitology, 2019
Curcumin in the diet of quail in cold stress improves performance and egg quality Maiara S. Marchiori, Rosilene C. Oliveira, Carine F. Souza, Matheus D. Baldissera, Quellen M. Ribeiro, Roger Wagner, Samanta S. Gündel, Aline F. Ourique, Jackeline K. Kirinus, Lenita M. Stefani, Marcel M. Boiago, Aleksandro S. da Silva Animal Feed Science and Technology, 2019
Glucose and urea levels in suckling piglets Vanessa Dazuk, Roger Rocha Gebert, João Henrique dos Reis, Matheus D. Baldissera, Diovani Paiano, Aleksandro Schafer da Silva Comparative Clinical Pathology, 2019
Oregano essential oil (Origanum vulgare) to feed laying hens and its effects on animal health MARCOS J. MIGLIORINI, MARCEL M. BOIAGO, LENILSON F. ROZA, MAURICIO BARRETA, ALESSANDRA ARNO, WEBER S. ROBAZZA, ALESSANDRO C. GALVÃO, GABRIELA M. GALLI, GUSTAVO MACHADO, MATHEUS D. BALDISSERA, ROGER WAGNER, LENITA C.M. STEFANI, ALEKSANDRO S. DA SILVA Anais Da Academia Brasileira De Ciencias, 2019
Health benefits of subcutaneous zinc edetate and diphenyl diselenide in calves during the weaning period DAIANE S. DOS SANTOS, JHONATAN P. BOITO, VANDERLEI KLAUCK, JOÃO H. DOS REIS, ROGER R. GEBERT, PATRÍCIA GLOMBOWSKY, ANGELISA H. BIAZUS, NATHIELI B. BOTTARI, REJANE S. SOUSA, GUSTAVO MACHADO, MARTA L.R. LEAL, MATHEUS D. BALDISSERA, JEAN C. BERWANGER, ALEKSANDRO S. DA SILVA Anais Da Academia Brasileira De Ciencias, 2019
Insecticidal and repellent effect of cinnamon oil on flies associated with livestock Jhonatan P. Boito, Aleksandro S. Da Silva, João H. dos Reis, Daiane S. Santos, Roger R. Gebert, Angelisa H. Biazus, Roberto C.V. Santos, Priscilla M. Quatrin, Aline F. Ourique, Aline A. Boligon, Dilmar Baretta, Matheus D. Baldissera, Lenita M. Stefani, Gustavo Machado Revista Mvz Cordoba, 2018
Injectable diphenyl diselenide supplementation in dairy sheep Angeliza H Biazus, Chrystian J Cazarotto, Roger R Gebert, João H. Dos Reis, Talyta Zortea, Dilmar Baretta, Gustavo Machado, Jhonatan P. Boito, Matheus D. Baldissera, Aleksandro S Da Silva Revista Mvz Cordoba, 2018
Oxidative stress in dairy cows seropositives for Neospora caninum Patrícia Glombowsky, Nathieli B. Bottari, Vanderlei Klauck, Juscivete F. Fávero, Natan M. Soldá, Matheus D. Baldissera, Gessica Perin, Vera M. Morsch, Maria Rosa C. Schetinger, Lenita M. Stefani, Aleksandro S. Da Silva Comparative Immunology Microbiology and Infectious Diseases, 2017
Avian antibodies (IgY) against Trypanosoma cruzi: Purification and characterization studies Thirssa H. Grando, Matheus D. Baldissera, Mariângela F. de Sá, Guilherme M. do Carmo, Bianca Carolina Z. Porto, Gisele S.V. Aguirre, Maria Isabel Azevedo, Francielli P.K. de Jesus, Janio M. Santurio, Michele R. Sagrillo, Lenita Moura Stefani, Silvia Gonzalez Monteiro Journal of Immunological Methods, 2017
Nanostructured cinnamon oil has the potential to control Rhipicephalus microplus ticks on cattle Daiane S. dos Santos, Jhonatan P. Boito, Roberto C. V. Santos, Priscilla M. Quatrin, Aline Ferreira Ourique, João H. dos Reis, Roger R. Gebert, Patrícia Glombowsky, Vanderlei Klauck, Aline A. Boligon, Matheus D. Baldissera, Aleksandro S. Da Silva Experimental and Applied Acarology, 2017
Oxidative stress in rats experimentally infected by Sporothrix schenckii Verônica S.P. Castro, Aleksandro S. Da Silva, Gustavo R. Thomé, Patrícia Wolkmer, Jorge L.C. Castro, Márcio M. Costa, Dominguita L. Graça, Daniele C. Oliveira, Sydney H. Alves, Maria R.C. Schetinger, Sonia T.A. Lopes, Lenita M. Stefani, Maria I. Azevedo, Matheus D. Baldissera, Cinthia M. Andrade Microbial Pathogenesis, 2017
Fowl typhoid in laying hens cause hepatic oxidative stress Angelisa H. Biazus, Aleksandro S. Da Silva, Nathieli B. Bottari, Matheus D. Baldissera, Guilherme M. do Carmo, Vera M. Morsch, Maria Rosa C. Schetinger, Renata Casagrande, Naiara S. Guarda, Rafael N. Moresco, Lenita M. Stefani, Gabriela Campigotto, Marcel M. Boiago Microbial Pathogenesis, 2017
Cytotoxic and genotoxic effects of the trypanocidal drug diminazene aceturate Matheus D. Baldissera, Michele R. Sagrillo, Thirssa H. Grando, Luciana Dalla Rosa, Mariângela F. de Sá, Sônia C. A. da Luz, Sergio O. Silveira, Kátia Nascimento, Diulle S. Peres, Priscila M. Copetti, Aleksandro S. da Silva, Lenita M. Stefani, Silvia G. Monteiro Comparative Clinical Pathology, 2017
Oxidative stress in the heart of rats infected with Trypanosoma Evansi Matheus D. Baldissera, Carine de F. Souza, Cláudia M. Bertoncheli, Karine L. da Silveira, Thirssa H. Grando, Bianca C. Z. Porto, Daniela B. R. Leal, Aleksandro S. Da Silva, Ricardo E. Mendes, Lenita M. Stefani, Silvia G. Monteiro Korean Journal of Parasitology, 2016
Hepatic and seric levels of purines in rats experimentally infected by Fasciola hepatica Matheus D. Baldissera, Ricardo E. Mendes, Pedro H. Doleski, Nathieli B. Bottari, Emerson A. Casali, Cesar Eduardo Jacintho Moritz, Valesca V. Cardoso, Luan C. Henker, Ricardo Christ, Fernanda A. Stedille, Lenita M. Stefani, Aleksandro S. Da Silva Parasitology Research, 2016
Effects of treatment with the anti-parasitic drug diminazene aceturate on antioxidant enzymes in rat liver and kidney Matheus D. Baldissera, Ricardo A. Gonçalves, Michele R. Sagrillo, Thirssa H. Grando, Camila S. Ritter, Fabielly S. Grotto, Gerson F. Brum, Sônia C. A. da Luz, Sergio O. Silveira, Viviane P. Fausto, Aline A. Boligon, Rodrigo A. Vaucher, Lenita M. Stefani, Aleksandro S. da Silva, Carine F. Souza, Silvia G. Monteiro Naunyn Schmiedeberg S Archives of Pharmacology, 2016
Trypanocidal activity of free and nanoencapsulated curcumin on Trypanosoma evansi L. T. GRESSLER, C. B. OLIVEIRA, K. CORADINI, L. DALLA ROSA, T. H. GRANDO, M. D. BALDISSERA, C. E. ZIMMERMANN, A. S. DA SILVA, T. C. ALMEIDA, C. L. HERMES, P. WOLKMER, C. B. SILVA, K. L. S. MOREIRA, R. C. R. BECK, R. N. MORESCO, M. L. DA VEIGA, L. M. STEFANI, S. G. MONTEIRO Parasitology, 2015
In vitro cytotoxicity and genotoxicity of chicken egg yolk antibodies (IGY) against Trypanosoma evansi in human lymphocytes International Journal of Pharmacy and Pharmaceutical Sciences, 2014
Using of essential oils in the treatment of mice infected with Trypanosoma evansi Revista Mvz Cordoba, 2014
