MILENA BOTELHO PEREIRA SOARES

@bahia.fiocruz.br

Senior researcher, Instituto Gonçalo Moniz
Fundação Oswaldo Cruz

RESEARCH, TEACHING, or OTHER INTERESTS

Immunology, Biotechnology, Infectious Diseases, Drug Discovery
17133

Scholar Citations

68

Scholar h-index

316

Scholar i10-index

RECENT SCHOLAR PUBLICATIONS

  • Structure–Activity Relationship Analysis of Flavonoids Isolated from the Leaves of Erythroxylum rimosum O. E. Schulz
    IP dos Santos, MEV Costa, GA de Oliveira, FS Santos, DOS Vitória, ...
    Molecules 31 (10), 1669 , 2026
    2026
  • Prospective cohort study of TIMP-1 and myocardial fibrosis in Chagas disease at a reference clinic in Pernambuco, Brazil: PTICH trial protocol
    SM Martins, CT Macedo, CS Meira, LH Paim Santos, TF Larocca, ...
    BMJ open 16 (4), e107590 , 2026
    2026
  • Recent advances in drug discovery for Zika virus therapeutics
    RRM Souza, CM Orrico-Ferreira, DJPG Rocha, BVS Macêdo, ...
    Virology, 110889 , 2026
    2026
  • In silico and in vitro investigation of the safety and immunomodulatory mechanisms of 7-hydroxyflavone
    V da Silva Oliveira, DKC Silva, MVG das Neves, SSS Junior, ...
    Chemico-Biological Interactions, 111908 , 2026
    2026
  • Ruthenium Complexes Containing Thiobenzamide Act as Potent and Selective Anti- Trypanosoma cruzi Agents through Apoptotic Cell Death
    MVG das Neves, IS Cezar, E dos Santos Rodrigues, FCT Bomfim, ...
    ACS Infectious Diseases , 2026
    2026
    Citations: 1
  • Phenotypic and genomic features shaping the activity of a novel T4-like phage against clinical multidrug-resistant Klebsiella pneumoniae
    DDG Nunes, N Hitchcock, C de Araújo Rolo, D Rocha, ...
    2026
  • Cytotoxicity, Antibacterial Activity, Degradation and Release of ZnO‐NPs From PCL: PEO Electrospinning Membranes for Functional Wound Dressing Applications
    R Silveira, JL Vieira, MBP Soares, JDV Barbosa, T Gomes, ...
    Journal of Applied Polymer Science 143 (1), e57938 , 2026
    2026
    Citations: 1
  • Extracellular Vesicles Derived From Mesenchymal Bone Marrow Cells Promote Antinociception in a Murine Model of Diabetic Neuropathy via the Endogenous Opioid System
    GSA Silva, AF Evangelista, GC Santos, TA Santana, LCF Opretzka, ...
    Advanced Therapeutics 9 (1), e00195 , 2026
    2026
  • Phenanthrene Alkaloids From Guatteria Olivacea as Topoisomerase II Inhibitors: Theoretical Insights and Cytotoxic Evaluation
    RA Costa, VL Tananta, IO Corrêa, JS Al‐Otaibi, YS Mary, MBP Soares, ...
    ChemistrySelect 11 (2), e03648 , 2026
    2026
  • Monnieriside A from Evolvulus linarioides promotes antinociceptive effects in models of inflammatory and postoperative pain in male mice
    DF Agnelo-Silva, LCF Opretzka, MDM Viana, PSS Lauria, LCO Pereira, ...
    Natural Product Research 39 (24), 7003-7011 , 2025
    2025
    Citations: 1
  • Mesenchymal stem/stromal cells overexpressing leukemia inhibitory factor (LIF) promote arteriogenesis and functional recovery in a mouse model of critical hindlimb ischemia
    GC Santos, CM Azevedo, TO Ribeiro, BS Costa, IP Santos, ...
    Stem Cell Research & Therapy 16 (1), 660 , 2025
    2025
  • Alterations in Cardiac Metabolism by Trypanosoma cruzi Infection: A Metabolomic Assessment by RPLC-MS and GC–MS
    HC de Sá, B Cardim Barreto, MV Gomes das Neves, MGS Santos, ...
    ACS Infectious Diseases 11 (12), 3620-3630 , 2025
    2025
  • The effect of ancillary ligands on vasodilatory activity of nitrosyl ruthenium complexes
    IA Paz, CDS Silva, EM Carvalho, CS Meira, MBP Soares, ICN Diógenes, ...
    Journal of Inorganic Biochemistry, 113144 , 2025
    2025
  • Cordiaquinone B induces cytotoxicity and oxidative stress-mediated apoptosis in human colorectal cancer cells in vitro and in vivo
    SAN Matos Silva, FS Machado, LS Santos, MVL de Castro, ML Nogueira, ...
    CHEMICO-BIOLOGICAL INTERACTIONS 421 , 2025
    2025
  • Curcumin triggers reactive oxygen species-mediated apoptosis and suppresses tumor growth in metastatic oral squamous cell carcinoma
    TCF Ramos, RB Dias, LS Santos, LF Valverde, RLR Nogueira, IN Bastos, ...
    Frontiers in Oncology 15, 1668271 , 2025
    2025
    Citations: 2
  • CORDIAQUINONE B INDUCES CYTOTOXICITY AND OXIDATIVE STRESS-MEDIATED APOPTOSIS IN HUMAN COLORECTAL CANCER CELLS IN VITRO AND IN VIVO.
    SANM Silva, F dos Santos Machado, L de Souza Santos, MVL de Castro, ...
    Chemico-Biological Interactions, 111764 , 2025
    2025
  • The effects of fraxetin and monnieriside A on Cultured L929 fibroblasts
    D Leite Lopes, CF Villarreal, LC França Opretzka, MBP Soares, MS Silva, ...
    Natural Product Research 39 (18), 5277-5281 , 2025
    2025
    Citations: 1
  • Exploring Experimental and In Silico Approaches for Antibody–Drug Conjugates in Oncology Therapies
    VM de Almeida, MBP Soares, OA Santos-Filho
    Pharmaceuticals 18 (8), 1198 , 2025
    2025
    Citations: 3
  • In Vitro and In Vivo Efficacy of the Essential Oil from the Leaves of Annona amazonica R.E. Fries (Annonaceae) Against Liver Cancer
    MVL de Castro, MCF de Lima, GA da C. Barbosa, SG Carvalho, ...
    Molecules 30 (15), 3248 , 2025
    2025
  • FERAI, a novel brominated chalcone, induces ultrastructural alterations and apoptosis like-death in Leishmania braziliensis
    F da Silva Santos, GR Silva, LA Uzêda, CAM Campos, FL Ferreira, ...
    Acta Tropica 268, 107689 , 2025
    2025

MOST CITED SCHOLAR PUBLICATIONS

  • Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages
    CG Freire-de-Lima, DO Nascimento, MBP Soares, PT Bozza, ...
    Nature 403 (6766), 199-203 , 2000
    2000
    Citations: 550
  • In vitro and in vivo experimental models for drug screening and development for Chagas disease
    AJ Romanha, SL Castro, MNC Soeiro, J Lannes-Vieira, I Ribeiro, ...
    Memórias do Instituto Oswaldo Cruz 105, 233-238 , 2010
    2010
    Citations: 420
  • Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations
    S Garcia, CO Ramos, JFV Senra, F Vilas-Boas, MM Rodrigues, ...
    Antimicrobial agents and chemotherapy 49 (4), 1521-1528 , 2005
    2005
    Citations: 317
  • Anti-inflammatory effects of carvacrol: evidence for a key role of interleukin-10
    M da Silva Lima, LJ Quintans-Junior, WA de Santana, CM Kaneto, ...
    European journal of pharmacology 699 (1-3), 112-117 , 2013
    2013
    Citations: 299
  • Safety and neurological assessments after autologous transplantation of bone marrow mesenchymal stem cells in subjects with chronic spinal cord injury
    MVP Mendonça, TF Larocca, BS de Freitas Souza, CF Villarreal, ...
    Stem cell research & therapy 5 (6), 126 , 2014
    2014
    Citations: 264
  • Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells
    BSF Souza, GLA Sampaio, CS Pereira, GS Campos, SI Sardi, LAR Freitas, ...
    Scientific reports 6 (1), 39775 , 2016
    2016
    Citations: 256
  • A new chapter opens in anti-inflammatory treatments: the antidepressant bupropion lowers production of tumor necrosis factor-alpha and interferon-gamma in mice
    D Brustolim, R Ribeiro-dos-Santos, RE Kast, EL Altschuler, MBP Soares
    International immunopharmacology 6 (6), 903-907 , 2006
    2006
    Citations: 251
  • Inhibition of macrophage activation and lipopolysaccaride-induced death by seco-steroids purified from Physalis angulata L.
    MBP Soares, MC Bellintani, IM Ribeiro, TCB Tomassini, RR dos Santos
    European journal of pharmacology 459 (1), 107-112 , 2003
    2003
    Citations: 227
  • Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase–derived nitric oxide
    F Rios-Santos, JC Alves-Filho, FO Souto, F Spiller, A Freitas, CMC Lotufo, ...
    American journal of respiratory and critical care medicine 175 (5), 490-497 , 2007
    2007
    Citations: 223
  • Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease
    AC Lyra, MBP Soares, LFM da Silva, MF Fortes, AGP Silva, ...
    World journal of gastroenterology: WJG 13 (7), 1067 , 2007
    2007
    Citations: 187
  • Effects of umbelliferone in a murine model of allergic airway inflammation
    JF Vasconcelos, MM Teixeira, JM Barbosa-Filho, MF Agra, XP Nunes, ...
    European journal of pharmacology 609 (1-3), 126-131 , 2009
    2009
    Citations: 173
  • Current clinical landscape and global potential of bacteriophage therapy
    NM Hitchcock, D Devequi Gomes Nunes, J Shiach, ...
    Viruses 15 (4), 1020 , 2023
    2023
    Citations: 169
  • Infusion of autologous bone marrow mononuclear cells through hepatic artery results in a short-term improvement of liver function in patients with chronic liver disease: a …
    AC Lyra, MBP Soares, LFM da Silva, EL Braga, SA Oliveira, MF Fortes, ...
    European journal of gastroenterology & hepatology 22 (1), 33-42 , 2010
    2010
    Citations: 165
  • Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection
    MBP Soares, D Brustolim, LA Santos, MC Bellintani, FP Paiva, YM Ribeiro, ...
    International immunopharmacology 6 (3), 408-414 , 2006
    2006
    Citations: 163
  • Calcitonin gene-related peptide inhibits local acute inflammation and protects mice against lethal endotoxemia
    RN Gomes, HC Castro-Faria-Neto, PT Bozza, MBP Soares, ...
    Shock 24 (6), 590-594 , 2005
    2005
    Citations: 160
  • The vasoactive peptide maxadilan from sand fly saliva inhibits TNF-α and induces IL-6 by mouse macrophages through interaction with the pituitary adenylate cyclase-activating …
    MBP Soares, RG Titus, CB Shoemaker, JR David, M Bozza
    The Journal of Immunology 160 (4), 1811-1816 , 1998
    1998
    Citations: 160
  • Transplanted bone marrow cells repair heart tissue and reduce myocarditis in chronic chagasic mice
    MBP Soares, RS Lima, LL Rocha, CM Takyia, L Pontes-de-Carvalho, ...
    The American journal of pathology 164 (2), 441-447 , 2004
    2004
    Citations: 158
  • The use of biodiversity as source of new chemical entities against defined molecular targets for treatment of malaria, tuberculosis, and T-cell mediated diseases: a review
    LA Basso, LHP Silva, AG Fett-Neto, WF Azevedo Junior, ÍS Moreira, ...
    Memórias do Instituto Oswaldo Cruz 100, 475-506 , 2005
    2005
    Citations: 150
  • Exercise training-induced changes in microRNAs: beneficial regulatory effects in hypertension, type 2 diabetes, and obesity
    AC Improta Caria, CKV Nonaka, CS Pereira, MBP Soares, SG Macambira, ...
    International journal of molecular sciences 19 (11), 3608 , 2018
    2018
    Citations: 149
  • The pathogenesis of Chagas' disease: when autoimmune and parasite-specific immune responses meet
    MBP Soares, L Pontes-de-Carvalho, R Ribeiro-dos-Santos
    Anais da Academia Brasileira de Ciências 73 (4), 547-559 , 2001
    2001
    Citations: 148