Matheus Severino

@unicamp.br

Laboratório Muldisciplinar em Alimentos e Saúde / Faculdade de Ciências Aplicadas-Unicamp

Matheus Severino


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https://researchid.co/matheussev

EDUCATION

Ensino fundamental completo: Colégio Jesus Adolescente Anglo - Catanduva
Ensino médio completo: Colégio Jesus Adolescente Anglo - Catanduva
Graduação bacharel em nutrição completo: Faculdade de Ciências Aplicadas - UNICAMP.
Graduação bacharel em farmácia em andamento: Universidade Paulista.
Mestrado em Ciêcias do Esporte Nutrição e Metabolismo em andamento: Faculdade de Ciências Aplicadas - UNICAMP.

RESEARCH INTERESTS

Atualmente, venho tentando compreender através da pesquisa meanismos de progressão tumoral, voltado ao metabolismo tumoral com foco na via de mTOR, S6Ks e microambiente tumoral, utilizando a ferramenta de edicação CRISPR-CAS9 em modelos de cultura in vitro de células de câncer de pulmão humano A549.
364

Scholar Citations

8

Scholar h-index

7

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • S6K1 and S6K2 regulate homologous recombination DNA repair through control of BRCA1 protein stability
    MM Gois, L Bonafe, LGS Silva, MCS Mancini, RA Kampen, IB Pavan, ...
    bioRxiv, 2026.04. 28.721439 , 2026
    2026.0
  • Parkin alters myogenic markers during C2C12 differentiation changes ubiquitination patterns of myosins in skeletal muscle in mice
    IA Divino, AL da Silva, M Barbosa-Rosario, MB Severino, MV Esteca, ...
    ACTA PHYSIOLOGICA 241 , 2025
    2025.0
  • A CRISPR-edited isoform of the AMPK kinase LKB1 improves the response to cisplatin in A549 lung cancer cells
    MB Severino, AP Morelli, ICB Pavan, MCS Mancini, MM Góis, RJ Borges, ...
    Journal of Biological Chemistry 301 (3) , 2025
    2025.0
    Citations: 3
  • Partial Proliferating Cell Nuclear Antigen Functional Knockout Impairs Cisplatin Resistance and Clonogenic Potential in Lung Adenocarcinoma Cells
    AP Morelli, N Quintero-Ruiz, MCS Mancini, ICB Pavan, IL Flores, ...
    DNA 5 (1), 7 , 2025
    2025.0
  • Macrophage immunometabolic reprogramming impairs tissue regeneration in type 2 diabetes zebrafish model
    LW Junior, JD de Lima, A Guilherme Portela de Paula, TSB Bastos, ...
    Frontiers in Immunology 16, 1698674 , 2025
    2025.0
    Citations: 1
  • Parkin is a critical player in the effects of caffeine over mitochondrial quality control pathways during skeletal muscle regeneration in mice
    MV Esteca, IA Divino, AL Vieira da Silva, MB Severino, RR Braga, ...
    Acta Physiologica 240 (3), e14111 , 2024
    2024.0
    Citations: 6
  • Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4 +/− mice
    VR Muñoz, JD Botezelli, RC Gaspar, AL da Rocha, RFL Vieira, BM Crisol, ...
    Cellular and molecular life sciences 80 (5), 122 , 2023
    2023.0
    Citations: 9
  • NEK6 regulates redox balance and DNA damage response in DU-145 prostate cancer cells
    ICB Pavan, FL Basei, MB Severino, I Rosa e Silva, LK Issayama, ...
    Cells 12 (2), 256 , 2023
    2023.0
    Citations: 16
  • A edição do gene STK11 (LKB1) por CRISPR/Cas9 em células não pequenas de câncer de pulmão A549 e a resposta a metformina e cisplatina
    MB Severino
    [sn] , 2023
    2023.0
  • NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells. Cells 2023, 12, 256
    ICB Pavan, FL Basei, MB Severino, I Rosa e Silva, LK Issayama, ...
    2023.0
  • Knockout of NRF2 triggers prostate cancer cells death through ROS modulation and sensitizes to cisplatin
    MCS Mancini, AP Morelli, MB Severino, ICB Pavan, ÉP Zambalde, ...
    Journal of cellular biochemistry 123 (12), 2079-2092 , 2022
    2022.0
    Citations: 22
  • Characterization of the interaction between SARS-CoV-2 membrane protein (M) and proliferating cell nuclear antigen (PCNA) as a potential therapeutic target
    ÉP Zambalde, ICB Pavan, MCS Mancini, MB Severino, OB Scudero, ...
    Frontiers in cellular and infection microbiology 12, 849017 , 2022
    2022.0
    Citations: 15
  • STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma
    AP Morelli, TC Tortelli Jr, MCS Mancini, ICB Pavan, LGS Silva, ...
    Neoplasia 23 (10), 1048-1058 , 2021
    2021.0
    Citations: 33
  • Exercise counterbalances Rho/ROCK2 signaling impairment in the skeletal muscle and ameliorates insulin sensitivity in obese mice
    VR Muñoz, RC Gaspar, MB Severino, APA Macêdo, FM Simabuco, ...
    Frontiers in Immunology 12, 702025 , 2021
    2021.0
    Citations: 25
  • The hallmarks of flavonoids in cancer
    LGS Ponte, ICB Pavan, MCS Mancini, LGS da Silva, AP Morelli, ...
    Molecules 26 (7), 2029 , 2021
    2021.0
    Citations: 197
  • Loss of Parkin results in altered muscle stem cell differentiation during regeneration
    MV Esteca, MB Severino, JG Silvestre, G Palmeira dos Santos, ...
    International journal of molecular sciences 21 (21), 8007 , 2020
    2020.0
    Citations: 32
  • Effects of CPX on transfection efficiency and over differentiation in C2C12
    MB Severino, IL Baptista, MV Esteca, L Tamborlin, AD Luchessi
    Revista dos Trabalhos de Iniciação Científica da UNICAMP , 2009
    2009.0
  • Efeito da suplementação de leucina sobre a mitofagia durante a diferenciação de mioblastos
    M Chayamiti, I Baptista, M Severino, A Luchessi
    Revista dos Trabalhos de Iniciação Científica da UNICAMP, 1-1 , 2006
    2006.0
  • FM Simabuco The hallmarks of flavonoids in cancer., 2021, 26, 2029
    LGS Ponte, ICB Pavan, MCS Mancini, LGS Da Silva, AP Morelli, ...
    DOI: https://doi. org/10.3390/molecules26072029 , 0
    Citations: 5
  • Orientador Dr. Fernando Moreira Simabuco
    MB SEVERINO, AE DO GENE, POR CRISPR

MOST CITED SCHOLAR PUBLICATIONS

  • The hallmarks of flavonoids in cancer
    LGS Ponte, ICB Pavan, MCS Mancini, LGS da Silva, AP Morelli, ...
    Molecules 26 (7), 2029 , 2021
    2021.0
    Citations: 197
  • STAT3 contributes to cisplatin resistance, modulating EMT markers, and the mTOR signaling in lung adenocarcinoma
    AP Morelli, TC Tortelli Jr, MCS Mancini, ICB Pavan, LGS Silva, ...
    Neoplasia 23 (10), 1048-1058 , 2021
    2021.0
    Citations: 33
  • Loss of Parkin results in altered muscle stem cell differentiation during regeneration
    MV Esteca, MB Severino, JG Silvestre, G Palmeira dos Santos, ...
    International journal of molecular sciences 21 (21), 8007 , 2020
    2020.0
    Citations: 32
  • Exercise counterbalances Rho/ROCK2 signaling impairment in the skeletal muscle and ameliorates insulin sensitivity in obese mice
    VR Muñoz, RC Gaspar, MB Severino, APA Macêdo, FM Simabuco, ...
    Frontiers in Immunology 12, 702025 , 2021
    2021.0
    Citations: 25
  • Knockout of NRF2 triggers prostate cancer cells death through ROS modulation and sensitizes to cisplatin
    MCS Mancini, AP Morelli, MB Severino, ICB Pavan, ÉP Zambalde, ...
    Journal of cellular biochemistry 123 (12), 2079-2092 , 2022
    2022.0
    Citations: 22
  • NEK6 regulates redox balance and DNA damage response in DU-145 prostate cancer cells
    ICB Pavan, FL Basei, MB Severino, I Rosa e Silva, LK Issayama, ...
    Cells 12 (2), 256 , 2023
    2023.0
    Citations: 16
  • Characterization of the interaction between SARS-CoV-2 membrane protein (M) and proliferating cell nuclear antigen (PCNA) as a potential therapeutic target
    ÉP Zambalde, ICB Pavan, MCS Mancini, MB Severino, OB Scudero, ...
    Frontiers in cellular and infection microbiology 12, 849017 , 2022
    2022.0
    Citations: 15
  • Effects of short-term endurance and strength exercise in the molecular regulation of skeletal muscle in hyperinsulinemic and hyperglycemic Slc2a4 +/− mice
    VR Muñoz, JD Botezelli, RC Gaspar, AL da Rocha, RFL Vieira, BM Crisol, ...
    Cellular and molecular life sciences 80 (5), 122 , 2023
    2023.0
    Citations: 9
  • Parkin is a critical player in the effects of caffeine over mitochondrial quality control pathways during skeletal muscle regeneration in mice
    MV Esteca, IA Divino, AL Vieira da Silva, MB Severino, RR Braga, ...
    Acta Physiologica 240 (3), e14111 , 2024
    2024.0
    Citations: 6
  • FM Simabuco The hallmarks of flavonoids in cancer., 2021, 26, 2029
    LGS Ponte, ICB Pavan, MCS Mancini, LGS Da Silva, AP Morelli, ...
    DOI: https://doi. org/10.3390/molecules26072029 , 0
    Citations: 5
  • A CRISPR-edited isoform of the AMPK kinase LKB1 improves the response to cisplatin in A549 lung cancer cells
    MB Severino, AP Morelli, ICB Pavan, MCS Mancini, MM Góis, RJ Borges, ...
    Journal of Biological Chemistry 301 (3) , 2025
    2025.0
    Citations: 3
  • Macrophage immunometabolic reprogramming impairs tissue regeneration in type 2 diabetes zebrafish model
    LW Junior, JD de Lima, A Guilherme Portela de Paula, TSB Bastos, ...
    Frontiers in Immunology 16, 1698674 , 2025
    2025.0
    Citations: 1
  • S6K1 and S6K2 regulate homologous recombination DNA repair through control of BRCA1 protein stability
    MM Gois, L Bonafe, LGS Silva, MCS Mancini, RA Kampen, IB Pavan, ...
    bioRxiv, 2026.04. 28.721439 , 2026
    2026.0
  • Parkin alters myogenic markers during C2C12 differentiation changes ubiquitination patterns of myosins in skeletal muscle in mice
    IA Divino, AL da Silva, M Barbosa-Rosario, MB Severino, MV Esteca, ...
    ACTA PHYSIOLOGICA 241 , 2025
    2025.0
  • Partial Proliferating Cell Nuclear Antigen Functional Knockout Impairs Cisplatin Resistance and Clonogenic Potential in Lung Adenocarcinoma Cells
    AP Morelli, N Quintero-Ruiz, MCS Mancini, ICB Pavan, IL Flores, ...
    DNA 5 (1), 7 , 2025
    2025.0
  • A edição do gene STK11 (LKB1) por CRISPR/Cas9 em células não pequenas de câncer de pulmão A549 e a resposta a metformina e cisplatina
    MB Severino
    [sn] , 2023
    2023.0
  • NEK6 Regulates Redox Balance and DNA Damage Response in DU-145 Prostate Cancer Cells. Cells 2023, 12, 256
    ICB Pavan, FL Basei, MB Severino, I Rosa e Silva, LK Issayama, ...
    2023.0
  • Effects of CPX on transfection efficiency and over differentiation in C2C12
    MB Severino, IL Baptista, MV Esteca, L Tamborlin, AD Luchessi
    Revista dos Trabalhos de Iniciação Científica da UNICAMP , 2009
    2009.0
  • Efeito da suplementação de leucina sobre a mitofagia durante a diferenciação de mioblastos
    M Chayamiti, I Baptista, M Severino, A Luchessi
    Revista dos Trabalhos de Iniciação Científica da UNICAMP, 1-1 , 2006
    2006.0
  • Orientador Dr. Fernando Moreira Simabuco
    MB SEVERINO, AE DO GENE, POR CRISPR