Michchenko Ekaterina

@muctr.ru

Department of Nanomaterials and Nanotechnology
Mendeleev University of Chemical Technology of Russia



           

https://researchid.co/mishchenkoek

RESEARCH, TEACHING, or OTHER INTERESTS

Colloid and Surface Chemistry, Drug Guides

8

Scopus Publications

Scopus Publications

  • Nanoemulsions and Solid Lipid Nanoparticles with Encapsulated Doxorubicin and Thymoquinone
    E. V. Mishchenko, A. M. Gileva, E. A. Markvicheva, and M. Yu. Koroleva
    Pleiades Publishing Ltd


  • Bioavailability of nanoenulsions modified with curcumin and cerium dioxide nanoparticles
    A.D. Shirokikh, V.A. Anikina, E.A. Zamyatina, E.V. Mishchenko, M.Y. Koroleva, V.K. Ivanov, and N.R. Popova
    ITMO University

  • Microemulsions and nanoemulsions modified with cationic surfactants for improving the solubility and therapeutic efficacy of loaded drug indomethacin
    Alla B Mirgorodskaya, Marina Yu Koroleva, Rushana A Kushnazarova, Ekaterina V Mishchenko, Konstantin A Petrov, Oxana A Lenina, Alexandra B Vyshtakalyuk, Alexandra D Voloshina, and Lucia Ya Zakharova
    IOP Publishing
    Abstract In this work, a noncovalent strategy was successfully used to modify colloidal stability and in vitro and in vivo efficacy of two amphiphilic formulations of the anti-inflammatory drug indomethacin. Namely, nanoemulsions and microemulsions based on oleic acid and nonionic surfactants have been produced and compared. The influence of cationic surfactants cetyltrimethylammonium bromide and its carbamate bearing analogue on the size characteristics, stability and ability to provide prolonged action of loaded drug indomethacin has been evaluated. Adding the positively charged molecules in the surface layer of nanoemulsions and microemulsions has shown the stability increase along with maintaining the size characteristics and homogeneity in time. Moreover, the carbamate modified analogue demonstrated beneficial behavior. Indomethacin loaded in microemulsions and nanoemulsions showed prolonged-release (10%–15% release for 5 h) compared to a free drug (complete release for 5 h). The rate of release of indomethacin from nanoemulsions was slightly higher than from microemulsions and insignificantly decreased with an increase in the concentration of the cationic surfactant. For carbamate surfactant nanocarrier loaded with fluorescence probe Nile Red, the ability to penetrate into the cell was supported by flow cytometry study and visualized by fluorescence microscopy. In vitro tests on anti-inflammatory activity of the systems demonstrated that the blood cell membrane stabilization increased in the case of modified microemulsion. The anti-inflammatory activity of the encapsulated drug was tested in rats using a carrageenan-induced edema model. Nanoemulsions without cationic surfactants appeared more efficient compared to microemulsions. Indomethacin emulsion formulations with carbamate surfactant added showed slower carrageenan-induced edema progression compared to unmodified compositions. Meanwhile, the edema completely disappeared upon treatment with emulsion loaded indomethacin after 4 h in the case of microemulsions versus 5 h in the case of nanoemulsions.

  • Solid lipid nanoparticles and nanoemulsions with solid shell: Physical and thermal stability
    M. Koroleva, I. Portnaya, E. Mischenko, I. Abutbul-Ionita, L. Kolik-Shmuel, and D. Danino
    Elsevier BV

  • Nanoemulsions and Nanocapsules with Oleic Acid
    E. V. Mishchenko, E. E. Timofeeva, A. S. Artamonov, I. B. Portnaya, and M. Yu. Koroleva
    Pleiades Publishing Ltd

  • Economic and fast electro-flotation extraction of heavy metals from wastewater
    Imran Ali, Kon’kova Tatiana, Than Zaw Htay, Hein Thu Aung, Mishenko Ekaterina, Mohammad Nahid Siddiqui, Abdulraheem S. A. Almalki, A. Alhadhrami, Abdullah alsubaie, Ahmed M. Hameed,et al.
    Informa UK Limited
    ABSTRACT Fast electroflotation extraction of heavy metals from wastewater is described. The results of experimental investigations of the extraction of iron, aluminium and chromium hydroxides from aqueous solutions in the presence of surfactants of various natures and ions of calcium by electroflotation are presented. It was found that the presence of Ca2+ in the solution at a concentration of 0.5 g/L reduced the degree of electroflotation extraction of Al(OH)3, Fe(OH)3, Cr(OH)3 regardless of the nature of the electrolyte. The addition of surfactants in the system in the presence of Ca2+ increased the amount of extraction of the dispersed phase. The greatest effect is achieved with the help of anionic surfactant sodium dodecyl sulphate, while the degree of extraction reached 98%. The high efficiency of the process of electroflotation extraction of the dispersed phase was due to the hydrophobization of the particle surface owing to the adsorption of surfactants on the surface of hydroxides. The recent method is useful to treat wastewater contaminated with aluminium, iron and chromium metal ions. The reason is that this method is very fast working within 20 min; Moreover, pH 7.0 working made this method ideal for utilisation in natural water treatment economically. GRAPHICAL ABSTRACT

  • Mechanism of Inversion of Montmorillonite Sorption Properties by Cationic Surfactant
    T. V. Kon’kova, A. P. Rysev, and E. V. Mishchenko
    Pleiades Publishing Ltd