Mónica Guadalupe Retuerto-Figueroa

Química Farmacéutica egresada de la Universidad Nacional Mayor de san Marcos (UNMSM), Maestro en Medio Ambiente y Desarrollo Sostenible, con estudios de Maestría en Recursos Vegetales y Terapéuticos (UNMSM), estudios de Doctorado en Farmacia y Bioquímica. Investigadora de plantas medicinales y Medio Ambiente. Ganadora de Proyectos INNOVATE PERU y proyectos financiados por el Vicerrectorado de Investigación de la UNMSM. Formuladora y evaluadora de proyectos de Investigación por pares y asesora de tesis de pregrado y posgrado en el área de Salud y Medio Ambiente; perteneciente a los Grupos de Investigación de Farmacognosia y Medicina Tradicional - FARMA y Biotechnology and Omics in Life Sciences. Asociaciones ABC - Associação Brasileira de Cosmetologia y Sociedade Brasileira de Farmacognosia.

RESEARCH INTERESTS

Plantas medicinales con potencial farmacéutico, alimenticio, cosmético y productos naturales terapéuticos: (estudios fitoquímicos, estudios toxicológicos, estudios farmacológicos, procesos de su industrialización)
Alimentos funcionales y nutracéuticos
Toxicología y medio Ambiente

Scopus Publications

In vitro cytotoxic and genotoxic effect of the crude and ethanolic extract from the rhizome of curcuma longa l.
Martha F. Cosquillo-Rafael, Maritza D. Placencia-Medina, Tomás Y. Miranda-Tomasevich, Miriam Moreno-Hinojosa, and Mónica G. Retuerto-Figueroa
Instituto Nacional de Salud (Peru)
Objetivos: Determinar el efecto citotóxico y genotóxico in vitro del extracto crudo y etanólico del rizoma de Curcuma longa L. Materiales y métodos: El efecto citotóxico fue evaluado utilizando líneas celulares DU-145, HT-29, 3T3 BALB/c. Se hallaron los porcentajes de crecimiento en 48 horas y se determinó la concentración inhibitoria 50 (CI50). El efecto genotóxico en el ADN genómico humano se determinó mediante el método Tomasevich. Resultados: El extracto crudo produjo una CI50 de 12,98 ± 0,21 μg/mL para la línea celular tumoral HT-29, que es inferior a DU-145 con una CI50 de 36,77 ± 9,12 μg/mL; el extracto etanólico presentó una CI50 de 13,24 ± 0,77 y 20,54 ± 2,58 µg/mL para ambas líneas celulares, respectivamente; el compuesto estándar curcumina presentó una CI50 de 3,96 ± 0,60 y 13,94 ± 2,79 μg/mL, respectivamente. El extracto crudo a concentraciones de 50 y 100 mg/mL fragmentó entre el 40% a 95% de ADN genómico humano; mientras que, a 200 mg/mL, la fragmentación fue mayor al 95%. El extracto etanólico a todas las concentraciones no fragmentó el ADN. La curcumina a 200 mg/mL fragmentó menos del 5% de ADN genómico humano. Conclusiones: Los extractos crudo y etanólico de Curcuma longa L. demuestran efecto citotóxico in vitro diferencial para la línea celular tumoral humana DU-145 y HT29 semejante al compuesto estándar curcumina. El extracto crudo de Curcuma longa L. presenta una potente actividad genotóxica in vitro frente al ADN genómico humano, esta actividad está ausente en el extracto etanólico.


Morphoanatomical study and genomic DNA extraction for molecular characterization of Sinningia warmingii (Hiern) Chautems "papa madre"
Eva Ramos-Llica, Mónica G. Retuerto-Figueroa, Arilmí Gorriti-Gutierrez, César Fuertes-Ruitón, Teresa GallardoJugo, Celia Vargas de la Cruz, Elizabeth Ortega-Romero, and Md. Shariful Islam
Africa Health Research Organization
Introduction: Sinningia warmingii (Hiern) Chautems (Gesneriaceae) is used in north eastern from Peru to relieve postpartum diseases and vaginal descents. The objective of the present study: to carry out morpho-anatomic analysis and extraction of the genomic DNA of the Sinningia warmingii "mother potato" species to identify the species. The sample was collected in Utcubamba-Amazonas. The morpho-anatomic study applied histological cutting techniques and genetic characterization with rbc-L, matK, ITS and trnH-psbA markers. Method: Morphologically, it is a herbaceous species, with opposite leaves, shortly petiolated, the apical: sessile, oval, symmetrical, regularly closed edges, obtuse base, and acute apex. Flowers with greenish bell-shaped calyx, lobes with acute apex; tubular corolla, pink-fuchsia and yellow inside. Pubescent capsule fruit. Anatomically, abundant filiform and glandular multicellular trichomes, anomocitic stomata and vacuoles of phenolic substances (anthocyanins and tannins) were observed in the stem and leaves. open vascular bundle the stem has woody vessels (helicollen tracheids) and open lateral vascular bundles. In the root (“papa madre”), ovoid amyloplasts and brachisclereids were recognized. Results:For the genetic characterization, genomic DNA was obtained, which was used to amplify by PCR: segments of the genes used for the bar code have been amplified with chloroplastidial markers (rbc-L, matk and ITS2) whose amplifications were positive. Sequencing has been performed with other species of the Sinningia genus that have confirmed the molecular characteristics of the genus. Conclusión: the morpho-anatomic characteristics of the studied species correspond to the Sinningia warmingii species, which with this biomolecular study confirmed its correspondence to the Sinningia genus.


Evaluation of antimicrobial activity antioxidant and cytotoxicity of ethanolic and aqueous extracts of Tagetes multiflora Kunth chinche
David Velásquez, Teresa Gallardo-Jugo, Mónica G. Retuerto-Figueroa, Eva Ramos-Llica, María Calixto, Celia Vargas de la Cruz, Elizabeth C. Ortega-Romero, Nelson Bautista-Cruz, and Md. Shariful Islam
Africa Health Research Organization



Macronutrients, polyphenols and antioxidant capacity of the peel and pulp of the fruit Oenocarpus bataua mart. “Ungurahui”
María Rosario Calixto Cotos, Imad Hadi Hameed, Sofia Belinda Espinoza Escajadillo, Eva Ramos Llica, Mónica Guadalupe Retuerto Figueroa, and José E. Olivera Garcia
A and V Publications



Contribution of topical antioxidants to maintain healthy skin—A review
Tércio Elyan Azevedo Martins, Claudinéia Aparecida Sales de Oliveira Pinto, Andressa Costa de Oliveira, Maria Valéria Robles Velasco, Arilmí Rosa Gorriti Guitiérrez, Martha Francisca Cosquillo Rafael, Jossimar Paúl Huamaní Tarazona, and Mónica Guadalupe Retuerto-Figueroa
MDPI AG
The skin is constantly exposed to various environmental stresses, in particular to the damage caused by pollution and ultraviolet radiation (UV), and as a consequence, the horny extract can be negatively impacted by the harmful influence of some of its surface components. The mechanisms involved in the degradation processes promoted by UV radiation are driven by the direct absorption of radiation via cellular chromophores, the formation of excited states and the consequent chemical reactions, or even by the photosensitization mechanisms, in which UV light is absorbed by the sensitizers that are excited and their reactions promote the formation of reactive oxygen species (ROS). The mechanisms of polluting agents are not yet fully understood, however, they indicate that one of the main mechanisms involved is oxidative stress by lipid peroxidation, with the ability to promote damage to the composition of sebum, the quality of the stratum corneum and also, promote aging skin. Recent studies demonstrate the potential of antioxidant agents, with an emphasis on products of natural origin, which try to promote the maintenance of the physiological balance of the skin.


PARK11 and Gut-microbiota in Parkinson’s disease- Is there a link?
Celia-Vargas de la Cruz, Shariful Islam, T. G. Jugo, César-Fuertes Ruiton, Mónica G-Retuerto Figueroa, Eva Ramos-Llica, A. Gutierrez and Sixto-Gonzalez Elera
SynthesisHub Advance Scientific Research
Parkinson’s disease is a genetically heterogeneous, idiopathic and metacentric neurodegenerative disease of the nervous system characterized by progressive generalized slowing movements like bradykinesia, weakness, tremor, and rigidity, and postural instability in along with Parkinson’s disease has been pondered to be a non-genetic distemper. A different way, features are associated such as sleep dysfunction, loss of smell, mood disorder, constipation, excessive salivation, and excessive periodic limb movements in sleep. Feudatory factors encompass head injury, pesticide exposure, and agriculture background. Results with development and assembling of α- synuclein in the central nervous system in the substantia nigra. A little while back, in North American, Parkinson’s disease is a significant relationship indicated to 39.5cM of chromosome 2 (2q36-37; PARK11) portion on the deep arm. Immune-related disorder, notably Crohn’s and leprosy diseases are also associated with Parkinson’s disease, however around 15% persona with Parkinson’s disease have primary level correlative who has the distemper in the genes including LRRK2, SNCA, last one GBA found as a keek part for sporadic Parkinson’s disease.

Publications

Artículos en revistas de investigación especializadas y en base de dato relevantes
1 Título: Contribution of Topical Antioxidants to Maintain Healthy Skin—A Review
Año de publicación: 2020
Revista: Scientia Pharmaceutica
Base de Datos: ( ESCI - Web of Science), Scopus y otras bases de datos .
DOI:
CiteScore 2019 (Scopus): 2.9 , que equivale al rango 73/169 (Q2) en la categoría 'Ciencia Farmacéutica'.
2020
2 Título: “Evaluation of antimicrobial activity antioxidant and cytotoxicity of ethanolic and aqueous extracts of Tagetes multiflora Kunt Chinche”
Año de publicación: 2020
Revista: Annals of Tropical Medicine and Public Health

Base de Datos: SCOPUS
DOI:
2020
3 Título: “Morphoanatomical study and genomic DNA extration for biomolecule characterization of Sinningia warmingii ((Hiern) Chautems “papa madre”
Año de publicación: 2020
Revista: Annals of Tropical Medicine and Public Health

Base de Datos: SCOPUS
DOI: 2020
4 Título: Macronutrients, polyphenols and antioxidant capacity of the peel and Pulp of the fruit Oenocarpus bataua Mart. “ungurahui”
Año de publicación: 2020
Revista: Research Journal of Pharmacy and Technology

Base de Datos: SCOPUS, Google Scholar, CNKI Scholar, EBSCO Discovery, Summon(ProQuest)
DOI: 10.5958/0974-360X.2020.00394.7
2020
5 Título: Estudio farmacognóstico, antioxidante y citotóxico de Sinningia warmingii "papa madre"
Año de publicación: 2020
Revista de Toxicología AETOX

Base de Datos: Scopus, Latindex, REDALYC, REDIB, IBECS, ICYT, Index Copernicus, IME, Recolecta, EMBASE/ Excerpta Medica y Chemical Abstracts
Issn 0212-7113 2020
6 Título: Potential applications of calocybe indica ethanol extract in noniceptive and neuronal pain
Año de publicación: 2020
Revista:International Journal of Psychosocial Rehabilitation

Base de Datos: SCOPUS
DOI: 10.37200/IJPR/V24I2/PR200317
2020
7 Título: PARK11 and Gut-microbiota in Parkinson’s disease- Is there a link?
Año de publicación: 2020
Revista: Journal of Critical Reviews

Base de Datos: SCOPUS
DOI: doi: 10.31838/
2020
8 Título: caracterización físico-química y capacidad antioxidante de extractos del rizoma de Curcuma longa L.
Revista: Revista Peruana de Medicina Integrativa
Vol. 3, N° 4. ISSN electrónica 2415 – 2692.
Base de Datos: LILEPCS, LILACS y Google Académico.
DOI:
2018
9 Título: Efecto de la Humedad Relativa y la Temperatura en La Aplicación de Insecticidas Organofosforados y Carbamatos e Impacto en la Colinesterasa de Agro Productores de Tomate (Solanum Lycopersicum L.) en la localidad de “San Luis, Chimborazo, Ecuador
Revista: European Scientific Journal August 2018 Edition , ISSN: 1857 – 7881 (Print) e - ISSN 1857- 7431

Base de Datos:
DOI:
2018
10 Título: Impacto en los niveles de colinesterasa en agricultores de tomate (Solanum lycopersicum L) en la localidad de San Luis, Chimborazo por efecto del uso de insecticidas organofosforados y carbamatos
Revista: Revista del Instituto de Investigación de la Facultad de Ingeniería Geológica, Minera, Metalúrgica y Geográfica. Vol. 20, Núm. 40 (2017). Online ISSN: 1682-3087. Print ISSN: 1561-0888

Base de Datos: Latindex, REDIB, ALICIA,
DOI:
2017