Synthesis and Solvatochromism of Oxazolone Derivative: Combining Organic Synthesis and Physical Organic Chemistry in a Single Experiment Taianne D’Angelo Korb, Lucia Helena Franco Martires Da Costa, Mauricio Ferreira Da Rosa Orbital, 2022 This work presents a proposal of experimental activity involving organic synthesis and solvatochromism of an organic molecule, correlating the content of organic chemistry and physical organic chemistry. This experiment presents a good opportunity to work with the classroom some of the content related to the mechanisms of organic reactions and the relationship between energy, electronic states, solute-solvent interactions, spectroscopy, among others in the area of physical chemistry, thus integrating knowledge. Experimentally, we synthesized through the Plöchl-Erlenmeyer method the oxazolonic derivative 4-[(p-N,N-dimethylamino)benzylidene]-2-phenyloxazole-5-one (AZA2) with good yield (78%), while the solvatochromic study showed that this derivative presented reverse solvatochromism; since in non-hydroxyl solvents it presented positive solvatochromism, but in protic solvents it presented negative solvatochromism. These different behaviors can be justified by the different solute-solvent interactions existing in each medium, which favors the prevalence of different mesomeric structures.
Synthesis and characterization of nanoparticulate zinc oxide: Preparation via sol-gel method and applications as a catalyst in the ciprofloxacin hydrochloride degradation Mauricio Ferreira da Rosa, Bruna Loesch Bortolini, Alessandra Eugenio Carli da Silva, Vinicius Alexandre Carvalho, Viviane da Silva Lobo Fronteiras, 2020 O presente trabalho reporta a síntese pelo método sol-gel de ZnO nanoparticulado (nZnO) e avalia sua atividade frente ao ZnO comercial (cZnO) como fotocatalisador na degradação do antibiótico cloridrato de ciprofloxacino (CIP) em solução aquosa. A caracterização do nZnO foi realizada por DRX, MEV, MET e infravermelho com transformada de Fourier. Os experimentos de fotodegradação foram organizados em um planejamento experimental 23 e a influência dos parâmetros [ZnO], [H2O2] e pH foram avaliados estatisticamente. Os resultados experimentais mostraram que as melhores condições para o processo de fotodegradação, [H2O2] = 500 mg L-1 e [ZnO] = 20 mg L-1 em pH 4, foram idênticas para ambos fotocatlisadores, e a atividade do nZnO foi 6% superior à atividade do cZnO. A pequena diferença observada na atividade do nZnO em relação ao cZnO pode ser atribuída à heterogeneidade morfológica do nZnO obtido sinteticamente.
Essential oil and fractions isolated of Laurel to control adults and larvae of cattle ticks Carla Maria Mariano Fernandez, Maurício Ferreira da Rosa, Ana Claudia Aparecida Mariano Fernandez, Wanessa de Campos Bortolucci, Fabiana Borges Padilha Ferreira, et al. Natural Product Research, 2020 This study, was to evaluate the acaricidal effect of the essential oil (EO) and fractions (FR) obtained from Laurus nobilis leaves on Rhipicephalus (Boophilus) microplus. Eight fractions were obtained, however FR1: sabinene (37.83%), β-pinene (13.50%), 1,8-cineole (12.66%), α-pinene (12.56%) and FR8: α-terpineol (79.19%) were highlighted as to the larvicidal potential when submitted by Larval Packet Test. The EO was tested by the Adult Immersion Test, at concentrations of 200.00; 100.00 and 50.00 µL/mL caused mortality of engorged females, egg mass reduction and hatching inhibition. Two fractions are shown to be efficient in controlling larvae FR8 (LC50 = 0.13 µL/mL, LC99 = 0.51 µL/mL) and FR1 (LC50 = 0.20 µL/mL, LC99 = 0.56 µL/mL). The fractionation of EO was determinant to elucidate which compounds were responsible for the larvicidal potential. This study opens new perspectives to direct new bioassays with the compounds obtained in the fractionation, since they present high potential on cattle tick larvae.
Larvicidal activity against aedes aegypti of essential oil of laurus nobilis leaves obtained at different seasons Carla Maria Mariano Fernandez, Maurício Ferreira da Rosa, Ana Claudia Aparecida Mariano Fernandez, Fabiana Brusco Lorenzetti, Keila Fernanda Raimundo, et al. Journal of Essential Oil Research, 2018 Aedes aegypti is a mosquito and vector of dengue, chikungunya and Zika virus making it a serious global health problem. We aimed to evaluate the chemical composition of the essential oil (EO) of Laurus nobilis leaves obtained at different seasons and its A. aegypti larvicidal activity. The EO was obtained from fresh leaves by hydrodistillation. Larvicidal activity was determined by the larval immersion test. It was identified 37 EO chemical compounds and the major ones were 1,8-cineole and linalool. Seasonal variations affected EO larvicidal activity: spring LC50 was 0.41 mg/mL and LC99 0.77 mg/mL, autumn LC50 was 0.60 mg/mL and LC99 1.37 mg/mL, winter LC50 was 0.66 mg/mL and LC99 3.19 mg/mL and summer LC50 was 0.91 mg/mL and LC99 2.50 mg/mL. The EO extracted during spring showed the highest larvicidal activity on A. aegypti larvae. Our results present a new perspective of L. nobilis EO use as a larvicidal agent.
Employment of photolytical and photocatalytical methodologies for removal of cephalexin in aqueous solution Periodico Tche Quimica, 2018
Development and validation of analytical methodology for quantification of propranolol hydrochloride in a multiparticulate biphasic system by UV-vis spectrophotometry Sarah Moherdaui Martins, Mauricio Ferreira da Rosa, Fábio Souza, Vanderson Galan, Vinícius Muller, et al. Acta Scientiarum Technology, 2018 Hypertension is one of the most important mortality risks in the world and is considered the leading cause of deaths associated with cardiovascular disease. In an attempt to improve the treatments and apply them to a large number of disorders, a propranolol hydrochloride (Prop) based medicine it was developed in our laboratory, employing a multiparticulate system which operates in a biphasic manner, one portion of immediate and other of modified release. This study aimed at developing and validating a suitable method to quantify this new version of the drug using UV spectrophotometry, following what is recommended in RE 899/2003. The results showed that the method employed was linear, accurate, precise and robust in the range of 0.8 to 96.0 μg mL -1 , which allows it for routine use in quality control laboratories.
Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases Sarah Moherdaui Martins, Vinicius Müller, Vanderson Galan, Fabio Pinheiro de Souza, Itamar Francisco Andreazza, et al. Brazilian Journal of Pharmaceutical Sciences, 2018 Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of circadian diseases. This system was obtained by the combination of cellulosic polymers hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) in a 22 factorial experimental design, which allowed the optimization of the development stage. The pellets produced and used in biphasic formulations were evaluated for physical and chemical characteristics and presented acceptable results. The immediate fraction obtained showed the complete release in 30 min while the others kept the release of the drug for 24 h. This study showed that the combination of beads with different releasing characteristics allowed to obtain different release profiles, which can be modulated according to the pathological needs, especially with regard to circadian diseases that suffer alterations throughout the day.
Photodegradation of essential oil from marjoram (origanum majorana L.) studied by GC-MS and UV-VIS spectroscopy Revista Latinoamericana De Quimica, 2013
Removal of toxic heavy metals cadmium, lead and chromium from swine biofertilizer, using an aquatic macrophyte (Eichornia crassipes) as a bioindicator Acta Scientiarum Technology, 2008
