Antihyperglycemic Effect of Fenugreek and Ginger in Patients with Type 2 Diabetes: A Double-Blind, Placebo-controlled Study Mohamed A. Elsaadany, Hussah M. AlTwejry, Rwabi A. Zabran, Sara A. AlShuraim, Wala'a A. AlShaia, Omar I. Abuzaid, Waleed I. AlBaker Current Nutrition and Food Science, 2022 Background: Type 2 diabetes mellitus (T2DM) is a worldwide chronic, complex, and progressive disease that usually requires combination therapy for improved glycemic control. Although conventional medicine showed more potency than herbal medicine, a combination of both may result in better therapeutic outcomes with fewer side effects. Objective: This study was conducted to investigate the antihyperglycemic potential of fenugreek seeds (Trigonellafoenum-graecum L.) and ginger root (Zingiber officinalis) in patients with T2DM along with their usual antidiabetic medications. Methods: double-blind, placebo-controlled study was conducted using 33 cases, who were randomly divided into three groups. The first group received oral placebo capsules (1 g 3 times a day) and served as a control group, while the other two groups each received capsules of either fenugreek or ginger powder of the same dosage (1 g 3 times a day). The study was conducted for 8 weeks and treatment effects in patients were assessed through the measurements of serum’s fasting blood sugar (FBS), HbA1c, lipid profile, as well as kidney and liver functions. Results and Discussion: After 8 weeks of intervention, fenugreek and ginger induced a significant reduction in FBS by 19.1 ± 3.8% and 16.0 ± 8.0% compared to their baselines, respectively (p ≤ 0.05). Moreover, fenugreek significantly reduced HbA1c by 15.9 ± 4.9% compared to the baseline, while ginger did not. Creatinine and triglyceride levels were also reduced significantly (p ≤ 0.05) compared to their baselines in both fenugreek and ginger groups. However, all the other parameters did not significantly change. Conclusion: This study provides evidence that using fenugreek and ginger may enhance glycemic control in T2DM patients. Additionally, they might improve kidney function and lipids profile. Clinical Trial Registeration: The clinical trial has been registered with the number (2015-03‐229) at King Fahd University Hospital, Dammam, Saudi Arabia.
Antihyperglycemic effect of fenugreek and ginger in patients with type 2 diabetes: A double-blind, placebo-controlled study MA Elsaadany, HM AlTwejry, RA Zabran, SA AlShuraim, WA AlShaia, ... Current Nutrition & Food Science 18 (2), 231-237 , 2022 2022.0 Citations: 14
التأثير العلاجي لبعض النباتات على الفئران المصابة بالتوحد أحمد, عادل, الطحان, نهاد, الشريف, سارة, السعدنى مجلة الاقتصاد المنزلي. جامعة المنوفية 28 (4), 155-169 , 2018 2018.0
Effect of some plant extracts on blood glucose and other biological parameters of type 2 diabetic patients. تأثير بعض المستخلصات النباتية في تحسين مستوى جلوکوز الدم والقياسات … H Ahmed Helal, M Elsaadany, M Abd-Elnaby El-Gonimy المجلة العلمية لعلوم التربية النوعية 2 (2), 59-67 , 2015 2015.0
Use Of Some Dietary Supplements For Improving Liver Functions In Children Suffering From Hepatitis. MM Ali, AA Allam, MA El-Saadany, MA El-Khalefa Journal of Home Economics 25 (1) , 2015 2015.0
The use of dietary antioxidants to improve on CCl4 hepatotoxicity rats. TM Abd EL-Rahman, M El-Saadany, ZS Hashkyl Journal of Home Economics 25 (2) , 2015 2015.0
ANTI INFLAMMATORY EFFECT OF SELECTED DIETARY ANTI OXIDANTS TMA El Rahman, MA Meged, SMHA ElSaadany Journal of Home Economics 23 (1) , 2013 2013.0
Protective effect of dietary antioxidants and plant extracts on acute inflammation and hepatotoxicity in vitro FJS Mohamed El-saadany Potsdam , 2009 2009.0
Protective effect of dietary antioxidants and plant extracts on acute inflammation and hepatotoxicity in vitro MAMM El-Saadany Universität Potsdam , 2009 2009.0
Antioxidants modulate the IL‐6 induced inhibition of negative acute‐phase protein secretion in HepG2 cells MA El‐Saadany, HM Rawel, J Raila, MS El‐Dashloty, FJ Schweigert Cell Biochemistry and Function 26 (1), 95-101 , 2008 2008.0 Citations: 24
The effect of dietary phytochemicals on the prevention of liver cancer initiation induced by some chemical carcinogenesis MA El-Saadany M. Sc. Thesis, Fac. of Home Economics, Minufiya University, Shebin El-Kom, Egypt , 2001 2001.0 Citations: 19
Effect of some plant extracts on blood glucose and other biological parameters of type 2 diabetic patients. HA Helal, MAE El-Gonimy, MA Elsaadany
MOST CITED SCHOLAR PUBLICATIONS
Antioxidants modulate the IL‐6 induced inhibition of negative acute‐phase protein secretion in HepG2 cells MA El‐Saadany, HM Rawel, J Raila, MS El‐Dashloty, FJ Schweigert Cell Biochemistry and Function 26 (1), 95-101 , 2008 2008.0 Citations: 24
The effect of dietary phytochemicals on the prevention of liver cancer initiation induced by some chemical carcinogenesis MA El-Saadany M. Sc. Thesis, Fac. of Home Economics, Minufiya University, Shebin El-Kom, Egypt , 2001 2001.0 Citations: 19
Antihyperglycemic effect of fenugreek and ginger in patients with type 2 diabetes: A double-blind, placebo-controlled study MA Elsaadany, HM AlTwejry, RA Zabran, SA AlShuraim, WA AlShaia, ... Current Nutrition & Food Science 18 (2), 231-237 , 2022 2022.0 Citations: 14
التأثير العلاجي لبعض النباتات على الفئران المصابة بالتوحد أحمد, عادل, الطحان, نهاد, الشريف, سارة, السعدنى مجلة الاقتصاد المنزلي. جامعة المنوفية 28 (4), 155-169 , 2018 2018.0
Effect of some plant extracts on blood glucose and other biological parameters of type 2 diabetic patients. تأثير بعض المستخلصات النباتية في تحسين مستوى جلوکوز الدم والقياسات … H Ahmed Helal, M Elsaadany, M Abd-Elnaby El-Gonimy المجلة العلمية لعلوم التربية النوعية 2 (2), 59-67 , 2015 2015.0
Use Of Some Dietary Supplements For Improving Liver Functions In Children Suffering From Hepatitis. MM Ali, AA Allam, MA El-Saadany, MA El-Khalefa Journal of Home Economics 25 (1) , 2015 2015.0
The use of dietary antioxidants to improve on CCl4 hepatotoxicity rats. TM Abd EL-Rahman, M El-Saadany, ZS Hashkyl Journal of Home Economics 25 (2) , 2015 2015.0
ANTI INFLAMMATORY EFFECT OF SELECTED DIETARY ANTI OXIDANTS TMA El Rahman, MA Meged, SMHA ElSaadany Journal of Home Economics 23 (1) , 2013 2013.0
Protective effect of dietary antioxidants and plant extracts on acute inflammation and hepatotoxicity in vitro FJS Mohamed El-saadany Potsdam , 2009 2009.0
Protective effect of dietary antioxidants and plant extracts on acute inflammation and hepatotoxicity in vitro MAMM El-Saadany Universität Potsdam , 2009 2009.0
Effect of some plant extracts on blood glucose and other biological parameters of type 2 diabetic patients. HA Helal, MAE El-Gonimy, MA Elsaadany
